ES434151A1 - 2-substituted 4,5-diphenylthiazoles and synthesis thereof - Google Patents

2-substituted 4,5-diphenylthiazoles and synthesis thereof

Info

Publication number
ES434151A1
ES434151A1 ES434151A ES434151A ES434151A1 ES 434151 A1 ES434151 A1 ES 434151A1 ES 434151 A ES434151 A ES 434151A ES 434151 A ES434151 A ES 434151A ES 434151 A1 ES434151 A1 ES 434151A1
Authority
ES
Spain
Prior art keywords
formula
diphenylthiazoles
see formula
substituted
single bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES434151A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serono Laboratories Inc
Original Assignee
Laboratoires Serono SA
Serono Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono SA, Serono Laboratories Inc filed Critical Laboratoires Serono SA
Publication of ES434151A1 publication Critical patent/ES434151A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of 2-substituted 4,5-diphenylthiazoles of formula: **(See formula)** where: X represents a halogen atom or the radical: **(See formula)** wherein R1 and R2, when considered separately, are each hydrogen, C 1-4 alkyl, C 1-4 hydroxyalkyl, C 1-4 acyl or acyloxyalkyl having 1 to 4 4 carbon atoms in the alkyl chain and R1 and R2, when taken together with the nitrogen atom to which they are attached, form a heterocyclic amino radical with 5 to 6 ring members; and A represents an alkylene group or a single bond, but cannot represent a single bond when X is halogen; characterized in that an α-phenyl-acetophenone derivative of the formula is cyclized with P2S5 **(See formula)** in which A and X have the values previously determined. (Machine-translation by Google Translate, not legally binding)
ES434151A 1974-01-31 1975-01-25 2-substituted 4,5-diphenylthiazoles and synthesis thereof Expired ES434151A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH137774A CH587836A5 (en) 1974-01-31 1974-01-31

Publications (1)

Publication Number Publication Date
ES434151A1 true ES434151A1 (en) 1976-12-01

Family

ID=4208998

Family Applications (1)

Application Number Title Priority Date Filing Date
ES434151A Expired ES434151A1 (en) 1974-01-31 1975-01-25 2-substituted 4,5-diphenylthiazoles and synthesis thereof

Country Status (15)

Country Link
JP (1) JPS50121269A (en)
AT (1) AT339898B (en)
BE (1) BE825097A (en)
CA (1) CA1036600A (en)
CH (1) CH587836A5 (en)
DE (1) DE2503436A1 (en)
DK (1) DK33175A (en)
ES (1) ES434151A1 (en)
FR (1) FR2259603B1 (en)
GB (1) GB1490771A (en)
IL (1) IL46476A (en)
NL (1) NL7501086A (en)
NO (1) NO750278L (en)
SE (1) SE7501010L (en)
ZA (1) ZA75494B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168315A (en) * 1977-09-28 1979-09-18 The Upjohn Company Dianisyl thiazole compound, compositions and method of antithrombotic treatment
JPH0753666B2 (en) * 1987-09-14 1995-06-07 久光製薬株式会社 Anti-inflammatory agent consisting of substituted diphenylthiazole derivative
CA2012716A1 (en) * 1989-03-22 1990-09-22 Akito Tanaka Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same
ATE194338T1 (en) * 1991-03-07 2000-07-15 Hisamitsu Pharmaceutical Co DIPHENYLTHIAZOLE DERIVATIVES WITH ANTI-INFLAMMATORY ACTIVITY
CA2515119A1 (en) 2003-02-07 2004-08-19 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivative
WO2009041447A1 (en) 2007-09-28 2009-04-02 Takeda Pharmaceutical Company Limited 5-membered heterocyclic compound

Also Published As

Publication number Publication date
IL46476A0 (en) 1975-04-25
DE2503436A1 (en) 1975-08-07
ATA55975A (en) 1977-03-15
NL7501086A (en) 1975-08-04
SE7501010L (en) 1975-08-01
GB1490771A (en) 1977-11-02
CA1036600A (en) 1978-08-15
BE825097A (en) 1975-07-31
FR2259603A1 (en) 1975-08-29
DK33175A (en) 1975-09-29
AU7747875A (en) 1976-07-22
FR2259603B1 (en) 1978-07-21
IL46476A (en) 1978-12-17
AT339898B (en) 1977-11-10
JPS50121269A (en) 1975-09-23
ZA75494B (en) 1976-01-28
NO750278L (en) 1975-08-25
CH587836A5 (en) 1977-05-13

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