JPS5581854A - Sulfur-containing compound - Google Patents

Sulfur-containing compound

Info

Publication number
JPS5581854A
JPS5581854A JP15516678A JP15516678A JPS5581854A JP S5581854 A JPS5581854 A JP S5581854A JP 15516678 A JP15516678 A JP 15516678A JP 15516678 A JP15516678 A JP 15516678A JP S5581854 A JPS5581854 A JP S5581854A
Authority
JP
Japan
Prior art keywords
compound
carboxylic acid
group
diuretic
carboxyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15516678A
Other languages
Japanese (ja)
Inventor
Junichi Iwao
Masayuki Ooya
Tadashi Iso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Priority to JP15516678A priority Critical patent/JPS5581854A/en
Priority to US06/086,996 priority patent/US4483861A/en
Priority to GB7936988A priority patent/GB2038800B/en
Priority to IT26923/79A priority patent/IT1124841B/en
Priority to SE7908994A priority patent/SE448541B/en
Priority to FR7926983A priority patent/FR2440365A1/en
Priority to CH977979A priority patent/CH642351A5/en
Priority to DE19792944037 priority patent/DE2944037A1/en
Publication of JPS5581854A publication Critical patent/JPS5581854A/en
Priority to US06/395,128 priority patent/US4496578A/en
Pending legal-status Critical Current

Links

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The thioester compound of the carboxyl group of a carboxylic acid-type diuretic and the sulfhydryl group of an N-mercaptoacylamino acid, and its salt.
EXAMPLE: (4R)-3-[(2s)-S-{[2,3-dichloro-4-(2-methylenebutanoyl)-phenoxy] acetyl}-3-mercapto-2-methylpropanoyl]-4-thiazolidine-carboxylic acid.
USE: A long-acting diuretic hypotensive agent having high stability against lowering of the titer and generation of a ill-odor, etc.
PROCESS: A compound I (R4 is a carboxylic acid-type diuretic group wherein the OH of the carboxyl group is removed; Y is OH or halogen; Z is 1W3C alkylene) is subjected to the Schotten-Baumann reaction with a compound II (R1 is H or lower alkyl; R2 is H, phenyl, etc.; R3 is H or CH3) to give a thioester compound.
COPYRIGHT: (C)1980,JPO&Japio
JP15516678A 1978-10-31 1978-12-14 Sulfur-containing compound Pending JPS5581854A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP15516678A JPS5581854A (en) 1978-12-14 1978-12-14 Sulfur-containing compound
US06/086,996 US4483861A (en) 1978-10-31 1979-10-22 Antihypertensive sulfur-containing compounds
GB7936988A GB2038800B (en) 1978-10-31 1979-10-25 Antihypertensive sulphurcontaining compounds
IT26923/79A IT1124841B (en) 1978-10-31 1979-10-30 COMPOUNDS CONTAINING SULFUR ANTI-HYPERTENSION
SE7908994A SE448541B (en) 1978-10-31 1979-10-30 NEW TIAZOLIDINE AND PYRROLIDINE DERIVATIVES AND A PHARMACEUTICAL PREPARATION THEREOF
FR7926983A FR2440365A1 (en) 1978-10-31 1979-10-31 NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS
CH977979A CH642351A5 (en) 1978-10-31 1979-10-31 Antihypertensive, SULPHUR CONTAINING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND CONTAINING THEM Pharmaceutical Compositions.
DE19792944037 DE2944037A1 (en) 1978-10-31 1979-10-31 ANTI-HYPERTENSIVE SULFURING COMPOUNDS
US06/395,128 US4496578A (en) 1978-10-31 1982-07-06 Antihypertensive sulfur-containing compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15516678A JPS5581854A (en) 1978-12-14 1978-12-14 Sulfur-containing compound

Publications (1)

Publication Number Publication Date
JPS5581854A true JPS5581854A (en) 1980-06-20

Family

ID=15599945

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15516678A Pending JPS5581854A (en) 1978-10-31 1978-12-14 Sulfur-containing compound

Country Status (1)

Country Link
JP (1) JPS5581854A (en)

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