FI118923B - Menetelmä 2,6-di-isopropyylifenolin puhdistamiseksi - Google Patents

Menetelmä 2,6-di-isopropyylifenolin puhdistamiseksi Download PDF

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Publication number
FI118923B
FI118923B FI971264A FI971264A FI118923B FI 118923 B FI118923 B FI 118923B FI 971264 A FI971264 A FI 971264A FI 971264 A FI971264 A FI 971264A FI 118923 B FI118923 B FI 118923B
Authority
FI
Finland
Prior art keywords
acid
process according
propofol
carboxylic
ester
Prior art date
Application number
FI971264A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI971264A0 (fi
FI971264A (fi
Inventor
Maurizio Paiocchi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of FI971264A0 publication Critical patent/FI971264A0/fi
Publication of FI971264A publication Critical patent/FI971264A/fi
Application granted granted Critical
Publication of FI118923B publication Critical patent/FI118923B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/24—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/86—Purification; separation; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI971264A 1994-09-28 1997-03-26 Menetelmä 2,6-di-isopropyylifenolin puhdistamiseksi FI118923B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI941969 1994-09-28
ITMI941969A IT1270093B (it) 1994-09-28 1994-09-28 Processo per la purificazione di 2,6-diisopropilfenolo
PCT/EP1995/003676 WO1996010004A1 (en) 1994-09-28 1995-09-18 Process for the purification of 2,6-diisopropylphenol
EP9503676 1995-09-18

Publications (3)

Publication Number Publication Date
FI971264A0 FI971264A0 (fi) 1997-03-26
FI971264A FI971264A (fi) 1997-03-26
FI118923B true FI118923B (fi) 2008-05-15

Family

ID=11369606

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971264A FI118923B (fi) 1994-09-28 1997-03-26 Menetelmä 2,6-di-isopropyylifenolin puhdistamiseksi

Country Status (17)

Country Link
US (1) US5589598A (el)
EP (1) EP0783473B1 (el)
JP (1) JP3701974B2 (el)
AT (1) ATE178041T1 (el)
AU (1) AU687643B2 (el)
CA (1) CA2200317C (el)
CZ (1) CZ290597B6 (el)
DE (1) DE69508599T2 (el)
DK (1) DK0783473T3 (el)
ES (1) ES2130656T3 (el)
FI (1) FI118923B (el)
GR (1) GR3030327T3 (el)
HU (1) HU215409B (el)
IT (1) IT1270093B (el)
NO (1) NO306506B1 (el)
WO (1) WO1996010004A1 (el)
ZA (1) ZA957899B (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705039A (en) * 1995-10-13 1998-01-06 Albemarle Corporation Process for purifying a 2,6-dialkylphenol
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
WO2000017105A1 (en) * 1998-09-22 2000-03-30 Exxon Chemical Patents Inc. Preparation of high silica zeolites bound by zeolite and use thereof
KR20000047871A (ko) * 1998-12-04 2000-07-25 강재헌 고순도 2,6-디이소프로필페놀의 정제방법
KR20040080444A (ko) * 2001-12-28 2004-09-18 길포드 파마슈티컬스 인코포레이티드 수용성인 프로포폴 전구약물의 약학적 수성 제제
PL373850A1 (en) * 2002-04-08 2005-09-19 Guilford Pharmaceuticals, Inc. Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same
US8664452B2 (en) 2010-06-23 2014-03-04 Harman Finochem Limited Process for preparing extra pure 2, 6-diisopropyl phenol
EP2522651B1 (en) * 2011-05-12 2013-11-20 Siegfried AG Process for the purification of 2,6-diisopropyl phenol
CN103360219B (zh) * 2012-04-06 2015-08-19 辽宁诺康生物制药有限责任公司 一种高纯度丙泊酚的合成方法
EP3038997B1 (en) * 2013-08-30 2018-02-21 Synvina C.V. Process for purifying an acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid
CN104649867B (zh) * 2013-11-21 2017-02-15 辽宁药联制药有限公司 一种丙泊酚的制备方法
CN108530269A (zh) * 2018-04-11 2018-09-14 南安市创培电子科技有限公司 一种高纯度丙泊酚的生产方法
JP7288665B2 (ja) * 2019-08-02 2023-06-08 株式会社デ・ウエスタン・セラピテクス研究所 エチルアニリノトルエンスルホン酸誘導体の製造方法
WO2021156776A1 (en) * 2020-02-06 2021-08-12 Nandkumar Chodankar Simple manufacturing and purification technology for high purity propofol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3271314A (en) * 1958-12-04 1966-09-06 Ethyl Corp 2, 6-diisopropylphenol
GB1472793A (en) * 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
FI912102A (fi) * 1991-04-30 1992-10-31 Leiras Oy Foerfarande foer rening av 2,6-diisopropylfenol

Also Published As

Publication number Publication date
DE69508599T2 (de) 1999-11-18
HUT77183A (hu) 1998-03-02
CA2200317C (en) 2007-04-17
ITMI941969A1 (it) 1996-03-28
NO971425D0 (no) 1997-03-25
FI971264A0 (fi) 1997-03-26
ES2130656T3 (es) 1999-07-01
CZ93597A3 (en) 1997-09-17
JPH10506626A (ja) 1998-06-30
AU3650495A (en) 1996-04-19
GR3030327T3 (en) 1999-09-30
CZ290597B6 (cs) 2002-08-14
FI971264A (fi) 1997-03-26
CA2200317A1 (en) 1996-04-04
IT1270093B (it) 1997-04-28
DE69508599D1 (de) 1999-04-29
AU687643B2 (en) 1998-02-26
NO306506B1 (no) 1999-11-15
DK0783473T3 (da) 1999-10-18
US5589598A (en) 1996-12-31
EP0783473B1 (en) 1999-03-24
JP3701974B2 (ja) 2005-10-05
ATE178041T1 (de) 1999-04-15
ZA957899B (en) 1996-05-09
HU215409B (hu) 1998-12-28
EP0783473A1 (en) 1997-07-16
ITMI941969A0 (it) 1994-09-28
WO1996010004A1 (en) 1996-04-04
NO971425L (no) 1997-03-25

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