FI941537A - Uudet tehokkaat, terminaalisen erilaistumisen indusoivat aineet sekä menetelmät niiden käyttämiseksi - Google Patents
Uudet tehokkaat, terminaalisen erilaistumisen indusoivat aineet sekä menetelmät niiden käyttämiseksi Download PDFInfo
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- FI941537A FI941537A FI941537A FI941537A FI941537A FI 941537 A FI941537 A FI 941537A FI 941537 A FI941537 A FI 941537A FI 941537 A FI941537 A FI 941537A FI 941537 A FI941537 A FI 941537A
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- 230000011712 cell development Effects 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000005170 neoplastic cell Anatomy 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- -1 pyridineamino Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/06—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
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- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
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- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
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- Oncology (AREA)
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- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Networks Using Active Elements (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/771,760 US5369108A (en) | 1991-10-04 | 1991-10-04 | Potent inducers of terminal differentiation and methods of use thereof |
PCT/US1992/008454 WO1993007148A1 (fr) | 1991-10-04 | 1992-10-05 | Nouveaux inducteurs puissants de differentiation terminale et procedes d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
FI941537A0 FI941537A0 (fi) | 1994-03-31 |
FI941537A true FI941537A (fi) | 1994-05-31 |
Family
ID=25092893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI941537A FI941537A (fi) | 1991-10-04 | 1994-03-31 | Uudet tehokkaat, terminaalisen erilaistumisen indusoivat aineet sekä menetelmät niiden käyttämiseksi |
Country Status (14)
Country | Link |
---|---|
US (3) | US5369108A (fr) |
EP (1) | EP0642509B1 (fr) |
JP (4) | JP3432823B2 (fr) |
KR (2) | KR100263264B1 (fr) |
AT (1) | ATE183185T1 (fr) |
AU (1) | AU668696B2 (fr) |
CA (1) | CA2120619C (fr) |
CL (1) | CL2008002943A1 (fr) |
DE (1) | DE69229800T2 (fr) |
ES (1) | ES2134815T3 (fr) |
FI (1) | FI941537A (fr) |
HU (1) | HU225497B1 (fr) |
RU (1) | RU2128643C1 (fr) |
WO (1) | WO1993007148A1 (fr) |
Families Citing this family (192)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5700811A (en) * | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5393902A (en) * | 1994-04-26 | 1995-02-28 | Lever Brothers Company, Division Of Conopco, Inc. | Process for the preparation of bis(amidocarboxylic acids) |
US5981597A (en) * | 1995-02-13 | 1999-11-09 | Trustees Of The University Of Pennsylvania | Differentiating agents for the treatment of inflammatory intestinal diseases |
US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
AUPO721997A0 (en) * | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
US7745142B2 (en) | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
EP1127054A4 (fr) * | 1998-10-29 | 2006-11-02 | Bristol Myers Squibb Co | Nouveaux inhibiteurs de l'enzyme impdh |
EA007649B1 (ru) * | 1999-09-08 | 2006-12-29 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч | Ингибиторы гистондеацетилазы, вызывающие дифференцировку клеток, и их применение |
WO2001038322A1 (fr) | 1999-11-23 | 2001-05-31 | Methylgene, Inc. | Inhibiteurs de l'histone deacetylase |
US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
AU2001290131B2 (en) * | 2000-09-29 | 2007-11-15 | Topotarget Uk Limited | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors |
EP1598067B1 (fr) * | 2000-09-29 | 2009-05-06 | TopoTarget UK Limited | Derivées d'acide de carbamine contenant un group amide pour la traitement de malaria |
GB0023983D0 (en) * | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
AR035659A1 (es) * | 2000-12-07 | 2004-06-23 | Hoffmann La Roche | Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos |
AR035513A1 (es) * | 2000-12-23 | 2004-06-02 | Hoffmann La Roche | Derivados de tetrahidropiridina, proceso para prepararlos, composiciones farmaceuticas que los contienen, y uso de dichos compuestos en la preparacion de medicamentos |
US7314953B2 (en) | 2001-03-27 | 2008-01-01 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
AR035455A1 (es) | 2001-04-23 | 2004-05-26 | Hoffmann La Roche | Derivados triciclicos de alquilhidroxamato , procesos para su elaboracion, composiciones farmaceuticas que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos |
US20040142859A1 (en) * | 2002-05-02 | 2004-07-22 | Steffan Joan S. | Method for treating neurodegenerative, psychiatric, and other disorders with deacetylase inhibitors |
US20050227915A1 (en) * | 2001-05-02 | 2005-10-13 | Steffan Joan S | Methods and reagents for treating neurodegenerative diseases and motor deficit disorders |
US6784173B2 (en) * | 2001-06-15 | 2004-08-31 | Hoffmann-La Roche Inc. | Aromatic dicarboxylic acid derivatives |
AUPR738301A0 (en) * | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
US20040087657A1 (en) * | 2001-10-16 | 2004-05-06 | Richon Victoria M. | Treatment of neurodegenerative diseases and cancer of the brain using histone deacetylase inhibitors |
AU2003219803B8 (en) * | 2002-02-15 | 2005-08-25 | Sloan-Kettering Institute For Cancer Research | Method of treating TRX mediated diseases |
US20050288227A1 (en) * | 2002-02-15 | 2005-12-29 | Marks Paul A | Use of thioredoxin measurements for diagnostics and treatments |
US7148257B2 (en) | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
US20060276547A1 (en) * | 2002-03-04 | 2006-12-07 | Bacopoulos Nicholas G | Methods of treating cancer with HDAC inhibitors |
US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
EP1487426B1 (fr) * | 2002-03-04 | 2012-08-22 | Sloan-kettering Institute For Cancer Research | Procedes d'induction de differenciation terminale |
JP2005521401A (ja) | 2002-03-27 | 2005-07-21 | イミュネックス・コーポレーション | ポリペプチド産生を増加させる方法 |
CN100566711C (zh) * | 2002-04-15 | 2009-12-09 | 斯隆-凯特林癌症研究院 | 治疗癌症的化合物及其用途 |
EP1511477A4 (fr) | 2002-05-22 | 2008-04-09 | Errant Gene Therapeutics Llc | Inhibiteurs d'histone desacetylase bases sur des composes alpha-ceto-epoxydes |
GB0217777D0 (en) * | 2002-07-31 | 2002-09-11 | Novartis Ag | Organic compounds |
US6719310B1 (en) * | 2002-10-17 | 2004-04-13 | Teng Hsiang Lin | Self-movable vehicle |
US7098241B2 (en) | 2002-12-16 | 2006-08-29 | Hoffmann-La Roche Inc. | Thiophene hydroxamic acid derivatives |
WO2004059083A1 (fr) * | 2002-12-26 | 2004-07-15 | Canon Kabushiki Kaisha | Agent reducteur de tuilage, encre pour impression par jet d'encre, procede d'impression par jet d'encre et procede de reduction du tuilage |
US20040235733A1 (en) * | 2003-02-27 | 2004-11-25 | Steffan Joan S. | Methods and reagents for reducing polyglutamine toxicity |
JP2006523693A (ja) | 2003-04-01 | 2006-10-19 | メモリアル スローン−ケタリング キャンサー センター | ヒドロキサム酸化合物およびその使用方法 |
US7842835B2 (en) | 2003-07-07 | 2010-11-30 | Georgetown University | Histone deacetylase inhibitors and methods of use thereof |
DK1663194T3 (da) | 2003-08-26 | 2010-07-19 | Merck Hdac Res Llc | Anvendelse af SAHA til behandling af mesotheliom |
CN1964714B (zh) * | 2003-08-29 | 2011-09-28 | Hdac默克研究有限责任公司 | 辛二酰苯胺异羟肟酸和吉西他滨在制备用于治疗癌症的药物中的用途 |
CA2542096A1 (fr) * | 2003-10-09 | 2005-04-21 | Aton Pharma, Inc. | Derives thiophene et benzothiophene d'acide hydroxamique |
EP1694329A4 (fr) * | 2003-11-26 | 2009-06-03 | Aton Pharma Inc | Derives d'acide hydroxamique a base d'acide diamine et iminodiacetique |
CA2552279C (fr) | 2003-12-02 | 2014-07-15 | The Ohio State University Research Foundation | Acides gras a chaine courte lies a un motif de chelation zn<sp>2+</sp> utilises en tant que nouvelle classe d'inhibiteurs d'histone desacetylase |
US8017321B2 (en) * | 2004-01-23 | 2011-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Gefitinib sensitivity-related gene expression and products and methods related thereto |
ES2899590T3 (es) | 2004-01-23 | 2022-03-14 | Eden Research Plc | Métodos de eliminación de nematodos que comprenden la aplicación de un componente terpénico |
US20080113874A1 (en) * | 2004-01-23 | 2008-05-15 | The Regents Of The University Of Colorado | Gefitinib sensitivity-related gene expression and products and methods related thereto |
US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
JP4993374B2 (ja) * | 2004-04-05 | 2012-08-08 | メルク エイチディーエーシー リサーチ エルエルシー | ヒストン脱アセチル化酵素インヒビタープロドラッグ |
EP2338332B1 (fr) | 2004-05-20 | 2014-02-12 | Eden Research Plc | Particule creuse de glucane ou de paroi cellulaire encapsulant un composant de terpene |
US20080090233A1 (en) * | 2004-05-27 | 2008-04-17 | The Regents Of The University Of Colorado | Methods for Prediction of Clinical Outcome to Epidermal Growth Factor Receptor Inhibitors by Cancer Patients |
EP1773761A1 (fr) * | 2004-07-12 | 2007-04-18 | Merck & Co., Inc. | Inhibiteurs de l'histone désacétylase |
CA2573509A1 (fr) * | 2004-07-12 | 2006-02-16 | Merck & Co., Inc. | Inhibiteurs d'histone desacetylase |
CA2574035A1 (fr) * | 2004-07-19 | 2006-02-23 | Sandro Belvedere | Inhibiteurs de l'histone deacetylase |
CA2581639C (fr) * | 2004-09-30 | 2016-07-26 | Molecular Devices Corporation | Complexes de lanthanides luminescents |
US7772245B2 (en) | 2005-02-14 | 2010-08-10 | Miikana Therapeutics, Inc. | Inhibitors of histone deacetylase |
US7604939B2 (en) * | 2005-03-01 | 2009-10-20 | The Regents Of The University Of Michigan | Methods of identifying active BRM expression-promoting HDAC inhibitors |
US20100087328A1 (en) * | 2005-03-01 | 2010-04-08 | The Regents Of The University Of Michigan | Brm expression and related diagnostics |
MX2007011148A (es) * | 2005-03-11 | 2008-02-22 | Univ Colorado | Inhibidores de histona desacetilasa que sensibilizan celulas cancerosas respecto a los inhibidores de factor de crecimiento. |
CN101495116A (zh) | 2005-03-22 | 2009-07-29 | 哈佛大学校长及研究员协会 | 蛋白降解病症的治疗 |
JP2008536924A (ja) | 2005-04-20 | 2008-09-11 | メルク エンド カムパニー インコーポレーテッド | ベンゾチオフェンヒドロキサミン酸のカーバメート、ウレア、アミドおよびスルホンアミド置換誘導体 |
CN101163690A (zh) * | 2005-04-20 | 2008-04-16 | 默克公司 | 苯并噻吩异羟肟酸衍生物 |
WO2006115845A1 (fr) * | 2005-04-20 | 2006-11-02 | Merck & Co., Inc. | Derives du benzothiophene |
GB0509225D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
GB0509223D0 (en) | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
TWI365068B (en) * | 2005-05-20 | 2012-06-01 | Merck Sharp & Dohme | Formulations of suberoylanilide hydroxamic acid and methods for producing same |
AU2006262166A1 (en) * | 2005-06-24 | 2007-01-04 | Merck Sharp & Dohme Corp. | Modified malonate derivatives |
WO2007017728A2 (fr) * | 2005-08-05 | 2007-02-15 | Orchid Research Laboratories Limited | Nouveaux composes heterocycliques |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP2258359A3 (fr) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline |
EP1940389A2 (fr) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
WO2007055942A2 (fr) * | 2005-11-03 | 2007-05-18 | Merck & Co., Inc. | Composes de nicotinamide substitue |
CA2626897A1 (fr) | 2005-11-03 | 2007-05-18 | Joshua Close | Inhibiteurs de l'histone desacetylase a motifs d'aryle-pyrazolyle |
CA2622136A1 (fr) * | 2005-11-04 | 2007-05-18 | Merck & Co., Inc. | Procedes d'utilisation de saha et d'erlotinibe aux fins de traitement du cancer |
JP2009514889A (ja) * | 2005-11-04 | 2009-04-09 | メルク エンド カムパニー インコーポレーテッド | 癌を治療するためにsaha及びボルテゾミブを用いる方法 |
WO2007054776A2 (fr) * | 2005-11-10 | 2007-05-18 | Orchid Research Laboratories Limited | Composes semblables au stilbene comme inhibiteurs hdac atypiques |
AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
WO2007063267A1 (fr) | 2005-11-30 | 2007-06-07 | Eden Research Plc | Compositions contenant des terpenes et procedes de production et d'utilisation de celles-ci |
US20090012075A1 (en) * | 2006-01-12 | 2009-01-08 | Miller Thomas A | Fluorinated Arylamide Derivatives |
AU2007208495A1 (en) * | 2006-01-12 | 2007-08-02 | Merck Sharp & Dohme Corp. | Hydroxyalkylarylamide derivatives |
WO2008091349A1 (fr) | 2006-02-14 | 2008-07-31 | The President And Fellows Of Harvard College | Inhibiteurs bifonctionnels d'histone déacétylase |
AU2007221207A1 (en) * | 2006-02-28 | 2007-09-07 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007113644A2 (fr) * | 2006-04-05 | 2007-10-11 | Orchid Research Laboratories Limited | Nouveaux inhibiteurs d'hdac |
US20100137239A1 (en) * | 2006-04-24 | 2010-06-03 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
AU2007243519A1 (en) | 2006-04-26 | 2007-11-08 | Merck Sharp & Dohme Corp. | Disubstituted aniline compounds |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2021000A2 (fr) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenèse par modulation de l'angiotensine |
JP2009537529A (ja) * | 2006-05-18 | 2009-10-29 | メルク エンド カムパニー インコーポレーテッド | アリール縮合スピロ環化合物 |
WO2007146730A2 (fr) | 2006-06-08 | 2007-12-21 | Gloucester Pharmaceuticals | Thérapie à base d'inhibiteurs de désacétylase (dac) |
US7981874B2 (en) * | 2006-07-20 | 2011-07-19 | Merck Sharp & Dohme Corp. | Phosphorus derivatives as histone deacetylase inhibitors |
AU2007338601C1 (en) * | 2006-09-05 | 2014-07-24 | Emory University | Tyrosine kinase inhibitors for prevention or treatment of infection |
EP2068872A1 (fr) * | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinaisons contenant un dérivé de 4-acylaminopyridine |
WO2008033743A1 (fr) | 2006-09-11 | 2008-03-20 | Curis, Inc. | 2-indolinone substituée en tant qu'inhibiteur de la ptk contenant une fraction se liant au zinc |
JP5563300B2 (ja) * | 2006-09-11 | 2014-07-30 | キュリス,インコーポレイテッド | 亜鉛結合部分を含むチロシンキナーゼインヒビター |
US7547781B2 (en) * | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
SG174774A1 (en) * | 2006-09-11 | 2011-10-28 | Curis Inc | Quinazoline based egfr inhibitors containing a zinc binding moiety |
WO2008033745A2 (fr) * | 2006-09-11 | 2008-03-20 | Curis, Inc. | Pyrimidines bicycliques fusionnées servant d'inhibiteurs de ptk contenant un groupe de liaison au zinc |
KR20090077914A (ko) * | 2006-09-11 | 2009-07-16 | 쿠리스 인코퍼레이션 | 항증식제로서의 다작용성 소분자 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
MX2009003405A (es) | 2006-09-28 | 2009-04-09 | Merck & Co Inc | Composiciones farmaceuticas de inhibidores de la histona desacetilasa y compuestos quelantes de metal, y complejos de quelato de metal-inhibidor de histona desacetilasa. |
GB0619753D0 (en) | 2006-10-06 | 2006-11-15 | Chroma Therapeutics Ltd | Enzyme inhibitors |
EA017198B1 (ru) * | 2006-10-30 | 2012-10-30 | Хрома Терапьютикс Лтд. | Гидроксаматы в качестве ингибиторов гистон-деацетилазы |
EP2086323A4 (fr) * | 2006-11-03 | 2010-01-06 | Univ Maryland | Procédés d'utilisation de saha et de bortezomibe destinés à traiter un myélome multiple |
WO2008097654A1 (fr) * | 2007-02-08 | 2008-08-14 | Merck & Co., Inc. | Procédés d'utilisation du saha pour le traitement d'une infection à vih |
WO2008106524A1 (fr) * | 2007-02-27 | 2008-09-04 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Utilisation d'inhibiteurs de l'histone désacétylase dans le traitement des métastases du système nerveux central |
CN101674833A (zh) * | 2007-03-20 | 2010-03-17 | 柯瑞斯公司 | 含有锌结合半族的Raf激酶抑制剂 |
US20100056522A1 (en) | 2007-03-28 | 2010-03-04 | Santen Pharmaceutical Co., Ltd. | Intraocular pressure-lowering agent comprising compound having histone deacetylase inhibitor effect as active ingredient |
GB2454118B (en) | 2007-06-06 | 2010-06-02 | Univ Maryland | Hdac inhibitors and hormone targeted drugs for the treatment of cancer |
AU2008271170A1 (en) * | 2007-06-27 | 2009-01-08 | Merck Sharp & Dohme Corp. | Pyridyl and pyrimidinyl derivatives as histone deacetylase inhibitors |
EP3103791B1 (fr) | 2007-06-27 | 2018-01-31 | Merck Sharp & Dohme Corp. | Dérivés de 4-carboxybenzylamino utilisés comme inhibiteurs de l'histone désacétylase |
EP2190287B1 (fr) * | 2007-09-10 | 2014-10-29 | Curis, Inc. | Inhibiteurs d'egfr à base de sels de type tartrates ou de complexes de quinazoline contenant un groupe fonctionnel liant le zinc |
US8119616B2 (en) * | 2007-09-10 | 2012-02-21 | Curis, Inc. | Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety |
US20090076154A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched vorinostat |
US8476255B2 (en) * | 2007-10-10 | 2013-07-02 | Orchid Chemicals & Pharmaceuticals Limited | Histone deacetylase inhibitors |
BRPI0817860A2 (pt) * | 2007-10-22 | 2019-09-24 | Orchid Res Laboratories Limited | inibidores de histona deacetilase |
US20110053991A1 (en) * | 2007-11-19 | 2011-03-03 | Gore Lia | Treatment of Histone Deacetylase Mediated Disorders |
CA2708281A1 (fr) | 2007-12-11 | 2009-08-27 | Viamet Pharmaceuticals, Inc. | Inhibiteurs de metalloenzymes utilisant des fractions de liaison a un metal en combinaison avec des fractions de ciblage |
NZ586955A (en) | 2008-02-07 | 2012-06-29 | Generics Uk Ltd | Novel process for the preparation of vorinostat |
EP2133334A1 (fr) * | 2008-06-09 | 2009-12-16 | DAC S.r.l. | Dérivés hétéroclites en tant qu'inhibiteurs HDAC |
RU2515611C2 (ru) | 2008-07-23 | 2014-05-20 | Президент Энд Феллоуз Оф Гарвард Колледж | Ингибиторы деацетилазы и их применение |
IT1392908B1 (it) | 2008-09-29 | 2012-04-02 | Italfarmaco Spa | Uso degli inibitori delle istone-deacetilasi per la cura di sindromi mieloproliferative philadelphia-negative |
US20110212943A1 (en) * | 2008-10-15 | 2011-09-01 | Orchid Research Laboratories Limited | Novel bridged cyclic compounds as histone deacetylase inhibitors |
US8883851B2 (en) | 2008-10-15 | 2014-11-11 | Generics [Uk] Limited | Process for the preparation of vorinostat |
NZ593585A (en) | 2008-11-26 | 2012-12-21 | Generics Uk Ltd | Crystalline forms of vorinostat (suberoylanilide hydroxamic acid) |
RS54230B1 (en) | 2009-01-08 | 2015-12-31 | Curis Inc. | 3-KINASE PHOSPHOINOSITIDE INHIBITORS WITH ZINC BINDING PART |
CA2750413C (fr) | 2009-01-23 | 2016-06-21 | Northlake Biosciences Llc | Derives d'acide hydroxamique |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
GB0903480D0 (en) | 2009-02-27 | 2009-04-08 | Chroma Therapeutics Ltd | Enzyme Inhibitors |
KR101168801B1 (ko) | 2009-03-27 | 2012-07-25 | 주식회사종근당 | 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 |
US7994357B2 (en) * | 2009-04-03 | 2011-08-09 | Naturewise Biotech & Medicals Corporation | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase |
EP2236503B1 (fr) | 2009-04-03 | 2014-02-26 | NatureWise Biotech & Medicals Corporation | Composants cinnamiques et dérivés de celui-ci pour l'inhibition de l'histone désacétylase |
EP2454267A2 (fr) | 2009-07-16 | 2012-05-23 | Royal College of Surgeons in Ireland | Complexes métalliques ayant une double activité inhibitrice d'histone désacétylase et de liaison à l'adn |
EP2277387B1 (fr) | 2009-07-22 | 2016-10-19 | NatureWise Biotech & Medicals Corporation | Nouvelle utilisation d'inhibiteurs d'histone déacétylase pour le changement de protéine mrjp3 dans la gelée royale |
WO2011019393A2 (fr) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci |
WO2011056542A1 (fr) | 2009-10-26 | 2011-05-12 | Ramot At Tel-Aviv University Ltd. | Thérapie cancéreuse avec combinaisons de fts et d'inhibiteurs hdac |
US8217079B2 (en) | 2010-03-26 | 2012-07-10 | Italfarmaco Spa | Method for treating Philadelphia-negative myeloproliferative syndromes |
HUE026235T2 (en) | 2010-03-31 | 2016-06-28 | Gilead Pharmasset Llc | Crystalline (S) -isopropyl 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2H) -IL) - 4-Fluoro-3-hydroxy-4-methyltetrahydrofuran-2-IL) methoxy) (phenoxy) phosphoryl) amino) propanoate |
CA2800143A1 (fr) * | 2010-05-21 | 2011-11-24 | The Trustees Of Columbia University In The City Of New York | Inhibiteurs selectifs de hdac |
WO2012019772A1 (fr) * | 2010-08-12 | 2012-02-16 | Institut De Recherche Pour Le Developpement (I.R.D) | Procédé de traitement de maladies parasitaires dues à un protozoaire |
AT510456B1 (de) * | 2010-09-27 | 2012-11-15 | Univ Wien Tech | Thiazolamin-derivate als zelldifferenzierungsbeschleuniger |
DK2668210T3 (da) | 2011-01-26 | 2020-08-24 | Celldex Therapeutics Inc | Anti-kit antistoffer og anvendelser deraf |
CN110063951A (zh) | 2011-03-09 | 2019-07-30 | 赛伦诺科学有限公司 | 利用组蛋白脱乙酰酶抑制物改善受损的内源纤维蛋白溶解作用的化合物和方法 |
ES2733128T3 (es) | 2011-04-01 | 2019-11-27 | Curis Inc | Inhibidor de fosfoinosítido 3-quinasa con un resto de unión a cinc |
PL2734510T4 (pl) | 2011-07-22 | 2019-05-31 | Massachusetts Inst Technology | Aktywatory deacetylaz histonowych klasy I (HDAC) i ich zastosowania |
US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
AU2012319188B2 (en) | 2011-10-03 | 2016-11-24 | Sloan-Kettering Institute For Cancer Research | Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1 |
AR092790A1 (es) | 2012-02-01 | 2015-05-06 | Euro Celtique Sa | Derivados bencimidazolicos del acido hidroxamico |
WO2013151186A1 (fr) | 2012-04-06 | 2013-10-10 | 国立大学法人京都大学 | Méthode d'induction de cellules produisant de l'érythropoïétine |
CN116574185A (zh) | 2012-07-25 | 2023-08-11 | 塞尔德克斯医疗公司 | 抗kit抗体及其用途 |
US9133105B2 (en) | 2013-03-06 | 2015-09-15 | C&C Biopharma, Llc | Transcription factor modulators |
US9878986B2 (en) | 2013-04-29 | 2018-01-30 | Chong Kun Dang Pharmaceutical Corp. | Compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same |
WO2015100363A1 (fr) | 2013-12-23 | 2015-07-02 | The Trustees Of Columbia University In The City Of New York | Inhibiteurs sélectifs de hdac6 |
CN103922967B (zh) * | 2014-04-15 | 2016-06-01 | 北京化工大学 | 一种异羟肟酸类化合物及其在制备抑制癌细胞增殖和/或治疗癌症的药物中的应用 |
GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
WO2015184260A2 (fr) | 2014-05-30 | 2015-12-03 | The Johns Hopkins University | Méthodes de traitement de troubles mendélien de la machinerie épigénétiques |
CN104292133B (zh) * | 2014-09-29 | 2016-06-01 | 烟台市华文欣欣医药科技有限公司 | 一种抗癌药物伏立诺他的合成方法 |
CN104292134B (zh) * | 2014-10-10 | 2016-06-22 | 广东药学院 | 异羟肟酸类化合物及其制备方法和应用 |
JP5993066B2 (ja) * | 2015-06-26 | 2016-09-14 | 大阪ガスケミカル株式会社 | アミド化合物、防カビ剤およびそれを用いる防カビ方法 |
ITUB20155193A1 (it) | 2015-11-03 | 2017-05-03 | Italfarmaco Spa | Sospensioni orali di Givinostat fisicamente e chimicamente stabili |
SG10201913290QA (en) | 2016-03-15 | 2020-03-30 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for the treatment of hematological malignancies |
AU2017233898B2 (en) | 2016-03-15 | 2022-12-15 | Oryzon Genomics, S.A. | Combinations of LSD1 inhibitors for use in the treatment of solid tumors |
BR112018076812A2 (pt) * | 2016-06-21 | 2021-09-28 | The University Of Melbourne | Ativadores da latência de hiv |
WO2018015493A1 (fr) | 2016-07-20 | 2018-01-25 | Royal College Of Surgeons In Ireland | Complexes métalliques ayant des applications thérapeutiques |
CN106397102A (zh) * | 2016-08-29 | 2017-02-15 | 山东同成医药股份有限公司 | 卤代烃产品及其密封保温增压式生产方法 |
WO2018054960A1 (fr) | 2016-09-21 | 2018-03-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de prédiction et de traitement de la résistance à la chimiothérapie dans le lagc à npm-alk(+) |
AU2016426574B2 (en) | 2016-10-11 | 2023-07-13 | Euro-Celtique S.A. | Hodgkin lymphoma therapy |
CN106905191B (zh) * | 2017-03-05 | 2019-03-29 | 北京化工大学 | 一种含有羟肟酸基团的氮芥类化合物及其制备方法和用途 |
GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
EP3461488A1 (fr) | 2017-09-27 | 2019-04-03 | Onxeo | Combinaison d'une molécule dbait et un inhibiteur de hdac pour le traitement du cancer |
EP3461480A1 (fr) | 2017-09-27 | 2019-04-03 | Onxeo | Combinaison d'inhibiteurs de point de contrôle du cycle cellulaire de réponse à un dommage à l'adn et de belinostat pour traiter le cancer |
WO2020014409A1 (fr) | 2018-07-11 | 2020-01-16 | Rubedo Life Sciences, Inc. | Compositions sénolytiques et utilisations associées |
AU2019340376A1 (en) | 2018-09-11 | 2021-04-08 | Curis Inc. | Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
CN111533673B (zh) * | 2020-03-27 | 2022-05-20 | 徐州医科大学 | 一种含有缩氨基硫脲/缩氨基脲结构的化合物、其制备方法及医药用途 |
WO2023287984A1 (fr) * | 2021-07-14 | 2023-01-19 | University Of Maryland, Baltimore | Médicaments à base d'acide subéroylanilide hydroxamique (saha), conjugués et nanoparticules, et leurs procédés d'utilisation |
WO2023041805A1 (fr) | 2021-09-20 | 2023-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés pour l'amélioration de l'efficacité d'une thérapie par inhibiteur de hdac et la prédiction de la réponse à un traitement comprenant un inhibiteur de hdac |
WO2023194441A1 (fr) | 2022-04-05 | 2023-10-12 | Istituto Nazionale Tumori Irccs - Fondazione G. Pascale | Combinaison d'inhibiteurs de hdac et de statines pour une utilisation dans le traitement du cancer du pancréas |
CN114621754A (zh) * | 2022-04-18 | 2022-06-14 | 武汉轻工大学 | 一种荧光探针的制备及其在组蛋白去乙酰化酶中的应用 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2895991A (en) * | 1959-07-21 | New chloromethylated amlides | ||
US2346665A (en) * | 1940-05-08 | 1944-04-18 | Du Pont | Acid |
US2279560A (en) * | 1940-05-08 | 1942-04-14 | Du Pont | Viscous hydrocarbon oil |
US2279973A (en) * | 1940-05-08 | 1942-04-14 | Du Pont | Stabilization of organic substances |
CH421933A (fr) * | 1964-02-03 | 1966-10-15 | Rhodiaceta | Procédé de fabrication d'amides mixtes d'acides carboxyliques |
US3450673A (en) * | 1965-09-07 | 1969-06-17 | Ashland Oil Inc | Polyurethane compositions from diaminimides |
FR1479260A (fr) * | 1965-12-06 | 1967-05-05 | Nouveaux dérivés acylés de la nu-hydroxyglycine | |
US3632783A (en) * | 1969-05-27 | 1972-01-04 | Hall Co C P | Treatment of mosquito bites employing certain tetraalkyl diamides |
US4056524A (en) * | 1974-04-09 | 1977-11-01 | Stauffer Chemical Company | Bis-substituted succinamides and their utility as herbicides |
US3875301A (en) * | 1974-04-30 | 1975-04-01 | Interx Research Corp | Useful tetraalkyl diamides in the treatment of poison ivy |
IT1123574B (it) * | 1979-09-10 | 1986-04-30 | Anic Spa | Processo per la produzione di diesterediammidi |
US4442305A (en) * | 1981-08-24 | 1984-04-10 | The United States Of America As Represented By The United States Department Of Energy | Polycatecholamide chelating agents |
US4480125A (en) * | 1981-11-16 | 1984-10-30 | Polaroid Corporation | Itaconamide compounds and method of preparation |
DE3305569A1 (de) * | 1983-02-18 | 1984-08-23 | Bayer Ag, 5090 Leverkusen | Biscarboxamide zur bekaempfung von erkrankungen sowie verfahren zu ihrer herstellung |
US4537781A (en) * | 1983-09-16 | 1985-08-27 | Research Corporation | Pharmaceutically useful malonamides |
NL8500249A (nl) * | 1984-02-17 | 1985-09-16 | Ppg Industries Inc | Bis(polybroomfenyl)diamiden en preparaten die ze bevatten. |
US4611053A (en) * | 1985-02-15 | 1986-09-09 | Sasa Michiyuki Mitch | Polyhydroxamide polymer |
JPS61205221A (ja) * | 1985-03-08 | 1986-09-11 | Univ Osaka | ニトリルとアミンからのアミドの製造方法 |
US4863967A (en) * | 1986-06-16 | 1989-09-05 | Research Corporation | N,N-diaminophthalamides |
US4882346A (en) * | 1987-06-16 | 1989-11-21 | The United States Of America As Reprsented By The Department Of Health And Human Services | Chemical differentiating agents |
US5330744A (en) * | 1988-11-14 | 1994-07-19 | Sloan-Kettering Institute For Cancer Research | Method for increasing sensitivity to chemically induced terminal differentiation |
US5175191A (en) * | 1988-11-14 | 1992-12-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5055608A (en) * | 1988-11-14 | 1991-10-08 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of thermal differentiation and method of use thereof |
AU5927190A (en) * | 1989-06-30 | 1991-01-17 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of terminal differentiation and methods of use thereof |
ES2128314T3 (es) * | 1989-11-14 | 1999-05-16 | Sloan Kettering Inst Cancer | Nuevos inductores potentes de diferenciacion terminal y metodo de utilizacion de los mismos. |
AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
HU211995B (en) * | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
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1991
- 1991-10-04 US US07/771,760 patent/US5369108A/en not_active Ceased
-
1992
- 1992-10-05 EP EP92922033A patent/EP0642509B1/fr not_active Expired - Lifetime
- 1992-10-05 ES ES92922033T patent/ES2134815T3/es not_active Expired - Lifetime
- 1992-10-05 CA CA002120619A patent/CA2120619C/fr not_active Expired - Lifetime
- 1992-10-05 KR KR1019940701095A patent/KR100263264B1/ko not_active IP Right Cessation
- 1992-10-05 RU RU94021660A patent/RU2128643C1/ru active Protection Beyond IP Right Term
- 1992-10-05 AT AT92922033T patent/ATE183185T1/de active
- 1992-10-05 JP JP50710993A patent/JP3432823B2/ja not_active Expired - Lifetime
- 1992-10-05 DE DE69229800T patent/DE69229800T2/de not_active Expired - Lifetime
- 1992-10-05 WO PCT/US1992/008454 patent/WO1993007148A1/fr active Application Filing
- 1992-10-05 AU AU28703/92A patent/AU668696B2/en not_active Expired
- 1992-10-05 HU HU9400959A patent/HU225497B1/hu unknown
-
1994
- 1994-03-31 FI FI941537A patent/FI941537A/fi not_active Application Discontinuation
- 1994-04-04 US US08/222,685 patent/US5932616A/en not_active Expired - Lifetime
-
1999
- 1999-05-18 US US09/314,195 patent/US6087367A/en not_active Expired - Fee Related
- 1999-10-30 KR KR1019997010081A patent/KR100258680B1/ko not_active IP Right Cessation
-
2002
- 2002-11-20 JP JP2002337049A patent/JP2003226680A/ja not_active Withdrawn
-
2007
- 2007-04-24 JP JP2007114876A patent/JP2007291110A/ja not_active Withdrawn
- 2007-09-19 JP JP2007242963A patent/JP2008069158A/ja not_active Withdrawn
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2008
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Publication number | Publication date |
---|---|
US5932616A (en) | 1999-08-03 |
JP2007291110A (ja) | 2007-11-08 |
CL2008002943A1 (es) | 2009-03-06 |
DE69229800D1 (de) | 1999-09-16 |
KR100258680B1 (en) | 2000-05-15 |
EP0642509A4 (fr) | 1995-01-31 |
JP2008069158A (ja) | 2008-03-27 |
AU2870392A (en) | 1993-05-03 |
ATE183185T1 (de) | 1999-08-15 |
JP3432823B2 (ja) | 2003-08-04 |
HUT67421A (en) | 1995-04-28 |
WO1993007148A1 (fr) | 1993-04-15 |
RU2128643C1 (ru) | 1999-04-10 |
HU9400959D0 (en) | 1994-06-28 |
EP0642509B1 (fr) | 1999-08-11 |
JPH07502494A (ja) | 1995-03-16 |
HU225497B1 (en) | 2007-01-29 |
JP2003226680A (ja) | 2003-08-12 |
CA2120619A1 (fr) | 1993-04-15 |
DE69229800T2 (de) | 2000-04-27 |
US6087367A (en) | 2000-07-11 |
CA2120619C (fr) | 2006-11-21 |
US5369108A (en) | 1994-11-29 |
KR100263264B1 (ko) | 2000-08-01 |
ES2134815T3 (es) | 1999-10-16 |
FI941537A0 (fi) | 1994-03-31 |
EP0642509A1 (fr) | 1995-03-15 |
AU668696B2 (en) | 1996-05-16 |
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