CH609692A5 - Process for the preparation of new piperazinopyrimidines - Google Patents

Process for the preparation of new piperazinopyrimidines

Info

Publication number
CH609692A5
CH609692A5 CH1044275A CH1044275A CH609692A5 CH 609692 A5 CH609692 A5 CH 609692A5 CH 1044275 A CH1044275 A CH 1044275A CH 1044275 A CH1044275 A CH 1044275A CH 609692 A5 CH609692 A5 CH 609692A5
Authority
CH
Switzerland
Prior art keywords
carbon atoms
group
formula
piperazinopyrimidines
preparation
Prior art date
Application number
CH1044275A
Inventor
Gerard Loiseau
Georges Mattioda
Pierre Obellianne
Original Assignee
Ugine Kuhlmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ugine Kuhlmann filed Critical Ugine Kuhlmann
Publication of CH609692A5 publication Critical patent/CH609692A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A process for the production of compounds of formula (I) is described <IMAGE> In the formula, Z represents an alkyl group, having 1 to 4 carbon atoms, R1 a hydrogen atom or a methyl or ethyl group, and R2 a linear alkyl group having 3 to 6 carbon atoms, allyl, hydroxyethyl, cycloalkyl having 3 to 8 carbon atoms, benzyl or p-methoxyphenyl, it also being possible for the residue -NR1R2 to represent a morpholino group. The process is carried out by reacting a corresponding 4,6-dichloropyrimidine with a piperazine substituted on one of the nitrogen atoms of the ring by a group Z. The compounds obtained in the said process can be used in human therapeutics against vomiting, nausea, migraines or digestive spasms.
CH1044275A 1974-08-09 1975-08-11 Process for the preparation of new piperazinopyrimidines CH609692A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7427671A FR2281117A2 (en) 1974-08-09 1974-08-09 NEW PIPERAZINO-PYRIMIDINES FOR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
CH609692A5 true CH609692A5 (en) 1979-03-15

Family

ID=9142279

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1044275A CH609692A5 (en) 1974-08-09 1975-08-11 Process for the preparation of new piperazinopyrimidines

Country Status (13)

Country Link
JP (2) JPS51125089A (en)
AR (1) AR205579A1 (en)
BE (1) BE832277R (en)
CA (1) CA1036598A (en)
CH (1) CH609692A5 (en)
DE (1) DE2534963A1 (en)
ES (1) ES440153A2 (en)
FR (1) FR2281117A2 (en)
GB (1) GB1512101A (en)
LU (1) LU73175A1 (en)
NL (1) NL7509184A (en)
NO (1) NO752586L (en)
ZA (1) ZA755118B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2417507A2 (en) * 1977-07-28 1979-09-14 Ugine Kuhlmann DIAMINO-2,4 (OR -4,6) METHYLTHIO-5 PYRIMIDINES HERBICIDES
FR2503162A1 (en) * 1981-04-07 1982-10-08 Pharmindustrie NOVEL PIPERAZINO-2 PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS OR AS INTERMEDIATES FOR THE PRODUCTION OF MEDICAMENTS
JPS5973573A (en) * 1982-09-09 1984-04-25 ワ−ナ−−ランバ−ト・コンパニ− Diaminopyrimidine compound
US6825198B2 (en) 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
WO2005003099A2 (en) 2003-07-02 2005-01-13 Vertex Pharmaceuticals Incorporated Pyrimidines useful as modulators of voltage-gated ion channels
JP5388574B2 (en) 2005-05-31 2014-01-15 バーテックス ファーマシューティカルズ インコーポレイテッド Heterocyclics useful as modulators of ion channels

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2119234A5 (en) * 1970-12-24 1972-08-04 Ugine Kuhlmann 5-alkylthio amino halopyrimidines - fungicides herbicides insecticides and bactericides
FR2173746B1 (en) * 1972-03-01 1975-04-25 Ugine Kuhlmann

Also Published As

Publication number Publication date
ES440153A2 (en) 1977-07-01
FR2281117B2 (en) 1978-07-28
LU73175A1 (en) 1976-03-02
DE2534963A1 (en) 1976-02-19
JPS58150571A (en) 1983-09-07
BE832277R (en) 1976-02-09
CA1036598A (en) 1978-08-15
JPS51125089A (en) 1976-11-01
AR205579A1 (en) 1976-05-14
JPS5946943B2 (en) 1984-11-15
NO752586L (en) 1976-02-10
FR2281117A2 (en) 1976-03-05
ZA755118B (en) 1976-07-28
GB1512101A (en) 1978-05-24
NL7509184A (en) 1976-02-11

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Legal Events

Date Code Title Description
PL Patent ceased