GB1025050A - 1-(5-nitro-2-furyl)-2-(ª‰-pyridyl)-ethylenes and process for preparing thereof - Google Patents

1-(5-nitro-2-furyl)-2-(ª‰-pyridyl)-ethylenes and process for preparing thereof

Info

Publication number
GB1025050A
GB1025050A GB472265D GB472265D GB1025050A GB 1025050 A GB1025050 A GB 1025050A GB 472265 D GB472265 D GB 472265D GB 472265 D GB472265 D GB 472265D GB 1025050 A GB1025050 A GB 1025050A
Authority
GB
United Kingdom
Prior art keywords
pyridyl
furyl
nitro
ethylene
ethylenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB472265D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of GB1025050A publication Critical patent/GB1025050A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Abstract

The invention comprises 1-(5-nitro-2-furyl)-2-(b -pyridyl) -ethylene having the formula <FORM:1025050/C2/1> and its N-oxide derivative, and a process for the preparation thereof by condensing an alkali salt of (b -pyridyl)-acetic acid with 5-nitrofurfural in the presence of acetic anhydride to form 1 - (5 - nitro - 2 - furyl) - 2 - hydroxy-carbonyl - 2 - (b - pyridyl) - ethylene, followed by decarboxylation of said 1-(5-nitro-2-furyl)-2-hydroxycarbonyl - 2 - (b - pyridyl) - ethylene intermediate in the presence of copper chromite, and if desired, by oxidation of 1-(5-nitro-2-furyl) -(b -pyridyl)-ethylene. Pharmaceutical compositions having antibacterial, -fungal and -protozoal activities and containing the above compounds may be administered orally or topically.
GB472265D 1964-02-14 1965-02-03 1-(5-nitro-2-furyl)-2-(ª‰-pyridyl)-ethylenes and process for preparing thereof Expired GB1025050A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP777764 1964-02-14
JP777864 1964-02-14
JP1923564 1964-04-06

Publications (1)

Publication Number Publication Date
GB1025050A true GB1025050A (en) 1966-04-06

Family

ID=27277748

Family Applications (1)

Application Number Title Priority Date Filing Date
GB472265D Expired GB1025050A (en) 1964-02-14 1965-02-03 1-(5-nitro-2-furyl)-2-(ª‰-pyridyl)-ethylenes and process for preparing thereof

Country Status (3)

Country Link
DE (1) DE1545727A1 (en)
FR (1) FR5049M (en)
GB (1) GB1025050A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072066A1 (en) * 2003-02-11 2004-08-26 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004072066A1 (en) * 2003-02-11 2004-08-26 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
JP2007524577A (en) * 2003-02-11 2007-08-30 プロシディオン・リミテッド Tri (cyclo) substituted amide glucokinase activating compound

Also Published As

Publication number Publication date
FR5049M (en) 1967-05-08
DE1545727A1 (en) 1969-12-11

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