FR2441625A1 - (d2-imidazolinyl-2 amino)-5 pyrimidines, procede pour les preparer, et medicaments qui en contiennent - Google Patents

(d2-imidazolinyl-2 amino)-5 pyrimidines, procede pour les preparer, et medicaments qui en contiennent

Info

Publication number
FR2441625A1
FR2441625A1 FR7928169A FR7928169A FR2441625A1 FR 2441625 A1 FR2441625 A1 FR 2441625A1 FR 7928169 A FR7928169 A FR 7928169A FR 7928169 A FR7928169 A FR 7928169A FR 2441625 A1 FR2441625 A1 FR 2441625A1
Authority
FR
France
Prior art keywords
imidazolinyl
pyrimidines
amino
medicinal products
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7928169A
Other languages
English (en)
Other versions
FR2441625B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2849537A external-priority patent/DE2849537C2/de
Priority claimed from DE19792937023 external-priority patent/DE2937023A1/de
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of FR2441625A1 publication Critical patent/FR2441625A1/fr
Application granted granted Critical
Publication of FR2441625B1 publication Critical patent/FR2441625B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NOUVELLES (D-IMIDAZOLINYL-2 AMINO)-5 PYRIMIDINES. ELLES REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R, R ET R REPRESENTENT CHACUN, INDEPENDAMMENT LES UNS DES AUTRES, UN ATOME D'HYDROGENE OU D'HALOGENE, UN RADICAL ALCOXY, ALKYLTHIO OU ALKYLE EN C-C OU UN RADICAL CYCLOALKYLE EN C-C, ET R REPRESENTE UN ATOME D'HYDROGENE OU UN RADICAL ACYLE ALIPHATIQUE OU AROMATIQUE. CES COMPOSES, A L'ETAT DE BASES LIBRES OU DE SELS, PEUVENT ETRE UTILISES COMME SUBSTANCES ACTIVES DE MEDICAMENTS DESTINES NOTAMMENT AU TRAITEMENT DE L'HYPERTENSION OU DU GLAUCOME.
FR7928169A 1978-11-15 1979-11-15 (d2-imidazolinyl-2 amino)-5 pyrimidines, procede pour les preparer, et medicaments qui en contiennent Granted FR2441625A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2849537A DE2849537C2 (de) 1978-11-15 1978-11-15 Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE19792937023 DE2937023A1 (de) 1979-09-13 1979-09-13 Neue substituierte 5-(2-imidazolin-2-yl)-aminopyrimidine und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
FR2441625A1 true FR2441625A1 (fr) 1980-06-13
FR2441625B1 FR2441625B1 (fr) 1981-12-31

Family

ID=25776489

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7928169A Granted FR2441625A1 (fr) 1978-11-15 1979-11-15 (d2-imidazolinyl-2 amino)-5 pyrimidines, procede pour les preparer, et medicaments qui en contiennent

Country Status (12)

Country Link
US (1) US4323570A (fr)
AT (1) AT374197B (fr)
AU (1) AU541305B1 (fr)
CA (1) CA1138454A (fr)
CH (1) CH642965A5 (fr)
DK (1) DK150142C (fr)
ES (1) ES486349A1 (fr)
FR (1) FR2441625A1 (fr)
GB (1) GB2039275B (fr)
IT (1) IT1127225B (fr)
NL (2) NL190553C (fr)
SE (1) SE440079B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046241A1 (fr) * 1996-06-06 1997-12-11 Eli Lilly And Company Formulation et methode pour traiter l'insuffisance cardiaque congestive

Families Citing this family (49)

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GB2146986B (en) * 1983-09-23 1987-06-17 Lilly Co Eli Process for preparing 5-substituted pyrimidines
DE3729299A1 (de) * 1987-09-02 1989-03-23 Beiersdorf Ag Transdermales therapeutisches system
DE3739779A1 (de) * 1987-11-24 1989-06-08 Beiersdorf Ag Pharmazeutische praeparate
DE3904795C2 (de) * 1989-02-17 2000-10-12 Lilly Pharma Produktion Gmbh & Pharmazeutisches Präparat und dessen Verwendung
US5972948A (en) * 1994-07-01 1999-10-26 Solvay Pharmaceuticals Gmbh Method of inhibiting hyperglycemia and pharmaceutical composition for use therein
DE4423177A1 (de) * 1994-07-01 1996-01-04 Kali Chemie Pharma Gmbh Antihyperglykämisch wirksame Arzneimittel
AU4941796A (en) * 1995-02-28 1996-09-18 Beiersdorf-Lilly Gmbh Use of moxonidine for the treatment of atherosclerosis
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
IL118544A (en) * 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
CA2182851A1 (fr) * 1995-08-15 1997-02-16 August Masaru Watanabe Methode de traitement d'un etat resultant de l'arret de la consommation abusive de drogues
IL123232A0 (en) * 1997-02-11 1999-11-30 Lilly Co Eli Medicament for inhibiting glucose metabolism deterioration
DE19722322A1 (de) * 1997-05-28 1998-12-03 Solvay Pharm Gmbh Nephroprotektives Arzneimittel
CA2269971A1 (fr) * 1997-09-03 1999-03-11 Trent Lee Abraham Derives de pyrimidine
DE19911371A1 (de) 1999-03-15 2000-09-21 Solvay Pharm Gmbh Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen
PL372695A1 (en) * 2002-06-19 2005-07-25 Solvay Pharmaceuticals Gmbh Medicament for the treatment of diseases requiring inhibition or a reduction in the activity of ph value-regulating bicarbonate transporter proteins
JP2009524619A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のための２−イミダゾールの使用
EP1894926A1 (fr) * 2006-06-26 2008-03-05 Chemagis Ltd. Substances polymorphes de moxonidine et procédés de leur préparation
DK1873152T3 (da) * 2006-06-26 2009-02-09 Chemagis Ltd Hidtil ukendt fremgangsmåde til oprensning af Moxonidin
ATE407931T1 (de) * 2006-06-26 2008-09-15 Chemagis Ltd Verbessertes verfahren zur herstellung von moxonidine
WO2008020425A1 (fr) * 2006-08-17 2008-02-21 Chemagis Ltd. Moxonidine cristalline contenant un tautomère unique et son procédé de préparation
DE602006018139D1 (de) * 2006-08-31 2010-12-23 Chemagis Ltd Verwendung der Monoxidinssalze zur Reinigung von Monoxidin
JP5167265B2 (ja) * 2006-10-19 2013-03-21 エフ．ホフマン−ラ ロシュ アーゲー 微量アミン関連受容体に親和性を有するアミノメチル−２−イミダゾール
MX2009003801A (es) * 2006-10-19 2009-04-22 Hoffmann La Roche Aminometil-4-imidazoles.
MX2009004617A (es) * 2006-11-02 2009-05-22 Hoffmann La Roche 2-imidazoles sustituidos como moduladores de los receptores asociados con trazas de amina.
AU2007321376A1 (en) * 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
WO2008073125A1 (fr) * 2006-12-12 2008-06-19 Chemagis Ltd. Analogues de la moxonidine, procédés de préparation et utilisations de ceux-ci
BRPI0720047A2 (pt) * 2006-12-13 2013-12-24 Hoffmann La Roche 2-imidazóis como ligantes para receptores associados a aminas de traço (taar)
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
EP2114906B1 (fr) * 2007-02-02 2014-08-06 F. Hoffmann-La Roche AG Composés de 2-aminooxazoline comme ligands du taar1 pour des troubles du snc
ES2525229T3 (es) * 2007-02-15 2014-12-19 F. Hoffmann-La Roche Ag 2-aminooxazolinas como ligandos de TAAR1
EP2173720A2 (fr) 2007-07-02 2010-04-14 F. Hoffmann-Roche AG 2-imidazolines
JP2010531836A (ja) * 2007-07-03 2010-09-30 エフ．ホフマン−ラ ロシュ アーゲー ４−イミダゾリン及びそれらの抗うつ剤としての使用
CN101765587A (zh) * 2007-07-27 2010-06-30 弗·哈夫曼-拉罗切有限公司 作为taar配体的2-氮杂环丁烷甲胺类和2-吡咯烷甲胺类
AU2008281877A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of CNS disorders
WO2009019149A1 (fr) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Dérivés de pyridinecarboxamide et de benzamide servant de ligands de taar1
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
CN102083805A (zh) * 2008-07-24 2011-06-01 弗·哈夫曼-拉罗切有限公司 4,5-二氢-唑-2-基衍生物
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
EP2586779A1 (fr) 2011-10-24 2013-05-01 Hetero Research Foundation Procédé pour la préparation de moxonidine
DE102012215896A1 (de) 2012-09-07 2014-03-13 Wörwag Pharma GmbH & Co.KG Moxonidinsynthese mit Hilfe organischer Basen
EP2738165B1 (fr) 2012-12-03 2016-10-12 WÖRWAG PHARMA GmbH & Co. KG Procédé au moyen d'une catalyse par transfert de phase
EP2765131B1 (fr) 2013-02-08 2016-11-23 Arevipharma GmbH Procédé de production de monoxidine
WO2014140034A1 (fr) * 2013-03-14 2014-09-18 Farmak, A.S. Procédé perfectionné pour la fabrication de moxonidine
EP2829540A1 (fr) 2013-07-26 2015-01-28 Abbott Healthcare Products B.V. Synthèse d'aminopyridines substituées
EP3884935B1 (fr) 2013-08-09 2023-06-14 Ardelyx, Inc. Composés et procédés d'inhibition du transport de phosphate
SG11201807516UA (en) 2016-03-17 2018-09-27 Hoffmann La Roche 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
EP4243826A1 (fr) 2020-11-12 2023-09-20 3Z Ehf Nouveaux traitements du trouble du déficit de l'attention/hyperactivité

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (fr) 1969-08-14 1971-02-15 Beecham Group Ltd Iminazolines
GB1319840A (en) * 1970-08-27 1973-06-13 Beecham Group Ltd Substituted 5-amino imidazoles
BE795636A (fr) * 1972-02-19 1973-08-20 Schering Ag Nitroimidazolylpyrimidines, et leur procede de preparation
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
DE2220906A1 (de) * 1972-04-28 1973-11-15 Boehringer Sohn Ingelheim Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung
BE503170A (fr) * 1975-09-02

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997046241A1 (fr) * 1996-06-06 1997-12-11 Eli Lilly And Company Formulation et methode pour traiter l'insuffisance cardiaque congestive

Also Published As

Publication number Publication date
CA1138454A (fr) 1982-12-28
US4323570A (en) 1982-04-06
AU541305B1 (en) 1985-01-03
NL190553B (nl) 1993-11-16
SE440079B (sv) 1985-07-15
DK150142B (da) 1986-12-15
SE7909392L (sv) 1980-05-16
NL7908192A (nl) 1980-05-19
IT7927284A0 (it) 1979-11-14
NL940011I2 (nl) 1998-05-06
ES486349A1 (es) 1980-06-16
GB2039275B (en) 1982-11-17
IT1127225B (it) 1986-05-21
DK150142C (da) 1987-06-01
DK481879A (da) 1980-05-16
AT374197B (de) 1984-03-26
NL190553C (nl) 1994-04-18
NL940011I1 (nl) 1994-08-01
CH642965A5 (de) 1984-05-15
ATA727079A (de) 1983-08-15
GB2039275A (en) 1980-08-06
FR2441625B1 (fr) 1981-12-31

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Legal Events

Date Code Title Description
TP Transmission of property
CD Change of name or company name
CP Supplementary protection certificate (spc) filed

Free format text: PRODUCT NAME: MOXONIDINE; NAT. REGISTRATION NO/DATE: NL 18307 19940919; FIRST REGISTRATION: DE - 99530200 19910123

Spc suppl protection certif: 94C0021

Filing date: 19941103

CP Supplementary protection certificate (spc) filed

Free format text: 95C0021, 941103

CR Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992)

Free format text: 95C0021, 941103

CP Supplementary protection certificate (spc) filed
CY Supplementary certificate of protection granted (eec regulation of 18 june 1992)

Free format text: 94C0021, 941103, EXPIRES:20041114

CP Supplementary protection certificate (spc) filed