FR2440365A1 - Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs - Google Patents

Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs

Info

Publication number
FR2440365A1
FR2440365A1 FR7926983A FR7926983A FR2440365A1 FR 2440365 A1 FR2440365 A1 FR 2440365A1 FR 7926983 A FR7926983 A FR 7926983A FR 7926983 A FR7926983 A FR 7926983A FR 2440365 A1 FR2440365 A1 FR 2440365A1
Authority
FR
France
Prior art keywords
hypertensors
azolidine
carboxylic acid
acid derivatives
derivatives useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7926983A
Other languages
English (en)
Other versions
FR2440365B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13509378A external-priority patent/JPS5562060A/ja
Priority claimed from JP15516678A external-priority patent/JPS5581854A/ja
Priority claimed from JP1251979A external-priority patent/JPS55104275A/ja
Priority claimed from JP1881279A external-priority patent/JPS55111481A/ja
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of FR2440365A1 publication Critical patent/FR2440365A1/fr
Application granted granted Critical
Publication of FR2440365B1 publication Critical patent/FR2440365B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

L'INVENTION A POUR OBJET DE NOUVEAUX COMPOSES DE FORMULE: (CF DESSIN DANS BOPI) OU Q REPRESENTE UN RADICAL METHYLENE OU UN ATOME DE SOUFRE, Z EST UN RADICAL ALKYLENE EN C A C, ET R, R ET R REPRESENTENT DIFFERENTS RADICAUX ORGANIQUES. CES NOUVEAUX COMPOSES PRESENTENT UN EFFET ANTIHYPERTENSEUR PROLONGE.
FR7926983A 1978-10-31 1979-10-31 Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs Granted FR2440365A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP13509378A JPS5562060A (en) 1978-10-31 1978-10-31 Sulfur-containing compound
JP15516678A JPS5581854A (en) 1978-12-14 1978-12-14 Sulfur-containing compound
JP1251979A JPS55104275A (en) 1979-02-06 1979-02-06 Sulfur-containing compound
JP1881279A JPS55111481A (en) 1979-02-19 1979-02-19 Ester type hypotensive agent

Publications (2)

Publication Number Publication Date
FR2440365A1 true FR2440365A1 (fr) 1980-05-30
FR2440365B1 FR2440365B1 (fr) 1983-08-26

Family

ID=27455824

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7926983A Granted FR2440365A1 (fr) 1978-10-31 1979-10-31 Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs

Country Status (7)

Country Link
US (2) US4483861A (fr)
CH (1) CH642351A5 (fr)
DE (1) DE2944037A1 (fr)
FR (1) FR2440365A1 (fr)
GB (1) GB2038800B (fr)
IT (1) IT1124841B (fr)
SE (1) SE448541B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0031104A1 (fr) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Composés de thiazolidine, procédés pour leur préparation et compositions pharmaceutiques les contenant
FR2479827A1 (fr) * 1980-04-03 1981-10-09 Squibb & Sons Inc

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA794723B (en) * 1978-09-11 1980-08-27 Univ Miami Anti-hypertensive agents
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
DE3152643A1 (de) * 1980-12-29 1982-12-16 Santen Pharmaceutical Co Ltd Heterocyclic 5-membered ring compounds
JPS57112381A (en) * 1980-12-29 1982-07-13 Santen Pharmaceut Co Ltd Five-membered heterocyclic compound
US4661515A (en) * 1982-07-21 1987-04-28 Usv Pharmaceutical Corporation Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
HU203872B (en) * 1989-07-14 1991-10-28 Richter Gedeon Vegyeszet Process for producing amides of acrylic acid and their salts and pharmaceutical compositions containing them
JP5800801B2 (ja) * 2009-04-22 2015-10-28 マーケイター メドシステムズ， インコーポレイテッド 局所血管送達による、高血圧症を治療するためのグアネチジンの使用
CN103998047A (zh) 2011-10-19 2014-08-20 墨卡托医疗***公司 局部调节组织和细胞以提高疗效包括肾去神经支配

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372804A1 (fr) * 1976-12-03 1978-06-30 Squibb & Sons Inc Derives d'amino-acides, en tant qu'agents anti-hypertension
GB2000508A (en) * 1977-06-29 1979-01-10 Yoshitomi Pharmaceutical Thiazolidine compounds
FR2407204A1 (fr) * 1977-10-28 1979-05-25 Sandoz Sa Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments
EP0001978A1 (fr) * 1977-10-06 1979-05-30 Santen Pharmaceutical Co., Ltd Un dérivé de l'acide thiazolidine-4 carboxylique, procédé de préparation et compositions pharmaceutiques le contenant
EP0002392A2 (fr) * 1977-12-06 1979-06-13 Teijin Limited Dérivés de 3-acylepyrrole substitués en position 1, leur procédé de préparation et composés inhibiteurs de l'agrégation des plaquettes les contenant
LU80946A1 (fr) * 1978-02-21 1979-06-18 Squibb & Sons Inc Mercaptoacylamino-acides substitues par des halogenes
FR2412537A1 (fr) * 1977-12-22 1979-07-20 Science Union & Cie Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
GB2018248A (en) * 1978-04-08 1979-10-17 Santen Pharmaceutical Co Ltd Antihypertensive 4 thiazolidine carboxylic acids
FR2433515A1 (fr) * 1978-08-02 1980-03-14 Santen Pharmaceutical Co Ltd Acides pyrrolidinecarboxyliques-2 utiles comme antihypertenseurs
EP0008831A1 (fr) * 1978-09-07 1980-03-19 Océ-Andeno B.V. Procédé de préparation de 1-(3-mercapto-2-D-méthyl-propionyl)-L-proline et de ses dérivés
FR2435469A1 (fr) * 1978-08-11 1980-04-04 Squibb & Sons Inc Derives mercaptoacyles de prolines substituees a action hypotensive
FR2438036A1 (fr) * 1978-10-05 1980-04-30 Yoshitomi Pharmaceutical Derives d'acides iminocarboxyliques cycliques et medicament contenant ces substances

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046889A (en) * 1976-02-13 1977-09-06 E. R. Squibb & Sons, Inc. Azetidine-2-carboxylic acid derivatives
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
AU518147B2 (en) * 1976-12-03 1981-09-17 E.R. Squibb & Sons, Inc. Derivatives of thiazolidine, thiazine and morpholine carboxylic acids
US4113715A (en) * 1977-01-17 1978-09-12 E. R. Squibb & Sons, Inc. Amino acid derivatives
JPS5834474B2 (ja) * 1977-06-29 1983-07-27 ウェルファイド株式会社 チアゾリジン誘導体の製造法
US4282235A (en) * 1978-05-22 1981-08-04 E. R. Squibb & Sons, Inc. Derivatives of thiazolidinecarboxylic acids and related acids
US4290952A (en) * 1980-06-23 1981-09-22 American Home Products Corporation Aryl-1-mercaptoalkanoylproline and homoproline derivatives
JPS5756425A (en) * 1980-09-20 1982-04-05 Santen Pharmaceut Co Ltd Hypotensor

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2372804A1 (fr) * 1976-12-03 1978-06-30 Squibb & Sons Inc Derives d'amino-acides, en tant qu'agents anti-hypertension
GB2000508A (en) * 1977-06-29 1979-01-10 Yoshitomi Pharmaceutical Thiazolidine compounds
EP0001978A1 (fr) * 1977-10-06 1979-05-30 Santen Pharmaceutical Co., Ltd Un dérivé de l'acide thiazolidine-4 carboxylique, procédé de préparation et compositions pharmaceutiques le contenant
FR2407204A1 (fr) * 1977-10-28 1979-05-25 Sandoz Sa Nouveaux amides d'amino-acides cycliques, leur preparation et leur application comme medicaments
EP0002392A2 (fr) * 1977-12-06 1979-06-13 Teijin Limited Dérivés de 3-acylepyrrole substitués en position 1, leur procédé de préparation et composés inhibiteurs de l'agrégation des plaquettes les contenant
FR2412537A1 (fr) * 1977-12-22 1979-07-20 Science Union & Cie Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
LU80946A1 (fr) * 1978-02-21 1979-06-18 Squibb & Sons Inc Mercaptoacylamino-acides substitues par des halogenes
GB2018248A (en) * 1978-04-08 1979-10-17 Santen Pharmaceutical Co Ltd Antihypertensive 4 thiazolidine carboxylic acids
FR2433515A1 (fr) * 1978-08-02 1980-03-14 Santen Pharmaceutical Co Ltd Acides pyrrolidinecarboxyliques-2 utiles comme antihypertenseurs
FR2435469A1 (fr) * 1978-08-11 1980-04-04 Squibb & Sons Inc Derives mercaptoacyles de prolines substituees a action hypotensive
EP0008831A1 (fr) * 1978-09-07 1980-03-19 Océ-Andeno B.V. Procédé de préparation de 1-(3-mercapto-2-D-méthyl-propionyl)-L-proline et de ses dérivés
FR2438036A1 (fr) * 1978-10-05 1980-04-30 Yoshitomi Pharmaceutical Derives d'acides iminocarboxyliques cycliques et medicament contenant ces substances

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0031104A1 (fr) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Composés de thiazolidine, procédés pour leur préparation et compositions pharmaceutiques les contenant
FR2479827A1 (fr) * 1980-04-03 1981-10-09 Squibb & Sons Inc

Also Published As

Publication number Publication date
IT1124841B (it) 1986-05-14
IT7926923A0 (it) 1979-10-30
GB2038800B (en) 1983-05-05
DE2944037C2 (fr) 1988-04-14
DE2944037A1 (de) 1980-05-08
SE448541B (sv) 1987-03-02
SE7908994L (sv) 1980-05-01
US4496578A (en) 1985-01-29
FR2440365B1 (fr) 1983-08-26
US4483861A (en) 1984-11-20
GB2038800A (en) 1980-07-30
CH642351A5 (de) 1984-04-13

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