GB1490771A - 2-substituted 4,5-diphenylthiazoles and synthesis thereof - Google Patents
2-substituted 4,5-diphenylthiazoles and synthesis thereofInfo
- Publication number
- GB1490771A GB1490771A GB3224/75A GB322475A GB1490771A GB 1490771 A GB1490771 A GB 1490771A GB 3224/75 A GB3224/75 A GB 3224/75A GB 322475 A GB322475 A GB 322475A GB 1490771 A GB1490771 A GB 1490771A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- prepared
- diphenyl
- reacting
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1490771 4,5-Diphenyl-thiazoles SERONO LABORATORIES Inc 24 Jan 1975 [31 Jan 1974] 3224/75 Heading C2C Novel 4,5-diphenyl-thiazoles of the general formula wherein X is -NR 1 R 2 , each of R<SP>1</SP> and R<SP>2</SP> is a hydrogen atom or a C 1-4 alkyl, C 1-4 hydroxyalkyl, C 1-4 acyl or acyloxy-C 1-4 alkyl group or NR<SP>1</SP>R<SP>2</SP> is a 5- or 6-ring-membered heterocyclic amino group, and A is a single bond or an alkylene group, and acid addition salts and N- acylated derivatives thereof are prepared (a) by cyclizing with P 2 S 5 an α-phenylacetophenone derivative of the general formula wherein X is -NR<SP>1</SP>R<SP>2</SP>; (b) by reacting a halide of the general formula wherein Hal is a halogen atom, with HNR<SP>1</SP>R<SP>2</SP>; and (c) when at least one of R<SP>1</SP> and R<SP>2</SP> is a C 1-4 acyl or acyloxy-C 1-4 alkyl group, by acylating the corresponding compound in which at least one of R<SP>1</SP> and R<SP>2</SP> is a hydrogen atom or C 1-4 hydroxyalkyl group; followed optionally by salification or N-acylation of the product. α-Phenylacetophenone derivatives of the second general formula above are prepared by reacting the corresponding compound in which X is a halogen atom (itself prepared by reacting desylamine with Hal-CO-A-X) with HNR<SP>1</SP>R<SP>2</SP> Halides of the third general formula above wherein A is an alkylene group are prepared analogously to process (a) above. Pharmaceutical compositions having hypocholesterolemic and/or platelet aggregationinhibiting activity comprise, as active ingredient, a 4,5-diphenyl-thiazole of the first general formula above or a pharmaceutically acceptable acid addition salt or N-acylated derivative thereof, together with a pharmaceutically acceptable diluent, carrier or excipient.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH137774A CH587836A5 (en) | 1974-01-31 | 1974-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1490771A true GB1490771A (en) | 1977-11-02 |
Family
ID=4208998
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3224/75A Expired GB1490771A (en) | 1974-01-31 | 1975-01-24 | 2-substituted 4,5-diphenylthiazoles and synthesis thereof |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS50121269A (en) |
AT (1) | AT339898B (en) |
BE (1) | BE825097A (en) |
CA (1) | CA1036600A (en) |
CH (1) | CH587836A5 (en) |
DE (1) | DE2503436A1 (en) |
DK (1) | DK33175A (en) |
ES (1) | ES434151A1 (en) |
FR (1) | FR2259603B1 (en) |
GB (1) | GB1490771A (en) |
IL (1) | IL46476A (en) |
NL (1) | NL7501086A (en) |
NO (1) | NO750278L (en) |
SE (1) | SE7501010L (en) |
ZA (1) | ZA75494B (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0388909A2 (en) * | 1989-03-22 | 1990-09-26 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
AU654125B2 (en) * | 1991-03-07 | 1994-10-27 | Hisamitsu Pharmaceutical Co., Inc. | Novel diphenylthyazole derivative |
US8334301B2 (en) | 2007-09-28 | 2012-12-18 | Takeda Pharmaceutical Company Limited | 5-Membered heterocyclic compound |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4168315A (en) * | 1977-09-28 | 1979-09-18 | The Upjohn Company | Dianisyl thiazole compound, compositions and method of antithrombotic treatment |
JPH0753666B2 (en) * | 1987-09-14 | 1995-06-07 | 久光製薬株式会社 | Anti-inflammatory agent consisting of substituted diphenylthiazole derivative |
CA2515119A1 (en) | 2003-02-07 | 2004-08-19 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivative |
-
1974
- 1974-01-31 CH CH137774A patent/CH587836A5/xx not_active IP Right Cessation
-
1975
- 1975-01-21 IL IL46476A patent/IL46476A/en unknown
- 1975-01-23 ZA ZA00750494A patent/ZA75494B/en unknown
- 1975-01-24 GB GB3224/75A patent/GB1490771A/en not_active Expired
- 1975-01-24 AT AT55975A patent/AT339898B/en not_active IP Right Cessation
- 1975-01-25 ES ES434151A patent/ES434151A1/en not_active Expired
- 1975-01-27 CA CA218,709A patent/CA1036600A/en not_active Expired
- 1975-01-28 DE DE19752503436 patent/DE2503436A1/en not_active Ceased
- 1975-01-30 DK DK33175*#A patent/DK33175A/da not_active Application Discontinuation
- 1975-01-30 NL NL7501086A patent/NL7501086A/en not_active Application Discontinuation
- 1975-01-30 NO NO750278A patent/NO750278L/no unknown
- 1975-01-30 SE SE7501010A patent/SE7501010L/xx unknown
- 1975-01-31 BE BE152985A patent/BE825097A/en not_active IP Right Cessation
- 1975-01-31 FR FR7503048A patent/FR2259603B1/fr not_active Expired
- 1975-01-31 JP JP50012645A patent/JPS50121269A/ja active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0388909A2 (en) * | 1989-03-22 | 1990-09-26 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
EP0388909A3 (en) * | 1989-03-22 | 1991-05-08 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
AU654125B2 (en) * | 1991-03-07 | 1994-10-27 | Hisamitsu Pharmaceutical Co., Inc. | Novel diphenylthyazole derivative |
US8334301B2 (en) | 2007-09-28 | 2012-12-18 | Takeda Pharmaceutical Company Limited | 5-Membered heterocyclic compound |
Also Published As
Publication number | Publication date |
---|---|
IL46476A0 (en) | 1975-04-25 |
DE2503436A1 (en) | 1975-08-07 |
ES434151A1 (en) | 1976-12-01 |
ATA55975A (en) | 1977-03-15 |
NL7501086A (en) | 1975-08-04 |
SE7501010L (en) | 1975-08-01 |
CA1036600A (en) | 1978-08-15 |
BE825097A (en) | 1975-07-31 |
FR2259603A1 (en) | 1975-08-29 |
DK33175A (en) | 1975-09-29 |
AU7747875A (en) | 1976-07-22 |
FR2259603B1 (en) | 1978-07-21 |
IL46476A (en) | 1978-12-17 |
AT339898B (en) | 1977-11-10 |
JPS50121269A (en) | 1975-09-23 |
ZA75494B (en) | 1976-01-28 |
NO750278L (en) | 1975-08-25 |
CH587836A5 (en) | 1977-05-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |