FI121565B - Förfarande för att tillverka ett preparat som frigör kontrollerat tramadolin - Google Patents
Förfarande för att tillverka ett preparat som frigör kontrollerat tramadolin Download PDFInfo
- Publication number
- FI121565B FI121565B FI20030560A FI20030560A FI121565B FI 121565 B FI121565 B FI 121565B FI 20030560 A FI20030560 A FI 20030560A FI 20030560 A FI20030560 A FI 20030560A FI 121565 B FI121565 B FI 121565B
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- tramadol
- hours
- preparation
- alcohol
- process according
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (10)
1. Förfarande för tillverkmng av ett farmaceutiskt preparat mnefattande tramadol för oral administration, kännetecknat därav, att preparatet innefattar en vid be-5 handling av smärta effektiv mängd av tramadol eller ett farmaceutiskt acceptabelt sait därav och är lämpligt för dosering var 12:te timme, i vilket förfarande tramadol ellei' ett farmaceutiskt acceptabelt sait därav innesluts i en matris med kontrol-lerad frigörning, varvid preparatet innehäller 1 - 80 vilct-% av en eller flera hydro-fila eller hydrofoba polymerer, fördelaktigt en cellulosaeter, och varvid preparatet 10 har följande in vitro upplösningshastighet mätt med pH. Eur. paddelmetoden med hastigheten 100 varv/min i 900 ml 0,1 N saltsyra vid en temperatur av 37 °C med användning av UV-detektering med väglängden 270 nm; 5 — 50 vikt-% tramadol frigjort efter 1 timme, 10-75 vikt-% tramadol frigjort efler 2 timmar, 15 20 - 95 vikt-% tramadol frigjort efler 4 timmar, 40 - 100 vikt-% tramadol frigjort efter 8 timmar, över 50 vikt-% tramadol frigjort efter 12 timmar, över 70 vikt-% tramadol frigjort efter 18 timmar, över 80 vikt-% tramadol frigjort efter 24 timmar, 20 och varvid doseringsformen ästadkommer ett tmilx-värde, som är 2 - 7 timmar, varvid förfarandet omfattar följande steg: Ϊ 25 (a) en blandning bestäende av tramadol eller ett farmaceutiskt acceptabelt sait därav samt en eller flera hydrofila eller hydrofoba polymerer, fördelaktigt en cellulosaeter, granuleras; (b) med dessa koni innehällande polymer blandas en eller flera alifatiska C12-36-30 alkoholer, och valfritt (c) konien formas och sammanpressas och beläggs om sä Önskas med en fiini; eller Π (a) en blandning, som innehäller tramadol eller ett farmaceutiskt acceptabelt salt 5 därav, laktos samt en eller flera hydrofila eller hydrofoba polymerer, granuleras; (b) konien formas och sammanpressas och beläggs om sä önskas med en film; eller 10 m (a) en blandning bestäende av tramadol eller ett farmaceutiskt acceptabelt salt därav samt ett ämne som underlättar framställning av kulor granuleras; (b) denna granulerade blandning strängsprulas för erhällande av en slrängsprutad 15 komprett, och (c) av den strängsprutade kompretten formas kulor, och (d) kulorna beläggs med en filmbeläggning. 20
2. Förfarande enligt patentkravet 1, kännetecknat därav, att matrisen med kon-trollerad frigörning omfattar en polymer, som är ett gummi.
3. Förfarande enligt patentkravet 1, kännetecknat därav, att matrisen med kon-25 irolierad frigörning omfattar en cellulosaeter, som är en alkylcellulosa.
4. Förfarande enligt patentkravet 1, kännetecknat därav, att kulorna beläggs med ett material, som innefattar en vattenlöslig polymer, fördelaktigt polyvinylpyrroli-don. 30
5. Förfarande enligt patentkravet 1 eller 3, kännetecknat därav, att matrisen med kontiO 1 lerad frigörning omfattar minst en alkylcellulosa, fördelaktigt en Ci-CV alkylceilulosa, och minsl en C^-Csö-alifatisk alkohol, fördelaktigt en C14-C22-alifatisk alkohol, och valfritt minst en polyalkylenglykol, fördelaktigt en polyety-lenglykol. 5
6. Förfarande enligt patentkravet 5, kännetecknat därav, att minst en alkylcellulosa är en etylcellulosa.
7. Förfarande enligt patentkravet 5 ellei' 6, kännetecknat därav, att preparatet 10 innehäller 1 - 20 vikt-%, fördelaktigt 2-15 vikt-% av en ellei* flera alkylcellulo- sor,
8. Förfarande enligt nägot av patentkraven 5-7, kännetecknat därav, att den alifatiska alkoholen omfattar laurylalkohol, myristylalkohol, stearylalkohol eller 15 fördelaktigt cetylalkohol eller cetostearylaikohol.
9. Förfarande enligt nägot av patentkraven 5 - 8, kännetecknat därav, att preparatet innehäller 5-30 vikt-% alifatisk alkohol, fördelaktigt 10 - 25 vikt-% alifatisk alkohol. 20
10. Förfarande enligt nägot av patentkraven 1 - 9, kännetecknat därav, att preparatet innehäller 50 - 800 mg tramadol eller farmaceutiskt acceptabelt sait därav, särskilt 100, 200, 300, 400 - 600 mg (räknat soin tramadolhydroklorid) per dose-ringsenhet. 25
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4315525 | 1993-05-10 | ||
DE4315525A DE4315525B4 (de) | 1993-05-10 | 1993-05-10 | Pharmazeutische Zusammensetzung |
GB9324045 | 1993-11-23 | ||
GB9324045A GB2284760B (en) | 1993-11-23 | 1993-11-23 | A method of preparing pharmaceutical compositions by melt pelletisation |
GB9404544A GB9404544D0 (en) | 1994-03-09 | 1994-03-09 | Controlled release formulation |
GB9404544 | 1994-03-09 | ||
GB9404928 | 1994-03-14 | ||
GB9404928A GB2287880A (en) | 1994-03-14 | 1994-03-14 | Production of sustained release compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
FI20030560A FI20030560A (sv) | 2003-04-14 |
FI121565B true FI121565B (sv) | 2011-01-14 |
Family
ID=27435744
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI942092A FI942092A (sv) | 1993-05-10 | 1994-05-06 | Behärskat frigjord sammansättning |
FI20030560A FI121565B (sv) | 1993-05-10 | 2003-04-14 | Förfarande för att tillverka ett preparat som frigör kontrollerat tramadolin |
FI20105856A FI122717B (sv) | 1993-05-10 | 2010-08-17 | Förfarande för att framställa ett preparat med kontrollerad frigöring som innehåller tramadolhydroklorid |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI942092A FI942092A (sv) | 1993-05-10 | 1994-05-06 | Behärskat frigjord sammansättning |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20105856A FI122717B (sv) | 1993-05-10 | 2010-08-17 | Förfarande för att framställa ett preparat med kontrollerad frigöring som innehåller tramadolhydroklorid |
Country Status (22)
Country | Link |
---|---|
US (6) | US5591452A (sv) |
EP (6) | EP2103303B1 (sv) |
JP (3) | JP3045924B2 (sv) |
CN (2) | CN1094755C (sv) |
AT (5) | ATE303140T1 (sv) |
AU (2) | AU6196394A (sv) |
CA (1) | CA2123160C (sv) |
CZ (1) | CZ288517B6 (sv) |
DE (8) | DE69435295D1 (sv) |
DK (4) | DK0624366T3 (sv) |
ES (5) | ES2331046T1 (sv) |
FI (3) | FI942092A (sv) |
GR (2) | GR3020084T3 (sv) |
HU (1) | HU228177B1 (sv) |
ID (1) | ID25988A (sv) |
IL (3) | IL109460A (sv) |
NO (3) | NO306446B1 (sv) |
NZ (1) | NZ260408A (sv) |
PT (3) | PT1468679E (sv) |
SG (1) | SG67347A1 (sv) |
SK (2) | SK283143B6 (sv) |
TW (1) | TW496736B (sv) |
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1994
- 1994-04-27 IL IL109460A patent/IL109460A/en not_active IP Right Cessation
- 1994-04-27 NZ NZ260408A patent/NZ260408A/en not_active IP Right Cessation
- 1994-04-27 IL IL11966094A patent/IL119660A/en not_active IP Right Cessation
- 1994-04-29 ES ES09004973T patent/ES2331046T1/es active Pending
- 1994-04-29 EP EP09004973.5A patent/EP2103303B1/en not_active Expired - Lifetime
- 1994-04-29 SG SG1996008705A patent/SG67347A1/en unknown
- 1994-04-29 ES ES04030658T patent/ES2346651T3/es not_active Expired - Lifetime
- 1994-04-29 PT PT04014719T patent/PT1468679E/pt unknown
- 1994-04-29 AT AT04014719T patent/ATE303140T1/de active
- 1994-04-29 EP EP96101147A patent/EP0729751A1/en not_active Ceased
- 1994-04-29 DK DK94303128.6T patent/DK0624366T3/da active
- 1994-04-29 AT AT95114527T patent/ATE201989T1/de active
- 1994-04-29 DE DE69435295T patent/DE69435295D1/de not_active Expired - Lifetime
- 1994-04-29 EP EP95114527A patent/EP0699436B2/en not_active Expired - Lifetime
- 1994-04-29 DE DE9422335U patent/DE9422335U1/de not_active Expired - Lifetime
- 1994-04-29 ES ES95114527T patent/ES2159591T5/es not_active Expired - Lifetime
- 1994-04-29 ES ES94303128T patent/ES2088312T3/es not_active Expired - Lifetime
- 1994-04-29 AT AT04030658T patent/ATE468850T1/de active
- 1994-04-29 AT AT94303128T patent/ATE138566T1/de not_active IP Right Cessation
- 1994-04-29 DE DE69427472T patent/DE69427472T3/de not_active Expired - Lifetime
- 1994-04-29 DE DE69400215T patent/DE69400215T2/de not_active Revoked
- 1994-04-29 DE DE09004973T patent/DE09004973T8/de active Active
- 1994-04-29 EP EP04014719A patent/EP1468679B1/en not_active Expired - Lifetime
- 1994-04-29 DK DK95114527.5T patent/DK0699436T4/da active
- 1994-04-29 ES ES04014719T patent/ES2247574T3/es not_active Expired - Lifetime
- 1994-04-29 PT PT04030658T patent/PT1527775E/pt unknown
- 1994-04-29 DK DK04030658.1T patent/DK1527775T3/da active
- 1994-04-29 DK DK04014719T patent/DK1468679T3/da active
- 1994-04-29 EP EP04030658A patent/EP1527775B1/en not_active Expired - Lifetime
- 1994-04-29 PT PT95114527T patent/PT699436E/pt unknown
- 1994-04-29 EP EP94303128A patent/EP0624366B1/en not_active Revoked
- 1994-04-29 DE DE0699436T patent/DE699436T1/de active Pending
- 1994-04-29 DE DE0729751T patent/DE729751T1/de active Pending
- 1994-04-29 DE DE69434479T patent/DE69434479T2/de not_active Expired - Lifetime
- 1994-05-04 CZ CZ19941093A patent/CZ288517B6/cs not_active IP Right Cessation
- 1994-05-06 FI FI942092A patent/FI942092A/sv not_active Application Discontinuation
- 1994-05-06 HU HU9401478A patent/HU228177B1/hu unknown
- 1994-05-09 CA CA002123160A patent/CA2123160C/en not_active Expired - Lifetime
- 1994-05-09 AU AU61963/94A patent/AU6196394A/en not_active Abandoned
- 1994-05-09 NO NO941719A patent/NO306446B1/no not_active IP Right Cessation
- 1994-05-10 US US08/241,129 patent/US5591452A/en not_active Expired - Lifetime
- 1994-05-10 JP JP6096671A patent/JP3045924B2/ja not_active Expired - Lifetime
- 1994-05-10 CN CN94105356A patent/CN1094755C/zh not_active Expired - Lifetime
- 1994-05-10 SK SK1437-98A patent/SK283143B6/sk not_active IP Right Cessation
- 1994-05-10 ID IDP991104D patent/ID25988A/id unknown
- 1994-05-10 SK SK541-94A patent/SK279971B6/sk not_active IP Right Cessation
- 1994-05-12 TW TW085103273A patent/TW496736B/zh not_active IP Right Cessation
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1995
- 1995-05-24 US US08/449,772 patent/US6326027B1/en not_active Expired - Lifetime
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1996
- 1996-05-30 GR GR960401422T patent/GR3020084T3/el unknown
- 1996-07-10 US US08/677,798 patent/US6254887B1/en not_active Expired - Lifetime
- 1996-11-20 IL IL11966096A patent/IL119660A0/xx unknown
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1997
- 1997-10-07 AU AU39957/97A patent/AU3995797A/en not_active Abandoned
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1998
- 1998-08-14 JP JP22971898A patent/JP3267561B2/ja not_active Expired - Lifetime
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1999
- 1999-05-17 CN CNB991066421A patent/CN1146410C/zh not_active Expired - Lifetime
- 1999-07-15 NO NO19993484A patent/NO313124B1/no not_active IP Right Cessation
- 1999-11-25 AT AT0081699U patent/AT3413U3/de not_active IP Right Cessation
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2001
- 2001-03-06 US US09/800,204 patent/US7074430B2/en not_active Expired - Fee Related
- 2001-07-19 NO NO20013566A patent/NO331650B1/no unknown
- 2001-09-06 GR GR20010401419T patent/GR3036565T3/el unknown
- 2001-09-27 JP JP2001297270A patent/JP3443574B2/ja not_active Expired - Lifetime
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2003
- 2003-04-14 FI FI20030560A patent/FI121565B/sv not_active IP Right Cessation
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2006
- 2006-05-16 US US11/435,015 patent/US20060269603A1/en not_active Abandoned
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2008
- 2008-05-14 US US12/152,474 patent/US20090117191A1/en not_active Abandoned
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2010
- 2010-08-17 FI FI20105856A patent/FI122717B/sv not_active IP Right Cessation
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