JPS6419069A - Production of polyhalogenoquinoline derivative - Google Patents
Production of polyhalogenoquinoline derivativeInfo
- Publication number
- JPS6419069A JPS6419069A JP17511487A JP17511487A JPS6419069A JP S6419069 A JPS6419069 A JP S6419069A JP 17511487 A JP17511487 A JP 17511487A JP 17511487 A JP17511487 A JP 17511487A JP S6419069 A JPS6419069 A JP S6419069A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- acid
- lower alkyl
- piperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain the titled high-purity compound having excellent antibacterial action useful for medical purposes under a mild condition selectively and in high yield, by reacting a novel compound with piperazine and decomposing the prepared compound. CONSTITUTION:A novel compound shown by formula I [X1-X4 are halogen; R1 is lower alkyl, halogeno lower alkyl, cycloalkyl or (substituted)phenyl; Y is F or lower alkylcarboxyloxy] obtained by reaction between 1- cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and borohydrofluoric acid is reacted with a piperazine shown by formula II (R2-R4 are H or lower alkyl) in an inert solvent such as ethanol is the presence of an acid acceptor such as triethylamine at 10-150 deg.C for 30min-3hr to form a compound shown by formula III, which is decomposed with an acid or a base in a hydrous solvent at 10-150 deg.C to give the aimed compound shown by formula IV.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17511487A JPS6419069A (en) | 1987-07-14 | 1987-07-14 | Production of polyhalogenoquinoline derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17511487A JPS6419069A (en) | 1987-07-14 | 1987-07-14 | Production of polyhalogenoquinoline derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6419069A true JPS6419069A (en) | 1989-01-23 |
Family
ID=15990518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17511487A Pending JPS6419069A (en) | 1987-07-14 | 1987-07-14 | Production of polyhalogenoquinoline derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6419069A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990006922A1 (en) * | 1988-12-22 | 1990-06-28 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Process for the preparation of quinoline carboxylic acid derivatives |
US5091530A (en) * | 1987-04-08 | 1992-02-25 | Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. | Baron chelates of quinoline carboxylic acids |
US5409933A (en) * | 1992-06-09 | 1995-04-25 | Kim; Wan J. | Quinoline derivatives and processes for preparing the same |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59122470A (en) * | 1982-12-27 | 1984-07-14 | Dai Ichi Seiyaku Co Ltd | Preparation of quinoline-3-carboxylic acid derivative |
JPS6078986A (en) * | 1983-10-07 | 1985-05-04 | Dai Ichi Seiyaku Co Ltd | Preparation of oxazine derivative |
JPS60260573A (en) * | 1984-04-16 | 1985-12-23 | ワ−ナ−−ランバ−ト・コンパニ− | Antibacterial |
-
1987
- 1987-07-14 JP JP17511487A patent/JPS6419069A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59122470A (en) * | 1982-12-27 | 1984-07-14 | Dai Ichi Seiyaku Co Ltd | Preparation of quinoline-3-carboxylic acid derivative |
JPS6078986A (en) * | 1983-10-07 | 1985-05-04 | Dai Ichi Seiyaku Co Ltd | Preparation of oxazine derivative |
JPS60260573A (en) * | 1984-04-16 | 1985-12-23 | ワ−ナ−−ランバ−ト・コンパニ− | Antibacterial |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091530A (en) * | 1987-04-08 | 1992-02-25 | Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. | Baron chelates of quinoline carboxylic acids |
WO1990006922A1 (en) * | 1988-12-22 | 1990-06-28 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Process for the preparation of quinoline carboxylic acid derivatives |
GB2245562A (en) * | 1988-12-22 | 1992-01-08 | Chinoin Gyogyszer Es Vegyeszet | Process for the preparation of quinoline carboxylic acid derivatives |
GB2245562B (en) * | 1988-12-22 | 1992-12-23 | Chinoin Gyogyszer Es Vegyeszet | Process for the preparation of quinoline carboxylic acid derivatives |
US5409933A (en) * | 1992-06-09 | 1995-04-25 | Kim; Wan J. | Quinoline derivatives and processes for preparing the same |
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