FR2498188B1 - Nouveaux derives de l'indole, leur preparation et leur application comme medicaments - Google Patents

Nouveaux derives de l'indole, leur preparation et leur application comme medicaments

Info

Publication number
FR2498188B1
FR2498188B1 FR8200400A FR8200400A FR2498188B1 FR 2498188 B1 FR2498188 B1 FR 2498188B1 FR 8200400 A FR8200400 A FR 8200400A FR 8200400 A FR8200400 A FR 8200400A FR 2498188 B1 FR2498188 B1 FR 2498188B1
Authority
FR
France
Prior art keywords
medicaments
preparation
application
indole derivatives
new indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8200400A
Other languages
English (en)
Other versions
FR2498188A1 (fr
Inventor
Richard Berthold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2498188A1 publication Critical patent/FR2498188A1/fr
Application granted granted Critical
Publication of FR2498188B1 publication Critical patent/FR2498188B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR8200400A 1981-01-16 1982-01-11 Nouveaux derives de l'indole, leur preparation et leur application comme medicaments Expired FR2498188B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH27581 1981-01-16
CH47581 1981-01-26
CH85281 1981-02-09
CH84981 1981-02-09
CH84681 1981-02-09

Publications (2)

Publication Number Publication Date
FR2498188A1 FR2498188A1 (fr) 1982-07-23
FR2498188B1 true FR2498188B1 (fr) 1983-09-02

Family

ID=27508797

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8200400A Expired FR2498188B1 (fr) 1981-01-16 1982-01-11 Nouveaux derives de l'indole, leur preparation et leur application comme medicaments

Country Status (10)

Country Link
US (1) US4460586A (fr)
AU (1) AU7952682A (fr)
DE (1) DE3200304A1 (fr)
FR (1) FR2498188B1 (fr)
GB (1) GB2091262B (fr)
IL (1) IL64777A0 (fr)
IT (1) IT1189208B (fr)
NZ (1) NZ199489A (fr)
SE (1) SE8200171L (fr)
WO (1) WO1982002550A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3310891A1 (de) * 1983-03-25 1984-09-27 Boehringer Mannheim Gmbh, 6800 Mannheim Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
DE3423429A1 (de) * 1984-06-26 1986-01-02 Beiersdorf Ag, 2000 Hamburg Substituierte phenoxyalkylaminopropanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3424685A1 (de) * 1984-07-05 1986-02-06 Beiersdorf Ag, 2000 Hamburg Neue substituierte phenylpiperazinyl-propanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB2163150B (en) * 1984-07-19 1988-05-25 Sandoz Ltd 3-aminopropoxyaryl derivatives
DE3544172A1 (de) * 1985-12-13 1987-06-19 Lentia Gmbh Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung
DE3721260A1 (de) * 1987-06-27 1989-01-12 Beiersdorf Ag Neue indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US4980351A (en) * 1987-11-04 1990-12-25 Warner-Lambert Company 3-aminopropoxyaryl derivatives having cardiotonic and antihypertensive use and compositions thereof
US4876257A (en) * 1988-03-03 1989-10-24 Ortho Pharmaceutical Corporation 6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
DE4002391A1 (de) * 1990-01-27 1991-08-01 Beiersdorf Ag Indolylpropanole, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5215987A (en) * 1990-04-23 1993-06-01 Ortho Pharmaceutical Corporation Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
US5082847A (en) * 1990-07-18 1992-01-21 Syntex (U.S.A.) Inc. Carbostyril compounds connected via an oxyalkyl group with a piperidine ring and having pharmaceutical utility
TW205034B (fr) * 1990-09-13 1993-05-01 Pola Kasei Kogyo Kk
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5789402A (en) * 1995-01-17 1998-08-04 Eli Lilly Company Compounds having effects on serotonin-related systems
US5741789A (en) * 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5614523A (en) * 1995-01-17 1997-03-25 Eli Lilly And Company Compounds having effects on serotonin-related systems
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE0101769D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1129072A (en) * 1966-02-01 1968-10-02 Ici Ltd Benzofuran and indole derivatives
CH475981A (de) * 1966-12-13 1969-07-31 Sandoz Ag Verfahren zur Herstellung neuer Indol-Derivate
US3699123A (en) * 1970-03-24 1972-10-17 Sandoz Ltd 4-(3-amino-2-hydroxy-propoxy) indole derivatives
GB1410783A (en) * 1972-01-20 1975-10-22 Wyeth John & Brother Ltd N-substituted 4-amidopyridines tetrahydropyridines and piperidines
BE794333A (fr) * 1972-01-20 1973-07-19 Wyeth John & Brother Ltd Composes heterocycliques azotes therapeutiques
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
US4061641A (en) * 1973-10-10 1977-12-06 John Wyeth & Brother Limited Ureidopiperidino-ketoalkyl indoles
GB1543619A (en) * 1976-03-12 1979-04-04 Wyeth John & Brother Ltd Process for preparing 3-(heterocycloalkyl)-indole derivatives
US4146630A (en) * 1976-11-12 1979-03-27 Boehringer Mannheim Gmbh Blood pressure lowering and adrenergic β-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers
US4264599A (en) * 1977-07-08 1981-04-28 Ciba-Geigy Corporation Piperidino-propanols
EP0005828B1 (fr) * 1978-06-06 1981-03-11 Hoechst Aktiengesellschaft Nouvelles dérivés de la phénylpipérazine substitués, médicaments les contenant et procédés pour leur préparation
WO1980000152A1 (fr) * 1978-07-03 1980-02-07 Sandoz Ag Derives d'un 3-aminopropoxy-aryle, leur preparation et utilisation
DE2905876A1 (de) * 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh Neue piperidinopropylderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0025111B1 (fr) * 1979-08-10 1984-07-25 Sandoz Ag Dérivés 3-aminopropoxyaryliques, leur préparation et compositions pharmaceutiques les contenant
CH647235A5 (de) * 1980-02-13 1985-01-15 Sandoz Ag 4-(2,2-dialkylindan-1-yliden)piperidin derivate, ihre herstellung und verwendung.
JPS56142262A (en) * 1980-04-08 1981-11-06 Nippon Shinyaku Co Ltd Piperazine derivative

Also Published As

Publication number Publication date
AU7952682A (en) 1982-07-22
WO1982002550A1 (fr) 1982-08-05
SE8200171L (sv) 1982-07-17
IT1189208B (it) 1988-01-28
FR2498188A1 (fr) 1982-07-23
US4460586A (en) 1984-07-17
DE3200304A1 (de) 1982-08-26
GB2091262B (en) 1985-02-13
IL64777A0 (en) 1982-03-31
GB2091262A (en) 1982-07-28
NZ199489A (en) 1985-11-08

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Legal Events

Date Code Title Description
ST Notification of lapse