DE69028610D1 - Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte - Google Patents

Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte

Info

Publication number
DE69028610D1
DE69028610D1 DE69028610T DE69028610T DE69028610D1 DE 69028610 D1 DE69028610 D1 DE 69028610D1 DE 69028610 T DE69028610 T DE 69028610T DE 69028610 T DE69028610 T DE 69028610T DE 69028610 D1 DE69028610 D1 DE 69028610D1
Authority
DE
Germany
Prior art keywords
diiodo
benzyloxy
chiral
intermediates
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69028610T
Other languages
English (en)
Other versions
DE69028610T2 (de
Inventor
Daniela Faiardi
Alberto Bargiotti
Maria Grandi
Antonino Suarato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928654A external-priority patent/GB8928654D0/en
Priority claimed from GB909007513A external-priority patent/GB9007513D0/en
Application filed by Pharmacia SpA filed Critical Pharmacia SpA
Application granted granted Critical
Publication of DE69028610D1 publication Critical patent/DE69028610D1/de
Publication of DE69028610T2 publication Critical patent/DE69028610T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE69028610T 1989-12-19 1990-11-15 Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte Expired - Fee Related DE69028610T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898928654A GB8928654D0 (en) 1989-12-19 1989-12-19 Preparation of 2-methoxy-4-morpholinyl anthracyclines
GB909007513A GB9007513D0 (en) 1990-04-03 1990-04-03 Morpholinyl derivatives of doxorubicin and process for their preparation

Publications (2)

Publication Number Publication Date
DE69028610D1 true DE69028610D1 (de) 1996-10-24
DE69028610T2 DE69028610T2 (de) 1997-02-06

Family

ID=26296395

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028610T Expired - Fee Related DE69028610T2 (de) 1989-12-19 1990-11-15 Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte

Country Status (28)

Country Link
EP (1) EP0434960B1 (de)
JP (1) JP3300342B2 (de)
KR (1) KR0183033B1 (de)
CN (2) CN1024922C (de)
AT (1) ATE143023T1 (de)
AU (1) AU636429B2 (de)
CA (1) CA2046857C (de)
CZ (1) CZ281949B6 (de)
DE (1) DE69028610T2 (de)
DK (1) DK0434960T3 (de)
ES (1) ES2094136T3 (de)
FI (1) FI97389C (de)
GR (1) GR3021557T3 (de)
HR (1) HRP921226B1 (de)
HU (2) HU208148B (de)
IE (1) IE81174B1 (de)
IL (3) IL96643A (de)
MY (1) MY119192A (de)
NO (2) NO175533C (de)
NZ (1) NZ243695A (de)
PT (1) PT96226B (de)
RU (1) RU2100366C1 (de)
SI (1) SI9012379B (de)
SK (1) SK278994B6 (de)
TW (1) TW208019B (de)
UA (1) UA27108A1 (de)
WO (1) WO1991009046A1 (de)
YU (1) YU48136B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843903A (en) * 1995-11-27 1998-12-01 The Administrators Of The Tulane Educational Fund Targeted cytotoxic anthracycline analogs
AU767394C (en) * 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
DE60328486D1 (de) 2002-05-24 2009-09-03 Angiotech Int Ag Zusammensetzungen und verfahren zur beschichtung medizinischer implantate
US20040146546A1 (en) 2002-09-26 2004-07-29 Angiotech Pharmaceuticals, Inc. Perivascular wraps
EP2181704B1 (de) 2002-12-30 2015-05-06 Angiotech International Ag Wirkstofffreisetzung von schnell gelierender Polymerzusammensetzung
CA2519310A1 (en) * 2003-03-18 2004-09-30 Maria Adele Pacciarini Combined therapy comprising nemorubicin and a cyclooxygenase-2-inhibitor
EP2049530A2 (de) * 2006-07-12 2009-04-22 Nerviano Medical Sciences S.r.l. Kristallines nemorubicinhydrochlorid
WO2009124468A1 (zh) * 2008-04-11 2009-10-15 天津和美生物技术有限公司 具有高活性的四环蒽醌类抗生素的衍生物及其制备和应用
CN101353361B (zh) * 2008-08-08 2011-06-01 中国人民解放军第四军医大学 一种阿霉素前体药物的制备方法及其应用
US8470984B2 (en) * 2010-12-02 2013-06-25 Nerviano Medical Sciences S.R.L. Process for the preparation of morpholinyl anthracycline derivatives
WO2014177441A1 (en) 2013-04-29 2014-11-06 Nerviano Medical Sciences S.R.L. New morpholinyl anthracycline derivatives
EP3084445B1 (de) 2013-12-11 2020-10-28 University of Massachusetts Zusammensetzungen und verfahren zur behandlung einer krankheit mithilfe des salmonella-t3ss-effektorproteins (sipa)
KR102562864B1 (ko) 2014-11-05 2023-08-04 네르비아노 메디칼 사이언시스 에스.알.엘. 관능화된 모르폴리닐 안트라사이클린 유도체
CN115043895A (zh) * 2022-07-15 2022-09-13 戊言医药科技（上海）有限公司 一种pnu-159682及其中间体的制备方法
WO2024038065A1 (en) * 2022-08-15 2024-02-22 Synaffix B.V. Anthracyclins and conjugates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2883443A (en) * 1956-07-13 1959-04-21 Ruetschi Karl Lead-acid storage battery
US4423123A (en) * 1980-04-17 1983-12-27 Shin-Kobe Electric Machinery Co., Ltd. Electric storage battery and a method of making the same
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4363857A (en) * 1981-10-16 1982-12-14 General Motors Corporation Laminated metal-plastic battery grid
US4710564A (en) * 1985-01-18 1987-12-01 Microbial Chemistry Research Foundation Anthracycline compounds
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
JPS6215323A (ja) * 1986-02-14 1987-01-23 Dainippon Ink & Chem Inc 微多孔中空繊維の製造法
US4861836A (en) * 1986-12-23 1989-08-29 Daikin Industries Ltd. Novel, iodine-containing compound, preparation thereof and block copolymer comprising the same

Also Published As

Publication number Publication date
EP0434960A1 (de) 1991-07-03
DK0434960T3 (da) 1996-10-14
KR0183033B1 (ko) 1999-04-01
UA27108A1 (uk) 2000-02-28
AU6919491A (en) 1991-07-18
MY119192A (en) 2005-04-30
NO913176L (no) 1991-08-14
DE69028610T2 (de) 1997-02-06
PT96226A (pt) 1991-09-30
CA2046857A1 (en) 1991-06-20
JP3300342B2 (ja) 2002-07-08
PT96226B (pt) 1998-06-30
NZ243695A (en) 1993-06-25
ATE143023T1 (de) 1996-10-15
RU2100366C1 (ru) 1997-12-27
YU237990A (sh) 1993-05-28
EP0434960B1 (de) 1996-09-18
CN1039708C (zh) 1998-09-09
NO175533C (no) 1994-10-26
HU209433B (en) 1994-06-28
GR3021557T3 (en) 1997-02-28
IE904543A1 (en) 1991-06-19
HU208148B (en) 1993-08-30
HUT60232A (en) 1992-08-28
IL96643A (en) 1995-01-24
SK621990A3 (en) 1998-05-06
IL96643A0 (en) 1991-09-16
IL111527A (en) 1998-02-22
AU636429B2 (en) 1993-04-29
NO175533B (no) 1994-07-18
NO176911C (no) 1995-06-21
SI9012379B (sl) 2000-02-29
SI9012379A (en) 1997-12-31
CA2046857C (en) 2001-06-12
FI913887A0 (fi) 1991-08-16
CZ281949B6 (cs) 1997-04-16
IL111527A0 (en) 1995-01-24
FI97389B (fi) 1996-08-30
TW208019B (de) 1993-06-21
CN1024922C (zh) 1994-06-08
WO1991009046A1 (en) 1991-06-27
SK278994B6 (sk) 1998-05-06
JPH04503679A (ja) 1992-07-02
KR920701228A (ko) 1992-08-11
NO913176D0 (no) 1991-08-14
CN1053238A (zh) 1991-07-24
CN1079215A (zh) 1993-12-08
NO940831D0 (no) 1994-03-09
NO940831L (no) 1991-08-14
ES2094136T3 (es) 1997-01-16
YU48136B (sh) 1997-05-28
HRP921226A2 (en) 1995-12-31
HU912994D0 (en) 1992-01-28
FI97389C (fi) 1996-12-10
HUT59693A (en) 1992-06-29
CZ621990A3 (en) 1997-01-15
IE81174B1 (en) 2000-06-14
HRP921226B1 (en) 1998-10-31
HU9200656D0 (en) 1992-05-28
NO176911B (no) 1995-03-13

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN S.P.A., MAILAND/MILANO, IT

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee