FR2555987B1 - Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation - Google Patents

Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation

Info

Publication number
FR2555987B1
FR2555987B1 FR8418618A FR8418618A FR2555987B1 FR 2555987 B1 FR2555987 B1 FR 2555987B1 FR 8418618 A FR8418618 A FR 8418618A FR 8418618 A FR8418618 A FR 8418618A FR 2555987 B1 FR2555987 B1 FR 2555987B1
Authority
FR
France
Prior art keywords
medicaments
intermediates
preparation
methods
indole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8418618A
Other languages
English (en)
Other versions
FR2555987A1 (fr
Inventor
Alexander William Oxford
Brian Evans
Michael Dennis Dowle
Ian Harold Coates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2555987A1 publication Critical patent/FR2555987A1/fr
Application granted granted Critical
Publication of FR2555987B1 publication Critical patent/FR2555987B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR8418618A 1983-12-06 1984-12-06 Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation Expired FR2555987B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838332435A GB8332435D0 (en) 1983-12-06 1983-12-06 Chemical compounds

Publications (2)

Publication Number Publication Date
FR2555987A1 FR2555987A1 (fr) 1985-06-07
FR2555987B1 true FR2555987B1 (fr) 1987-07-17

Family

ID=10552845

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8418618A Expired FR2555987B1 (fr) 1983-12-06 1984-12-06 Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation

Country Status (27)

Country Link
US (1) US4994483A (fr)
JP (2) JPH062733B2 (fr)
KR (1) KR850004459A (fr)
CN (2) CN85104233A (fr)
AT (1) AT381934B (fr)
AU (1) AU575365B2 (fr)
BE (1) BE901224A (fr)
CA (1) CA1233183A (fr)
CH (1) CH663411A5 (fr)
CY (1) CY1562A (fr)
DE (1) DE3444572C2 (fr)
DK (2) DK583684A (fr)
ES (2) ES8607234A1 (fr)
FI (1) FI80260C (fr)
FR (1) FR2555987B1 (fr)
GB (2) GB8332435D0 (fr)
HK (1) HK85690A (fr)
HU (2) HU196752B (fr)
IL (1) IL73756A (fr)
IT (1) IT1178268B (fr)
NL (1) NL8403719A (fr)
NO (1) NO162764C (fr)
NZ (1) NZ210469A (fr)
PT (1) PT80572B (fr)
SE (1) SE458446B (fr)
SG (1) SG65790G (fr)
ZA (1) ZA849498B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8430624D0 (en) * 1984-12-04 1985-01-09 Glaxo Group Ltd Chemical compounds
SE8505715L (sv) * 1984-12-04 1986-06-05 Glaxo Group Ltd Indolderivat
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
GB2208646B (en) * 1987-08-13 1991-06-26 Glaxo Group Ltd Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JPH01312506A (ja) * 1988-06-13 1989-12-18 Mitsui Petrochem Ind Ltd カラーフィルター
IL98392A (en) * 1990-06-07 1996-01-19 Wellcome Found History of indole, their preparation and the pharmaceutical preparations containing them
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IT1264813B1 (it) * 1993-07-28 1996-10-10 Oxon Italia Spa Procedimento per la preparazione di alcansolfonammidi
EP0875513A1 (fr) * 1997-04-14 1998-11-04 Eli Lilly And Company Composés hétéroaromatiques substitués agonistes du récepteur 5-HT1F
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
JP4897221B2 (ja) * 2002-12-20 2012-03-14 チバ ホールディング インコーポレーテッド アミン類の合成及びその合成のための中間体
WO2004099141A1 (fr) * 2003-05-12 2004-11-18 Ramesh Babu Potluri Nouveau procede pour la preparation de derives d'indole
WO2005123043A2 (fr) * 2004-06-10 2005-12-29 Duramed Pharmaceuticals, Inc. Formulations de sumatriptan absorbables au travers des membranes biologiques, et methodes de production et d'utilisation desdites formulations
PL1883451T3 (pl) * 2005-04-13 2011-05-31 Neuraxon Inc Podstawione związki indolowe mające aktywność hamowania NOS
ZA200809659B (en) * 2006-04-13 2010-03-31 Neuraxon Inc 1,5 and 3,6-substituted indole compounds having NOS inhibitory activity
WO2008056378A2 (fr) * 2006-11-09 2008-05-15 Natco Pharma Limited Nouveau procédé destiné à la préparation de naratriptan
US8148377B2 (en) 2007-02-11 2012-04-03 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile
CA2705422A1 (fr) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Procedes de traitement de la douleur viscerale
WO2009062318A1 (fr) * 2007-11-16 2009-05-22 Neuraxon, Inc. Composés d'indole 3,5-substitués ayant une activité d'inhibition de la réabsorption de la nos et de la noradrénaline
MX356032B (es) 2007-11-16 2018-04-11 Neuraxon Inc Compuestos indola y métodos para tratar el dolor visceral.
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
EP2480197B1 (fr) 2009-09-25 2015-11-11 Dr. Reddy's Laboratories Ltd. Formulations comprenant des composés triptan
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
US20140094521A1 (en) * 2011-05-27 2014-04-03 The University Of Tokushima Benzylamine derivative
US9399053B2 (en) 2011-07-22 2016-07-26 The University Of Chicago Treatments for migraine and related disorders
CN102827062A (zh) * 2012-09-17 2012-12-19 扬子江药业集团四川海蓉药业有限公司 苹果酸阿莫曲坦的制备方法
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322787A (en) * 1964-09-25 1967-05-30 Merck & Co Inc Alpha-hydrazino-beta-(3-indolyl) alkanoic acid derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
IT1036004B (it) * 1968-05-21 1979-10-30 Abc Ist Biolog Chem Spa Acidt 3 indolil adetoidrossamici
US3730723A (en) * 1971-06-17 1973-05-01 Eastman Kodak Co Direct positive processes utilizing silver halide surface image emulsions containing desensitizers
US4283410A (en) * 1978-06-15 1981-08-11 Miles Laboratories, Inc. 3-Amino or amido-2-(1H-indol-3-yl) propanoic acid derivatives
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
NZ197998A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 5-amino(methyl)-1h-indol-3-ylalkaneamines
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
AU548467B2 (en) * 1980-08-12 1985-12-12 Glaxo Group Limited Tryptamines and their isoindolylethyl derivatives
GR79215B (fr) * 1982-06-07 1984-10-22 Glaxo Group Ltd
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
SE8505715L (sv) * 1984-12-04 1986-06-05 Glaxo Group Ltd Indolderivat

Also Published As

Publication number Publication date
FR2555987A1 (fr) 1985-06-07
IT8449265A0 (it) 1984-12-06
FI80260B (fi) 1990-01-31
GB8430810D0 (en) 1985-01-16
SG65790G (en) 1990-10-26
DK214090A (da) 1990-09-06
HUT36455A (en) 1985-09-30
FI80260C (fi) 1990-05-10
AU575365B2 (en) 1988-07-28
JPS60155156A (ja) 1985-08-15
US4994483A (en) 1991-02-19
SE8406200L (sv) 1985-06-07
NZ210469A (en) 1989-01-27
KR850004459A (ko) 1985-07-15
CN85104233A (zh) 1987-01-07
IL73756A (en) 1988-02-29
NO162764B (no) 1989-11-06
DE3444572A1 (de) 1985-06-20
HK85690A (en) 1990-10-25
DK214090D0 (da) 1990-09-06
ES546631A0 (es) 1987-10-16
AT381934B (de) 1986-12-10
AU3636784A (en) 1985-06-13
CA1233183A (fr) 1988-02-23
ES8800150A1 (es) 1987-10-16
IL73756A0 (en) 1985-03-31
JPH062733B2 (ja) 1994-01-12
NL8403719A (nl) 1985-07-01
GB2150932B (en) 1987-10-28
DK583684D0 (da) 1984-12-06
BE901224A (fr) 1985-06-06
ZA849498B (en) 1986-09-24
PT80572B (en) 1986-12-22
CN85106225A (zh) 1987-02-18
CH663411A5 (fr) 1987-12-15
IT1178268B (it) 1987-09-09
HU196752B (en) 1989-01-30
GB2150932A (en) 1985-07-10
ES538336A0 (es) 1986-06-01
NO844879L (no) 1985-06-07
HUT40624A (en) 1987-01-28
JPH03184958A (ja) 1991-08-12
GB8332435D0 (en) 1984-01-11
DE3444572C2 (de) 1993-10-14
SE8406200D0 (sv) 1984-12-06
CY1562A (en) 1991-05-17
CN1015055B (zh) 1991-12-11
DK583684A (da) 1985-06-07
ES8607234A1 (es) 1986-06-01
FI844789L (fi) 1985-06-07
SE458446B (sv) 1989-04-03
FI844789A0 (fi) 1984-12-05
ATA387384A (de) 1986-05-15
NO162764C (no) 1990-02-14
PT80572A (en) 1985-06-01

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Legal Events

Date Code Title Description
ST Notification of lapse