FI961220A0 - Asyloitu insuliini - Google Patents
Asyloitu insuliiniInfo
- Publication number
- FI961220A0 FI961220A0 FI961220A FI961220A FI961220A0 FI 961220 A0 FI961220 A0 FI 961220A0 FI 961220 A FI961220 A FI 961220A FI 961220 A FI961220 A FI 961220A FI 961220 A0 FI961220 A0 FI 961220A0
- Authority
- FI
- Finland
- Prior art keywords
- amino acid
- acid residue
- lys
- present
- cys
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK104493 | 1993-09-17 | ||
DK104493A DK104493D0 (da) | 1993-09-17 | 1993-09-17 | Hidtil ukendte peptider |
US19082994A | 1994-02-02 | 1994-02-02 | |
US19082994 | 1994-02-02 | ||
DK9400347 | 1994-09-16 | ||
PCT/DK1994/000347 WO1995007931A1 (en) | 1993-09-17 | 1994-09-16 | Acylated insulin |
Publications (3)
Publication Number | Publication Date |
---|---|
FI961220A0 true FI961220A0 (fi) | 1996-03-15 |
FI961220A FI961220A (fi) | 1996-05-14 |
FI117055B FI117055B (fi) | 2006-05-31 |
Family
ID=26065125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI961220A FI117055B (fi) | 1993-09-17 | 1996-03-15 | Menetelmä asyloidun insuliinin valmistamiseksi |
Country Status (30)
Country | Link |
---|---|
US (1) | US5750497A (fi) |
EP (2) | EP1132404A3 (fi) |
JP (3) | JP3014764B2 (fi) |
KR (1) | KR100310122B1 (fi) |
CN (1) | CN1056618C (fi) |
AT (1) | ATE204882T1 (fi) |
AU (2) | AU682061B2 (fi) |
BG (1) | BG61611B1 (fi) |
BR (1) | BR9407508A (fi) |
CA (1) | CA2171424C (fi) |
CZ (1) | CZ287945B6 (fi) |
DE (2) | DE122004000035I2 (fi) |
DK (1) | DK0792290T3 (fi) |
ES (1) | ES2163451T3 (fi) |
FI (1) | FI117055B (fi) |
FR (1) | FR04C0020I2 (fi) |
HU (1) | HU217684B (fi) |
IL (1) | IL110977A (fi) |
LU (1) | LU91101I2 (fi) |
NL (1) | NL300160I2 (fi) |
NO (3) | NO316944B1 (fi) |
NZ (1) | NZ273285A (fi) |
PL (1) | PL178466B1 (fi) |
PT (1) | PT792290E (fi) |
RO (1) | RO112873B1 (fi) |
RU (1) | RU2164520C2 (fi) |
SI (1) | SI0792290T1 (fi) |
SK (1) | SK282495B6 (fi) |
UA (1) | UA45321C2 (fi) |
WO (1) | WO1995007931A1 (fi) |
Families Citing this family (184)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9316895D0 (en) * | 1993-08-13 | 1993-09-29 | Guy S And St Thomas Hospitals | Hepatoselective insulin analogues |
US6342225B1 (en) | 1993-08-13 | 2002-01-29 | Deutshces Wollforschungsinstitut | Pharmaceutical active conjugates |
US6869930B1 (en) * | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
DE4437604A1 (de) * | 1994-10-21 | 1996-04-25 | Basf Ag | Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung |
US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
CZ289343B6 (cs) * | 1995-03-17 | 2002-01-16 | Novo Nordisk A/S | Inzulinový derivát a farmaceutický prostředek pro léčení diabetes |
US20010041786A1 (en) * | 1995-06-07 | 2001-11-15 | Mark L. Brader | Stabilized acylated insulin formulations |
GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
ATE208208T1 (de) * | 1996-06-20 | 2001-11-15 | Novo Nordisk As | Halogenid-enthaltende insulinzubereitungen |
US5905140A (en) * | 1996-07-11 | 1999-05-18 | Novo Nordisk A/S, Novo Alle | Selective acylation method |
WO1998002460A1 (en) * | 1996-07-11 | 1998-01-22 | Novo Nordisk A/S | Selective acylation method |
US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
US20020025933A1 (en) * | 1996-08-30 | 2002-02-28 | Knudsen Liselotte Bjerre | GLP-2 derivatives |
US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
WO1998042749A1 (en) * | 1997-03-20 | 1998-10-01 | Novo Nordisk A/S | Zinc free insulin crystals for use in pulmonary compositions |
US6043214A (en) * | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
US6310038B1 (en) | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
EP0911035A3 (en) * | 1997-10-24 | 2002-08-21 | Eli Lilly And Company | Insoluble insulin compositions |
IL134901A0 (en) * | 1997-10-24 | 2001-05-20 | Lilly Co Eli | Insoluble insulin compositions |
US6451762B1 (en) | 1997-10-24 | 2002-09-17 | Novo Nordisk A/S | Aggregates of human insulin derivatives |
US6444641B1 (en) | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
EP1396272A1 (en) * | 1997-12-23 | 2004-03-10 | Eli Lilly & Company | Insoluble Insulin Compositions for Controlling Blood Glucose |
CO4970787A1 (es) * | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
DE69924232D1 (de) * | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
EP1060192A2 (en) * | 1998-02-27 | 2000-12-20 | Novo Nordisk A/S | Glp-2 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates |
DE19825447A1 (de) * | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
AU8029798A (en) * | 1998-06-12 | 2000-01-05 | Deutsches Wollforschungsinstitut | Insulin analogue |
US7169889B1 (en) * | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
JP2003528149A (ja) | 2000-03-24 | 2003-09-24 | ジェネンテック・インコーポレーテッド | 軟骨性疾患の治療のためのインスリンの使用 |
WO2001085256A2 (en) * | 2000-05-05 | 2001-11-15 | Novo Nordisk A/S | Critical illness neuropathy |
US7316999B2 (en) | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
EP1299418A1 (en) * | 2000-07-10 | 2003-04-09 | BTG INTERNATIONAL LIMITED (Company No. 2664412) | Insulin derivatives and synthesis thereof |
KR20030005204A (ko) * | 2000-12-25 | 2003-01-17 | 가부시키가이샤 시세이도 | 교감신경 활성화 향료 조성물 |
US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
ATE338055T1 (de) * | 2001-05-02 | 2006-09-15 | Novo Nordisk As | Verfahren zur herstellung von gallensäure |
US6653492B2 (en) | 2001-05-02 | 2003-11-25 | Novo Nordick A/S | Preparation of bile acids |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7595172B2 (en) | 2001-07-24 | 2009-09-29 | Novo Nordisk A/S | Method for making acylated polypeptides |
JP2005508895A (ja) | 2001-08-28 | 2005-04-07 | イーライ・リリー・アンド・カンパニー | Glp−1および基礎インスリンの予備混合物 |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
PT1430082E (pt) | 2001-09-07 | 2010-01-15 | Biocon Ltd | Métodos de síntese de conjugados de polipéptido de insulina-oligómero, e conjugados de polipéptido de pró-insulina-oligómero e método de síntese dos mesmos |
WO2003031432A1 (en) | 2001-10-12 | 2003-04-17 | Novo Nordisk A/S | Substituted piperidines and their use for the treatment of diseases related to the histamine h3 receptor |
WO2003035099A1 (en) | 2001-10-19 | 2003-05-01 | Eli Lilly And Company | Biphasic mixtures of glp-1 and insulin |
KR100925381B1 (ko) | 2001-11-19 | 2009-11-09 | 노보 노르디스크 에이/에스 | 인슐린 화합물의 제조 방법 |
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WO2003094956A1 (en) * | 2002-05-07 | 2003-11-20 | Novo Nordisk A/S | Soluble formulations comprising monomeric insulin and acylated insulin |
US20040038864A1 (en) * | 2002-06-27 | 2004-02-26 | Per Balschmidt | Use of dimethyl sulfone as isotonicity agent |
US7273921B2 (en) | 2002-09-25 | 2007-09-25 | Novo Nordisk A/S | Method for producing acylated peptides |
CN100586926C (zh) * | 2002-09-25 | 2010-02-03 | 诺沃娜第克公司 | 制备酰化肽的方法 |
US7411039B2 (en) | 2002-10-14 | 2008-08-12 | Novo Nordisk A/S | GLP-2 compounds, formulations, and uses thereof |
US20040138099A1 (en) * | 2002-11-29 | 2004-07-15 | Draeger Eberhard Kurt | Insulin administration regimens for the treatment of subjects with diabetes |
WO2004085472A1 (en) * | 2003-03-27 | 2004-10-07 | Novo Nordisk A/S | Method for making human insulin precursors and human insulin |
EP1615698B1 (en) | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
WO2004096266A1 (en) * | 2003-05-02 | 2004-11-11 | Novo Nordisk A/S | Improved physical stability of insulin formulations |
WO2005000580A1 (en) | 2003-06-27 | 2005-01-06 | Novo Nordisk A/S | High moisture barrier container for medical liquid compositions |
RU2352581C2 (ru) | 2003-08-05 | 2009-04-20 | Ново Нордиск А/С | Производные инсулина |
WO2005012347A2 (en) | 2003-08-05 | 2005-02-10 | Novo Nordisk A/S | Novel insulin derivatives |
WO2005047508A1 (en) | 2003-11-14 | 2005-05-26 | Novo Nordisk A/S | Processes for making acylated insulin |
CN104826116A (zh) | 2003-11-20 | 2015-08-12 | 诺沃挪第克公司 | 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂 |
EP1692168B1 (en) | 2003-12-03 | 2011-07-20 | Novo Nordisk A/S | Single-chain insulin |
DE602004029496D1 (de) | 2003-12-22 | 2010-11-18 | Novo Nordisk As | Offbehälter zur lagerung von pharmazeutischen flüssigkeiten |
EP2842576B1 (en) | 2004-01-21 | 2017-06-28 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
PT1740154E (pt) * | 2004-03-12 | 2009-09-11 | Biodel Inc | Composições de insulina com absorção melhorada |
WO2006008238A1 (en) * | 2004-07-16 | 2006-01-26 | Novo Nordisk A/S | Method for selective acylation |
UA91512C2 (ru) | 2004-07-19 | 2010-08-10 | Биокон Лимитед | Коньюгати олигомеров инсулина, их композиция (варианты) и применение |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
ES2438145T3 (es) | 2005-02-02 | 2014-01-16 | Novo Nordisk A/S | Nuevos derivados de insulina |
US20080171695A1 (en) | 2005-02-02 | 2008-07-17 | Novo Nordisk A/S | Insulin Derivatives |
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US8097584B2 (en) | 2005-05-25 | 2012-01-17 | Novo Nordisk A/S | Stabilized formulations of insulin that comprise ethylenediamine |
EP1888104A2 (en) * | 2005-05-26 | 2008-02-20 | Novo Nordisk A/S | Acylated insulin with high purity |
CN103110635A (zh) | 2005-07-04 | 2013-05-22 | 海波因特制药有限责任公司 | 组胺h3受体拮抗剂 |
ES2426345T3 (es) | 2005-07-20 | 2013-10-22 | Eli Lilly And Company | Compuesto unidos en posición 1-amino |
US9056921B2 (en) | 2005-08-16 | 2015-06-16 | Novo Nordisk A/S | Method for making mature insulin polypeptides |
US7741281B2 (en) * | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
ES2393757T3 (es) | 2005-11-17 | 2012-12-27 | Eli Lilly & Company | Antagonistas de receptor de glucagón, preparación y usos terapéuticos |
EP2505593A1 (en) | 2005-12-28 | 2012-10-03 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
US20070196416A1 (en) | 2006-01-18 | 2007-08-23 | Quest Pharmaceutical Services | Pharmaceutical compositions with enhanced stability |
ES2387955T3 (es) * | 2006-02-27 | 2012-10-04 | Novo Nordisk A/S | Derivados de insulina |
WO2007104737A1 (en) * | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
WO2007104786A1 (en) | 2006-03-15 | 2007-09-20 | Novo Nordisk A/S | Mixtures of amylin and insulin |
AU2007229492B2 (en) | 2006-03-28 | 2011-11-03 | High Point Pharmaceuticals, Llc | Benzothiazoles having histamine H3 receptor activity |
EP2049475B1 (en) | 2006-04-24 | 2012-02-01 | Eli Lilly & Company | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
CN101437849B (zh) * | 2006-05-09 | 2015-09-30 | 诺沃-诺迪斯克有限公司 | 胰岛素衍生物 |
ES2395738T3 (es) | 2006-05-09 | 2013-02-14 | Novo Nordisk A/S | Derivado de insulina |
EP2024390B1 (en) * | 2006-05-09 | 2015-08-19 | Novo Nordisk A/S | Insulin derivative |
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DK2054073T3 (da) | 2006-07-11 | 2015-03-02 | Foresee Pharmaceuticals Inc | Farmaceutiske præparater til fremføring med langvarig frigivelse af peptider |
CN101573133B (zh) | 2006-07-31 | 2014-08-27 | 诺沃-诺迪斯克有限公司 | Peg化延长的胰岛素 |
BRPI0717098B8 (pt) | 2006-09-22 | 2021-05-25 | Novo Nordisk As | análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação |
JP5503968B2 (ja) | 2006-09-27 | 2014-05-28 | ノボ・ノルデイスク・エー/エス | 成熟インスリンポリペプチドの作製方法 |
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JP2011504871A (ja) | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー/エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
CN101677947B (zh) | 2007-06-13 | 2013-07-17 | 诺沃-诺迪斯克有限公司 | 包含胰岛素衍生物的药物制剂 |
US8575096B2 (en) | 2007-08-13 | 2013-11-05 | Novo Nordisk A/S | Rapid acting insulin analogues |
US9241908B2 (en) * | 2007-10-16 | 2016-01-26 | Biocon Limited | Orally administrable solid pharmaceutical composition and a process thereof |
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WO2009060071A1 (en) * | 2007-11-08 | 2009-05-14 | Novo Nordisk A/S | Insulin derivative |
ES2612736T3 (es) | 2007-11-16 | 2017-05-18 | Novo Nordisk A/S | Composiciones farmacéuticas estables que comprenden liraglutida y degludec |
CA2711561A1 (en) * | 2008-01-04 | 2009-07-16 | Biodel, Inc. | Insulin formulations for insulin release as a function of tissue glucose levels |
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