FI963148A - 3'-substituoidut nukleosidijohdannaiset - Google Patents

3'-substituoidut nukleosidijohdannaiset Download PDF

Info

Publication number: FI963148A
Authority: FI; Finland
Prior art keywords: group; substituted nucleoside; substituted; chem; ester
Prior art date: 1994-12-13

Application number

FI963148A

Other languages

English (en)

Swedish (sv)

Other versions

FI963148A0 (fi

FI118967B (fi

Inventor

Akira Matsuda

Takuma Sasaki

Original Assignee

Akira Matsuda

Takuma Sasaki

Taiho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-13

Filing date

1996-08-12

Publication date

1996-08-12

1996-08-12 Application filed by Akira Matsuda, Takuma Sasaki, Taiho Pharmaceutical Co Ltd filed Critical Akira Matsuda

1996-08-12 Publication of FI963148A publication Critical patent/FI963148A/fi

1996-08-12 Publication of FI963148A0 publication Critical patent/FI963148A0/fi

2008-05-30 Application granted granted Critical

2008-05-30 Publication of FI118967B publication Critical patent/FI118967B/fi

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI963148A 1994-12-13 1996-08-12 3'-substituoidut nukleosidijohdannaiset FI118967B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP30891294		1994-12-13
JP30891294		1994-12-13
JP20864595		1995-08-16
JP20864595		1995-08-16
PCT/JP1995/002554 WO1996018636A1 (fr)	1994-12-13	1995-12-13	Derives de nucleoside substitues en 3'
JP9502554		1995-12-13

Publications (3)

Publication Number	Publication Date
FI963148A true FI963148A (fi)	1996-08-12
FI963148A0 FI963148A0 (fi)	1996-08-12
FI118967B FI118967B (fi)	2008-05-30

Family

ID=26516961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI963148A FI118967B (fi)	1994-12-13	1996-08-12	3'-substituoidut nukleosidijohdannaiset

Country Status (18)

Country	Link
US (2)	US5763418A (fi)
EP (1)	EP0747389B1 (fi)
JP (1)	JP3142874B2 (fi)
KR (1)	KR0177372B1 (fi)
CN (1)	CN1195768C (fi)
AT (1)	ATE249471T1 (fi)
AU (1)	AU674639B2 (fi)
CA (1)	CA2182707C (fi)
DE (1)	DE69531729T2 (fi)
DK (1)	DK0747389T3 (fi)
ES (1)	ES2206522T3 (fi)
FI (1)	FI118967B (fi)
HU (1)	HU217772B (fi)
NO (1)	NO305702B1 (fi)
NZ (1)	NZ297100A (fi)
PT (1)	PT747389E (fi)
RU (1)	RU2130029C1 (fi)
WO (1)	WO1996018636A1 (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2130029C1 (ru) *	1994-12-13	1999-05-10	Тайхо Фармасьютикал Ко., Лтд.	3'-замещенные производные нуклеозида, способ их получения (варианты), лекарственное средство, способ лечения и профилактики
CA2172471C (en) *	1995-03-29	1999-01-26	Hua Qi	Apparatus for and method of simulating ocular optical system
US6235782B1 (en)	1998-11-12	2001-05-22	Rifat Pamukcu	Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en)	1998-11-12	2001-05-22	Cell Pathways, Inc.	Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
MY164523A (en)	2000-05-23	2017-12-29	Univ Degli Studi Cagliari	Methods and compositions for treating hepatitis c virus
NZ547204A (en)	2000-05-26	2008-01-31	Idenix Cayman Ltd	Methods and compositions for treating flaviviruses and pestiviruses
EP1435974A4 (en)	2001-09-28	2006-09-06	Idenix Cayman Ltd	METHOD AND COMPOSITIONS FOR TREATING HEPATITIS C VIRUS WITH 4'-MODIFIED NUCLEOSIDES
US7012100B1 (en)	2002-06-04	2006-03-14	Avolix Pharmaceuticals, Inc.	Cell migration inhibiting compositions and methods and compositions for treating cancer
NZ537662A (en) *	2002-06-28	2007-10-26	Idenix Cayman Ltd	2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
KR20050055630A (ko) *	2002-06-28	2005-06-13	이데닉스 (케이만) 리미티드	플라비비리다에 감염 치료를 위한 1'-, 2'- 및 3'-변형된뉴클레오시드 유도체
JP2005533824A (ja) *	2002-06-28	2005-11-10	イデニクス（ケイマン）リミテツド	フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン
US7608600B2 (en) *	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2004046331A2 (en) *	2002-11-15	2004-06-03	Idenix (Cayman) Limited	2’-branched nucleosides and flaviviridae mutation
WO2004052899A2 (en) *	2002-12-12	2004-06-24	Idenix (Cayman) Limited	Process for the production of 2'-branched nucleosides
BRPI0407374A (pt) *	2003-02-19	2006-01-10	Univ Yale	Análogos de nucleosìdeo antiviral e métodos para tratar infecções virais, especialmente infecções de hiv
WO2006000922A2 (en) *	2004-06-23	2006-01-05	Idenix (Cayman) Limited	5-aza-7-deazapurine derivatives for treating infections with flaviviridae
JP4516863B2 (ja) *	2005-03-11	2010-08-04	株式会社ケンウッド	音声合成装置、音声合成方法及びプログラム
US7781576B2 (en)	2005-12-23	2010-08-24	Idenix Pharmaceuticals, Inc.	Process for preparing a synthetic intermediate for preparation of branched nucleosides
KR101426101B1 (ko) *	2006-07-24	2014-08-13	다이호야쿠힌고교 가부시키가이샤	3＇-에티닐시티딘 유도체
JP5066737B2 (ja)	2007-04-06	2012-11-07	大鵬薬品工業株式会社	シチジン誘導体を含有する持続静脈内投与用抗腫瘍剤
JP4954004B2 (ja)	2007-08-09	2012-06-13	株式会社バイオダイナミクス研究所	任意の化合物が導入された新規核酸誘導体、及びその製造方法
KR20100131457A (ko)	2008-03-27	2010-12-15	다이호야쿠힌고교 가부시키가이샤	시티딘 유도체 및 카르보플라틴을 함유하는 항종양제
US9556216B2 (en)	2012-08-31	2017-01-31	Novartis Ag	2′-Ethynyl nucleoside derivatives for treatment of viral infections
WO2018119284A1 (en) *	2016-12-22	2018-06-28	Calithera Biosciences, Inc.	Ectonucleotidase inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3480613A (en) *	1967-07-03	1969-11-25	Merck & Co Inc	2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof
BE739821A (fi) *	1968-10-04	1970-03-16
DE3924424A1 (de) *	1989-07-24	1991-01-31	Boehringer Mannheim Gmbh	Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
DE4204032A1 (de) *	1992-02-12	1993-08-19	Boehringer Mannheim Gmbh	Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
EP0598910A1 (en) *	1992-03-11	1994-06-01	Japan Tobacco Inc.	Process for producing nucleoside derivative
DE4418690A1 (de) *	1994-05-28	1996-01-11	Boehringer Mannheim Gmbh	Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US5681940A (en) *	1994-11-02	1997-10-28	Icn Pharmaceuticals	Sugar modified nucleosides and oligonucleotides
RU2130029C1 (ru) *	1994-12-13	1999-05-10	Тайхо Фармасьютикал Ко., Лтд.	3'-замещенные производные нуклеозида, способ их получения (варианты), лекарственное средство, способ лечения и профилактики

1995
- 1995-12-13 RU RU96118248A patent/RU2130029C1/ru active
- 1995-12-13 US US08/693,161 patent/US5763418A/en not_active Ceased
- 1995-12-13 US US09/584,171 patent/USRE38090E1/en not_active Expired - Lifetime
- 1995-12-13 CN CNB95191605XA patent/CN1195768C/zh not_active Expired - Lifetime
- 1995-12-13 AT AT95940427T patent/ATE249471T1/de active
- 1995-12-13 DE DE69531729T patent/DE69531729T2/de not_active Expired - Lifetime
- 1995-12-13 AU AU41884/96A patent/AU674639B2/en not_active Expired
- 1995-12-13 WO PCT/JP1995/002554 patent/WO1996018636A1/ja active IP Right Grant
- 1995-12-13 NZ NZ297100A patent/NZ297100A/en not_active IP Right Cessation
- 1995-12-13 PT PT95940427T patent/PT747389E/pt unknown
- 1995-12-13 HU HU9602214A patent/HU217772B/hu unknown
- 1995-12-13 CA CA002182707A patent/CA2182707C/en not_active Expired - Lifetime
- 1995-12-13 DK DK95940427T patent/DK0747389T3/da active
- 1995-12-13 EP EP95940427A patent/EP0747389B1/en not_active Expired - Lifetime
- 1995-12-13 JP JP08518600A patent/JP3142874B2/ja not_active Expired - Lifetime
- 1995-12-13 ES ES95940427T patent/ES2206522T3/es not_active Expired - Lifetime
- 1995-12-13 KR KR1019960704407A patent/KR0177372B1/ko not_active IP Right Cessation
1996
- 1996-08-12 NO NO963350A patent/NO305702B1/no not_active IP Right Cessation
- 1996-08-12 FI FI963148A patent/FI118967B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU674639B2 (en)	1997-01-02
HUT75227A (en)	1997-04-28
US5763418A (en)	1998-06-09
CN1195768C (zh)	2005-04-06
NO305702B1 (no)	1999-07-12
HU9602214D0 (en)	1996-11-28
NO963350D0 (no)	1996-08-12
RU2130029C1 (ru)	1999-05-10
NO963350L (no)	1996-10-11
NZ297100A (en)	1997-10-24
USRE38090E1 (en)	2003-04-22
HU217772B (hu)	2000-04-28
JP3142874B2 (ja)	2001-03-07
KR0177372B1 (ko)	1999-04-01
CA2182707C (en)	2000-05-30
CN1140453A (zh)	1997-01-15
PT747389E (pt)	2003-12-31
AU4188496A (en)	1996-07-03
KR970701198A (ko)	1997-03-17
FI963148A0 (fi)	1996-08-12
EP0747389A1 (en)	1996-12-11
DE69531729D1 (de)	2003-10-16
ATE249471T1 (de)	2003-09-15
DE69531729T2 (de)	2004-08-05
DK0747389T3 (da)	2004-01-26
EP0747389A4 (en)	1998-12-30
EP0747389B1 (en)	2003-09-10
ES2206522T3 (es)	2004-05-16
WO1996018636A1 (fr)	1996-06-20
FI118967B (fi)	2008-05-30

Legal Events

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2008-05-30

FG

Patent granted

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Patent expired

Publication	Publication Date	Title
ATE249471T1 (de)	2003-09-15	3'-substuierte nukleosidderivate
DK0536936T3 (da)	1997-01-13	Pyrimidinnukleosidderivater med anti-tumor-aktivitet, deres fremstilling og anvendelse
DK535789D0 (da)	1989-10-27	Pyrimidindionderivater, fremgangsmaade til fremstilling heraf og antiarytmika omfattende samme
ES2118069T3 (es)	1998-09-16	Profarmacos de fosfonatos.
DE69814375D1 (de)	2003-06-12	Fungizide trifluoromethylalkylamino-triazolopyrimidine-derivate
PL351500A1 (en)	2003-04-22	Use of cytidine derivatives for the treatment of leukaemia
NL300247I2 (nl)	2007-02-01	2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten.
DE69025529D1 (de)	1996-04-04	Weitere antivirale Pyrimidin-Nukleosiden
DE69109482D1 (en)	1995-06-08	Pyrimidinnucleosidderivat.
YU47802A (sh)	2006-03-03	Postupci i kompozicije za levovirin
ATE86866T1 (de)	1993-04-15	Antikrebs-zusammensetzung.
PT92080A (pt)	1990-04-30	Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral
DE69813231D1 (de)	2003-05-15	Natürliche antitumor- oder antivirale substanzen und ihre anwendung
DE3683836D1 (de)	1992-03-19	Glucopyranose-derivate.
ES2037401T3 (es)	1993-06-16	Procedimiento para preparar derivados de nucleosidos.
ES2061544T3 (es)	1994-12-16	Nuevos derivados de glucopiranosa.
DE69331814D1 (de)	2002-05-23	Salze von Glukopyranosederivate und ihre Zwischenprodukte
ES2164013A1 (es)	2002-02-01	Glicosidos de n-acetil-6-o-(2,2-bis(hidroximetil)-3-hidroxipropil)-d-glucosamina, procedimiento de obtencion y uso en el tratamiento de tumores cerebrales.
KR970702869A (ko)	1997-06-10	항종양성 인돌로피롤로카르바졸 유도체(antitumor indolopyprolocarbazole derivative)
ES2067395A1 (es)	1995-03-16	Derivados de nucleosidos o analogos a nucleosidos.