FI801857A - Hyperkolesterolemiska fermentprodukter och foerfarande foer framstaellning av dessa - Google Patents
Hyperkolesterolemiska fermentprodukter och foerfarande foer framstaellning av dessaInfo
- Publication number
- FI801857A FI801857A FI801857A FI801857A FI801857A FI 801857 A FI801857 A FI 801857A FI 801857 A FI801857 A FI 801857A FI 801857 A FI801857 A FI 801857A FI 801857 A FI801857 A FI 801857A
- Authority
- FI
- Finland
- Prior art keywords
- hypercholesterolemical
- dessa
- framstaellning
- farms
- fermentation products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/048,946 US4231938A (en) | 1979-06-15 | 1979-06-15 | Hypocholesteremic fermentation products and process of preparation |
US4894679 | 1979-06-15 | ||
US7780779A | 1979-09-21 | 1979-09-21 | |
US7780779 | 1979-09-21 | ||
US11445980A | 1980-01-23 | 1980-01-23 | |
US11445980 | 1980-01-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI801857A true FI801857A (fi) | 1980-12-16 |
FI67231B FI67231B (fi) | 1984-10-31 |
FI67231C FI67231C (fi) | 1985-02-11 |
Family
ID=27367450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI801857A FI67231C (fi) | 1979-06-15 | 1980-06-10 | Foerfarande foer framstaellning av en hypokolesteremisk foerening |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0022478B1 (fi) |
AR (1) | AR224008A1 (fi) |
AT (1) | ATE2620T1 (fi) |
AU (1) | AU535944B2 (fi) |
CA (1) | CA1161380A (fi) |
DD (1) | DD157344A5 (fi) |
DE (1) | DE3062122D1 (fi) |
DK (1) | DK149003C (fi) |
EG (1) | EG16957A (fi) |
ES (1) | ES492384A0 (fi) |
FI (1) | FI67231C (fi) |
GR (1) | GR69216B (fi) |
IE (1) | IE49685B1 (fi) |
IL (1) | IL60219A (fi) |
NO (1) | NO155699C (fi) |
NZ (1) | NZ193922A (fi) |
PL (1) | PL125843B1 (fi) |
PT (1) | PT71371B (fi) |
RO (1) | RO79487A (fi) |
ZW (1) | ZW13480A1 (fi) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
US4282155A (en) * | 1980-02-04 | 1981-08-04 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Mb−530a誘導体 |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb−530b誘導体およびその製造法 |
DE8533814U1 (de) * | 1985-11-30 | 1986-01-16 | Beiersdorf Ag, 2000 Hamburg | Vorrichtung zum Spülen des Darmes |
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
DE3739882A1 (de) * | 1987-11-25 | 1989-06-08 | Bayer Ag | Substituierte hydroxylamine |
NO890522L (no) * | 1988-02-25 | 1989-08-28 | Bayer Ag | Substituerte imidazolinoner og imidazolinthioner. |
AU618158B2 (en) * | 1989-01-07 | 1991-12-12 | Bayer Aktiengesellschaft | New substituted pyrido(2,3-d)pyrimidines |
DE3911064A1 (de) * | 1989-04-06 | 1990-10-11 | Bayer Ag | Substituierte 1,8-naphthyridine |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
CA2062023A1 (en) | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
NZ245713A (en) * | 1992-02-10 | 1994-12-22 | Novopharm Ltd | Production of the antibiotic lovastatin from genetically engineered aspergillus strains |
WO1993017991A1 (en) * | 1992-03-04 | 1993-09-16 | Fujisawa Pharmaceutical Co., Ltd. | TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
DE4244029A1 (de) * | 1992-12-24 | 1994-06-30 | Bayer Ag | Neue substituierte Pyridine |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
NO318765B1 (no) * | 1995-07-03 | 2005-05-02 | Sankyo Co | Anvendelse av en HMG-CoA reduktaseinhibitor og en insulinsensibilisator til fremstilling av et medikament for forebyggelse eller behandling av arteriosklerose eller xantom, samt pakket farmasoytisk preparat som omfatter de to midlene i separate porsjoner. |
CN1171400A (zh) | 1996-03-05 | 1998-01-28 | 武田药品工业株式会社 | 呫吨衍生物,其制备和用途 |
BR9807362A (pt) * | 1997-02-20 | 2000-04-18 | Dsm Nv | Produção fermentativa de compostos úteis em escala industrial usando meios quimicamente definidos |
US6083497A (en) | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
SI9800057A (sl) | 1998-02-26 | 1999-08-31 | Krka, Tovarna Zdravil, D.D. | Postopek za pripravo simvastatina in njegovih derivatov |
UA98466C2 (uk) | 2006-07-05 | 2012-05-25 | Нікомед Гмбх | КОМБІНАЦІЯ ІНГІБІТОРА HMG-CоA-РЕДУКТАЗИ Й ІНГІБІТОРА ФОСФОДІЕСТЕРАЗИ 4, ПРИЗНАЧЕНА ДЛЯ ЛІКУВАННЯ ЗАПАЛЬНИХ ЗАХВОРЮВАНЬ ЛЕГЕНІВ |
EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
WO2010069593A1 (en) | 2008-12-19 | 2010-06-24 | Krka, D. D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049495A (en) * | 1974-06-07 | 1977-09-20 | Sankyo Company Limited | Physiologically active substances and fermentative process for producing the same |
JPS5559180A (en) * | 1978-10-30 | 1980-05-02 | Sankyo Co Ltd | 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent |
-
1980
- 1980-06-03 GR GR62115A patent/GR69216B/el unknown
- 1980-06-03 AU AU59017/80A patent/AU535944B2/en not_active Expired
- 1980-06-03 IL IL60219A patent/IL60219A/xx unknown
- 1980-06-04 AR AR281295A patent/AR224008A1/es active
- 1980-06-04 NZ NZ193922A patent/NZ193922A/xx unknown
- 1980-06-06 ZW ZW134/80A patent/ZW13480A1/xx unknown
- 1980-06-09 RO RO80101368A patent/RO79487A/ro unknown
- 1980-06-10 FI FI801857A patent/FI67231C/fi not_active IP Right Cessation
- 1980-06-11 PT PT71371A patent/PT71371B/pt unknown
- 1980-06-11 CA CA000353777A patent/CA1161380A/en not_active Expired
- 1980-06-12 AT AT80103286T patent/ATE2620T1/de active
- 1980-06-12 PL PL1980224920A patent/PL125843B1/pl unknown
- 1980-06-12 ES ES492384A patent/ES492384A0/es active Granted
- 1980-06-12 EP EP80103286A patent/EP0022478B1/en not_active Expired
- 1980-06-12 DE DE8080103286T patent/DE3062122D1/de not_active Expired
- 1980-06-13 IE IE1232/80A patent/IE49685B1/en not_active IP Right Cessation
- 1980-06-13 DD DD80221832A patent/DD157344A5/de unknown
- 1980-06-13 NO NO801775A patent/NO155699C/no unknown
- 1980-06-13 DK DK254180A patent/DK149003C/da not_active IP Right Cessation
- 1980-06-14 EG EG355/80A patent/EG16957A/xx active
Also Published As
Publication number | Publication date |
---|---|
IL60219A (en) | 1985-05-31 |
CA1161380A (en) | 1984-01-31 |
IE49685B1 (en) | 1985-11-27 |
AU5901780A (en) | 1980-12-18 |
ES8105389A1 (es) | 1981-06-01 |
PT71371A (en) | 1980-07-01 |
NZ193922A (en) | 1982-05-25 |
EP0022478B1 (en) | 1983-02-23 |
DD157344A5 (de) | 1982-11-03 |
RO79487A (ro) | 1982-07-06 |
NO801775L (no) | 1980-12-16 |
DK149003C (da) | 1986-08-18 |
GR69216B (fi) | 1982-05-07 |
IE801232L (en) | 1980-12-15 |
FI67231B (fi) | 1984-10-31 |
DK149003B (da) | 1985-12-16 |
FI67231C (fi) | 1985-02-11 |
AU535944B2 (en) | 1984-04-12 |
DE3062122D1 (en) | 1983-03-31 |
ES492384A0 (es) | 1981-06-01 |
PL125843B1 (en) | 1983-06-30 |
EG16957A (en) | 1990-06-30 |
NO155699C (no) | 1987-05-13 |
ZW13480A1 (en) | 1982-02-03 |
NO155699B (no) | 1987-02-02 |
DK254180A (da) | 1980-12-16 |
EP0022478A1 (en) | 1981-01-21 |
IL60219A0 (en) | 1980-09-16 |
PT71371B (en) | 1981-10-21 |
PL224920A1 (fi) | 1981-03-27 |
ATE2620T1 (de) | 1983-03-15 |
AR224008A1 (es) | 1981-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ND | Supplementary protection certificate (spc) granted | ||
SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L1 Extension date: 20030622 |
|
MA | Patent expired |
Owner name: MERCK & CO INC. |