FR2503418A1 - DEVICE FOR PROGRAMMING THE COMPOSITION OF A LIQUID, IN PARTICULAR FOR LIQUID-PHASE CHROMATOGRAPHY - Google Patents
DEVICE FOR PROGRAMMING THE COMPOSITION OF A LIQUID, IN PARTICULAR FOR LIQUID-PHASE CHROMATOGRAPHY Download PDFInfo
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- FR2503418A1 FR2503418A1 FR8205792A FR8205792A FR2503418A1 FR 2503418 A1 FR2503418 A1 FR 2503418A1 FR 8205792 A FR8205792 A FR 8205792A FR 8205792 A FR8205792 A FR 8205792A FR 2503418 A1 FR2503418 A1 FR 2503418A1
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- liquid
- mixing chamber
- composition
- programming
- mixer
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- 239000007788 liquid Substances 0.000 title claims abstract description 48
- 239000000203 mixture Substances 0.000 title claims description 16
- 238000004587 chromatography analysis Methods 0.000 title description 8
- 239000007791 liquid phase Substances 0.000 title description 3
- 238000004891 communication Methods 0.000 claims description 2
- 238000004811 liquid chromatography Methods 0.000 claims description 2
- 241000238876 Acari Species 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000010276 construction Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- BTFMCMVEUCGQDX-UHFFFAOYSA-N 1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone Chemical compound C12=CC(C(=O)C)=CC=C2SC2=CC=CC=C2N1CCCN1CCC(CCO)CC1 BTFMCMVEUCGQDX-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- POIUWJQBRNEFGX-XAMSXPGMSA-N cathelicidin Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C1=CC=CC=C1 POIUWJQBRNEFGX-XAMSXPGMSA-N 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960004265 piperacetazine Drugs 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/94—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with rotary cylinders or cones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
- B01F35/717613—Piston pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
- G01N2030/347—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient mixers
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Accessories For Mixers (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
LE DISPOSITIF COMPORTE UNE CHAMBRE DE MELANGE ET DES SOUPAPES ELECTROMAGNETIQUES RACCORDEES A DES RESERVOIRS DE LIQUIDES. DANS LE MELANGEUR 1, AU VOISINAGE DIRECT DES ENTREES 3 DE LIQUIDES VERS LA CHAMBRE DE MELANGE 2, DES SIEGES 9 D'AU MOINS DE DEUX SOUPAPES ELECTROMAGNETIQUES 10, ONT DES ORGANES OBTURATEURS 11 AVEC UNE PARTIE SUPERIEURE DE FORME TRONCONIQUE INVERSEE, DONT LA PARTIE LA PLUS LARGE EST SITUEE ENTRE LA PAROI DE LA CHAMBRE 2 ET LE SIEGE 9. LE MELANGEUR 1 PRESENTE LA FORME D'UN CYLINDRE, ET LES ENTREES 3 DU LIQUIDE VERS LA CHAMBRE DE MELANGE 2 SONT AMENAGEES SUR LE POURTOUR DE CETTE DERNIERE.THE DEVICE INCLUDES A MIXING CHAMBER AND ELECTROMAGNETIC VALVES CONNECTED TO LIQUID TANKS. IN THE MIXER 1, IN THE DIRECT NEIGHBORHOOD OF THE LIQUID INPUTS 3 TOWARDS THE MIXING CHAMBER 2, SEATS 9 WITH AT LEAST TWO ELECTROMAGNETIC VALVES 10, HAVE SHUTTERS 11 WITH AN UPPER PART OF INVERTED TRUNCONIC SHAPE, OF WHICH THE PART THE WIDEST IS SITUATED BETWEEN THE WALL OF CHAMBER 2 AND THE SEAT 9. MIXER 1 SHOWS THE SHAPE OF A CYLINDER, AND THE INPUTS 3 FOR THE LIQUID TO MIXING CHAMBER 2 ARE LAYED ON THE PERIOD OF THE LATTER.
Description
L'invention a pour objet un dispositif de programmation de la compositionThe subject of the invention is a device for programming the composition
d'un liquide, notamment applicable à la of a liquid, in particular applicable to the
chromatographie en phase liquide.liquid chromatography.
On connaît déjà, selon le brevet US 4 004 884 une dispo- Already known, according to US Pat. No. 4,004,884, a provision
sition de programmation de la composition d'un liquide équi- pée d'un reccord, qui est, par l'intermédiaire de n soupapes à double voies électromagnétiques à commande électronique, raccordée à n réservoirs de liquides différents, communiquant programming section for the composition of a liquid equipped with a reccord, which is, via n double electromagnetic electronically controlled valves, connected to n different liquid tanks, communicating
avec une source commune de gaz sous pression. with a common source of pressurized gas.
Durant la programmation de la composition du liquide, au moment consigné, une seule soupape à deux voies est ouverte pour la durée de temps proportionnelle au taux consigné de During the programming of the composition of the liquid, at the set point, only one two-way valve is open for the duration of time proportional to the set rate of
liquide communiqué par elle à une chambre de mélange. liquid communicated by it to a mixing chamber.
Le défaut de cette disposition consiste en la présence de tous les n liquides dans la chambre de mélange, o les divers jets de liquide s'assemblent en un seul flux, ce qui The defect of this arrangement consists in the presence of all the n liquids in the mixing chamber, where the various jets of liquid are assembled in a single flow, which
implique dans ces conditions la pollution inévitable du li- implies in these conditions the inevitable pollution of the li-
quide par les autres, qui ne devraient pas prendre part au processus. En chromatographie, ce fait peut entraîner la perte d'activité de la colonne ou l'engendrement de sommets complémentaires sur le chromatogramme ou encore la dérive de that of others, who should not be part of the process. In chromatography, this fact can cause the loss of activity of the column or the generation of additional vertices on the chromatogram or the drift of
la ligne zéro.the zero line.
Un autre inconvénient de cette disposition consiste en ce que les divers liquides sont affectés dans les réservoirs Another drawback of this arrangement is that the various liquids are assigned to the tanks
par la présence du gaz sous pression. Du fait qu'en chromato- by the presence of gas under pressure. Because in chromato-
graphie on utilise en général de hautes pressions de l'ordre de 50 à 500 atm, le liquide dans le réservoir est chargé de In general we use high pressures of the order of 50 to 500 atm, the liquid in the tank is responsible for
gaz en quelques minutes. Le gaz dissout dans le liquide impli- gas in minutes. The gas dissolved in the liquid involved
que des changements défavorables de ses propriétés et il nuit au travail du chromatographe à cause du dégazage du liquide only adverse changes in its properties and it interferes with the work of the chromatograph due to degassing of the liquid
dans la cuvette d'écoulement du détecteur. in the detector drain pan.
En outre, dans la chambre de mélange appliquée dans la In addition, in the mixing chamber applied in the
disposition, les composants ne sont pas mélangés, c'est pour- disposal, the components are not mixed, that is why
quoi le processus de la composition des liquides programmés what the process of composition of programmed liquids
se différenciera de celui consigné aux divers moments. will differ from that recorded at various times.
En plus, le montage des soupapes à deux voies et des In addition, the mounting of the two-way valves and the
réservoirs à liquides dans la partie refoulante de la dispo- liquid tanks in the pressure side of the device
sition impose à ces éléments une construction apte à résister aux hautes pressions, Le dispositif connu jusqu'à présent de programmation de la composition d'un liquide de la société américaine dite sition imposes on these elements a construction capable of withstanding high pressures, The device known until now for programming the composition of a liquid from the so-called American company
Spectra Physics, comporte une soupape à quatre voies, commu- Spectra Physics, includes a four-way valve, common
niquant d'une part par des conduites avec trois réservoirs de liquide, et d'autre part par un mélangeur avec le conduit connecting on the one hand by pipes with three liquid tanks, and on the other hand by a mixer with the pipe
d'aspiration d'une pompe à piston.of a piston pump.
Le mélangeur présente un volume mort de l'ordre de 1,9 ml. La sortie de chacun de ces trois conduits communiquant le liquide à la soupape est équipée d'une membrane mise en The mixer has a dead volume of the order of 1.9 ml. The outlet of each of these three conduits communicating the liquid to the valve is equipped with a membrane
mouvement au moyen d'une bobine électromagnétique. movement by means of an electromagnetic coil.
A l'endroit du raccord des trois conduits contenant cha- At the location of the connection of the three conduits containing each
cun un liquide différent, à chaque instant sont présents tous cun a different liquid, at all times are present all
les liquides sans égard à la quantité de liquides programmés. liquids regardless of the quantity of liquids programmed.
L'inconvénient principal d'un tel dispositif consiste en le contact permanent des liquides proportionnés en présence dans The main drawback of such a device consists in the permanent contact of the proportioned liquids present in
les réservoirs mis en communication par la soupape. Cela im- the tanks placed in communication by the valve. It im-
plique la pollution de la solution proportionnée par les au- plique the pollution of the solution proportioned by the au-
tres liquides, fait qui peut provoquer la désactivation de la colonne chromatographique, la dérive de la ligne zéro, et autres inconvénients semblables. En plus, un défaut gênant very liquid, a fact which can cause deactivation of the chromatographic column, drift of the zero line, and other similar disadvantages. In addition, an annoying defect
résultent également du grand volume mort du dispositif, dé- also result from the large dead volume of the device,
terminé par le raccordement de la soupape, du mélangeur et de finished by connecting the valve, mixer and
la pompe.the pump.
Le dispositif de programmation de la composition d'un The device for programming the composition of a
liquide, notamment applicable en chromatographie en phase li- liquid, particularly applicable in liquid phase chromatography
quide, comportant une chambre de mélange et des électrovannes quide, comprising a mixing chamber and solenoid valves
se caractérise selon l'invention par le fait que dans le mé- is characterized according to the invention by the fact that in the mete
langeur, au voisinage direct des entrées de liquide vers la chambre de mélange, on a prévu le montage solidaire de sièges d'au moins deux soupapes électromagnétiques, dont les organes langor, in the immediate vicinity of the liquid inlets to the mixing chamber, provision has been made for the integral mounting of seats of at least two electromagnetic valves, the members
obturateurs ont une partie supérieure en forme de cône tron- shutters have a tapered cone-shaped top
qué inversé, et en ce que la partie la plus large du cône est logée entre la paroi de la chambre de mélange et le siège de inverted, and in that the widest part of the cone is housed between the wall of the mixing chamber and the seat of
la soupape électromagnétique.the electromagnetic valve.
Le mélangeur présente la forme d'un cylindre, et les en- The mixer has the shape of a cylinder, and the
trées de liquide vers la chambre de mélange sont aménagées liquid flows to the mixing chamber are arranged
sur son pourtour.around its perimeter.
Les soupapes électromagnétiques sont du type à deux voies. The electromagnetic valves are of the two-way type.
Le dispositif peut tout aussi bien fonctionner du côté refoulement que du côté aspiration de la pompe. En cas de son montage du côté refoulement de la pompe, les réservoirs de liquide présentent la forme d'une conduite enroulée en vis The device can work just as well on the discharge side as on the suction side of the pump. When mounted on the discharge side of the pump, the liquid tanks have the form of a screw-wound pipe
sans fin.unending.
Par construction, le profil du mélangeur et celui de la By construction, the profile of the mixer and that of the
chambre de mélange en forme de cylindre, assure le remplis- cylinder-shaped mixing chamber, ensures filling
sage maximum de la chambre de mélange, donc réduisant ainsi maximum sage from the mixing chamber, thus reducing
le volume mort de la chambre au minimum. the minimum volume of the chamber.
Grâce à cela, on peut fidèlement programmer la composi- Thanks to this, one can faithfully program the composition
tion de la phase mobile, même sans le mélange des liquides introduit dans la chambre, tout au moins dans la gamme des tion of the mobile phase, even without the mixture of liquids introduced into the chamber, at least in the range of
concentrations de 10 à 90%.concentrations from 10 to 90%.
On a pu vérifier expérimentalement la répétabilité et la précision des allures de gradient en fonction du volume mort de la chambre de mélange, de la vitesse de la phase mobile We were able to verify experimentally the repeatability and the accuracy of the gradient patterns as a function of the dead volume of the mixing chamber, of the speed of the mobile phase.
ainsi qu'en fonction de la durée de mélange de ses composants. as well as according to the duration of mixing of its components.
Les avantages du dispositif consistent en l'élimination The advantages of the device consist in the elimination
du processus de mélange des liquides, qui dans ledit proces- of the process of mixing liquids, which in said process
sus ne sont pas soumis à la programmation, et aussi en la possibilité de programmation de la composition du liquide à partir de n composants, dont les taux de concentration en above are not subject to programming, and also to the possibility of programming the composition of the liquid from n components, including the concentration rates of
divers composants en fonction du temps seront quelconques. various components as a function of time will be arbitrary.
En outre, les réservoirs de liquide, les soupapes élec- In addition, the liquid tanks, the electric valves
tromagnétiques et le mélangeur peuvent être montés indifférem- tromagnetic and the mixer can be mounted indifferently
ment côté refoulement ou aspiration de la pompe. on the discharge or suction side of the pump.
En plus, il y a la possibilité d'ajustage d'un volume convenable de la chambre de mélange en fonction du débit de In addition, there is the possibility of adjusting a suitable volume of the mixing chamber according to the flow of
la pompe et de la durée des temps de programmation de la com- the pump and the duration of the programming times of the
position du liquide transmis vers la colonne de chromatogra- position of the liquid transmitted to the chromatography column
phie.phie.
Une forme de réalisation de l'invention est décrite à titre d'exemple en référence aux dessins annexés o: - la figure 1 présente le dispositif de programmation de la composition d'un liquide en coupe longitudinale, et An embodiment of the invention is described by way of example with reference to the accompanying drawings o: - Figure 1 shows the device for programming the composition of a liquid in longitudinal section, and
- la figure 2 est un schéma-bloc général du chromatogra- - Figure 2 is a general block diagram of the chromatography
phe en phase liquide avec le dispositif branché de programma- phe in liquid phase with the connected programming device
tion de la composition d'un liquide. tion of the composition of a liquid.
Suivant la forme de réalisation choisie et représentée (figure 1), le dispositif comporte un mélangeur 1 en forme de cylindre à chambre de mélange 2, sur le pourtour de laquelle on a aménagé deux entrées 3 de liquide. La chambre de mélange 2 est limitée en haut par un piston 4, dans l'axe de symétrie duquel est aménagé un canal 5 d'évacuation du liquide, et elle est équipée d'un agitateur mécanique 6 en forme de cylin- According to the embodiment chosen and shown (Figure 1), the device comprises a mixer 1 in the form of a cylinder with mixing chamber 2, on the periphery of which two liquid inlets 3 have been arranged. The mixing chamber 2 is limited at the top by a piston 4, in the axis of symmetry of which is arranged a channel 5 for discharging the liquid, and it is equipped with a mechanical agitator 6 in the form of a cylinder.
dre, à arbre d'entraînement 7 monté dans un presse-étoupe 8. dre, with drive shaft 7 mounted in a cable gland 8.
Le diamètre de l'agitateur 6 est inférieur à celui de la The diameter of the agitator 6 is less than that of the
chambre 2 de lmm environ. Dans le voisinage direct de l'en- bedroom 2 of lmm approximately. In the direct vicinity of the
trée 3 de liquide, on a prévu le montage d'un siège 9 d'une inlet 3 of liquid, provision has been made for mounting a seat 9 of a
soupape électromagnétique à deux voies 10, dont l'organe ob- two-way electromagnetic valve 10, the component of which
turateur 11 présente à la partie supérieure le profil d' un cône tronqué inversé sa partie la plus large surmontant le siège 9 de la soupape 10. L'organe 11 est solidaire d'un aimant 12 coulissant dans la carcasse-bâti 13 de la soupape 10, turateur 11 has at the upper part the profile of an inverted truncated cone, its widest part surmounting the seat 9 of the valve 10. The member 11 is integral with a magnet 12 sliding in the carcass-frame 13 of the valve 10,
dont la paroi intérieure présente un canal 14 d'entrée de li- whose inner wall has a channel 14 for inlet of
quide communiquant par une conduite 15 avec un réservoir de which communicates via a line 15 with a reservoir of
liquide 16. La carcasse 13 est équipée d'une bobine d'induc- liquid 16. The carcass 13 is equipped with a coil of induc-
tance 17. Le presse-étoupe 8 comporte un chapeau 18 et une tance 17. The cable gland 8 has a cap 18 and a
bague d'étanchéité 19.sealing ring 19.
Le siège 9 de la soupape 10 est étanché entre le bâti 13 de la soupape et l'agitateur 1 au moyen de rondelles 20 The seat 9 of the valve 10 is sealed between the frame 13 of the valve and the agitator 1 by means of washers 20
en polytétraflu6réthylène. Conformément à la figure 2, le mé- in polytetraflu6rethylene. According to Figure 2, the met-
langeur 1 communique avec la pompe à piston 21, tandis que les bobines d'inductance 17 associées à la carcasse 13 de la soupape électromagnétique 10 sont reliées au circuit de commande électronique 22. La pompe à piston 21 refoule le langeur 1 communicates with the piston pump 21, while the inductance coils 17 associated with the carcass 13 of the electromagnetic valve 10 are connected to the electronic control circuit 22. The piston pump 21 delivers the
liquide mélangé par le doseur 23 et la colonne de chromato- liquid mixed by the doser 23 and the chromatography column
graphie 24 vers un détecteur 25 qui est connecté à un enregis- writing 24 to a detector 25 which is connected to a recorder
treur 26.sorrow 26.
En fonctionnement, on met d'abord en marche la pompe à In operation, the pump is first started
piston 21 et l'agitateur mécanique 6. Les bobines d'inductan- piston 21 and the mechanical stirrer 6. The inductor coils
ce 17 des soupapes 10 sont connectées au circuit de commande 22, et on règle le programme de travail de chaque soupape 10 de manière à ce qu'elles soient ouvertes alternativement. A partir du réservoir 16 la pompe aspire le liquide qui s'écoule par la soupape 10 actuellement ouverte et l'entrée 3 vers la chambre de mélange 2, o il sera mélangé avec celui présent ce 17 of the valves 10 are connected to the control circuit 22, and the working program of each valve 10 is adjusted so that they are opened alternately. From the reservoir 16 the pump sucks the liquid which flows through the valve 10 currently open and the inlet 3 towards the mixing chamber 2, where it will be mixed with that present
dans la chambre 2 par injection en continu. Le taux en pour- in chamber 2 by continuous injection. The rate in
cent de liquide injecté à travers la soupape ouverte 10 est cent of liquid injected through the open valve 10 is
25034 1 825034 1 8
proportionnel à la durée de son ouverture. Après l'obtention de la composition des divers liquides à composition consignée à l'avance en quantité, la solution est transférée par la proportional to the duration of its opening. After obtaining the composition of the various liquids with composition consigned in advance in quantity, the solution is transferred by the
pompe 21 et le doseur 23 à la colonne de chromatographie 24. pump 21 and the metering device 23 to the chromatography column 24.
Après le passage par la colonne de chromatographie 24, la so- lution est dirigée vers l'évacuation à travers le détecteur 25. Le signal électrique du détecteur 25 est enregistré par After passing through the chromatography column 24, the solution is directed to the discharge through the detector 25. The electrical signal from the detector 25 is recorded by
l'enregistreur 26. Le nombre de soupapes 10 équipant le mé- the recorder 26. The number of valves 10 equipping the
langeur 1 détermine celui des composants du mélange programmé langeur 1 determines that of the components of the programmed mixture
de la solution.of the solution.
Claims (3)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL1981230992A PL134765B1 (en) | 1981-04-06 | 1981-04-06 | Apparatus for programming compositions of liquids in particular for use in gas chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2503418A1 true FR2503418A1 (en) | 1982-10-08 |
Family
ID=20008338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8205792A Withdrawn FR2503418A1 (en) | 1981-04-06 | 1982-04-02 | DEVICE FOR PROGRAMMING THE COMPOSITION OF A LIQUID, IN PARTICULAR FOR LIQUID-PHASE CHROMATOGRAPHY |
Country Status (7)
Country | Link |
---|---|
CS (1) | CS233727B2 (en) |
DD (1) | DD202247A5 (en) |
DE (1) | DE3212604A1 (en) |
FR (1) | FR2503418A1 (en) |
GB (1) | GB2096012B (en) |
HU (1) | HU183880B (en) |
PL (1) | PL134765B1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4496245A (en) * | 1983-03-07 | 1985-01-29 | International Business Machines Corporation | Liquid chromatography proportioning valve and mixer |
US6299767B1 (en) * | 1999-10-29 | 2001-10-09 | Waters Investments Limited | High pressure capillary liquid chromatography solvent delivery system |
US6780315B2 (en) * | 2002-12-09 | 2004-08-24 | Waters Investments Limited | Backflow prevention for high pressure gradient systems |
WO2019186223A1 (en) * | 2018-03-28 | 2019-10-03 | Bio-Rad Laboratories, Inc. | Fluid mixer, pressure sensor |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB329839A (en) * | 1929-05-18 | 1930-05-29 | Frank Peto Barber | Improvements in mixing valves for liquids |
FR1201127A (en) * | 1958-08-05 | 1959-12-28 | Majeste La Reine De Droit Du C | Valve device for selective outlets of tilting and reversing tanks of aircraft |
FR1436373A (en) * | 1964-05-30 | 1966-04-22 | Hoechst Ag | Process and apparatus for the preparation of alkali salts of aromatic hydroxy compounds |
FR2236458A1 (en) * | 1973-07-13 | 1975-02-07 | Brand Willi | |
US4004884A (en) * | 1976-07-02 | 1977-01-25 | Hoffmann-La Roche Inc. | Time division metering system |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2758297A1 (en) * | 1977-12-27 | 1979-06-28 | Desma Werke Gmbh | Polyurethane foam mixing head - with rotary valves for mixing chamber or reflux system |
-
1981
- 1981-04-06 PL PL1981230992A patent/PL134765B1/en unknown
-
1982
- 1982-03-30 GB GB8209325A patent/GB2096012B/en not_active Expired
- 1982-04-01 CS CS822352A patent/CS233727B2/en unknown
- 1982-04-02 DD DD82238708A patent/DD202247A5/en unknown
- 1982-04-02 FR FR8205792A patent/FR2503418A1/en not_active Withdrawn
- 1982-04-05 DE DE19823212604 patent/DE3212604A1/en not_active Ceased
- 1982-04-06 HU HU821055A patent/HU183880B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB329839A (en) * | 1929-05-18 | 1930-05-29 | Frank Peto Barber | Improvements in mixing valves for liquids |
FR1201127A (en) * | 1958-08-05 | 1959-12-28 | Majeste La Reine De Droit Du C | Valve device for selective outlets of tilting and reversing tanks of aircraft |
FR1436373A (en) * | 1964-05-30 | 1966-04-22 | Hoechst Ag | Process and apparatus for the preparation of alkali salts of aromatic hydroxy compounds |
FR2236458A1 (en) * | 1973-07-13 | 1975-02-07 | Brand Willi | |
US4004884A (en) * | 1976-07-02 | 1977-01-25 | Hoffmann-La Roche Inc. | Time division metering system |
Also Published As
Publication number | Publication date |
---|---|
DD202247A5 (en) | 1983-09-07 |
GB2096012B (en) | 1984-08-22 |
DE3212604A1 (en) | 1982-10-14 |
GB2096012A (en) | 1982-10-13 |
PL230992A1 (en) | 1982-10-11 |
HU183880B (en) | 1984-06-28 |
PL134765B1 (en) | 1985-09-30 |
CS233727B2 (en) | 1985-03-14 |
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