DE68914495T2 - Antihypercholesterolemisches Mittel. - Google Patents

Antihypercholesterolemisches Mittel.

Info

Publication number
DE68914495T2
DE68914495T2 DE68914495T DE68914495T DE68914495T2 DE 68914495 T2 DE68914495 T2 DE 68914495T2 DE 68914495 T DE68914495 T DE 68914495T DE 68914495 T DE68914495 T DE 68914495T DE 68914495 T2 DE68914495 T2 DE 68914495T2
Authority
DE
Germany
Prior art keywords
antihypercholesterolemic agent
antihypercholesterolemic
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68914495T
Other languages
English (en)
Other versions
DE68914495D1 (de
Inventor
Henry Joshua
Michael S Schwartz
Kenneth E Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE68914495D1 publication Critical patent/DE68914495D1/de
Publication of DE68914495T2 publication Critical patent/DE68914495T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
DE68914495T 1988-03-02 1989-02-23 Antihypercholesterolemisches Mittel. Expired - Lifetime DE68914495T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16278588A 1988-03-02 1988-03-02

Publications (2)

Publication Number Publication Date
DE68914495D1 DE68914495D1 (de) 1994-05-19
DE68914495T2 true DE68914495T2 (de) 1994-10-27

Family

ID=22587122

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68914495T Expired - Lifetime DE68914495T2 (de) 1988-03-02 1989-02-23 Antihypercholesterolemisches Mittel.

Country Status (6)

Country Link
US (1) US4968693A (de)
EP (1) EP0331250B1 (de)
JP (1) JPH023623A (de)
KR (1) KR910000695A (de)
CA (1) CA1328878C (de)
DE (1) DE68914495T2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059696A (en) * 1990-03-15 1991-10-22 Merck & Co., Inc. Processes and intermediates for the preparation of 5-oxygenated hmg-coa reductase inhibitors
KR20010073232A (ko) 1998-11-20 2001-07-31 추후제출 분산성 인지질로 안정화된 마이크로입자
WO2001032162A1 (en) * 1999-11-03 2001-05-10 Howard J. Smith & Associates Pty Ltd Liver selective therapy
WO2001056596A1 (en) 2000-02-04 2001-08-09 Children's Hospital Research Foundation Use of lysosomal acid lipase for treating atherosclerosis and related diseases
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
AU2003209990B8 (en) * 2002-02-25 2008-10-30 Kudos Pharmaceuticals Ltd Pyranones useful as ATM inhibitors
ES2375181T3 (es) 2002-05-09 2012-02-27 The Brigham And Women's Hospital, Inc. 1l 1rl-1 como un marcador de enfermedades cardiovasculares.
CA2510319A1 (en) 2002-12-20 2004-07-15 Thomas J. Smith High pressure compaction for pharmaceutical formulations
EP1510208A1 (de) 2003-08-22 2005-03-02 Fournier Laboratories Ireland Limited Metformin-Statin-Kombination enthaltende pharmazeutische Zusammensetzungen
US7803838B2 (en) * 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
WO2006042192A2 (en) 2004-10-06 2006-04-20 The Brigham And Womens's Hospital, Inc. Relevance of achieved levels of markers of systemic inflammation following treatment
EP1848424B1 (de) * 2005-01-31 2017-04-05 Mylan Laboratories, Inc Pharmazeutische zusammensetzung enthaltend hydroxyliertes nebivolol
AP2896A (en) 2005-05-31 2014-05-31 Mylan Lab Inc Compositions comprising nebivolol
US8119358B2 (en) 2005-10-11 2012-02-21 Tethys Bioscience, Inc. Diabetes-related biomarkers and methods of use thereof
EP2030025A2 (de) 2006-06-07 2009-03-04 Tethys Bioscience, Inc. Mit arteriovaskulären ereignissen assoziierte marker und verfahren zu ihrer verwendung
EP2057987B1 (de) 2006-08-30 2015-03-04 Kyushu University, National University Corporation Pharmazeutische zusammensetzung mit statin-verkapseltem nanopartikel
ES2434215T3 (es) 2007-04-18 2013-12-16 Tethys Bioscience, Inc. Biomarcadores relacionados con la diabetes y métodos de uso de los mismos
CN103037829A (zh) 2010-02-01 2013-04-10 儿童医院 用于治疗和预防再狭窄的远程缺血调节
CA2795053A1 (en) 2010-03-31 2011-10-06 The Hospital For Sick Children Use of remote ischemic conditioning to improve outcome after myocardial infarction
CA2800520A1 (en) 2010-04-08 2011-10-13 The Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
AU2013296803B2 (en) 2012-08-01 2018-03-08 Eric Ostertag Free flowing, frozen compositions comprising a therapeutic agent
CN110575445B (zh) 2013-03-21 2023-08-18 优普顺药物公司美国分部 可注射的持续释放组合物及其用于治疗关节炎症及相关疼痛的方法
ES2672993T3 (es) 2015-10-27 2018-06-19 Eupraxia Pharmaceuticals Inc. Formulaciones de liberación sostenida de anestésicos locales

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56150037A (en) * 1980-04-22 1981-11-20 Sankyo Co Ltd Hydronaphthalene compound
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
JPS59186972A (ja) * 1983-03-09 1984-10-23 Suntory Ltd オクタヒドロナフタレン誘導体並びにその製造法
US4582915A (en) * 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
US4857522A (en) * 1988-03-21 1989-08-15 E. R. Squibb & Sons, Inc. Derivatives of pravastatin for inhibiting cholesterol biosynthesis

Also Published As

Publication number Publication date
CA1328878C (en) 1994-04-26
EP0331250A2 (de) 1989-09-06
EP0331250B1 (de) 1994-04-13
JPH023623A (ja) 1990-01-09
EP0331250A3 (en) 1990-05-16
KR910000695A (ko) 1991-01-30
DE68914495D1 (de) 1994-05-19
US4968693A (en) 1990-11-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee