FI67231C - Foerfarande foer framstaellning av en hypokolesteremisk foerening - Google Patents
Foerfarande foer framstaellning av en hypokolesteremisk foerening Download PDFInfo
- Publication number
- FI67231C FI67231C FI801857A FI801857A FI67231C FI 67231 C FI67231 C FI 67231C FI 801857 A FI801857 A FI 801857A FI 801857 A FI801857 A FI 801857A FI 67231 C FI67231 C FI 67231C
- Authority
- FI
- Finland
- Prior art keywords
- culture
- solution
- compound
- flask
- hours
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (5)
1. Förfarande för framställning av en hypokolesteremisk förening med formeIn Q J “· ι^ΐ f CH3 CH3 där vid den streckade linjen kan finnas en enkel bindning eller en dubbelbindning, och Q är ΗΟγ-γ° _ eller OH V V kännetecknat därav, att man i ett odlingsmedium odlar en mlkroorganlsm av släktet Aspergillus terreus, och föreningen isoleras ur odlingsmediet.
2. Förfarande enligt patentkravet 1 för framställning av en förening med formeIn 67231 31 ΗΟγ^γ° -λ y ΓΗ ^ 0 f
3. Förfarande enligt patentkravet 2, kännetecknat därav, att den använda mikroorganismens deponeringsnummer är ATCC 20541 eller 20542.
3. I Λγ\- ’ ch3 kännetecknat därav, att man i ett odlingsmedium odlar en mikroorganism av släktet Aspergillus terreus, och föreningen iso-leras ur odlingsmediet.
4. Förfarande enligt patentkravet 1 för framställning av en förening med formeln H0v _ 0 OH L\C)H ΐ f kännetecknat därav, att man i ett odlingsmedium odlar en mikroorganism av släktet Aspergillus terreus, och föreningen isoleras ur odlingsmediet.
5. Förfarande enligt patentkravet 4, kännetecknat därav, att man använder en mikroorganism med deponerings-numret ATCC 20541 eller 20542.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/048,946 US4231938A (en) | 1979-06-15 | 1979-06-15 | Hypocholesteremic fermentation products and process of preparation |
US4894679 | 1979-06-15 | ||
US7780779A | 1979-09-21 | 1979-09-21 | |
US7780779 | 1979-09-21 | ||
US11445980A | 1980-01-23 | 1980-01-23 | |
US11445980 | 1980-01-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI801857A FI801857A (fi) | 1980-12-16 |
FI67231B FI67231B (fi) | 1984-10-31 |
FI67231C true FI67231C (fi) | 1985-02-11 |
Family
ID=27367450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI801857A FI67231C (fi) | 1979-06-15 | 1980-06-10 | Foerfarande foer framstaellning av en hypokolesteremisk foerening |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0022478B1 (sv) |
AR (1) | AR224008A1 (sv) |
AT (1) | ATE2620T1 (sv) |
AU (1) | AU535944B2 (sv) |
CA (1) | CA1161380A (sv) |
DD (1) | DD157344A5 (sv) |
DE (1) | DE3062122D1 (sv) |
DK (1) | DK149003C (sv) |
EG (1) | EG16957A (sv) |
ES (1) | ES8105389A1 (sv) |
FI (1) | FI67231C (sv) |
GR (1) | GR69216B (sv) |
IE (1) | IE49685B1 (sv) |
IL (1) | IL60219A (sv) |
NO (1) | NO155699C (sv) |
NZ (1) | NZ193922A (sv) |
PL (1) | PL125843B1 (sv) |
PT (1) | PT71371B (sv) |
RO (1) | RO79487A (sv) |
ZW (1) | ZW13480A1 (sv) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
US4282155A (en) * | 1980-02-04 | 1981-08-04 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Mb−530a誘導体 |
DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb−530b誘導体およびその製造法 |
DE8533814U1 (de) * | 1985-11-30 | 1986-01-16 | Beiersdorf Ag, 2000 Hamburg | Vorrichtung zum Spülen des Darmes |
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
DE3739882A1 (de) * | 1987-11-25 | 1989-06-08 | Bayer Ag | Substituierte hydroxylamine |
NO890522L (no) * | 1988-02-25 | 1989-08-28 | Bayer Ag | Substituerte imidazolinoner og imidazolinthioner. |
AU618158B2 (en) * | 1989-01-07 | 1991-12-12 | Bayer Aktiengesellschaft | New substituted pyrido(2,3-d)pyrimidines |
DE3911064A1 (de) * | 1989-04-06 | 1990-10-11 | Bayer Ag | Substituierte 1,8-naphthyridine |
FI94339C (sv) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Förfarande för framställning av farmaceutiskt användbar /R-(R*,R*)/-2-(4-fluorfenyl)- , -dihydroxi-5-(1-metyletyl)-3-fenyl-4-/(fenylamino)karbonyl/-1H-pyrrol-1-heptansyra och farmaceutiskt användbara salter därav |
CA2062023A1 (en) | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
NZ245713A (en) * | 1992-02-10 | 1994-12-22 | Novopharm Ltd | Production of the antibiotic lovastatin from genetically engineered aspergillus strains |
EP0629184A1 (en) * | 1992-03-04 | 1994-12-21 | Fujisawa Pharmaceutical Co., Ltd. | TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
DE4244029A1 (de) * | 1992-12-24 | 1994-06-30 | Bayer Ag | Neue substituierte Pyridine |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
US5798375A (en) * | 1995-07-03 | 1998-08-25 | Sankyo Company, Limited | Treatment of arteriosclerosis and xanthoma |
EP0795554A3 (en) * | 1996-03-05 | 1998-01-28 | Takeda Chemical Industries, Ltd. | (Oxo-)xanthene derivatives, their preparation and their use as immunomodulators |
SI0970236T1 (sl) * | 1997-02-20 | 2006-10-31 | Dsm Ip Assets Bv | Fermentativna proizvodnja dragocenih spojin v industrijskem merilu z uporabo kemicno definiranih medijev |
US6083497A (en) | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
SI9800057A (sl) | 1998-02-26 | 1999-08-31 | Krka, Tovarna Zdravil, D.D. | Postopek za pripravo simvastatina in njegovih derivatov |
CN102772411A (zh) | 2006-07-05 | 2012-11-14 | 奈科明有限责任公司 | 用于治疗炎症性肺部疾病的HMG-CoA还原酶抑制剂与磷酸二酯酶4抑制剂的组合 |
EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
SI2373609T1 (sl) | 2008-12-19 | 2013-12-31 | Krka, D.D., Novo Mesto | Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049495A (en) * | 1974-06-07 | 1977-09-20 | Sankyo Company Limited | Physiologically active substances and fermentative process for producing the same |
JPS5559180A (en) * | 1978-10-30 | 1980-05-02 | Sankyo Co Ltd | 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent |
-
1980
- 1980-06-03 IL IL60219A patent/IL60219A/xx unknown
- 1980-06-03 GR GR62115A patent/GR69216B/el unknown
- 1980-06-03 AU AU59017/80A patent/AU535944B2/en not_active Expired
- 1980-06-04 NZ NZ193922A patent/NZ193922A/xx unknown
- 1980-06-04 AR AR281295A patent/AR224008A1/es active
- 1980-06-06 ZW ZW134/80A patent/ZW13480A1/xx unknown
- 1980-06-09 RO RO80101368A patent/RO79487A/ro unknown
- 1980-06-10 FI FI801857A patent/FI67231C/fi not_active IP Right Cessation
- 1980-06-11 PT PT71371A patent/PT71371B/pt unknown
- 1980-06-11 CA CA000353777A patent/CA1161380A/en not_active Expired
- 1980-06-12 DE DE8080103286T patent/DE3062122D1/de not_active Expired
- 1980-06-12 EP EP80103286A patent/EP0022478B1/en not_active Expired
- 1980-06-12 ES ES492384A patent/ES8105389A1/es not_active Expired
- 1980-06-12 AT AT80103286T patent/ATE2620T1/de active
- 1980-06-12 PL PL1980224920A patent/PL125843B1/pl unknown
- 1980-06-13 NO NO801775A patent/NO155699C/no unknown
- 1980-06-13 DK DK254180A patent/DK149003C/da not_active IP Right Cessation
- 1980-06-13 DD DD80221832A patent/DD157344A5/de unknown
- 1980-06-13 IE IE1232/80A patent/IE49685B1/en not_active IP Right Cessation
- 1980-06-14 EG EG355/80A patent/EG16957A/xx active
Also Published As
Publication number | Publication date |
---|---|
EP0022478B1 (en) | 1983-02-23 |
DK149003C (da) | 1986-08-18 |
NO155699B (no) | 1987-02-02 |
FI67231B (fi) | 1984-10-31 |
NZ193922A (en) | 1982-05-25 |
GR69216B (sv) | 1982-05-07 |
DK149003B (da) | 1985-12-16 |
NO801775L (no) | 1980-12-16 |
NO155699C (no) | 1987-05-13 |
EP0022478A1 (en) | 1981-01-21 |
PT71371A (en) | 1980-07-01 |
PL224920A1 (sv) | 1981-03-27 |
AR224008A1 (es) | 1981-10-15 |
ES492384A0 (es) | 1981-06-01 |
FI801857A (fi) | 1980-12-16 |
IE49685B1 (en) | 1985-11-27 |
IL60219A (en) | 1985-05-31 |
ZW13480A1 (en) | 1982-02-03 |
PT71371B (en) | 1981-10-21 |
RO79487A (ro) | 1982-07-06 |
AU5901780A (en) | 1980-12-18 |
PL125843B1 (en) | 1983-06-30 |
ATE2620T1 (de) | 1983-03-15 |
IE801232L (en) | 1980-12-15 |
IL60219A0 (en) | 1980-09-16 |
DD157344A5 (de) | 1982-11-03 |
EG16957A (en) | 1990-06-30 |
CA1161380A (en) | 1984-01-31 |
DE3062122D1 (en) | 1983-03-31 |
AU535944B2 (en) | 1984-04-12 |
ES8105389A1 (es) | 1981-06-01 |
DK254180A (da) | 1980-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ND | Supplementary protection certificate (spc) granted | ||
SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L1 Extension date: 20030622 |
|
MA | Patent expired |
Owner name: MERCK & CO INC. |