FR2612924B1 - Derives de tetrazole antihypercholesterolemiques - Google Patents
Derives de tetrazole antihypercholesterolemiquesInfo
- Publication number
- FR2612924B1 FR2612924B1 FR888802211A FR8802211A FR2612924B1 FR 2612924 B1 FR2612924 B1 FR 2612924B1 FR 888802211 A FR888802211 A FR 888802211A FR 8802211 A FR8802211 A FR 8802211A FR 2612924 B1 FR2612924 B1 FR 2612924B1
- Authority
- FR
- France
- Prior art keywords
- tetrazole derivatives
- antihypercholesterolemic
- antihypercholesterolemic tetrazole
- derivatives
- tetrazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000326 anti-hypercholesterolaemic effect Effects 0.000 title 1
- 150000003536 tetrazoles Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1854287A | 1987-02-25 | 1987-02-25 | |
US07/151,513 US4897490A (en) | 1987-02-25 | 1988-02-18 | Antihypercholesterolemic tetrazole compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2612924A1 FR2612924A1 (fr) | 1988-09-30 |
FR2612924B1 true FR2612924B1 (fr) | 1991-01-11 |
Family
ID=26691223
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR888802211A Expired - Lifetime FR2612924B1 (fr) | 1987-02-25 | 1988-02-24 | Derives de tetrazole antihypercholesterolemiques |
Country Status (31)
Country | Link |
---|---|
US (1) | US4897490A (fr) |
JP (1) | JP2603324B2 (fr) |
KR (1) | KR960001203B1 (fr) |
CN (1) | CN1026110C (fr) |
AT (1) | AT395589B (fr) |
AU (1) | AU1395088A (fr) |
BE (1) | BE1002116A3 (fr) |
CA (1) | CA1328268C (fr) |
CH (1) | CH676848A5 (fr) |
CS (1) | CS271481B2 (fr) |
DE (1) | DE3805801C2 (fr) |
DK (1) | DK174822B1 (fr) |
EG (1) | EG18341A (fr) |
ES (2) | ES2010246A6 (fr) |
FI (1) | FI96601C (fr) |
FR (1) | FR2612924B1 (fr) |
GR (1) | GR1000472B (fr) |
HU (3) | HU204516B (fr) |
IE (1) | IE61619B1 (fr) |
IL (1) | IL85529A (fr) |
IT (1) | IT1216751B (fr) |
LU (1) | LU87144A1 (fr) |
MX (1) | MX9202847A (fr) |
MY (1) | MY103214A (fr) |
NL (1) | NL8800465A (fr) |
NO (1) | NO169438C (fr) |
NZ (1) | NZ223620A (fr) |
PT (1) | PT86820B (fr) |
SE (1) | SE503618C2 (fr) |
WO (1) | WO1988006584A1 (fr) |
YU (1) | YU36388A (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3741509A1 (de) * | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
US4824959A (en) * | 1988-02-18 | 1989-04-25 | Bristol-Myers Company | Intermediates for antihypercholesterolemic tetrazole compounds |
GB2244706B (en) * | 1988-02-18 | 1992-07-15 | Bristol Myers Co | Preparation of antihypercholesterolemic tetrazole intermediates |
US4870187A (en) * | 1988-08-23 | 1989-09-26 | Bristol-Myers Company | Antihypercholesterolemic tetrazol-1-yl compounds |
US5010205A (en) * | 1988-08-23 | 1991-04-23 | Bristol-Myers Company | Antihypercholesterolemic tetrazol-1-yl intermediates |
US4927944A (en) * | 1988-08-25 | 1990-05-22 | Bristol-Myers Company | Antihypercholesterolemic nitrile compounds |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US5413935A (en) * | 1991-04-24 | 1995-05-09 | E. R. Squibb & Sons, Inc. | Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase |
US5134155A (en) * | 1991-08-08 | 1992-07-28 | Ortho Pharmaceutical Corporation | Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors |
US5986095A (en) * | 1992-01-06 | 1999-11-16 | E.R. Squibb & Sons, Inc. | Enantioselective preparation of halophenyl alcohols and acylates |
US5278313A (en) * | 1992-03-27 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors |
US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
JPH06329679A (ja) * | 1993-01-20 | 1994-11-29 | Nissan Chem Ind Ltd | 光学活性β−アミノアルコキシボラン錯体 |
CA2137049A1 (fr) * | 1993-12-15 | 1995-06-16 | John K. Thottathil | Sels d'acides amines de composes antihypercholesterolemiques a base de tetrazole et leur methode de preparation |
DE19714343A1 (de) | 1997-04-08 | 1998-10-15 | Bayer Ag | Chromatographische Enantiomerentrennung von Lactonen |
ATE360608T1 (de) * | 1997-12-19 | 2007-05-15 | Pfizer Ireland Pharmaceuticals | Verfahren zur herstellung von 1,3-diolen |
DE10216967A1 (de) * | 2002-04-16 | 2003-11-13 | Bayer Ag | Verfahren zur Herstellung spezieller aromatischer Aldehyde |
WO2009009152A1 (fr) * | 2007-07-12 | 2009-01-15 | Teva Pharmaceutical Industries Ltd. | Intermédiaires de la rosuvastatine et leur préparation |
KR101681041B1 (ko) | 2015-07-15 | 2016-12-22 | 경북대학교병원 | ERRγ 비활성화 리간드로서의 신규한 방향족 고리 화합물 유도체 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4160100A (en) * | 1973-03-23 | 1979-07-03 | American Home Products Corporation | Oxamic acid derivatives |
US4054666A (en) * | 1973-03-23 | 1977-10-18 | American Home Products Corporation | Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives |
US4013647A (en) * | 1976-03-23 | 1977-03-22 | American Home Products Corporation | Morpholine containing tetrazole-5-carboxamide derivatives |
JPS53147073A (en) * | 1977-05-24 | 1978-12-21 | Sankyo Co Ltd | Mevalonolactone derivatives |
US4375475A (en) * | 1979-08-17 | 1983-03-01 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
NZ194557A (en) * | 1979-08-17 | 1984-09-28 | Merck & Co Inc | Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions |
EP0068038B1 (fr) * | 1981-06-29 | 1985-09-25 | Merck & Co. Inc. | (+)-(4R.6S)-(E)-6-(2-(4'-fluoro-3,3',5-triméthyl-(1,1'-biphényl)-2-yle)éthenyl)-3,4,5,6-tétrahydro-4-hydroxy-2H-pyran-2-one, un procédé pour sa fabrication et une composition pharmaceutique la contenant |
DE3153060D2 (en) * | 1981-12-10 | 1984-10-04 | Willy Bayer | Internal combustion engine |
US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
HU204253B (en) * | 1982-11-22 | 1991-12-30 | Sandoz Ag | Process for producing mevalonolactone analogues and derivatives and pharmaceutical compositions containing them |
GR81711B (fr) * | 1983-01-24 | 1984-12-12 | Sandoz Ag | |
CA1327360C (fr) * | 1983-11-14 | 1994-03-01 | William F. Hoffman | Analogues oxo d'agents antihypercholesterolemiants ayant les caracteristiques de la mevinoline |
US4613610A (en) * | 1984-06-22 | 1986-09-23 | Sandoz Pharmaceuticals Corp. | Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives |
HU198711B (en) * | 1984-06-22 | 1989-11-28 | Sandoz Ag | Process for producing mevalolacton, derivatives and pyrazol analogues and pharmaceutical composition containing them |
US4668794A (en) * | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
US4621099A (en) * | 1985-09-23 | 1986-11-04 | Usv Pharmaceutical Corporation | Polyene compounds useful in the treatment of allergic responses |
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
-
1988
- 1988-02-18 US US07/151,513 patent/US4897490A/en not_active Expired - Lifetime
- 1988-02-24 AU AU13950/88A patent/AU1395088A/en not_active Abandoned
- 1988-02-24 NZ NZ223620A patent/NZ223620A/en unknown
- 1988-02-24 HU HU896737A patent/HU204516B/hu unknown
- 1988-02-24 NO NO880809A patent/NO169438C/no not_active IP Right Cessation
- 1988-02-24 FR FR888802211A patent/FR2612924B1/fr not_active Expired - Lifetime
- 1988-02-24 AT AT0046188A patent/AT395589B/de not_active IP Right Cessation
- 1988-02-24 KR KR1019880002010A patent/KR960001203B1/ko not_active IP Right Cessation
- 1988-02-24 HU HU90669A patent/HU203329B/hu unknown
- 1988-02-24 CH CH692/88A patent/CH676848A5/de not_active IP Right Cessation
- 1988-02-24 GR GR880100101A patent/GR1000472B/el not_active IP Right Cessation
- 1988-02-24 EG EG107/88A patent/EG18341A/xx active
- 1988-02-24 IL IL85529A patent/IL85529A/xx not_active IP Right Cessation
- 1988-02-24 CA CA000559667A patent/CA1328268C/fr not_active Expired - Fee Related
- 1988-02-24 MY MYPI88000178A patent/MY103214A/en unknown
- 1988-02-24 JP JP63502491A patent/JP2603324B2/ja not_active Expired - Lifetime
- 1988-02-24 IE IE50188A patent/IE61619B1/en not_active IP Right Cessation
- 1988-02-24 WO PCT/US1988/000462 patent/WO1988006584A1/fr unknown
- 1988-02-24 ES ES8800532A patent/ES2010246A6/es not_active Expired
- 1988-02-24 SE SE8800638A patent/SE503618C2/xx not_active IP Right Cessation
- 1988-02-24 DK DK198800972A patent/DK174822B1/da not_active IP Right Cessation
- 1988-02-24 CS CS881180A patent/CS271481B2/cs not_active IP Right Cessation
- 1988-02-24 IT IT8819525A patent/IT1216751B/it active
- 1988-02-24 HU HU88886A patent/HU204038B/hu unknown
- 1988-02-24 DE DE3805801A patent/DE3805801C2/de not_active Expired - Lifetime
- 1988-02-24 NL NL8800465A patent/NL8800465A/nl not_active Application Discontinuation
- 1988-02-24 PT PT86820A patent/PT86820B/pt not_active IP Right Cessation
- 1988-02-24 FI FI880869A patent/FI96601C/fi active IP Right Grant
- 1988-02-25 LU LU87144A patent/LU87144A1/fr unknown
- 1988-02-25 YU YU00363/88A patent/YU36388A/xx unknown
- 1988-02-25 BE BE8800220A patent/BE1002116A3/fr not_active IP Right Cessation
- 1988-02-25 CN CN88100911A patent/CN1026110C/zh not_active Expired - Lifetime
-
1989
- 1989-06-23 ES ES8902217A patent/ES2026746A6/es not_active Expired - Fee Related
-
1992
- 1992-06-12 MX MX9202847A patent/MX9202847A/es unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CD | Change of name or company name |