GB973892A - Process for the manufacture of d-homo-steroids and new d-homo-steroids - Google Patents
Process for the manufacture of d-homo-steroids and new d-homo-steroidsInfo
- Publication number
- GB973892A GB973892A GB1460261A GB1460261A GB973892A GB 973892 A GB973892 A GB 973892A GB 1460261 A GB1460261 A GB 1460261A GB 1460261 A GB1460261 A GB 1460261A GB 973892 A GB973892 A GB 973892A
- Authority
- GB
- United Kingdom
- Prior art keywords
- homo
- pregnadiene
- steroids
- above process
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises D-homo-D 4,17(17a)-pregnadiene-3, 20-dione, D-homo-D 17(17a)-5a -pregnen-3b -ol-20-one, and D-homo-D 5,17(17a)-pregnadiene-3, 21-diol-20-one, and the preparation of D 17(17a)-unsaturated-D-homo-20 -ketopregnenes by treating the corresponding 16, 17a -methylene-20-keto-pregnanes with a carboxylic anhydride such as acetic anhydride, in the presence of a strong acid catalyst such as p-toluenesulphonic acid or perchloric acid, and hydrolysing the resulting 20-enol ester. The above process may be modified in that instead of using a 16, 17a -methylene-20-keto-steroid as the reactant the corresponding D 11-pyrazolino-41,51:16,17-compound is used. In the examples the following are prepared by the above process D-homo-D 5,17 (17a) - pregnadien - 3 BETA-ol-20-one. (This compound may then be acetylated to form the corresponding 3-acetoxy compound or oxidized to form D-homo-D 4,17(17a)-pregnadiene-3, 20-dione which may also be obtained by the above process), D-homo-D 17(17a)-5a -pregnen-3b -ol-20-one, and D-homo-D 5,17(17a)-pregnadiene-3, 21-diol-20-one. Specification 948,269 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESCH27970A DE1135903B (en) | 1960-05-31 | 1960-05-31 | Process for the production of? (17ª ‡) -unsaturated D-homosteroids of the 20-ketopregnane series |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB973892A true GB973892A (en) | 1964-10-28 |
Family
ID=7430968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1460261A Expired GB973892A (en) | 1960-05-31 | 1961-04-21 | Process for the manufacture of d-homo-steroids and new d-homo-steroids |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1135903B (en) |
| GB (1) | GB973892A (en) |
-
1960
- 1960-05-31 DE DESCH27970A patent/DE1135903B/en active Pending
-
1961
- 1961-04-21 GB GB1460261A patent/GB973892A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1135903B (en) | 1962-09-06 |
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