FI71058C - Foerfarande foer framstaellning av en magsyraneutraliserande suspension - Google Patents

Foerfarande foer framstaellning av en magsyraneutraliserande suspension Download PDF

Info

Publication number: FI71058C
Authority: FI; Finland
Prior art keywords: suspension; magnesium; acid; aluminum hydroxide; sorbitol
Prior art date: 1979-07-09

Application number

FI802139A

Other languages

English (en)

Finnish (fi)

Other versions

FI71058B (fi

FI802139A (fi

Inventor

Eva Kristina Byroed

John Albert Sjoegren

Original Assignee

Haessle Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-07-09

Filing date

1980-07-03

Publication date

1986-11-24

1980-07-03 Application filed by Haessle Ab filed Critical Haessle Ab

1981-01-10 Publication of FI802139A publication Critical patent/FI802139A/fi

1986-08-14 Publication of FI71058B publication Critical patent/FI71058B/fi

1986-11-24 Application granted granted Critical

1986-11-24 Publication of FI71058C publication Critical patent/FI71058C/fi

Links

239000000725 suspension Substances 0.000 title claims description 96
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 47
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 43
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 34
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 34
239000000600 sorbitol Substances 0.000 claims description 34
235000010356 sorbitol Nutrition 0.000 claims description 34
239000001095 magnesium carbonate Substances 0.000 claims description 24
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 24
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 24
239000000347 magnesium hydroxide Substances 0.000 claims description 23
229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 23
229910000021 magnesium carbonate Inorganic materials 0.000 claims description 22
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 21
229910000019 calcium carbonate Inorganic materials 0.000 claims description 18
239000000395 magnesium oxide Substances 0.000 claims description 15
230000003472 neutralizing effect Effects 0.000 claims description 13
210000004211 gastric acid Anatomy 0.000 claims description 11
150000005846 sugar alcohols Chemical class 0.000 claims description 11
239000000159 acid neutralizing agent Substances 0.000 claims description 9
229920000642 polymer Polymers 0.000 claims description 9
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 9
229910018072 Al 2 O 3 Inorganic materials 0.000 claims description 8
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 8
229930195725 Mannitol Natural products 0.000 claims description 8
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 8
239000008103 glucose Substances 0.000 claims description 8
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 8
239000000594 mannitol Substances 0.000 claims description 8
235000010355 mannitol Nutrition 0.000 claims description 8
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 8
239000000811 xylitol Substances 0.000 claims description 8
235000010447 xylitol Nutrition 0.000 claims description 8
229960002675 xylitol Drugs 0.000 claims description 8
235000011187 glycerol Nutrition 0.000 claims description 7
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
229930006000 Sucrose Natural products 0.000 claims description 6
239000005720 sucrose Substances 0.000 claims description 6
239000003795 chemical substances by application Substances 0.000 claims description 5
150000002482 oligosaccharides Polymers 0.000 claims description 5
229920001282 polysaccharide Polymers 0.000 claims description 5
239000005017 polysaccharide Substances 0.000 claims description 5
230000000087 stabilizing effect Effects 0.000 claims description 5
239000005715 Fructose Substances 0.000 claims description 4
229930091371 Fructose Natural products 0.000 claims description 4
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 4
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
239000007900 aqueous suspension Substances 0.000 claims description 3
239000012467 final product Substances 0.000 claims 1
150000004676 glycans Chemical class 0.000 claims 1
239000003381 stabilizer Substances 0.000 claims 1
239000000375 suspending agent Substances 0.000 claims 1
239000002253 acid Substances 0.000 description 50
239000000047 product Substances 0.000 description 47
239000000203 mixture Substances 0.000 description 38
235000010449 maltitol Nutrition 0.000 description 37
229940024545 aluminum hydroxide Drugs 0.000 description 35
239000000499 gel Substances 0.000 description 33
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 32
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 26
235000012254 magnesium hydroxide Nutrition 0.000 description 25
238000002360 preparation method Methods 0.000 description 20
229910052782 aluminium Inorganic materials 0.000 description 19
229940069428 antacid Drugs 0.000 description 19
239000003159 antacid agent Substances 0.000 description 19
230000000694 effects Effects 0.000 description 19
235000010216 calcium carbonate Nutrition 0.000 description 17
235000014380 magnesium carbonate Nutrition 0.000 description 17
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 16
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 16
229960002216 methylparaben Drugs 0.000 description 16
235000012245 magnesium oxide Nutrition 0.000 description 15
ADKOXSOCTOWDOP-UHFFFAOYSA-L magnesium;aluminum;dihydroxide;trihydrate Chemical compound O.O.O.[OH-].[OH-].[Mg+2].[Al] ADKOXSOCTOWDOP-UHFFFAOYSA-L 0.000 description 15
239000011777 magnesium Substances 0.000 description 14
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 13
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 13
244000246386 Mentha pulegium Species 0.000 description 12
235000016257 Mentha pulegium Nutrition 0.000 description 12
235000004357 Mentha x piperita Nutrition 0.000 description 12
235000001050 hortel pimenta Nutrition 0.000 description 12
WKHMXCIUCCIPOU-UHFFFAOYSA-N perfluoro-1-methyladamantane Chemical compound FC1(F)C(C2(F)F)(F)C(F)(F)C3(F)C(F)(F)C2(F)C(F)(F)C1(C(F)(F)F)C3(F)F WKHMXCIUCCIPOU-UHFFFAOYSA-N 0.000 description 12
235000013599 spices Nutrition 0.000 description 12
230000001458 anti-acid effect Effects 0.000 description 10
239000000470 constituent Substances 0.000 description 10
229910052749 magnesium Inorganic materials 0.000 description 10
239000004615 ingredient Substances 0.000 description 9
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 8
LHPJBAIYHPWIOT-UHFFFAOYSA-K aluminum;magnesium;carbonate;hydroxide Chemical compound [OH-].[Mg+2].[Al+3].[O-]C([O-])=O LHPJBAIYHPWIOT-UHFFFAOYSA-K 0.000 description 8
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 8
235000000346 sugar Nutrition 0.000 description 8
239000011230 binding agent Substances 0.000 description 7
150000001875 compounds Chemical class 0.000 description 7
235000017557 sodium bicarbonate Nutrition 0.000 description 7
229910000030 sodium bicarbonate Inorganic materials 0.000 description 7
229920002472 Starch Polymers 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 6
PWZFXELTLAQOKC-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide;tetrahydrate Chemical compound O.O.O.O.[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O PWZFXELTLAQOKC-UHFFFAOYSA-A 0.000 description 6
150000002681 magnesium compounds Chemical class 0.000 description 6
239000008107 starch Substances 0.000 description 6
235000019698 starch Nutrition 0.000 description 6
238000003860 storage Methods 0.000 description 6
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 5
150000001298 alcohols Chemical class 0.000 description 5
150000002303 glucose derivatives Chemical class 0.000 description 5
239000007787 solid Substances 0.000 description 5
210000002784 stomach Anatomy 0.000 description 5
150000008163 sugars Chemical class 0.000 description 5
235000020357 syrup Nutrition 0.000 description 5
239000006188 syrup Substances 0.000 description 5
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
235000005979 Citrus limon Nutrition 0.000 description 4
244000131522 Citrus pyriformis Species 0.000 description 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
239000006096 absorbing agent Substances 0.000 description 4
VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 4
LCWAOCHOPBSGMU-UHFFFAOYSA-J aluminum;magnesium;sodium;hydrogen carbonate;oxygen(2-);silicon;trihydroxide Chemical compound [OH-].[OH-].[OH-].[O-2].[Na+].[Mg+2].[Al+3].[Si].OC([O-])=O LCWAOCHOPBSGMU-UHFFFAOYSA-J 0.000 description 4
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 4
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
229940045140 gaviscon Drugs 0.000 description 4
239000008101 lactose Substances 0.000 description 4
235000011160 magnesium carbonates Nutrition 0.000 description 4
150000004804 polysaccharides Chemical class 0.000 description 4
230000003389 potentiating effect Effects 0.000 description 4
239000000843 powder Substances 0.000 description 4
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 4
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 4
229960003415 propylparaben Drugs 0.000 description 4
-1 salt salts Chemical class 0.000 description 4
239000000126 substance Substances 0.000 description 4
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
239000005913 Maltodextrin Substances 0.000 description 3
RYXPMWYHEBGTRV-UHFFFAOYSA-N Omeprazole sodium Chemical compound [Na+].N=1C2=CC(OC)=CC=C2[N-]C=1S(=O)CC1=NC=C(C)C(OC)=C1C RYXPMWYHEBGTRV-UHFFFAOYSA-N 0.000 description 3
208000007107 Stomach Ulcer Diseases 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
239000011575 calcium Substances 0.000 description 3
239000000084 colloidal system Substances 0.000 description 3
238000009472 formulation Methods 0.000 description 3
229940035034 maltodextrin Drugs 0.000 description 3
239000003755 preservative agent Substances 0.000 description 3
239000010453 quartz Substances 0.000 description 3
239000002516 radical scavenger Substances 0.000 description 3
230000009257 reactivity Effects 0.000 description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
239000000243 solution Substances 0.000 description 3
239000002562 thickening agent Substances 0.000 description 3
229910018134 Al-Mg Inorganic materials 0.000 description 2
229910017119 AlPO Inorganic materials 0.000 description 2
229910018467 Al—Mg Inorganic materials 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
206010010774 Constipation Diseases 0.000 description 2
206010012735 Diarrhoea Diseases 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
239000001828 Gelatine Substances 0.000 description 2
208000037147 Hypercalcaemia Diseases 0.000 description 2
229920002774 Maltodextrin Polymers 0.000 description 2
MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
KFVBMBOOLFSJHV-DEDIIKBZSA-K [Na+].[Al+2]O.[O-]C([O-])=O.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO Chemical compound [Na+].[Al+2]O.[O-]C([O-])=O.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO KFVBMBOOLFSJHV-DEDIIKBZSA-K 0.000 description 2
229910021502 aluminium hydroxide Inorganic materials 0.000 description 2
229940024546 aluminum hydroxide gel Drugs 0.000 description 2
SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 2
239000000872 buffer Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000001175 calcium sulphate Substances 0.000 description 2
235000011132 calcium sulphate Nutrition 0.000 description 2
150000004649 carbonic acid derivatives Chemical class 0.000 description 2
238000012512 characterization method Methods 0.000 description 2
125000004122 cyclic group Chemical group 0.000 description 2
PPQREHKVAOVYBT-UHFFFAOYSA-H dialuminum;tricarbonate Chemical compound [Al+3].[Al+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O PPQREHKVAOVYBT-UHFFFAOYSA-H 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
235000019441 ethanol Nutrition 0.000 description 2
230000009969 flowable effect Effects 0.000 description 2
239000012530 fluid Substances 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
201000005917 gastric ulcer Diseases 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
230000036571 hydration Effects 0.000 description 2
238000006703 hydration reaction Methods 0.000 description 2
239000000413 hydrolysate Substances 0.000 description 2
229960001545 hydrotalcite Drugs 0.000 description 2
229910001701 hydrotalcite Inorganic materials 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
230000000148 hypercalcaemia Effects 0.000 description 2
208000030915 hypercalcemia disease Diseases 0.000 description 2
231100000566 intoxication Toxicity 0.000 description 2
230000035987 intoxication Effects 0.000 description 2
230000002475 laxative effect Effects 0.000 description 2
229910001629 magnesium chloride Inorganic materials 0.000 description 2
150000002772 monosaccharides Chemical class 0.000 description 2
238000006386 neutralization reaction Methods 0.000 description 2
235000019645 odor Nutrition 0.000 description 2
239000001814 pectin Substances 0.000 description 2
235000010987 pectin Nutrition 0.000 description 2
229920001277 pectin Polymers 0.000 description 2
230000004526 pharmaceutical effect Effects 0.000 description 2
230000002335 preservative effect Effects 0.000 description 2
239000002002 slurry Substances 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
230000009974 thixotropic effect Effects 0.000 description 2
XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 description 1
241000272808 Anser Species 0.000 description 1
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229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
244000024675 Eruca sativa Species 0.000 description 1
235000014755 Eruca sativa Nutrition 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
240000002329 Inga feuillei Species 0.000 description 1
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
208000001647 Renal Insufficiency Diseases 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
230000009858 acid secretion Effects 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
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150000004781 alginic acids Chemical class 0.000 description 1
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
229940118662 aluminum carbonate Drugs 0.000 description 1
RJZNFXWQRHAVBP-UHFFFAOYSA-I aluminum;magnesium;pentahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Al+3] RJZNFXWQRHAVBP-UHFFFAOYSA-I 0.000 description 1
230000003466 anti-cipated effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000004061 bleaching Methods 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 1
235000008504 concentrate Nutrition 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
HBYOLNPZXLHVQA-UHFFFAOYSA-J dicalcium dicarbonate Chemical compound [Ca+2].[Ca+2].[O-]C([O-])=O.[O-]C([O-])=O HBYOLNPZXLHVQA-UHFFFAOYSA-J 0.000 description 1
WUEJAKIJDOEDJD-UHFFFAOYSA-K dimagnesium;carbonate;hydroxide Chemical compound [OH-].[Mg+2].[Mg+2].[O-]C([O-])=O WUEJAKIJDOEDJD-UHFFFAOYSA-K 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
230000037406 food intake Effects 0.000 description 1
JGBUYEVOKHLFID-UHFFFAOYSA-N gelred Chemical compound [I-].[I-].C=1C(N)=CC=C(C2=CC=C(N)C=C2[N+]=2CCCCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCCC[N+]=3C4=CC(N)=CC=C4C4=CC=C(N)C=C4C=3C=3C=CC=CC=3)C=1C=2C1=CC=CC=C1 JGBUYEVOKHLFID-UHFFFAOYSA-N 0.000 description 1
125000003147 glycosyl group Chemical group 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
230000000147 hypnotic effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
208000017169 kidney disease Diseases 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
238000013160 medical therapy Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
238000012261 overproduction Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000013618 particulate matter Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
231100000572 poisoning Toxicity 0.000 description 1
230000000607 poisoning effect Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
235000013324 preserved food Nutrition 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
239000008213 purified water Substances 0.000 description 1
239000002994 raw material Substances 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
230000001739 rebound effect Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000007670 refining Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000028327 secretion Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
230000008961 swelling Effects 0.000 description 1
206010042772 syncope Diseases 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
229940035893 uracil Drugs 0.000 description 1
210000002268 wool Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

FI802139A 1979-07-09 1980-07-03 Foerfarande foer framstaellning av en magsyraneutraliserande suspension FI71058C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE7905972A SE7905972L (sv)	1979-07-09	1979-07-09	Forfarande for framstellning av magsyraneutraliserande medel, magsyraneutraliserande medel, samt metod for behandling av hyperaciditet och dermed relaterande sjukdomstillstand
SE7905972		1979-07-09

Publications (3)

Publication Number	Publication Date
FI802139A FI802139A (fi)	1981-01-10
FI71058B FI71058B (fi)	1986-08-14
FI71058C true FI71058C (fi)	1986-11-24

Family

ID=20338481

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI802139A FI71058C (fi)	1979-07-09	1980-07-03	Foerfarande foer framstaellning av en magsyraneutraliserande suspension

Country Status (21)

Country	Link
US (1)	US4465667A (fr)
EP (1)	EP0022429B1 (fr)
JP (1)	JPS5618922A (fr)
AR (1)	AR228854A1 (fr)
AT (1)	ATE1968T1 (fr)
AU (1)	AU535403B2 (fr)
CA (1)	CA1146860A (fr)
DE (1)	DE3061333D1 (fr)
DK (1)	DK154265C (fr)
ES (1)	ES8106835A1 (fr)
FI (1)	FI71058C (fr)
GR (1)	GR69623B (fr)
HK (1)	HK43484A (fr)
IE (1)	IE50141B1 (fr)
MY (1)	MY8500445A (fr)
NO (1)	NO152892C (fr)
NZ (1)	NZ194165A (fr)
PH (2)	PH16372A (fr)
PT (1)	PT71503B (fr)
SE (1)	SE7905972L (fr)
SG (1)	SG9384G (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0642001B2 (ja) *	1983-10-20	1994-06-01	セイコーエプソン株式会社	合成樹脂製レンズ
JPS6486101A (en) *	1987-06-18	1989-03-30	Toray Industries	Production of antireflecting article
JPH0696536B2 (ja) *	1988-02-26	1994-11-30	佐藤製薬株式会社	制酸剤含有内用懸濁液
US5158770A (en) *	1989-12-29	1992-10-27	Freund Industrial Co., Ltd.	Aqueous solution containing ginkgo leaf extract
AU657882B2 (en) *	1993-03-26	1995-03-23	Wallace Victor Wind	Improvements in or relating to the treatment of diarrhoea
US5360793A (en) *	1993-05-24	1994-11-01	Sterling Winthrop Inc.	Rafting antacid formulation
SE509300C2 (sv) *	1995-02-02	1999-01-11	Sueddeutsche Kalkstickstoff	Katjoniskt dispergerade aluminiumhydroxiduppslamningar
US5569466A (en) *	1995-05-17	1996-10-29	R. P. Scherer Corporation	Fill compositions for soft elastic gel capsules
US6187317B1 (en)	1999-07-14	2001-02-13	Judith Taylor	Natural anti-diarrheal composition and method
DE50305909D1 (de) *	2003-10-13	2007-01-18	Salama Zoser B	Pharmazeutische Zusammensetzung umfassend Oxoplatin und dessen Salze
US20060073202A1 (en) *	2004-10-05	2006-04-06	Rocca Jose G	Dual component medicament delivery system

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2211745A (en) *	1940-04-18	1940-08-13	Alba Pharmaceutical Company In	Compound of aluminum hydroxide and process of making the same
US2999790A (en) *	1959-08-24	1961-09-12	Sterling Drug Inc	Stable aluminum hydroxide suspension
US3239416A (en) *	1963-05-29	1966-03-08	Armour Pharma	Aluminum hydroxide-metal hydroxide antacid and process of making the same
US3272704A (en) *	1963-06-06	1966-09-13	Armour Pharma	Stable aluminum hydroxide-magnesium compound codried gel antacids and process of making the same
US3499963A (en) *	1964-04-15	1970-03-10	Armour Pharma	Codried aluminum hydroxide-aluminum chelate antacid
US3350266A (en) *	1964-06-04	1967-10-31	Bristol Myers Co	Antacid composition comprising aluminum hydroxide, magnesium hydroxide and magnesium gluconate
GB1269987A (en) *	1968-04-18	1972-04-12	Garland Richard Brown	Antacid composition
US3599150A (en) *	1969-08-01	1971-08-10	Miles Lab	Stabilized aluminum hydroxide suspensions
GB1414121A (en) *	1971-09-15	1975-11-19	Smith W J	Antacid composition and its preparation
US3873694A (en) *	1973-09-27	1975-03-25	Cpc International Inc	Direct compression tabletting composition and pharmaceutical tablets produced therefrom

1979
- 1979-07-09 SE SE7905972A patent/SE7905972L/ not_active Application Discontinuation
1980
- 1980-06-06 AT AT80850081T patent/ATE1968T1/de not_active IP Right Cessation
- 1980-06-06 EP EP80850081A patent/EP0022429B1/fr not_active Expired
- 1980-06-06 DE DE8080850081T patent/DE3061333D1/de not_active Expired
- 1980-06-18 PH PH24163A patent/PH16372A/en unknown
- 1980-06-27 AU AU59734/80A patent/AU535403B2/en not_active Expired
- 1980-06-27 NZ NZ194165A patent/NZ194165A/en unknown
- 1980-07-03 FI FI802139A patent/FI71058C/fi not_active IP Right Cessation
- 1980-07-04 NO NO802030A patent/NO152892C/no unknown
- 1980-07-04 DK DK290080A patent/DK154265C/da not_active IP Right Cessation
- 1980-07-07 GR GR62397A patent/GR69623B/el unknown
- 1980-07-07 IE IE1402/80A patent/IE50141B1/en unknown
- 1980-07-07 PT PT71503A patent/PT71503B/pt unknown
- 1980-07-08 CA CA000355688A patent/CA1146860A/fr not_active Expired
- 1980-07-08 ES ES493187A patent/ES8106835A1/es not_active Expired
- 1980-07-09 JP JP9281580A patent/JPS5618922A/ja active Granted
1981
- 1981-11-27 PH PH26541A patent/PH16705A/en unknown
1982
- 1982-01-11 US US06/338,302 patent/US4465667A/en not_active Expired - Lifetime
1983
- 1983-01-01 AR AR22885483D patent/AR228854A1/es active
1984
- 1984-02-04 SG SG93/84A patent/SG9384G/en unknown
- 1984-05-17 HK HK434/84A patent/HK43484A/xx not_active IP Right Cessation
1985
- 1985-12-30 MY MY445/85A patent/MY8500445A/xx unknown

Also Published As

Publication number	Publication date
JPS6411008B2 (fr)	1989-02-23
ES493187A0 (es)	1981-09-01
DE3061333D1 (en)	1983-01-20
ATE1968T1 (de)	1982-12-15
FI71058B (fi)	1986-08-14
EP0022429A1 (fr)	1981-01-14
PT71503B (en)	1981-12-11
FI802139A (fi)	1981-01-10
CA1146860A (fr)	1983-05-24
NO802030L (no)	1981-01-12
EP0022429B1 (fr)	1982-12-15
IE50141B1 (en)	1986-02-19
US4465667A (en)	1984-08-14
PT71503A (en)	1980-08-01
MY8500445A (en)	1985-12-31
PH16372A (en)	1983-09-14
NZ194165A (en)	1984-07-06
AU5973480A (en)	1981-01-15
ES8106835A1 (es)	1981-09-01
IE801402L (en)	1981-01-09
SE7905972L (sv)	1981-01-10
JPS5618922A (en)	1981-02-23
NO152892C (no)	1985-12-11
SG9384G (en)	1985-02-15
HK43484A (en)	1984-05-25
AU535403B2 (en)	1984-03-22
DK290080A (da)	1981-01-10
PH16705A (en)	1984-01-20
DK154265B (da)	1988-10-31
DK154265C (da)	1989-03-28
AR228854A1 (es)	1983-04-29
NO152892B (no)	1985-09-02
GR69623B (fr)	1982-07-06

Legal Events

Date	Code	Title	Description
2004-08-31	MA	Patent expired	Owner name: AKTIEBOLAGET HAESSLE

Publication	Publication Date	Title
AU610556B2 (en)	1991-05-23	Cholestyramine composition and process for its preparation
US4885281A (en)	1989-12-05	Sucralfate suspension
FI71058C (fi)	1986-11-24	Foerfarande foer framstaellning av en magsyraneutraliserande suspension
JPH06505511A (ja)	1994-06-23	脱泡性組成物
HU211236A9 (en)	1995-11-28	Antacide compositions with prolonged gastric residence time
JPH08175976A (ja)	1996-07-09	発泡性カップル含有のヒスタミンｈ２−拮抗剤発泡性組成物
JPH11514629A (ja)	1999-12-14	安定な甲状腺ホルモン含有薬剤
EP0193400B1 (fr)	1991-10-23	Compositions pharmaceutiques
AU578690B2 (en)	1988-11-03	Antacid composition
KR910004479B1 (ko)	1991-06-29	슈우크럴페이트를 유효성분으로 함유하는 현탁액
JP2004099558A (ja)	2004-04-02	医薬用ゼリー組成物
JPWO2005084703A1 (ja)	2007-11-29	徐放性の口腔用組成物
TW446562B (en)	2001-07-21	Pharmaceutical composition for increasing calcium uptake
HU179814B (en)	1982-12-28	Process for producing pharmaceutical compositions containing polysaccharide-gum
EP0136006B1 (fr)	1991-01-09	Compositions pharmaceutiques
AU2001258538A1 (en)	2002-02-14	Pepsin inhibition by alginates
WO2001087282A2 (fr)	2001-11-22	Inhibition de pepsine par des alginates
JP2000136150A (ja)	2000-05-16	熱安定性制酸及び制ガス懸濁液、及びそれを末端滅菌する方法
EP0143576A1 (fr)	1985-06-05	Une composition antacide et un procédé pour sa préparation
US5661137A (en)	1997-08-26	Antacid pharmaceutical composition in the form of a suspension based on sucralfate gel
US3208906A (en)	1965-09-28	Glycine-stabilized aluminum hydroxidemagnesium compound codried gel antacids and process of making the same
JPH0696536B2 (ja)	1994-11-30	制酸剤含有内用懸濁液
JP2002509539A (ja)	2002-03-26	制酸剤とパパインの組合せ物
JP6641626B2 (ja)	2020-02-05	制酸用医薬組成物
JP2024525095A (ja)	2024-07-09	アルギネート、ポリリジン、及び種子防腐剤栄養製品並びに消化補助剤