GB925282A - Fermentation process for the production of demethyltetracycline - Google Patents

Fermentation process for the production of demethyltetracycline

Info

Publication number
GB925282A
GB925282A GB15783/60A GB1578360A GB925282A GB 925282 A GB925282 A GB 925282A GB 15783/60 A GB15783/60 A GB 15783/60A GB 1578360 A GB1578360 A GB 1578360A GB 925282 A GB925282 A GB 925282A
Authority
GB
United Kingdom
Prior art keywords
demethyltetracycline
antibiotic
medium
extracting
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB15783/60A
Inventor
Abramo Virgilio
Carlo Hengeller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Priority to GB15783/60A priority Critical patent/GB925282A/en
Priority to BR128911/61A priority patent/BR6128911D0/en
Publication of GB925282A publication Critical patent/GB925282A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Abstract

The antibiotic 6-demethyltetracycline is produced by cultivating a 6-demethyltetracycline-producing strain of Streptomyces psammoticus especially s. psammoticus ATCC 14125 in an aqueous nutrient medium, e.g. an aqueous medium pH 4-8 containing a water-soluble carbon source, a source of assimilable nitrogen and essential mineral salts, under aerobic submerged conditions until substantial antibiotic activity is imparted to said medium and recovering the antibiotic thereform. Preferably cultivation is carried out at 25 DEG -37 DEG C. for 36-120 hrs. The antibiotic is isolated by acidifying the fermented broth to pH 1.5, filtering, adjusting the filtrate to alkaline pH (pH 8.5-9.0), extracting with a water immiscible aliphatic alcohol of 1-8 carbon atoms, e.g. butanol, extracting the organic phase with a dilute mineral acid, e.g. hydrochloric or sulphuric acid, evaporating the aqueous phase to small volume and adjusting the pH to 5.0 to precipitate 6-demethyltetracycline hydrochloride.
GB15783/60A 1960-05-04 1960-05-04 Fermentation process for the production of demethyltetracycline Expired GB925282A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB15783/60A GB925282A (en) 1960-05-04 1960-05-04 Fermentation process for the production of demethyltetracycline
BR128911/61A BR6128911D0 (en) 1960-05-04 1961-05-03 PREPARATION OF 6-DIMETHYLTHETRACYCLINE BY FERMENTATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB15783/60A GB925282A (en) 1960-05-04 1960-05-04 Fermentation process for the production of demethyltetracycline

Publications (1)

Publication Number Publication Date
GB925282A true GB925282A (en) 1963-05-08

Family

ID=10065386

Family Applications (1)

Application Number Title Priority Date Filing Date
GB15783/60A Expired GB925282A (en) 1960-05-04 1960-05-04 Fermentation process for the production of demethyltetracycline

Country Status (2)

Country Link
BR (1) BR6128911D0 (en)
GB (1) GB925282A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704383A (en) * 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
USRE34656E (en) * 1983-12-29 1994-07-05 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704383A (en) * 1983-12-29 1987-11-03 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
USRE34656E (en) * 1983-12-29 1994-07-05 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency

Also Published As

Publication number Publication date
BR6128911D0 (en) 1973-06-07

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