FI885623A0 - Menetelmä lääkeaineina käyttökelpoisten substituoitujen propaani-fosfiinihappoyhdisteiden valmistamiseksi - Google Patents

Menetelmä lääkeaineina käyttökelpoisten substituoitujen propaani-fosfiinihappoyhdisteiden valmistamiseksi

Info

Publication number: FI885623A0
Authority: FI; Finland
Prior art keywords: hydrogen; denotes; group; drugs; preparation
Prior art date: 1987-12-04

Application number

FI885623A

Other languages

English (en)

Swedish (sv)

Other versions

FI91412C (fi

FI885623A (fi

FI91412B (fi

Inventor

Eric Keith Baylis

Helmut Bittiger

Wolfgang Froestl

Roger Graham Hall

Ludwig Maier

Stuart John Mickel

Hans-Rudolf Olpe

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-04

Filing date

1988-12-02

Publication date

1988-12-02

1988-12-02 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1988-12-02 Publication of FI885623A0 publication Critical patent/FI885623A0/fi

1989-06-05 Publication of FI885623A publication Critical patent/FI885623A/fi

1994-03-15 Application granted granted Critical

1994-03-15 Publication of FI91412B publication Critical patent/FI91412B/fi

1994-06-27 Publication of FI91412C publication Critical patent/FI91412C/fi

Links

UQZPTVULCJDKIV-UHFFFAOYSA-N CCC.O[PH2]=O Chemical group CCC.O[PH2]=O UQZPTVULCJDKIV-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
125000001931 aliphatic group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI885623A 1987-12-04 1988-12-02 Menetelmä lääkeaineina käyttökelpoisten substituoitujen propaani-fosfiinihappoyhdisteiden valmistamiseksi FI91412C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8728483		1987-12-04
GB878728483A GB8728483D0 (en)	1987-12-04	1987-12-04	Chemical compounds

Publications (4)

Publication Number	Publication Date
FI885623A0 true FI885623A0 (fi)	1988-12-02
FI885623A FI885623A (fi)	1989-06-05
FI91412B FI91412B (fi)	1994-03-15
FI91412C FI91412C (fi)	1994-06-27

Family

ID=10628049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI885623A FI91412C (fi)	1987-12-04	1988-12-02	Menetelmä lääkeaineina käyttökelpoisten substituoitujen propaani-fosfiinihappoyhdisteiden valmistamiseksi

Country Status (22)

Country	Link
US (3)	US5013863A (fi)
EP (2)	EP0319479A3 (fi)
JP (1)	JP2716761B2 (fi)
KR (1)	KR890009955A (fi)
AT (1)	ATE105840T1 (fi)
AU (1)	AU614316B2 (fi)
CA (1)	CA1337352C (fi)
DD (1)	DD283630A5 (fi)
DE (1)	DE3889638T2 (fi)
DK (1)	DK673588A (fi)
ES (1)	ES2054869T3 (fi)
FI (1)	FI91412C (fi)
GB (1)	GB8728483D0 (fi)
HU (1)	HU202543B (fi)
IE (1)	IE63607B1 (fi)
IL (1)	IL88514A0 (fi)
MX (1)	MX14033A (fi)
NO (1)	NO177674C (fi)
NZ (1)	NZ227182A (fi)
PT (1)	PT89134B (fi)
YU (1)	YU218788A (fi)
ZA (1)	ZA889015B (fi)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5243062A (en) *	1984-10-12	1993-09-07	Ciba-Geigy Corporation	Substituted propane-phosphonous acid compounds
US5457095A (en) *	1984-10-12	1995-10-10	Ciba-Geigy Corporation	Substituted propane-phosponous acid compounds
US5190933A (en) *	1987-12-04	1993-03-02	Ciba-Geigy Corporation	Substituted propane-phosphinic acid compounds
US5300679A (en) *	1987-12-04	1994-04-05	Ciba-Geigy Corporation	Substituted propane-phosphinic acid compounds
US5281747A (en) *	1989-05-13	1994-01-25	Ciba-Geigy Corporation	Substituted aminoalkylphosphinic acids
US5567840A (en) *	1989-05-13	1996-10-22	Ciba-Geigy Corporation	Substituted aminoalkylphosphinic acids
GB8911017D0 (en) *	1989-05-13	1989-06-28	Ciba Geigy Ag	Substituted aminoalkylphosphinic acids
US5190934A (en) *	1989-06-03	1993-03-02	Ciba-Geigy Corporation	P-subsituted propane-phosphinic acid compounds
GB8912814D0 (en) *	1989-06-03	1989-07-19	Ciba Geigy Ag	P-substituted propane-phospinic acid compounds
IL98502A (en) *	1990-06-22	1998-04-05	Ciba Geigy Ag	History of Aminoalkene Phosphine Acid, Process for Their Preparation and Pharmaceutical Preparations Containing Them
US5179173A (en) *	1991-04-10	1993-01-12	Nalco Chemical Company	Aminoalkylphosphinates and phosphinic acid-containing polymers therefrom
EP0767174A1 (de) *	1991-11-21	1997-04-09	Ciba-Geigy Ag	Neue Aminoalkanphosphinsäuren und ihre Salze
GB9125615D0 (en) *	1991-12-02	1992-01-29	Wyeth John & Brother Ltd	Amines
AU662404B2 (en) *	1992-05-08	1995-08-31	Novartis Ag	Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
US5298625A (en) *	1992-12-07	1994-03-29	E. R. Squibb & Sons, Inc.	Process for the preparation of 4-phosphinyl-3-keto-carboxylate and 4-phosphonyl-3-keto-carboxylate intermediates useful in the preparation of phosphorus containing HMG-CoA reductase inhibitors
GB9304619D0 (en) *	1993-03-06	1993-04-21	Ciba Geigy Ag	Esters
US5385939A (en) *	1993-04-30	1995-01-31	The Trustees Of The University Of Pennsylvania	GABA-ergic modulation of eye growth
DE19604195C1 (de)	1996-02-06	1997-04-17	Hoechst Ag	Verfahren zur Herstellung von Phosphonigsäuremonoalkylestern
DE19634706A1 (de) *	1996-08-28	1998-03-05	Hoechst Ag	Verfahren zur Herstellung von 2-Cyanoethyl-phosphinsäureestern
GB9906882D0 (en) *	1999-03-25	1999-05-19	Novartis Ag	Organic compounds
EP1372620A2 (en) *	2001-03-15	2004-01-02	Saegis Pharmaceuticals	Methods for restoring cognitive function following systemic stress
US20060014801A1 (en) *	2002-11-22	2006-01-19	The Johns Hopkins University	Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
JP4015176B2 (ja)	2003-04-29	2007-11-28	ファイザー・インク	高血圧症の治療に有用な５，７−ジアミノピラゾロ４，３−ジピリミジン類
AR045794A1 (es) *	2003-09-23	2005-11-16	Aventis Pharma Inc	Procedimiento para preparar derivados de acido 3- amino-2- hidroxipropilfosfinico
EP1677757A2 (en) *	2003-10-31	2006-07-12	Alza Corporation	Compositions and dosage forms for enhanced absorption
DE10356410A1 (de) *	2003-11-24	2005-06-23	Bioagency Ag	Phosphororganische Verbindungen und deren Verwendung
US7572799B2 (en)	2003-11-24	2009-08-11	Pfizer Inc	Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
DK1742950T3 (da)	2004-04-07	2009-03-16	Pfizer Ltd	Pyrazolo-[4,3-D]-pyrimidiner
CA2566204A1 (en) *	2004-05-14	2005-12-01	The Johns Hopkins University	Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor
SE0402199D0 (sv) *	2004-09-13	2004-09-13	Astrazeneca Ab	New process I
US7566738B2 (en) *	2004-11-03	2009-07-28	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006050472A2 (en) *	2004-11-03	2006-05-11	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
MX2007008392A (es) *	2005-02-11	2007-09-06	Aventis Pharma Inc	Esteres de acido propano-fosfinico sustituido.
GB0608359D0 (en) *	2006-04-28	2006-06-07	Johnson Matthey Plc	Catalyst additives
WO2008033572A1 (en) *	2006-09-15	2008-03-20	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
JP2011516649A (ja) *	2008-04-03	2011-05-26	ビーエーエスエフソシエタス・ヨーロピア	ホスフィン酸化合物によるポリエステルの固相重合方法
DE102008055916A1 (de)	2008-11-05	2010-05-06	Clariant International Limited	Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Allylalkoholen und ihre Verwendung
CN102177164B (zh)	2008-11-05	2015-02-11	科莱恩金融(Bvi)有限公司	利用烯丙醇/丙烯醛制备二烷基次膦酸、二烷基次膦酸酯和二烷基次膦酸盐的方法,以及它们的用途
DE102008055914A1 (de)	2008-11-05	2010-05-06	Clariant International Limited	Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acroleinen und ihre Verwendung
DE102008056228A1 (de) *	2008-11-06	2010-05-12	Clariant International Limited	Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, deren Salze und Ester und ihre Verwendung
DE102008056341A1 (de) *	2008-11-07	2010-05-12	Clariant International Limited	Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
DE102008056342A1 (de)	2008-11-07	2010-05-12	Clariant International Limited	Verfahren zur Herstellung von Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
EP2352740B1 (de)	2008-11-07	2014-09-24	Clariant Finance (BVI) Limited	Verfahren zur herstellung von dialkylphosphinsäuren, -estern und -salzen mittels acrylsäurederivaten und ihre verwendung
DE102008056339A1 (de) *	2008-11-07	2010-05-12	Clariant International Limited	Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
CN102171226B (zh)	2008-11-11	2015-02-11	科莱恩金融(Bvi)有限公司	利用烯丙基化合物制备单烯丙基官能化的二烷基次膦酸、其盐或酯的方法以及它们的用途
DE102008060036A1 (de)	2008-12-02	2010-06-10	Clariant International Limited	Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060035A1 (de)	2008-12-02	2010-06-10	Clariant International Limited	Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060535A1 (de)	2008-12-04	2010-06-10	Clariant International Limited	Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung
DE102008063668A1 (de)	2008-12-18	2010-07-01	Clariant International Limited	Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung
DE102008063640A1 (de) *	2008-12-18	2010-06-24	Clariant International Limited	Verfahren zur Herstellung von gemischtsubstituierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
ES2446666T3 (es)	2008-12-18	2014-03-10	Clariant Finance (Bvi) Limited	Procedimiento para la preparación de ácidos etilen-dialquil-fosfínicos, o de sus ésteres y sales, mediante acetileno, y su utilización
DE102008063642A1 (de)	2008-12-18	2010-06-24	Clariant International Limited	Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung
DE102008063627A1 (de)	2008-12-18	2010-06-24	Clariant International Limited	Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung
DE102008064003A1 (de) *	2008-12-19	2010-06-24	Clariant International Limited	Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
DE102008064012A1 (de)	2008-12-19	2010-06-24	Clariant International Limited	Halogenfreie Addukte von Alkylphosphonigsäurederivaten und diesterbildenden Olefinen, halogenfreie Verfahren zu deren Herstellung und ihre Verwendung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3184496A (en) *	1961-02-27	1965-05-18	Hooker Chemical Corp	Process for the preparation and recovery of triethyl phosphite and derivatives thereof
DE2032712C3 (de) *	1970-07-02	1978-10-19	Bayer Ag, 5090 Leverkusen	Verfahren zur Herstellung von w-Amino-alkanphosphonsäure bzw.- phosphinsäurederivaten
DE2440239A1 (de) *	1974-08-22	1976-03-04	Hoechst Ag	Innere ammoniumsalze von phosphinsaeuren
US4064163A (en) *	1976-12-30	1977-12-20	Amchem Products, Inc.	Process for the manufacture of aliphatic phosphonic acids
EP0014684B1 (de) *	1979-02-06	1982-05-19	Ciba-Geigy Ag	2-Substituierte 5-Phenoxy-phenylphosphonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide
EP0093081B1 (de) *	1982-04-23	1986-03-19	Ciba-Geigy Ag	Herbizide und pflanzenwuchsregulierende Mittel
US4536355A (en) *	1982-10-08	1985-08-20	Zoecon Corporation	Phenoxyphenylaminoalkylphosphinates useful in weed control
GB8425872D0 (en) *	1984-10-12	1984-11-21	Ciba Geigy Ag	Chemical compounds
GB8820266D0 (en) *	1988-08-26	1988-09-28	Smith Kline French Lab	Compounds
GB8912814D0 (en) *	1989-06-03	1989-07-19	Ciba Geigy Ag	P-substituted propane-phospinic acid compounds

1987
- 1987-12-04 GB GB878728483A patent/GB8728483D0/en active Pending
1988
- 1988-11-28 IL IL88514A patent/IL88514A0/xx unknown
- 1988-11-28 EP EP88810813A patent/EP0319479A3/en not_active Withdrawn
- 1988-12-01 ZA ZA889015A patent/ZA889015B/xx unknown
- 1988-12-01 YU YU02187/88A patent/YU218788A/xx unknown
- 1988-12-01 NO NO885361A patent/NO177674C/no unknown
- 1988-12-02 NZ NZ227182A patent/NZ227182A/en unknown
- 1988-12-02 HU HU886155A patent/HU202543B/hu not_active IP Right Cessation
- 1988-12-02 AU AU26544/88A patent/AU614316B2/en not_active Ceased
- 1988-12-02 MX MX1403388A patent/MX14033A/es unknown
- 1988-12-02 PT PT89134A patent/PT89134B/pt not_active IP Right Cessation
- 1988-12-02 IE IE361788A patent/IE63607B1/en not_active IP Right Cessation
- 1988-12-02 FI FI885623A patent/FI91412C/fi not_active IP Right Cessation
- 1988-12-02 CA CA000584925A patent/CA1337352C/en not_active Expired - Lifetime
- 1988-12-02 DD DD88322553A patent/DD283630A5/de not_active IP Right Cessation
- 1988-12-02 DK DK673588A patent/DK673588A/da not_active Application Discontinuation
- 1988-12-03 KR KR1019880016196A patent/KR890009955A/ko not_active Application Discontinuation
- 1988-12-05 DE DE3889638T patent/DE3889638T2/de not_active Expired - Lifetime
- 1988-12-05 JP JP63306192A patent/JP2716761B2/ja not_active Expired - Lifetime
- 1988-12-05 ES ES88810831T patent/ES2054869T3/es not_active Expired - Lifetime
- 1988-12-05 EP EP88810831A patent/EP0319482B1/en not_active Expired - Lifetime
- 1988-12-05 AT AT88810831T patent/ATE105840T1/de not_active IP Right Cessation
1989
- 1989-07-12 US US07/378,887 patent/US5013863A/en not_active Expired - Lifetime
1990
- 1990-02-26 US US07/484,716 patent/US5051524A/en not_active Expired - Lifetime
- 1990-03-30 US US07/502,399 patent/US5064819A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE883617L (en)	1989-06-04
DE3889638T2 (de)	1994-09-15
MX14033A (es)	1994-02-28
DD283630A5 (de)	1990-10-17
AU614316B2 (en)	1991-08-29
YU218788A (en)	1990-12-31
NO885361D0 (no)	1988-12-01
EP0319482A2 (en)	1989-06-07
NO885361L (no)	1989-06-05
HU202543B (en)	1991-03-28
GB8728483D0 (en)	1988-01-13
IE63607B1 (en)	1995-05-17
NZ227182A (en)	1991-03-26
EP0319482B1 (en)	1994-05-18
NO177674B (no)	1995-07-24
ATE105840T1 (de)	1994-06-15
EP0319482A3 (en)	1990-07-11
KR890009955A (ko)	1989-08-05
HUT48897A (en)	1989-07-28
FI91412C (fi)	1994-06-27
ZA889015B (en)	1989-08-30
US5051524A (en)	1991-09-24
US5064819A (en)	1991-11-12
US5013863A (en)	1991-05-07
DE3889638D1 (de)	1994-06-23
DK673588A (da)	1989-06-05
CA1337352C (en)	1995-10-17
JPH01301687A (ja)	1989-12-05
IL88514A0 (en)	1989-06-30
PT89134A (pt)	1989-12-29
EP0319479A2 (en)	1989-06-07
NO177674C (no)	1995-11-01
FI885623A (fi)	1989-06-05
FI91412B (fi)	1994-03-15
PT89134B (pt)	1993-12-31
ES2054869T3 (es)	1994-08-16
AU2654488A (en)	1989-06-08
JP2716761B2 (ja)	1998-02-18
DK673588D0 (da)	1988-12-02
EP0319479A3 (en)	1990-07-04

Legal Events

Date	Code	Title	Description
1994-02-16	BB	Publication of examined application
1997-08-26	PC	Transfer of assignment of patent	Owner name: NOVARTIS AG
1998-12-02	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: NOVARTIS AG

Publication	Publication Date	Title
FI885623A0 (fi)	1988-12-02	Menetelmä lääkeaineina käyttökelpoisten substituoitujen propaani-fosfiinihappoyhdisteiden valmistamiseksi
ATE147750T1 (de)	1997-02-15	Phosphotriester-typ biologisch-aktiver verbindungen
AU649849B2 (en)	1994-06-02	New vanadium complexes, process for preparing them and pharmaceutical compositions containing them
ES8706763A1 (es)	1987-07-01	Procedimiento para estabilizar peliculas, revestimientos o articulos de naturaleza polimerica contra la accion de la luz
DK0544812T3 (da)	1995-08-21	Bisphosphonsyrederivater som anti-arthritiske midler
JPS6425777A (en)	1989-01-27	Organic salt of physostigmine
NO177675C (no)	1995-11-01	Analogifremgangsmåte for fremstilling av terapeutisk aktive P-substituerte propan-fosfinsyre forbindelser
FI925875A (fi)	1993-06-28	Foerfarande foer framstaellning av nya som inhibitorer av proteolytiska enzymer anvaendbara 2-sackarinylmetyl- och 4,5,6,7-tetrahydro-2-sackarinylmetylfosfater, -fosfonater och -fosfinater
GB1429906A (en)	1976-03-31	Imidazolidino-1,5-c-thiazolidine-3-spiro-4,piperidines and pharmaceutical compositions containing them
DE3587915D1 (de)	1994-10-06	Verfahren zur Herstellung von Cephalosporinen.