FI913887A0 - Menetelmä doksorubisiinin morfolinyyli-johdannaisten valmistamiseksi, menetelmässä käytettävä dijodivälituote ja menetelmä sen valmistamiseksi - Google Patents

Menetelmä doksorubisiinin morfolinyyli-johdannaisten valmistamiseksi, menetelmässä käytettävä dijodivälituote ja menetelmä sen valmistamiseksi

Info

Publication number
FI913887A0
FI913887A0 FI913887A FI913887A FI913887A0 FI 913887 A0 FI913887 A0 FI 913887A0 FI 913887 A FI913887 A FI 913887A FI 913887 A FI913887 A FI 913887A FI 913887 A0 FI913887 A0 FI 913887A0
Authority
FI
Finland
Prior art keywords
preparation
doxorubicin
intermediate used
morpholinyl derivatives
diiodo
Prior art date
Application number
FI913887A
Other languages
English (en)
Swedish (sv)
Other versions
FI97389C (fi
FI97389B (fi
Inventor
Alberto Bargiotti
Maria Grandi
Antonino Suarato
Daniela Faiardi
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of FI913887A0 publication Critical patent/FI913887A0/fi
Application granted granted Critical
Publication of FI97389B publication Critical patent/FI97389B/fi
Publication of FI97389C publication Critical patent/FI97389C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
FI913887A 1989-12-19 1991-08-16 Menetelmä doksorubisiinin morfolinyyli-johdannaisten valmistamiseksi, menetelmässä käytettävä dijodivälituote ja menetelmä sen valmistamiseksi FI97389C (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8928654 1989-12-19
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB9007513 1990-04-03
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation
EP9002229 1990-12-18
PCT/EP1990/002229 WO1991009046A1 (en) 1989-12-19 1990-12-18 Morpholinyl derivatives of doxorubicin and process for their preparation

Publications (3)

Publication Number Publication Date
FI913887A0 true FI913887A0 (fi) 1991-08-16
FI97389B FI97389B (fi) 1996-08-30
FI97389C FI97389C (fi) 1996-12-10

Family

ID=26296395

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913887A FI97389C (fi) 1989-12-19 1991-08-16 Menetelmä doksorubisiinin morfolinyyli-johdannaisten valmistamiseksi, menetelmässä käytettävä dijodivälituote ja menetelmä sen valmistamiseksi

Country Status (28)

Country Link
EP (1) EP0434960B1 (fi)
JP (1) JP3300342B2 (fi)
KR (1) KR0183033B1 (fi)
CN (2) CN1024922C (fi)
AT (1) ATE143023T1 (fi)
AU (1) AU636429B2 (fi)
CA (1) CA2046857C (fi)
CZ (1) CZ281949B6 (fi)
DE (1) DE69028610T2 (fi)
DK (1) DK0434960T3 (fi)
ES (1) ES2094136T3 (fi)
FI (1) FI97389C (fi)
GR (1) GR3021557T3 (fi)
HR (1) HRP921226B1 (fi)
HU (2) HU208148B (fi)
IE (1) IE81174B1 (fi)
IL (3) IL111527A (fi)
MY (1) MY119192A (fi)
NO (2) NO175533C (fi)
NZ (1) NZ243695A (fi)
PT (1) PT96226B (fi)
RU (1) RU2100366C1 (fi)
SI (1) SI9012379B (fi)
SK (1) SK621990A3 (fi)
TW (1) TW208019B (fi)
UA (1) UA27108A1 (fi)
WO (1) WO1991009046A1 (fi)
YU (1) YU48136B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
CA2395660A1 (en) * 1999-12-29 2001-07-12 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
CA2484761C (en) 2002-05-24 2010-11-09 Angiotech International Ag Compositions and methods for coating medical implants
KR20050084599A (ko) 2002-09-26 2005-08-26 안지오테크 인터내셔날 아게 혈관주위 랩
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1605951A1 (en) * 2003-03-18 2005-12-21 Pharmacia Italia S.p.A. Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
MX2009000029A (es) * 2006-07-12 2009-01-23 Nerviano Medical Sciences Srl Clorhidrato de nemorubicina cristalino.
AU2009235897B2 (en) * 2008-04-11 2012-04-12 Tianjin Hemay Oncology Pharmaceutical Co., Ltd Anthracycline antibiotic derivatives with high activity, preparation methods and uses thereof
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
ES2533710T3 (es) * 2010-12-02 2015-04-14 Nerviano Medical Sciences S.R.L. Proceso para la preparación de derivados de morfolinil antraciclina
US9828405B2 (en) 2013-04-29 2017-11-28 Nerviano Medical Sciences S.R.L. Morpholinyl anthracycline derivatives
JP2017502950A (ja) 2013-12-11 2017-01-26 ユニバーシティー オブ マサチューセッツＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ サルモネラＴ３ＳＳエフェクタータンパク質（ＳｉｐＡ）を使用した疾患を治療するための組成物および方法
KR102562864B1 (ko) 2014-11-05 2023-08-04 네르비아노 메디칼 사이언시스 에스.알.엘. 관능화된 모르폴리닐 안트라사이클린 유도체
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
IL96643A0 (en) 1991-09-16
KR920701228A (ko) 1992-08-11
RU2100366C1 (ru) 1997-12-27
HRP921226A2 (en) 1995-12-31
NZ243695A (en) 1993-06-25
PT96226A (pt) 1991-09-30
YU237990A (sh) 1993-05-28
EP0434960A1 (en) 1991-07-03
IL111527A (en) 1998-02-22
CN1039708C (zh) 1998-09-09
CA2046857A1 (en) 1991-06-20
DE69028610T2 (de) 1997-02-06
CN1079215A (zh) 1993-12-08
FI97389C (fi) 1996-12-10
CA2046857C (en) 2001-06-12
ATE143023T1 (de) 1996-10-15
ES2094136T3 (es) 1997-01-16
DE69028610D1 (de) 1996-10-24
NO176911C (no) 1995-06-21
UA27108A1 (uk) 2000-02-28
HU209433B (en) 1994-06-28
IL96643A (en) 1995-01-24
SI9012379B (sl) 2000-02-29
CZ281949B6 (cs) 1997-04-16
JP3300342B2 (ja) 2002-07-08
JPH04503679A (ja) 1992-07-02
EP0434960B1 (en) 1996-09-18
NO940831D0 (no) 1994-03-09
SK278994B6 (sk) 1998-05-06
DK0434960T3 (da) 1996-10-14
HUT60232A (en) 1992-08-28
IE81174B1 (en) 2000-06-14
AU6919491A (en) 1991-07-18
NO913176D0 (no) 1991-08-14
HU912994D0 (en) 1992-01-28
IL111527A0 (en) 1995-01-24
NO176911B (no) 1995-03-13
NO175533C (no) 1994-10-26
NO940831L (no) 1991-08-14
CN1053238A (zh) 1991-07-24
WO1991009046A1 (en) 1991-06-27
NO913176L (no) 1991-08-14
AU636429B2 (en) 1993-04-29
HU208148B (en) 1993-08-30
HU9200656D0 (en) 1992-05-28
CN1024922C (zh) 1994-06-08
HUT59693A (en) 1992-06-29
SI9012379A (en) 1997-12-31
KR0183033B1 (ko) 1999-04-01
GR3021557T3 (en) 1997-02-28
HRP921226B1 (en) 1998-10-31
TW208019B (fi) 1993-06-21
PT96226B (pt) 1998-06-30
YU48136B (sh) 1997-05-28
MY119192A (en) 2005-04-30
NO175533B (no) 1994-07-18
SK621990A3 (en) 1998-05-06
IE904543A1 (en) 1991-06-19
FI97389B (fi) 1996-08-30
CZ621990A3 (en) 1997-01-15

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GB Transfer or assigment of application

Owner name: PHARMACIA & UPJOHN S.P.A.