GR3030327T3 - Process for the purification of 2,6-diisopropylphenol - Google Patents

Process for the purification of 2,6-diisopropylphenol

Info

Publication number
GR3030327T3
GR3030327T3 GR990401414T GR990401414T GR3030327T3 GR 3030327 T3 GR3030327 T3 GR 3030327T3 GR 990401414 T GR990401414 T GR 990401414T GR 990401414 T GR990401414 T GR 990401414T GR 3030327 T3 GR3030327 T3 GR 3030327T3
Authority
GR
Greece
Prior art keywords
diisopropylphenol
purification
propofol
crystallization
hydrolysis
Prior art date
Application number
GR990401414T
Other languages
English (en)
Inventor
Maurizio Paiocchi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of GR3030327T3 publication Critical patent/GR3030327T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/24—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/86—Purification; separation; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GR990401414T 1994-09-28 1999-05-27 Process for the purification of 2,6-diisopropylphenol GR3030327T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI941969A IT1270093B (it) 1994-09-28 1994-09-28 Processo per la purificazione di 2,6-diisopropilfenolo
PCT/EP1995/003676 WO1996010004A1 (en) 1994-09-28 1995-09-18 Process for the purification of 2,6-diisopropylphenol

Publications (1)

Publication Number Publication Date
GR3030327T3 true GR3030327T3 (en) 1999-09-30

Family

ID=11369606

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401414T GR3030327T3 (en) 1994-09-28 1999-05-27 Process for the purification of 2,6-diisopropylphenol

Country Status (17)

Country Link
US (1) US5589598A (el)
EP (1) EP0783473B1 (el)
JP (1) JP3701974B2 (el)
AT (1) ATE178041T1 (el)
AU (1) AU687643B2 (el)
CA (1) CA2200317C (el)
CZ (1) CZ290597B6 (el)
DE (1) DE69508599T2 (el)
DK (1) DK0783473T3 (el)
ES (1) ES2130656T3 (el)
FI (1) FI118923B (el)
GR (1) GR3030327T3 (el)
HU (1) HU215409B (el)
IT (1) IT1270093B (el)
NO (1) NO306506B1 (el)
WO (1) WO1996010004A1 (el)
ZA (1) ZA957899B (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705039A (en) * 1995-10-13 1998-01-06 Albemarle Corporation Process for purifying a 2,6-dialkylphenol
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
ATE240266T1 (de) * 1998-09-22 2003-05-15 Exxonmobil Chem Patents Inc Verfahren zur herstellung von durch zeolith gebundenen zeolithen mit hohem sio2-gehalt und ihre verwendung
KR20000047871A (ko) * 1998-12-04 2000-07-25 강재헌 고순도 2,6-디이소프로필페놀의 정제방법
UA76802C2 (uk) * 2001-12-28 2006-09-15 Мгі Гп, Інк. Фармацевтичний препарат водорозчинних проліків пропофолу на водній основі (варіанти)
RU2297216C2 (ru) * 2002-04-08 2007-04-20 Эм-Джи-Ай Джи-Пи,Инк. Фармацевтические композиции, содержащие растворимые в воде пролекарства пропофола, и способы их применения
WO2011161687A1 (en) 2010-06-23 2011-12-29 Harman Finochem Limited Process for preparing extra pure 2, 6-diisopropyl phenol
EP2522651B1 (en) * 2011-05-12 2013-11-20 Siegfried AG Process for the purification of 2,6-diisopropyl phenol
CN103360219B (zh) * 2012-04-06 2015-08-19 辽宁诺康生物制药有限责任公司 一种高纯度丙泊酚的合成方法
KR20160048123A (ko) * 2013-08-30 2016-05-03 퓨라닉스 테크놀러지스 비.브이. 2-포밀-퓨란-5카복실산과 2, 5-퓨란디카복실산을 포함하는 산성 조성물을 정제하는 방법
CN104649867B (zh) * 2013-11-21 2017-02-15 辽宁药联制药有限公司 一种丙泊酚的制备方法
CN108530269A (zh) * 2018-04-11 2018-09-14 南安市创培电子科技有限公司 一种高纯度丙泊酚的生产方法
JP7288665B2 (ja) * 2019-08-02 2023-06-08 株式会社デ・ウエスタン・セラピテクス研究所 エチルアニリノトルエンスルホン酸誘導体の製造方法
US11767281B2 (en) 2020-02-06 2023-09-26 Nandkumar Kashinath Chodankar Manufacturing and purification technology for high purity Propofol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3271314A (en) * 1958-12-04 1966-09-06 Ethyl Corp 2, 6-diisopropylphenol
GB1472793A (en) * 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
FI912102A (fi) * 1991-04-30 1992-10-31 Leiras Oy Foerfarande foer rening av 2,6-diisopropylfenol

Also Published As

Publication number Publication date
FI118923B (fi) 2008-05-15
ZA957899B (en) 1996-05-09
NO306506B1 (no) 1999-11-15
FI971264A0 (fi) 1997-03-26
EP0783473A1 (en) 1997-07-16
AU3650495A (en) 1996-04-19
HUT77183A (hu) 1998-03-02
DE69508599T2 (de) 1999-11-18
JPH10506626A (ja) 1998-06-30
ITMI941969A0 (it) 1994-09-28
CZ93597A3 (en) 1997-09-17
CA2200317A1 (en) 1996-04-04
CA2200317C (en) 2007-04-17
ES2130656T3 (es) 1999-07-01
DE69508599D1 (de) 1999-04-29
FI971264A (fi) 1997-03-26
NO971425D0 (no) 1997-03-25
CZ290597B6 (cs) 2002-08-14
AU687643B2 (en) 1998-02-26
WO1996010004A1 (en) 1996-04-04
JP3701974B2 (ja) 2005-10-05
US5589598A (en) 1996-12-31
ITMI941969A1 (it) 1996-03-28
EP0783473B1 (en) 1999-03-24
ATE178041T1 (de) 1999-04-15
NO971425L (no) 1997-03-25
DK0783473T3 (da) 1999-10-18
HU215409B (hu) 1998-12-28
IT1270093B (it) 1997-04-28

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