GB963287A - New steroid compounds and processes for their preparation - Google Patents

New steroid compounds and processes for their preparation

Info

Publication number
GB963287A
GB963287A GB3724061A GB3724061A GB963287A GB 963287 A GB963287 A GB 963287A GB 3724061 A GB3724061 A GB 3724061A GB 3724061 A GB3724061 A GB 3724061A GB 963287 A GB963287 A GB 963287A
Authority
GB
United Kingdom
Prior art keywords
norpregn
ene
methyl
trione
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3724061A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB963287A publication Critical patent/GB963287A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises 17a -hydroxy-16a -methyl -18- norpregn -4- ene-3, 11, 20-trione derivatives having the formula: <FORM:0963287/C1/1> where R represents a hydrogen atom or a group convertible to a hydrogen atom by simple hydrolysis and process for the preparation thereof by hydroxylating 17a -hydroxy-16a -methyl -18- norpregn -4- ene-3, 11, 20-trione so as to introduce a hydroxyl or esterified hydroxyl group thereinto. Said hydroxylation may be effected microbiologically e.g. with Colletotrichum lindemuthianum or chemically by iodinating 17a -hydroxy -16a - methyl-18-norpregn -4- ene-3, 11, 20-trione in the presence of calcium chloride and calcium oxide to yield the corresponding 17a -hydroxy -21- diiodo -16a - methyl -18- norpregn -4- ene-3, 11, 20-trione, treating the resulting 21-diiodo derivative with an acyloxylating agent appropriate to the ester which it is sought to form, to obtain the corresponding 21-acyloxy -17a - hydroxy -16a - methyl -18- norpregn -4- ene-3, 11, 20-trione, which is saponified to yield 17a 21-dihydroxy -16a - methyl -18- norpregn -4- ene-3, 11, 20-trione. Specifications 807,203, 877,227, 934,707, 963,288 and 963,289 are referred to.
GB3724061A 1960-10-20 1961-10-17 New steroid compounds and processes for their preparation Expired GB963287A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR841707A FR1365265A (en) 1960-10-20 1960-10-20 New cortisone compound and method of preparation

Publications (1)

Publication Number Publication Date
GB963287A true GB963287A (en) 1964-07-08

Family

ID=8741143

Family Applications (3)

Application Number Title Priority Date Filing Date
GB4713163A Expired GB963289A (en) 1960-10-20 1961-10-17 New steroid compounds and processes for their preparation
GB3724061A Expired GB963287A (en) 1960-10-20 1961-10-17 New steroid compounds and processes for their preparation
GB4713063A Expired GB963288A (en) 1960-10-20 1961-10-17 New steroid compounds and processes for their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4713163A Expired GB963289A (en) 1960-10-20 1961-10-17 New steroid compounds and processes for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB4713063A Expired GB963288A (en) 1960-10-20 1961-10-17 New steroid compounds and processes for their preparation

Country Status (3)

Country Link
CH (1) CH400147A (en)
FR (1) FR1365265A (en)
GB (3) GB963289A (en)

Also Published As

Publication number Publication date
GB963288A (en) 1964-07-08
FR1365265A (en) 1964-07-03
GB963289A (en) 1964-07-08
CH400147A (en) 1965-10-15

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