GB2145409B - Crystalline cefuroxime axetil - Google Patents
Crystalline cefuroxime axetilInfo
- Publication number
- GB2145409B GB2145409B GB08419202A GB8419202A GB2145409B GB 2145409 B GB2145409 B GB 2145409B GB 08419202 A GB08419202 A GB 08419202A GB 8419202 A GB8419202 A GB 8419202A GB 2145409 B GB2145409 B GB 2145409B
- Authority
- GB
- United Kingdom
- Prior art keywords
- cefuroxime axetil
- crystalline cefuroxime
- crystalline
- axetil
- cefuroxime
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838320521A GB8320521D0 (en) | 1983-07-29 | 1983-07-29 | Chemical process |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8419202D0 GB8419202D0 (en) | 1984-08-30 |
GB2145409A GB2145409A (en) | 1985-03-27 |
GB2145409B true GB2145409B (en) | 1987-02-18 |
Family
ID=10546505
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB838320521A Pending GB8320521D0 (en) | 1983-07-29 | 1983-07-29 | Chemical process |
GB08419202A Expired GB2145409B (en) | 1983-07-29 | 1984-07-27 | Crystalline cefuroxime axetil |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB838320521A Pending GB8320521D0 (en) | 1983-07-29 | 1983-07-29 | Chemical process |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPH0613526B2 (en) |
KR (1) | KR910008377B1 (en) |
AT (1) | AT392470B (en) |
AU (2) | AU582121B2 (en) |
BE (1) | BE900241A (en) |
CA (1) | CA1265511A (en) |
CH (1) | CH662121A5 (en) |
DE (1) | DE3427828A1 (en) |
DK (1) | DK165505C (en) |
ES (1) | ES8601869A1 (en) |
FI (1) | FI76808C (en) |
FR (1) | FR2549837B1 (en) |
GB (2) | GB8320521D0 (en) |
IE (1) | IE57726B1 (en) |
IL (1) | IL72536A (en) |
NL (1) | NL8402372A (en) |
NO (1) | NO167292C (en) |
NZ (1) | NZ209046A (en) |
PT (1) | PT78985B (en) |
SE (1) | SE463263B (en) |
ZA (1) | ZA845830B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8400024D0 (en) * | 1984-01-03 | 1984-02-08 | Glaxo Group Ltd | Cephalosporin antibiotics |
GB8524001D0 (en) * | 1985-09-30 | 1985-11-06 | Glaxo Group Ltd | Pharmaceutical composition |
US5063224A (en) * | 1990-07-09 | 1991-11-05 | Eli Lilly And Company | R-cefuroxime axetil |
IT1277426B1 (en) * | 1995-08-03 | 1997-11-10 | Acs Dobfar Spa | BIOAVAILABLE CRYSTALLINE FORM OF CEFUROXIMA AXETIL |
CN1111537C (en) * | 1997-05-15 | 2003-06-18 | 第一制糖株式会社 | The preparation method of highly pure crystalline form of cefuroxime axetil |
KR100228264B1 (en) * | 1997-08-02 | 1999-11-01 | 김선진 | The synthetic method of crystalline cefuroxime axetil |
CA2209868C (en) * | 1997-08-15 | 2001-08-14 | Bernard Charles Sherman | Pharmaceutical compositions comprising cefuroxime axetil |
IN186539B (en) * | 1997-09-29 | 2001-09-29 | Ranbaxy Lab Ltd | |
ATE212638T1 (en) * | 1998-02-20 | 2002-02-15 | Fako Ilaclari A S | METHOD FOR PRODUCING SOLUBLE CRYSTALLINE CEFUROXIM AXETIL |
IN190849B (en) | 2000-07-17 | 2003-08-23 | Ranbaxy Lab Ltd | |
AT411996B (en) | 2000-09-11 | 2004-08-26 | Sandoz Ag | METHOD FOR PRODUCING CEFUROXIME IN THE FORM OF ITS N-BUTYL LAMONIUM SALTS |
ITMI20011763A1 (en) * | 2001-08-10 | 2003-02-10 | Antibioticos Spa | HIGH-PURITY CEFUROXIME AXELITE PREPARATION PROCESS |
ITMI20011925A1 (en) * | 2001-09-14 | 2003-03-14 | Antibioticos Spa | METHOD APPLICABLE ON INDUSTRIAL SCALE FOR THE PREPARATION OF CEFUROXIME AXETILE CRISTALLINO |
TWI328006B (en) * | 2003-12-26 | 2010-08-01 | Nissan Chemical Ind Ltd | Crystal form of quinoline compound and process for its production |
CN100448879C (en) * | 2004-07-22 | 2009-01-07 | 北京化工大学 | Method for preparing unformed cefuroxime axetil |
DE102005019458A1 (en) * | 2005-04-25 | 2006-10-26 | Grünenthal GmbH | Composition, useful in the preparation of pellets and the multi-particular-presentation form, comprises cefuroximaxetil and carrageenan of the group of lambda carrageenan, tau carrageenan and kappa carrageenan |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1571683A (en) * | 1976-02-16 | 1980-07-16 | Glaxo Operations Ltd | Ester derivatives of cefuroxime |
CA1094545A (en) * | 1976-02-16 | 1981-01-27 | Michael Gregson | Cephalosporin antibiotics |
GB1598568A (en) * | 1977-04-19 | 1981-09-23 | Glaxo Lab Ltd | Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid |
JPS577485A (en) * | 1980-06-13 | 1982-01-14 | Takeda Chem Ind Ltd | Cephalosporin |
YU44680B (en) * | 1982-07-30 | 1990-12-31 | Glaxo Lab Ltd | Process for obtaining very pure amorphous form of cephuroxim axetile |
GB8400024D0 (en) * | 1984-01-03 | 1984-02-08 | Glaxo Group Ltd | Cephalosporin antibiotics |
-
1983
- 1983-07-29 GB GB838320521A patent/GB8320521D0/en active Pending
-
1984
- 1984-07-27 AU AU31256/84A patent/AU582121B2/en not_active Ceased
- 1984-07-27 ES ES534695A patent/ES8601869A1/en not_active Expired
- 1984-07-27 SE SE8403897A patent/SE463263B/en not_active IP Right Cessation
- 1984-07-27 GB GB08419202A patent/GB2145409B/en not_active Expired
- 1984-07-27 KR KR1019840004465A patent/KR910008377B1/en not_active IP Right Cessation
- 1984-07-27 NO NO843055A patent/NO167292C/en not_active IP Right Cessation
- 1984-07-27 ZA ZA845830A patent/ZA845830B/en unknown
- 1984-07-27 FI FI843011A patent/FI76808C/en not_active IP Right Cessation
- 1984-07-27 IE IE1938/84A patent/IE57726B1/en not_active IP Right Cessation
- 1984-07-27 FR FR8412011A patent/FR2549837B1/en not_active Expired
- 1984-07-27 CA CA000459929A patent/CA1265511A/en not_active Expired - Fee Related
- 1984-07-27 PT PT78985A patent/PT78985B/en unknown
- 1984-07-27 CH CH3672/84A patent/CH662121A5/en not_active IP Right Cessation
- 1984-07-27 AT AT2444/84A patent/AT392470B/en not_active IP Right Cessation
- 1984-07-27 BE BE0/213398A patent/BE900241A/en not_active IP Right Cessation
- 1984-07-27 NL NL8402372A patent/NL8402372A/en not_active Application Discontinuation
- 1984-07-27 JP JP59155694A patent/JPH0613526B2/en not_active Expired - Lifetime
- 1984-07-27 DK DK366684A patent/DK165505C/en not_active IP Right Cessation
- 1984-07-27 DE DE19843427828 patent/DE3427828A1/en not_active Ceased
- 1984-07-29 IL IL72536A patent/IL72536A/en not_active IP Right Cessation
- 1984-07-30 NZ NZ209046A patent/NZ209046A/en unknown
-
1989
- 1989-06-16 AU AU36601/89A patent/AU634965B2/en not_active Ceased
Also Published As
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Publication | Publication Date | Title |
---|---|---|
GB2127401B (en) | Amorphous cefuroxime axetil | |
EP0223365A3 (en) | Cefuroxime axetil dragee cefuroxime axetil dragee | |
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EP0127992A3 (en) | Cephalosporin derivatives | |
GB2145409B (en) | Crystalline cefuroxime axetil | |
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PH18429A (en) | Crystalline cephalosporin | |
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AU571040B2 (en) | Crystalline silicophosphoaluminates | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20020727 |