GB1449802A - Piperazine derivatives and compositions containing them for treating parkinsons disease - Google Patents
Piperazine derivatives and compositions containing them for treating parkinsons diseaseInfo
- Publication number
- GB1449802A GB1449802A GB453675A GB453675A GB1449802A GB 1449802 A GB1449802 A GB 1449802A GB 453675 A GB453675 A GB 453675A GB 453675 A GB453675 A GB 453675A GB 1449802 A GB1449802 A GB 1449802A
- Authority
- GB
- United Kingdom
- Prior art keywords
- piperazine
- naphthylmethyl
- substituted
- chloromethylnaphthalene
- piperazines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1449802 N-(#-Naphthylmethyl)-piperazines SMITHKLINE CORP 3 Feb 1975 [7 Feb 1974] 4536/75 Heading C2C Novel N-(#-naphthylmethyl)-piperazines of the general formula wherein R is a phenyl, C-pyridyl or C-pyrimidinyl ring which is optionally substituted by C 1-5 alkyl, halogen, hydroxy or C 1-5 alkoxy and R 1 is hydrogen, C 1-5 alkyl, halogen, hydroxy or C 1-5 alkoxy, and pharmaceutically acceptable acid addition salts thereof are prepared by reacting a #-chloromethylnaphthalene and a piperazine of the general formulµ or by reacting the said #-chloromethylnaphthalene with piperazine and introducing the desired N<SP>4</SP>-substituent into the resulting N<SP>1</SP>-(R 1 - substituted - # - naphthylmethyl) - piperazine, followed optionally by salification of the product. R 1 - Substituted - # - chloromethylnaphthalenes are prepared by reducing the appropriate #- naphthoic acid with LiAlH 4 and chlorinating the resulting #-naphthalenemethanol. Pharmaceutical compositions having anti- Parkinsonism activity comprises, as active ingredient, a N-(#-naphthylmethyl)-piperazine of the first general formula above or pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutical carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US440431A US3919230A (en) | 1974-02-07 | 1974-02-07 | {62 -Naphthylmethyl piperazinyl derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1449802A true GB1449802A (en) | 1976-09-15 |
Family
ID=23748733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB453675A Expired GB1449802A (en) | 1974-02-07 | 1975-02-03 | Piperazine derivatives and compositions containing them for treating parkinsons disease |
Country Status (16)
Country | Link |
---|---|
US (1) | US3919230A (en) |
JP (1) | JPS50108278A (en) |
AU (1) | AU501049B2 (en) |
BE (1) | BE825178A (en) |
CA (1) | CA1042434A (en) |
CH (1) | CH616678A5 (en) |
DE (1) | DE2505002A1 (en) |
ES (1) | ES434433A1 (en) |
FR (1) | FR2260353B1 (en) |
GB (1) | GB1449802A (en) |
HU (1) | HU171352B (en) |
IE (1) | IE40593B1 (en) |
IL (1) | IL46568A (en) |
LU (1) | LU71803A1 (en) |
NL (1) | NL7501362A (en) |
ZA (1) | ZA75160B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4130646A (en) * | 1975-07-25 | 1978-12-19 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof |
JPS52133993A (en) * | 1976-04-29 | 1977-11-09 | Takeda Chem Ind Ltd | 1.2-dihydronaphthalene derivatives and method of preparing the same |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
US4620006A (en) * | 1982-08-11 | 1986-10-28 | Eastman Kodak Company | Acid salts of 1-(cyanoalkyl)-4-guanylpiperazines |
US6335343B1 (en) | 1999-03-03 | 2002-01-01 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
CN107652156B (en) * | 2017-11-18 | 2023-11-10 | 辽宁科技学院 | Crystallization method and device of beta-methylnaphthalene |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL127996C (en) * | 1963-11-19 |
-
1974
- 1974-02-07 US US440431A patent/US3919230A/en not_active Expired - Lifetime
-
1975
- 1975-01-09 ZA ZA00750160A patent/ZA75160B/en unknown
- 1975-02-03 JP JP50014791A patent/JPS50108278A/ja active Pending
- 1975-02-03 GB GB453675A patent/GB1449802A/en not_active Expired
- 1975-02-03 AU AU77840/75A patent/AU501049B2/en not_active Expired
- 1975-02-03 CA CA219,288A patent/CA1042434A/en not_active Expired
- 1975-02-04 CH CH132675A patent/CH616678A5/de not_active IP Right Cessation
- 1975-02-04 IL IL46568A patent/IL46568A/en unknown
- 1975-02-04 BE BE153056A patent/BE825178A/en not_active IP Right Cessation
- 1975-02-04 ES ES434433A patent/ES434433A1/en not_active Expired
- 1975-02-05 FR FR7503627A patent/FR2260353B1/fr not_active Expired
- 1975-02-05 NL NL7501362A patent/NL7501362A/en not_active Application Discontinuation
- 1975-02-06 LU LU71803A patent/LU71803A1/xx unknown
- 1975-02-06 DE DE19752505002 patent/DE2505002A1/en not_active Ceased
- 1975-02-07 IE IE254/75A patent/IE40593B1/en unknown
- 1975-02-07 HU HU75SI00001455A patent/HU171352B/en unknown
Also Published As
Publication number | Publication date |
---|---|
FR2260353A1 (en) | 1975-09-05 |
HU171352B (en) | 1977-12-28 |
AU7784075A (en) | 1976-08-05 |
ZA75160B (en) | 1976-01-28 |
JPS50108278A (en) | 1975-08-26 |
IL46568A0 (en) | 1975-04-25 |
AU501049B2 (en) | 1979-06-07 |
US3919230A (en) | 1975-11-11 |
DE2505002A1 (en) | 1975-08-14 |
IL46568A (en) | 1979-01-31 |
IE40593B1 (en) | 1979-07-04 |
LU71803A1 (en) | 1975-06-24 |
NL7501362A (en) | 1975-08-11 |
FR2260353B1 (en) | 1980-01-04 |
CH616678A5 (en) | 1980-04-15 |
BE825178A (en) | 1975-08-04 |
CA1042434A (en) | 1978-11-14 |
ES434433A1 (en) | 1976-11-16 |
IE40593L (en) | 1975-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE421001B (en) | INTERMEDIATE FOR USE FOR THE PREPARATION OF 1,2,5-THIADIAZOLIC COMPOUNDS AND PROCEDURE FOR PREPARING THIS | |
GB1294763A (en) | 3-oxo-2,3-dihydro-1,4-benzoxazine derivatives | |
GB1369248A (en) | Amides the preparation thereof and their use in pharmacjeutical compositions | |
GB1449802A (en) | Piperazine derivatives and compositions containing them for treating parkinsons disease | |
GB1342558A (en) | Substituted 3-benzylpyridines | |
GB1489711A (en) | 1-phenoxyphenyl-piperazine derivatives process for their preparation and pharmaceutical compositions containing the | |
GB1456627A (en) | Pyridobenzodiazepinones | |
GB1462036A (en) | Aminoindane derivatives | |
GB1342828A (en) | Pyrimidinyl-piperazines and processes for their preparation | |
GB1394504A (en) | 1,2-bis-4-phenyl-1-piperazinyl-ethane derivatives | |
GB1490507A (en) | Piperazine derivatives | |
GB1505899A (en) | 3,4-dihydrocarbostyril derivatives | |
GB1432660A (en) | Piperazine derivatives processes for their preparation and and pharamacueitcal compositions containing them | |
GB1490771A (en) | 2-substituted 4,5-diphenylthiazoles and synthesis thereof | |
ES8207505A1 (en) | Substituted phenoxy-aminopropanol derivatives, intermediates and processes for their production, and pharmaceutical preparations containing them. | |
GB1053301A (en) | ||
GB1332008A (en) | Piperazine derivatives their preparation and pharmaceutical compositions containing them | |
GB1268469A (en) | Halomethylquinolylamino-benzamides | |
GB1511505A (en) | Pyrazole derivatives | |
GB1307256A (en) | Piperazine derivatives and a process for their preparation | |
GB1514225A (en) | Paracetamol derivatives | |
GB1417355A (en) | Substituted piperazine and homopiperazine derivatives | |
GB1464242A (en) | Benzoyl benzofurans and compositions comprising them | |
GB1462521A (en) | Triazole derivatives | |
GB1467761A (en) | Phenoxypropylamine derivatives and preparation thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |