GB1044309A - Substituted 1-aralklyl-piperidines - Google Patents

Substituted 1-aralklyl-piperidines

Info

Publication number
GB1044309A
GB1044309A GB19095/64A GB1909564A GB1044309A GB 1044309 A GB1044309 A GB 1044309A GB 19095/64 A GB19095/64 A GB 19095/64A GB 1909564 A GB1909564 A GB 1909564A GB 1044309 A GB1044309 A GB 1044309A
Authority
GB
United Kingdom
Prior art keywords
halophenyl
reacting
piperidine
reducing
new compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19095/64A
Inventor
Johan Gootjes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Priority to GB19095/64A priority Critical patent/GB1044309A/en
Priority to BE663333D priority patent/BE663333A/xx
Priority to DK230665A priority patent/DK111072B/en
Priority to DE19651620074 priority patent/DE1620074A1/en
Priority to NL6505764A priority patent/NL6505764A/xx
Priority to CH633565A priority patent/CH456592A/en
Priority to FR16316A priority patent/FR1462199A/en
Priority to FR16315A priority patent/FR4626M/fr
Priority to DK321466A priority patent/DK111031B/en
Priority to DK321566A priority patent/DK112524B/en
Publication of GB1044309A publication Critical patent/GB1044309A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New compounds of formula <FORM:1044309/C2/1> where R1 is alkyl (1-6 C), R2 is halogen and m is an integer not greater than 4, and nontoxic acid addition salts thereof, are prepared by (1) reacting a dialkoxyphenylalkylamine with a halophenyl-glutaric anhydride to form a compound <FORM:1044309/C2/2> which is dehydrated by boiling with the anhydride of a lower aliphatic carboxylic acid to form a C-(halophenyl)-N-(dialkoxyphenylalkyl)-glutarimide and reducing the carbonyl groups; (2) reacting a halophenyl-piperidine with an appropriate aldehyde and reducing; (3) reacting a halophenyl-piperidine with an appropriate aralkylhalide. Pharmaceutical compositions comprise the new compounds and salts with carriers. Oral and parenteral preparations having analgesic, anaesthetic, hypotensive and narcosis-potentiating action are described.
GB19095/64A 1964-05-07 1964-05-07 Substituted 1-aralklyl-piperidines Expired GB1044309A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB19095/64A GB1044309A (en) 1964-05-07 1964-05-07 Substituted 1-aralklyl-piperidines
BE663333D BE663333A (en) 1964-05-07 1965-05-03
DK230665A DK111072B (en) 1964-05-07 1965-05-06 Process for the preparation of N-aralkylpiperidine derivatives or acid addition salts thereof.
DE19651620074 DE1620074A1 (en) 1964-05-07 1965-05-06 Piperidine derivatives
NL6505764A NL6505764A (en) 1964-05-07 1965-05-06
CH633565A CH456592A (en) 1964-05-07 1965-05-06 Process for the preparation of piperidine derivatives
FR16316A FR1462199A (en) 1964-05-07 1965-05-07 Preparation of new n-aralkylpiperidines
FR16315A FR4626M (en) 1964-05-07 1966-05-07
DK321466A DK111031B (en) 1964-05-07 1966-06-22 Process for the preparation of N-aralkylpiperidine derivatives or acid addition salts thereof.
DK321566A DK112524B (en) 1964-05-07 1966-06-22 Process for the preparation of N-aralkylpiperidine derivatives or acid addition salts thereof.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB19095/64A GB1044309A (en) 1964-05-07 1964-05-07 Substituted 1-aralklyl-piperidines

Publications (1)

Publication Number Publication Date
GB1044309A true GB1044309A (en) 1966-09-28

Family

ID=10123700

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19095/64A Expired GB1044309A (en) 1964-05-07 1964-05-07 Substituted 1-aralklyl-piperidines

Country Status (7)

Country Link
BE (1) BE663333A (en)
CH (1) CH456592A (en)
DE (1) DE1620074A1 (en)
DK (3) DK111072B (en)
FR (1) FR4626M (en)
GB (1) GB1044309A (en)
NL (1) NL6505764A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489599A (en) * 1991-01-10 1996-02-06 Shell Research Limited Piperidine derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI792076A (en) * 1978-07-05 1980-01-06 Ciba Geigy Ag FOERFARANDE FOER FRAMSTAELLNING AV NYA FENYLPIPERIDINDERIVAT
US4593037A (en) * 1984-07-26 1986-06-03 Pfizer Inc. 1,3-disubstituted piperidine compounds as neuroleptic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489599A (en) * 1991-01-10 1996-02-06 Shell Research Limited Piperidine derivatives

Also Published As

Publication number Publication date
NL6505764A (en) 1965-11-08
BE663333A (en) 1965-11-03
DK112524B (en) 1968-12-23
FR4626M (en) 1966-11-28
DE1620074A1 (en) 1970-03-12
DK111031B (en) 1968-05-13
DK111072B (en) 1968-05-27
CH456592A (en) 1968-07-31

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