GT201600168A - Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti dll3) y medicamentos para usarse en el tratamiento contra melanoma. - Google Patents
Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti dll3) y medicamentos para usarse en el tratamiento contra melanoma.Info
- Publication number
- GT201600168A GT201600168A GT201600168A GT201600168A GT201600168A GT 201600168 A GT201600168 A GT 201600168A GT 201600168 A GT201600168 A GT 201600168A GT 201600168 A GT201600168 A GT 201600168A GT 201600168 A GT201600168 A GT 201600168A
- Authority
- GT
- Guatemala
- Prior art keywords
- conjugates
- drosophila
- medicines
- delta
- dll3
- Prior art date
Links
- 229940127276 delta-like ligand 3 Drugs 0.000 title abstract 2
- 201000001441 melanoma Diseases 0.000 title abstract 2
- 102100036466 Delta-like protein 3 Human genes 0.000 title 1
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000003745 diagnosis Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68035—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a pyrrolobenzodiazepine
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6865—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from skin, nerves or brain cancer cell
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K—PEPTIDES
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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Abstract
LA PRESENTE INVENCIÓN DESCRIBE ANTICUERPOS ANTI-DLL3 Y CONJUGADOS DE ANTICUERPO Y MEDICAMENTO PARA USARSE EN EL DIAGNÓSTICO Y TRATAMIENTO DE MELANOMA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461942796P | 2014-02-21 | 2014-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT201600168A true GT201600168A (es) | 2018-12-20 |
Family
ID=53879125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT201600168A GT201600168A (es) | 2014-02-21 | 2016-08-19 | Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti dll3) y medicamentos para usarse en el tratamiento contra melanoma. |
Country Status (20)
Country | Link |
---|---|
US (1) | US10308721B2 (es) |
EP (1) | EP3107576A4 (es) |
JP (1) | JP2017514143A (es) |
KR (1) | KR20170008202A (es) |
CN (1) | CN106550593A (es) |
AU (1) | AU2015218633A1 (es) |
BR (1) | BR112016018891A2 (es) |
CA (1) | CA2939941A1 (es) |
CL (2) | CL2016002105A1 (es) |
CR (1) | CR20160437A (es) |
DO (1) | DOP2016000214A (es) |
EA (1) | EA201691683A1 (es) |
EC (1) | ECSP16075472A (es) |
GT (1) | GT201600168A (es) |
IL (1) | IL247248A0 (es) |
MX (1) | MX2016010677A (es) |
PE (1) | PE20161209A1 (es) |
PH (1) | PH12016501618A1 (es) |
SG (1) | SG11201606898TA (es) |
WO (1) | WO2015127407A1 (es) |
Families Citing this family (32)
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DK3342786T3 (en) * | 2010-01-29 | 2021-09-27 | Chugai Pharmaceutical Co Ltd | Anti-dll3-antistof |
US9534058B2 (en) | 2012-02-08 | 2017-01-03 | Abbvie Stemcentrx Llc | Anti-CD324 monoclonal antibodies and uses thereof |
EP2817338B1 (en) | 2012-02-24 | 2017-07-26 | AbbVie Stemcentrx LLC | Dll3 modulators and methods of use |
PT2888283T (pt) | 2012-08-24 | 2018-11-16 | Univ California | Anticorpos e vacinas para serem utilizados no tratamento de cancros que expressam ror1 e inibição de metástases |
WO2014130879A2 (en) | 2013-02-22 | 2014-08-28 | Stem Centrx, Inc. | Novel antibody conjugates and uses thereof |
CN105873612A (zh) * | 2013-08-28 | 2016-08-17 | 施特姆森特克斯股份有限公司 | 改造的抗-dll3缀合物以及应用方法 |
ES2871418T3 (es) | 2013-08-28 | 2021-10-28 | Abbvie Stemcentrx Llc | Composiciones y métodos de conjugación de anticuerpos específicos de sitio |
US10308721B2 (en) | 2014-02-21 | 2019-06-04 | Abbvie Stemcentrx Llc | Anti-DLL3 antibodies and drug conjugates for use in melanoma |
TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗mfi2抗體及使用方法 |
JP6767096B2 (ja) * | 2014-12-11 | 2020-10-14 | リティックス バイオファーマ エイエス | 免疫チェックポイント阻害剤の組み合わせ |
JP6813258B2 (ja) | 2014-12-11 | 2021-01-13 | リティックス バイオファーマ エイエス | 化学療法の組み合わせ |
CA2971734A1 (en) * | 2014-12-22 | 2016-06-30 | Enumeral Biomedical Holdings, Inc. | Anti-pd-1 antibodies |
US11639385B2 (en) | 2014-12-22 | 2023-05-02 | Pd-1 Acquisition Group, Llc | Anti-PD-1 antibodies |
KR20220004226A (ko) | 2016-03-22 | 2022-01-11 | 바이오노믹스 리미티드 | 항-lgr5 단클론성 항체의 투여 |
TW201805309A (zh) | 2016-04-21 | 2018-02-16 | 艾伯維史坦森特瑞斯有限責任公司 | 新穎抗-bmpr1b抗體及使用方法 |
AU2017267789A1 (en) * | 2016-05-20 | 2018-12-06 | Abbvie Stemcentrx Llc | Anti-DLL3 drug conjugates for treating tumors at risk of neuroendocrine transition |
KR20230047507A (ko) | 2016-06-27 | 2023-04-07 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 암 치료 조합 |
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AU2017361521B2 (en) | 2016-11-21 | 2020-08-27 | Nanostring Technologies, Inc. | Chemical compositions and methods of using same |
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CN111465612A (zh) | 2017-10-13 | 2020-07-28 | 哈普恩治疗公司 | B细胞成熟抗原结合蛋白 |
EP3732195A4 (en) | 2017-12-28 | 2022-02-09 | Chugai Seiyaku Kabushiki Kaisha | CYTOTOXICITY-INDUCING THERAPEUTIC |
US11327078B2 (en) * | 2018-02-27 | 2022-05-10 | Eisai R&D Management Co., Ltd. | Monoclonal antibody against APOA4, immunological measurement method, and kit for measurement |
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-
2015
- 2015-02-23 US US15/120,499 patent/US10308721B2/en not_active Expired - Fee Related
- 2015-02-23 SG SG11201606898TA patent/SG11201606898TA/en unknown
- 2015-02-23 JP JP2016570928A patent/JP2017514143A/ja active Pending
- 2015-02-23 BR BR112016018891A patent/BR112016018891A2/pt not_active Application Discontinuation
- 2015-02-23 AU AU2015218633A patent/AU2015218633A1/en not_active Abandoned
- 2015-02-23 CR CR20160437A patent/CR20160437A/es unknown
- 2015-02-23 MX MX2016010677A patent/MX2016010677A/es unknown
- 2015-02-23 KR KR1020167026083A patent/KR20170008202A/ko unknown
- 2015-02-23 CN CN201580015510.9A patent/CN106550593A/zh active Pending
- 2015-02-23 EP EP15752054.5A patent/EP3107576A4/en not_active Withdrawn
- 2015-02-23 WO PCT/US2015/017171 patent/WO2015127407A1/en active Application Filing
- 2015-02-23 EA EA201691683A patent/EA201691683A1/ru unknown
- 2015-02-23 PE PE2016001508A patent/PE20161209A1/es not_active Application Discontinuation
- 2015-02-23 CA CA2939941A patent/CA2939941A1/en not_active Abandoned
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2016
- 2016-08-11 IL IL247248A patent/IL247248A0/en unknown
- 2016-08-15 PH PH12016501618A patent/PH12016501618A1/en unknown
- 2016-08-19 DO DO2016000214A patent/DOP2016000214A/es unknown
- 2016-08-19 GT GT201600168A patent/GT201600168A/es unknown
- 2016-08-19 CL CL2016002105A patent/CL2016002105A1/es unknown
- 2016-09-20 EC ECIEPI201675472A patent/ECSP16075472A/es unknown
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2018
- 2018-06-18 CL CL2018001646A patent/CL2018001646A1/es unknown
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SG11201606898TA (en) | 2016-09-29 |
EP3107576A1 (en) | 2016-12-28 |
CN106550593A (zh) | 2017-03-29 |
MX2016010677A (es) | 2017-04-10 |
WO2015127407A1 (en) | 2015-08-27 |
KR20170008202A (ko) | 2017-01-23 |
BR112016018891A2 (pt) | 2017-10-10 |
EA201691683A1 (ru) | 2017-04-28 |
CL2018001646A1 (es) | 2018-10-05 |
US10308721B2 (en) | 2019-06-04 |
PE20161209A1 (es) | 2016-11-10 |
EP3107576A4 (en) | 2017-09-06 |
US20170137533A1 (en) | 2017-05-18 |
IL247248A0 (en) | 2016-09-29 |
DOP2016000214A (es) | 2016-11-30 |
AU2015218633A1 (en) | 2016-09-01 |
CL2016002105A1 (es) | 2017-03-31 |
CR20160437A (es) | 2017-02-20 |
ECSP16075472A (es) | 2017-03-31 |
PH12016501618A1 (en) | 2017-02-06 |
JP2017514143A (ja) | 2017-06-01 |
CA2939941A1 (en) | 2015-08-27 |
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