FR2907452B1 - "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" - Google Patents

"nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"

Info

Publication number
FR2907452B1
FR2907452B1 FR0609114A FR0609114A FR2907452B1 FR 2907452 B1 FR2907452 B1 FR 2907452B1 FR 0609114 A FR0609114 A FR 0609114A FR 0609114 A FR0609114 A FR 0609114A FR 2907452 B1 FR2907452 B1 FR 2907452B1
Authority
FR
France
Prior art keywords
preparing
novel
pharmaceutical compositions
compositions containing
indolic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0609114A
Other languages
English (en)
Other versions
FR2907452A1 (fr
Inventor
Pascal Marchand
Vincent Babonneau
Sylvie Piessard
Sylvie Duflos
Jean Albert Boutin
Valerie Audinot
Philippe Delagrange
Daniel Henri Caignard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0609114A priority Critical patent/FR2907452B1/fr
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to EA200900480A priority patent/EA200900480A1/ru
Priority to JP2009532843A priority patent/JP2010506889A/ja
Priority to US12/311,787 priority patent/US8003682B2/en
Priority to AU2007310769A priority patent/AU2007310769B2/en
Priority to PCT/FR2007/001707 priority patent/WO2008049996A2/fr
Priority to ZA200902413A priority patent/ZA200902413B/xx
Priority to BRPI0717453-5A2A priority patent/BRPI0717453A2/pt
Priority to EP07858467A priority patent/EP2086933A2/fr
Priority to KR1020097010134A priority patent/KR20090089323A/ko
Priority to MX2009004007A priority patent/MX2009004007A/es
Priority to CNA200780036361XA priority patent/CN101522617A/zh
Priority to GEAP200711252A priority patent/GEP20115192B/en
Priority to UAA200904633A priority patent/UA91646C2/ru
Priority to CA002666497A priority patent/CA2666497A1/fr
Publication of FR2907452A1 publication Critical patent/FR2907452A1/fr
Application granted granted Critical
Publication of FR2907452B1 publication Critical patent/FR2907452B1/fr
Priority to MA31791A priority patent/MA30795B1/fr
Priority to NO20091794A priority patent/NO20091794L/no
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
FR0609114A 2006-10-18 2006-10-18 "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" Expired - Fee Related FR2907452B1 (fr)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR0609114A FR2907452B1 (fr) 2006-10-18 2006-10-18 "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
GEAP200711252A GEP20115192B (en) 2006-10-18 2007-10-17 Novel indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US12/311,787 US8003682B2 (en) 2006-10-18 2007-10-17 Indole compounds, a process for their preparation and pharmaceutical compositions containing them
AU2007310769A AU2007310769B2 (en) 2006-10-18 2007-10-17 Novel indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
PCT/FR2007/001707 WO2008049996A2 (fr) 2006-10-18 2007-10-17 Nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ZA200902413A ZA200902413B (en) 2006-10-18 2007-10-17 Novel indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
BRPI0717453-5A2A BRPI0717453A2 (pt) 2006-10-18 2007-10-17 Derivados indólicos, o respectivo processo de preparo e as composições farmacêuticas que os contêm
EP07858467A EP2086933A2 (fr) 2006-10-18 2007-10-17 Nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA200900480A EA200900480A1 (ru) 2006-10-18 2007-10-17 Новые соединения индола, способ их получения и фармацевтические композиции, которые их содержат
MX2009004007A MX2009004007A (es) 2006-10-18 2007-10-17 Nuevos derivados de indol, proceso para la preparacion de los mismos y composiciones farmaceuticas que los contienen.
CNA200780036361XA CN101522617A (zh) 2006-10-18 2007-10-17 新的吲哚衍生物、其制备方法以及含有它们的药用组合物
JP2009532843A JP2010506889A (ja) 2006-10-18 2007-10-17 新規インドール誘導体、その製造法、およびそれを含有する医薬組成物
UAA200904633A UA91646C2 (ru) 2006-10-18 2007-10-17 Соединения индола, способ их получения и фармацевтическая композиция (варианты), которая их содержит
CA002666497A CA2666497A1 (fr) 2006-10-18 2007-10-17 Nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR1020097010134A KR20090089323A (ko) 2006-10-18 2007-10-17 인돌 유도체，이의 제조 방법 및 이를 함유하는 약제학적 조성물
MA31791A MA30795B1 (fr) 2006-10-18 2009-04-16 Nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO20091794A NO20091794L (no) 2006-10-18 2009-05-06 Nye indolforbindelser en prosess for deres fremstilling og farmasoytiske sammensetninger som inneholder dem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0609114A FR2907452B1 (fr) 2006-10-18 2006-10-18 "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"

Publications (2)

Publication Number Publication Date
FR2907452A1 FR2907452A1 (fr) 2008-04-25
FR2907452B1 true FR2907452B1 (fr) 2008-12-12

Family

ID=37944765

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0609114A Expired - Fee Related FR2907452B1 (fr) 2006-10-18 2006-10-18 "nouveaux derives indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"

Country Status (17)

Country Link
US (1) US8003682B2 (fr)
EP (1) EP2086933A2 (fr)
JP (1) JP2010506889A (fr)
KR (1) KR20090089323A (fr)
CN (1) CN101522617A (fr)
AU (1) AU2007310769B2 (fr)
BR (1) BRPI0717453A2 (fr)
CA (1) CA2666497A1 (fr)
EA (1) EA200900480A1 (fr)
FR (1) FR2907452B1 (fr)
GE (1) GEP20115192B (fr)
MA (1) MA30795B1 (fr)
MX (1) MX2009004007A (fr)
NO (1) NO20091794L (fr)
UA (1) UA91646C2 (fr)
WO (1) WO2008049996A2 (fr)
ZA (1) ZA200902413B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2000272667A1 (en) 2000-09-13 2002-04-29 Jiangsu Kanion Pharmaceutical Co. Pharmaceutical composition treating gynecological blood stasis diseases, cardio and cerebral vascular diseases, respiratory diseases and the like
AR091699A1 (es) 2012-07-10 2015-02-25 Astellas Pharma Inc Derivado de indol carboxamida
CN107405265A (zh) 2015-03-27 2017-11-28 株式会社高丝 脂质体组合物

Also Published As

Publication number Publication date
BRPI0717453A2 (pt) 2013-12-24
AU2007310769B2 (en) 2011-08-11
NO20091794L (no) 2009-05-06
AU2007310769A1 (en) 2008-05-02
CA2666497A1 (fr) 2008-05-02
US20100063128A1 (en) 2010-03-11
GEP20115192B (en) 2011-03-25
CN101522617A (zh) 2009-09-02
FR2907452A1 (fr) 2008-04-25
JP2010506889A (ja) 2010-03-04
US8003682B2 (en) 2011-08-23
MA30795B1 (fr) 2009-10-01
WO2008049996A3 (fr) 2008-06-19
MX2009004007A (es) 2009-04-27
UA91646C2 (ru) 2010-08-10
ZA200902413B (en) 2010-07-28
KR20090089323A (ko) 2009-08-21
EP2086933A2 (fr) 2009-08-12
WO2008049996A2 (fr) 2008-05-02
EA200900480A1 (ru) 2009-10-30

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Effective date: 20120629