GB1216667A - The antibiotic diumycin - Google Patents
The antibiotic diumycinInfo
- Publication number
- GB1216667A GB1216667A GB57923/67A GB5792367A GB1216667A GB 1216667 A GB1216667 A GB 1216667A GB 57923/67 A GB57923/67 A GB 57923/67A GB 5792367 A GB5792367 A GB 5792367A GB 1216667 A GB1216667 A GB 1216667A
- Authority
- GB
- United Kingdom
- Prior art keywords
- diumycin
- extracted
- antibiotic
- butanol
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 2
- 241000192125 Firmicutes Species 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 241000946770 Streptomyces umbrinus Species 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000006286 aqueous extract Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 230000000249 desinfective effect Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
Abstract
1,216,667. Antibiotic diumycin. E. R. SQUIBB & SONS Inc. 20 Dec., 1967 [27 Dec., 1966; 15 Nov., 1967], No. 57923/67. Heading C2A. An antibiotic diumycin and its components A and B, which are effective against gram positive bacteria, yeasts and fungi are coproduced with antibiotic umbrinomycin (Specification 1,216,668) by the cultivation of Streptomyces umbrinus ATCC 15972, or a mutant thereof, in an aqueous nutrient medium under aerobic conditions. The mycelium is separated from the broth at pH 3À0, is extracted with methanol and the methanol is removed at pH 6 to 8 to leave an aqueous suspension of the antibiotics. The aqueous suspension is extracted with butanol at pH 8À0 to remove umbrinomycin and the residual aqueous layer is extracted with water-saturated butanol at pH 3À0 and then back-extracted with water at pH 7À0. The aqueous extracts are concentrated to dryness, the residue dissolved in CH 3 OH, the insolubles removed and acetone added to precipitate the diumycin. It is purified by chromatography and countercurrent distribution. Components A and B are obtained by the countercurrent distribution of diumycin complex using the solvent system n-propanol, n-butanol, 0À5N. NH 4 OH. The diumycins have growth-promoting properties and may be added to animal feeds. They have general disinfecting properties.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60496466A | 1966-12-27 | 1966-12-27 | |
| US69303867A | 1967-11-15 | 1967-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1216667A true GB1216667A (en) | 1970-12-23 |
Family
ID=27084817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB57923/67A Expired GB1216667A (en) | 1966-12-27 | 1967-12-20 | The antibiotic diumycin |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE708601A (en) |
| CH (1) | CH499620A (en) |
| DE (1) | DE1618995A1 (en) |
| FR (2) | FR1549839A (en) |
| GB (1) | GB1216667A (en) |
| NL (1) | NL160877B (en) |
| SE (1) | SE333555B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2471354A1 (en) * | 1979-12-14 | 1981-06-19 | Motte Bernadette | Blue porcelain objects with coloured decorative patterns - where baked blue enamel coating is covered by opaque layer and then by coloured enamel |
-
1967
- 1967-12-20 GB GB57923/67A patent/GB1216667A/en not_active Expired
- 1967-12-22 SE SE17753/67A patent/SE333555B/xx unknown
- 1967-12-22 CH CH1806967A patent/CH499620A/en not_active IP Right Cessation
- 1967-12-22 DE DE19671618995 patent/DE1618995A1/en active Pending
- 1967-12-27 FR FR1549839D patent/FR1549839A/fr not_active Expired
- 1967-12-27 FR FR133930A patent/FR6961M/fr not_active Expired
- 1967-12-27 BE BE708601D patent/BE708601A/xx not_active IP Right Cessation
- 1967-12-27 NL NL6717696.A patent/NL160877B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL160877B (en) | 1979-07-16 |
| BE708601A (en) | 1968-06-27 |
| DE1618995A1 (en) | 1971-06-03 |
| SE333555B (en) | 1971-03-22 |
| FR6961M (en) | 1969-05-19 |
| CH499620A (en) | 1970-11-30 |
| NL6717696A (en) | 1968-06-28 |
| FR1549839A (en) | 1968-12-13 |
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