FI885559A0 - Anvaendning av d-cykloserin och dess prodrug som cognition oekande medel. - Google Patents
Anvaendning av d-cykloserin och dess prodrug som cognition oekande medel.Info
- Publication number
- FI885559A0 FI885559A0 FI885559A FI885559A FI885559A0 FI 885559 A0 FI885559 A0 FI 885559A0 FI 885559 A FI885559 A FI 885559A FI 885559 A FI885559 A FI 885559A FI 885559 A0 FI885559 A0 FI 885559A0
- Authority
- FI
- Finland
- Prior art keywords
- prodrug
- oekande
- cycloserin
- medel
- anvaendning
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/127,121 US4904681A (en) | 1987-12-01 | 1987-12-01 | D-cycloserine and its prodrugs as cognitive enhancers |
Publications (1)
Publication Number | Publication Date |
---|---|
FI885559A0 true FI885559A0 (fi) | 1988-11-30 |
Family
ID=22428413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI885559A FI885559A0 (fi) | 1987-12-01 | 1988-11-30 | Anvaendning av d-cykloserin och dess prodrug som cognition oekande medel. |
Country Status (20)
Country | Link |
---|---|
US (1) | US4904681A (fi) |
EP (2) | EP0319824B1 (fi) |
JP (2) | JPH0621065B2 (fi) |
KR (1) | KR0134198B1 (fi) |
AT (1) | ATE68698T1 (fi) |
AU (4) | AU622630B2 (fi) |
CA (1) | CA1328617C (fi) |
DE (1) | DE3865817D1 (fi) |
DK (1) | DK173589B1 (fi) |
ES (1) | ES2040314T3 (fi) |
FI (1) | FI885559A0 (fi) |
GR (1) | GR3003571T3 (fi) |
IE (1) | IE61825B1 (fi) |
IL (1) | IL88531A (fi) |
NO (1) | NO885337D0 (fi) |
NZ (1) | NZ227131A (fi) |
PH (1) | PH26467A (fi) |
PT (1) | PT89109B (fi) |
WO (1) | WO1989005144A1 (fi) |
ZA (1) | ZA888981B (fi) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5187171A (en) * | 1989-01-09 | 1993-02-16 | G. D. Searle & Co. | Use of a glycine b partial agonist as an antipsychotic |
US5061721A (en) * | 1989-03-15 | 1991-10-29 | G. D. Searle & Co. | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
US5260324A (en) * | 1990-02-06 | 1993-11-09 | G. D. Searle & Company | Composition containing D-cycloserine and D-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
US5066665A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Co. | Substituted isoxazolidin-3-ones and derivatives thereof acting at muscarinic receptors |
JPH07505908A (ja) * | 1992-09-28 | 1995-06-29 | マックセチーニ、マリア ルイザ | Nmda受容体のアロステリックモジュレーター |
US5428069A (en) * | 1993-01-11 | 1995-06-27 | The United States Of America As Represented By The Department Of Health & Human Services | Treating cognition with, aminocyclopropanecarboxylic derivatives |
US5523323A (en) * | 1993-09-14 | 1996-06-04 | Maccecchini; Maria-Luisa | Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence |
NZ260302A (en) * | 1994-04-13 | 1996-05-28 | New Zealand Meat Ind Res Inst | Treating bait aversion by including substances which disrupt the associative learning process into bait compositions |
WO1996015787A1 (en) * | 1994-11-23 | 1996-05-30 | G.D. Searle & Co. | Use of amino-isoxazolidone compounds for treatment of memory impairment following traumatic brain injury |
AU4019395A (en) | 1994-11-23 | 1996-06-17 | G.D. Searle & Co. | Use of amino-isoxazolidone compounds for improvement of implicit memory |
ATE204852T1 (de) * | 1995-02-15 | 2001-09-15 | Bearsden Bio Inc | Alkylcarboxy-aminosäure modulatoren für den kainat-rezeptor |
US6355681B2 (en) * | 1995-12-07 | 2002-03-12 | Glytech, Inc. | Glycine substitutes and precursors for treating a psychosis |
PT871440E (pt) * | 1995-12-07 | 2006-07-31 | Daniel C Javitt | Tratamento de sintomas negativos e cognitivos de esquizofrenia com antagonistas da captacao de glicina |
US6361957B1 (en) * | 1999-08-03 | 2002-03-26 | Glytech, Inc. | Assay for D-serine transport antagonist and use for treating psychosis |
FR2742748B1 (fr) * | 1995-12-21 | 1998-01-30 | Adir | Nouveau derive de 4-imidazolidinone, son procede de preparation et les compositions pharmaceutiques qui le contiennent |
KR100396114B1 (ko) * | 1996-10-31 | 2003-11-20 | 동아제약 주식회사 | D-시클로세린의 제조방법 |
AU765603C (en) * | 1998-04-14 | 2004-08-05 | General Hospital Corporation, The | Methods for treating neuropsychiatric disorders |
DE69930624T2 (de) * | 1998-06-10 | 2006-09-14 | Meiji Seika Kaisha Ltd. | Arzneimittel für hinterstrangataxie und zusammensetzung zur behandlung von hinterstrangataxie |
US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
US20060252761A1 (en) * | 2001-03-29 | 2006-11-09 | Michael Davis | Augmentation of extinction via administration of sub-antimicrobial doses of D-cycloserine |
AU2002311784B2 (en) * | 2001-03-29 | 2007-11-22 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
EP1389181A4 (en) | 2001-04-02 | 2005-10-19 | Panorama Res Inc | ANTIOXIDANT NITROXIDES AND NITRONES AS THERAPEUTIC AGENTS |
US7160913B2 (en) * | 2002-09-13 | 2007-01-09 | Thomas Jefferson University | Methods and kit for treating Parkinson's disease |
KR20060030469A (ko) | 2003-05-27 | 2006-04-10 | 포레스트 래보러토리즈, 인코포레이티드 | 우울증 및 그 밖의 기분장애의 치료를 위한 nmda수용체 길항제 및 선택적 세로토닌 재흡수 억제제의 배합물 |
EP1660634A4 (en) * | 2003-08-08 | 2009-02-18 | Burnham Inst | P16-mediated regulation of NMDA receptors |
US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
KR101406456B1 (ko) * | 2005-04-06 | 2014-06-20 | 아다마스 파마슈티칼스, 인코포레이티드 | Cns 장애의 치료를 위한 방법 및 조성물 |
MX2011003015A (es) | 2008-09-18 | 2011-11-18 | Univ Northwestern | Moduladores del receptor de n-metil-d-aspartato, y usos de los mismos. |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
US9101612B2 (en) | 2010-02-11 | 2015-08-11 | Northwestern University | Secondary structure stabilized NMDA receptor modulators and uses thereof |
KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
WO2014120800A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
LT3514158T (lt) | 2013-01-29 | 2023-02-10 | Aptinyx Inc. | Spirolaktaminiai nmda receptoriaus moduliatoriai ir jų panaudojimas |
EA201591404A1 (ru) | 2013-01-29 | 2016-01-29 | Аптиникс Инк. | Спиролактамные модуляторы рецептора nmda и их применение |
BR112015018092A2 (pt) | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor de nmda de espiro-lactama e usos dos mesmos |
EA032153B1 (ru) | 2013-01-29 | 2019-04-30 | Аптиникс Инк. | Спиролактамные модуляторы nmda-рецептора и их применение |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
MX2018014202A (es) | 2016-05-19 | 2019-06-20 | Aptinyx Inc | Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos. |
AU2017306152A1 (en) | 2016-08-01 | 2019-01-31 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
AU2017305240B2 (en) | 2016-08-01 | 2021-12-09 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
MX2019001322A (es) | 2016-08-01 | 2019-09-11 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos. |
PE20190500A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y uso de los mismos |
BR112019001923A2 (pt) | 2016-08-01 | 2019-05-14 | Aptinyx Inc. | moduladores de nmda de espiro-lactama e métodos de sua utilização |
EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
JP7210599B2 (ja) | 2018-01-31 | 2023-01-23 | アプティニックス インコーポレイテッド | スピロラクタム系nmda受容体修飾因子およびその使用 |
US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3050800C2 (fi) * | 1979-03-22 | 1989-06-22 | Continental Pharma Inc., Bruessel/Bruxelles, Be |
-
1987
- 1987-12-01 US US07/127,121 patent/US4904681A/en not_active Expired - Lifetime
-
1988
- 1988-11-28 PH PH37866A patent/PH26467A/en unknown
- 1988-11-29 PT PT89109A patent/PT89109B/pt not_active IP Right Cessation
- 1988-11-29 EP EP88119863A patent/EP0319824B1/en not_active Expired - Lifetime
- 1988-11-29 AU AU26319/88A patent/AU622630B2/en not_active Ceased
- 1988-11-29 IL IL88531A patent/IL88531A/xx not_active IP Right Cessation
- 1988-11-29 IE IE356788A patent/IE61825B1/en not_active IP Right Cessation
- 1988-11-29 AT AT88119863T patent/ATE68698T1/de not_active IP Right Cessation
- 1988-11-29 DE DE88119863T patent/DE3865817D1/de not_active Expired - Fee Related
- 1988-11-29 ES ES88119863T patent/ES2040314T3/es not_active Expired - Lifetime
- 1988-11-29 NZ NZ227131A patent/NZ227131A/xx unknown
- 1988-11-30 KR KR1019880015895A patent/KR0134198B1/ko not_active IP Right Cessation
- 1988-11-30 NO NO885337A patent/NO885337D0/no unknown
- 1988-11-30 DK DK198806690A patent/DK173589B1/da not_active IP Right Cessation
- 1988-11-30 CA CA000584621A patent/CA1328617C/en not_active Expired - Fee Related
- 1988-11-30 FI FI885559A patent/FI885559A0/fi not_active Application Discontinuation
- 1988-11-30 JP JP63303873A patent/JPH0621065B2/ja not_active Expired - Lifetime
- 1988-11-30 ZA ZA888981A patent/ZA888981B/xx unknown
- 1988-12-01 AU AU28130/89A patent/AU2813089A/en not_active Abandoned
- 1988-12-01 EP EP89900543A patent/EP0421997A1/en not_active Withdrawn
- 1988-12-01 WO PCT/US1988/004244 patent/WO1989005144A1/en not_active Application Discontinuation
-
1992
- 1992-01-15 GR GR910401170T patent/GR3003571T3/el unknown
- 1992-02-10 AU AU10839/92A patent/AU1083992A/en not_active Abandoned
- 1992-07-03 JP JP4177094A patent/JPH05201859A/ja active Pending
-
1994
- 1994-10-26 AU AU77467/94A patent/AU7746794A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
GR3003571T3 (fi) | 1993-03-16 |
JPH05201859A (ja) | 1993-08-10 |
IL88531A0 (en) | 1989-06-30 |
KR0134198B1 (ko) | 1998-04-21 |
US4904681A (en) | 1990-02-27 |
DK173589B1 (da) | 2001-04-02 |
ZA888981B (en) | 1990-01-31 |
PH26467A (en) | 1992-07-27 |
AU2813089A (en) | 1989-07-05 |
JPH01193220A (ja) | 1989-08-03 |
DK669088A (da) | 1989-06-02 |
IL88531A (en) | 1993-02-21 |
EP0421997A1 (en) | 1991-04-17 |
EP0319824B1 (en) | 1991-10-23 |
ES2040314T3 (es) | 1995-04-01 |
IE61825B1 (en) | 1994-11-30 |
CA1328617C (en) | 1994-04-19 |
NZ227131A (en) | 1991-09-25 |
AU1083992A (en) | 1992-05-07 |
JPH0621065B2 (ja) | 1994-03-23 |
WO1989005144A1 (en) | 1989-06-15 |
DE3865817D1 (fi) | 1991-11-28 |
ATE68698T1 (de) | 1991-11-15 |
KR890009392A (ko) | 1989-08-01 |
EP0319824A1 (en) | 1989-06-14 |
DK669088D0 (da) | 1988-11-30 |
NO885337D0 (no) | 1988-11-30 |
IE883567L (en) | 1989-06-01 |
PT89109B (pt) | 1993-07-30 |
AU2631988A (en) | 1989-06-01 |
AU622630B2 (en) | 1992-04-16 |
AU7746794A (en) | 1995-01-05 |
PT89109A (pt) | 1989-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |
Owner name: G D SEARLE & CO. |