FI863471A - Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi Download PDF

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Publication number
FI863471A
FI863471A FI863471A FI863471A FI863471A FI 863471 A FI863471 A FI 863471A FI 863471 A FI863471 A FI 863471A FI 863471 A FI863471 A FI 863471A FI 863471 A FI863471 A FI 863471A
Authority
FI
Finland
Prior art keywords
preparation
acid derivatives
therapeutically useful
desmethylmevalonic
desmethylmevalonic acid
Prior art date
Application number
FI863471A
Other languages
English (en)
Swedish (sv)
Other versions
FI90868B (fi
FI863471A0 (fi
FI90868C (fi
Inventor
Gerhard Beck
Kerekjarto Bela Von
Hans-Hermann Lau
Guenther Wess
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853530797 external-priority patent/DE3530797A1/de
Priority claimed from DE19863615446 external-priority patent/DE3615446A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI863471A0 publication Critical patent/FI863471A0/fi
Publication of FI863471A publication Critical patent/FI863471A/fi
Publication of FI90868B publication Critical patent/FI90868B/fi
Application granted granted Critical
Publication of FI90868C publication Critical patent/FI90868C/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5456Arylalkanephosphonium compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
FI863471A 1985-08-29 1986-08-27 Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi FI90868C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19853530797 DE3530797A1 (de) 1985-08-29 1985-08-29 3-desmethyl-mevalonsaeurederivate, verfahren zu ihrer herstellung pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung sowie zwischenprodukte
DE3530797 1985-08-29
DE19863615446 DE3615446A1 (de) 1986-05-07 1986-05-07 3-desmethyl-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihrer verwendung sowie zwischenprodukte
DE3615446 1986-05-07

Publications (4)

Publication Number Publication Date
FI863471A0 FI863471A0 (fi) 1986-08-27
FI863471A true FI863471A (fi) 1987-03-01
FI90868B FI90868B (fi) 1993-12-31
FI90868C FI90868C (fi) 1994-04-11

Family

ID=25835463

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863471A FI90868C (fi) 1985-08-29 1986-08-27 Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi

Country Status (17)

Country Link
US (1) US4914127A (fi)
EP (1) EP0217092B1 (fi)
JP (1) JPH0830027B2 (fi)
KR (1) KR870002114A (fi)
AR (1) AR242206A1 (fi)
AU (1) AU583943B2 (fi)
CA (1) CA1294284C (fi)
DE (1) DE3669874D1 (fi)
DK (1) DK169127B1 (fi)
ES (1) ES2001595A6 (fi)
FI (1) FI90868C (fi)
GR (1) GR862210B (fi)
HU (1) HU195799B (fi)
IE (1) IE59312B1 (fi)
IL (1) IL79855A0 (fi)
NO (1) NO171108C (fi)
PT (1) PT83269B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789682A (en) * 1987-03-17 1988-12-06 Merck & Co., Inc. Antihypercholesterolemic compounds
DE3722809A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag 3-desmethyl-4-fluor-mevalonsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen, ihre verwendung und zwischenprodukte
US4863957A (en) * 1987-12-21 1989-09-05 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US5470982A (en) * 1988-01-20 1995-11-28 Bayer Aktiengesellschaft Disubstituted pyridines
FR2669031A1 (fr) * 1990-11-09 1992-05-15 Rhone Poulenc Sante Procede de preparation de derives du tetrahydropyranne.
US5840620A (en) * 1994-06-15 1998-11-24 Seager; Carleton H. Method for restoring the resistance of indium oxide semiconductors after heating while in sealed structures
CN101570510B (zh) * 2008-04-30 2011-08-31 上海医药工业研究院 喹啉类化合物及其药物组合物、制备方法和应用
JP5789430B2 (ja) 2011-06-27 2015-10-07 イハラニッケイ化学工業株式会社 2−クロロメチルベンズアルデヒドの製造方法、2−クロロメチルベンズアルデヒド含有組成物及びその保管方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710513A (en) * 1979-08-17 1987-12-01 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4440927A (en) * 1981-06-19 1984-04-03 Merck & Co., Inc. Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase via a chiral synthon
DE3580863D1 (de) * 1984-06-04 1991-01-24 Merck & Co Inc Herstellungsverfahren von hemmstoffen der hmg-coa-reduktase mit einer 3,5-dihydroxypentanoatteilstruktur.
US4588715A (en) * 1984-06-04 1986-05-13 Sandoz, Inc. Heptenoic acid derivatives
US4622338A (en) * 1985-03-11 1986-11-11 G. D. Searle & Co. Substituted glutaric acid lactones in the treatment of hyperlipidemia
FR2719387B1 (fr) * 1994-04-28 1996-05-24 Commissariat Energie Atomique Dispositif de contrôle de la position et/ou de la focalisation d'un faisceau lumineux focalisé.

Also Published As

Publication number Publication date
NO171108B (no) 1992-10-19
FI90868B (fi) 1993-12-31
IL79855A0 (en) 1986-11-30
AR242206A1 (es) 1993-03-31
IE59312B1 (en) 1994-02-09
US4914127A (en) 1990-04-03
NO863461L (no) 1987-03-02
ES2001595A6 (es) 1988-06-01
PT83269B (pt) 1989-05-12
KR870002114A (ko) 1987-03-30
PT83269A (de) 1986-09-01
FI863471A0 (fi) 1986-08-27
EP0217092A2 (de) 1987-04-08
GR862210B (en) 1986-12-23
FI90868C (fi) 1994-04-11
IE862302L (en) 1987-02-28
NO863461D0 (no) 1986-08-28
DE3669874D1 (de) 1990-05-03
NO171108C (no) 1993-01-27
EP0217092B1 (de) 1990-03-28
HU195799B (en) 1988-07-28
HUT41757A (en) 1987-05-28
DK409986D0 (da) 1986-08-28
AU583943B2 (en) 1989-05-11
JPH0830027B2 (ja) 1996-03-27
DK409986A (da) 1987-03-01
JPS6251641A (ja) 1987-03-06
DK169127B1 (da) 1994-08-22
EP0217092A3 (en) 1987-06-16
CA1294284C (en) 1992-01-14
AU6202886A (en) 1987-03-05

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Owner name: HOECHST AKTIENGESELLSCHAFT