FI118061B - Förfarande och biogivare för analys - Google Patents

Förfarande och biogivare för analys Download PDF

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Publication number
FI118061B
FI118061B FI20011877A FI20011877A FI118061B FI 118061 B FI118061 B FI 118061B FI 20011877 A FI20011877 A FI 20011877A FI 20011877 A FI20011877 A FI 20011877A FI 118061 B FI118061 B FI 118061B
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FI
Finland
Prior art keywords
biomolecules
substrate
molecules
signal
attached
Prior art date
Application number
FI20011877A
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English (en)
Finnish (fi)
Other versions
FI20011877A (sv
FI20011877A0 (sv
Inventor
Janusz Sadowski
Inger Vikholm
Original Assignee
Beanor Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beanor Oy filed Critical Beanor Oy
Publication of FI20011877A0 publication Critical patent/FI20011877A0/sv
Priority to FI20011877A priority Critical patent/FI118061B/sv
Priority to US10/164,652 priority patent/US7332327B2/en
Priority to PCT/FI2002/000763 priority patent/WO2003027679A1/en
Priority to BR0212988-4A priority patent/BR0212988A/pt
Priority to CNB028232828A priority patent/CN1281957C/zh
Priority to EP02762479A priority patent/EP1436622A1/en
Priority to JP2003531180A priority patent/JP4234596B2/ja
Publication of FI20011877A publication Critical patent/FI20011877A/sv
Priority to US11/785,238 priority patent/US7510882B2/en
Application granted granted Critical
Publication of FI118061B publication Critical patent/FI118061B/sv

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick

Claims (17)

1. Förfarande för analys, väri biomolekyler (3) som har fästs pä en fast yta av ett underlag (1) används för detektering av närvaro av analyter (4) i 5 ett prov genom att binda analyterna vid biomolekyler, kännetecknat av att biomolekylerna (3) fästs kovalent direkt pä ytan av underlaget tillsammans med molekyler (5) som fränstöter hydrofila biomolekyler, vilka molekyler täcker ytan mellan biomolekylerna (3) för att hindra icke-specifik bindning av analyter (4) och andra biomolekyler. 10
2. Förfarande enligt patentkrav 1, kännetecknat av att mole- kylerna (5) som fränstöter hydrofila biomolekyler har fästs pa ytan av underlaget (1) kovalent genom förmedling av funktionella grupper, sasom sulfid-, disul-fid- eller tiolgrupper.
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat av att 15 underlaget är ett sensorunderlag, som förmär inducera en förändring i en signal, vilket är en indikering pa en ökning av den vid biomolekylerna (3) bundna analyten pa ytan, signalen anbringas pä underlaget (1), den förändrade signa- . ,, Ien detekteras och mängden av den vid biomolekylerna (3) bundna analyten (4) pa ytan mäts med hjälp av den detekterade signalen. 20
4. Förfarande enligt patentkrav 1, 2 eller 3, k ä n n et e c k n at av att vid sidan av de direkt pä ytan av underlaget (1) fästa biomolekylerna (3) och molekylerna (5) som utstöter hydrofila biomolekyler används separata par-tiklar (2), vilka innehäller immobiliserade biomolekyler, som fästs pä underlaget , genom förmedling av analyterna (4) som är bundna vid nämnda biomolekyler 25 (3) pä underlaget (1).
** 5. Förfarande enligt nägot av de föregäende patentkraven, k ä n - 9 · .v netecknat av att biomolekylen (3) är protein, peptid, enzym, antikropp, * ***" antikroppsfragment, antigen eller del av antigen, och biomolekylerna har fästs genom förmedling av tiol-, disulfid- eller sulfidgrupper pä ytan av underlaget (1) ***: 30 och/eller pä partiklarna (2). * * ·
6. Förfarande enligt nägot av de föregäende patentkraven, k ä n - \ netecknat av att molekylen (5) som fränstöter biomolekyler är en hydrofil ···, polymer. *** * * * · * -V · • · * 0 • * · 9*9 9 * * * • * • « m f 16 118061
7. Förfarande enligt nagot av de föregaende patentkraven 3-6, kännetecknat avatt underlaget (1) är ett underlag, som förmar ästad-komma ett ytplasmonresonans (SPR) -fenomen, och analysen utförs med SPR-mätning. 5
8. Förfarande enligt nagot av de föregaende patentkraven 3-6, kännetecknat avatt analysen utförs med en tjocklekssnittformresona-tor, säsom en kvartskristallmikrovag (QCM).
9. Förfarande enligt nagot av de föregaende patentkraven, kännetecknat avatt underlaget (1) är metall, halvledare eller polymer som 10 leder elektricitet.
10. Förfarande enligt nagot av de föregaende patentkraven, k ä n -netecknat avatt biomolekylen (3) är en immunologisk bindarmolekyl, säsom antikropp eller dess immunologiskt aktiva fragment, och analysen är en immunologisk analys.
11. Biosensor för analys, vilken omfattar ett underlag (1) och biomo- lekyler (3) som har fästs pä underlaget (1), kännetecknad avatt biomo-lekylerna (3) har fästs kovalent direkt pä underlaget tillsammans med moleky-ler (5) som fränstöter hydrofila biomolekyler, vilka molekyler täcker ytan mellan biomolekylerna (3) för att hindra icke-specifik bindning av analyter (4) och and- 20 ra biomolekyler. 1
12. Biosensor enligt patentkrav 11, k ä n n e t e c k n ad av att mo-lekylerna (5) som fränstöter hydrofila biomolekyler har fästs pä underlaget kovalent genom förmedling av funktionella grupper, säsom sulfid-, disulfid- eller , tiolgrupper.
13. Biosensor enligt patentkrav 11 eller 12, k ä n n e t e c k n a d av ** att molekylerna (5) som fränstöter biomolekyler är hydrofila polymerer. .V
14. Biosensor enligt nagot av patentkraven 11, 12 eller 13, kän- netecknad av att molekylerna (5) som utstöter hydrofila biomolekyler :**: självassembleras pä ytan.
15. Biosensor enligt nägot av patentkraven 11 - 14, känne tecknad av att underlaget (1) är av en typ, som förmär inducera en föränd-*.# ring i en signal, vilket är en indikering pä en ökning (3) av den vid biomoleky- ···. lerna (3) bundna analyten (4) pä dess yta, varvid sensorn dessutom omfattar *" ett medel för att emittera signalen mot underlaget (1) och ett medel för att de- 35 tektera signalen som ändrats av en reaktion med underlaget (1). • · · ··* * • * • · * » · * *· • * • * ·· 17 1 1 8061
16. Biosensor enligt patentkrav 15, känneteckn ad av att un- derlaget (1) är av ett material, som är kompatibelt med en ytplasmonresonans (SPR), medlet for att emittera en signal är ett ljusemitterande medel och med-let för att detektera en signal är en eller flera ljusdetektorer, som anordnats för 5 att konstatera signalen som reflekteras fran ytan mellan underlaget och ett di-elektriskt material.
17. Biosensor enligt patentkrav 15, kännetecknad av att den är en tjocklekssnittformresonatorsensor, sasom en kvartskristallmikrovag (QCM)-sensor. ♦ « · # ·« » m m * • · • · ; · · · ® • · * ····* ... • · Φ * * * · • * • · · • · • * · • ... ♦ · ... • · • · ♦ • · · ··· • · • · « · * • * • · ··♦ ♦ * • · ♦ • · · ··♦··.. ♦ ·· « · • · »··
FI20011877A 2001-09-24 2001-09-24 Förfarande och biogivare för analys FI118061B (sv)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FI20011877A FI118061B (sv) 2001-09-24 2001-09-24 Förfarande och biogivare för analys
US10/164,652 US7332327B2 (en) 2001-09-24 2002-06-10 Method and biosensor for analysis
CNB028232828A CN1281957C (zh) 2001-09-24 2002-09-24 用于分析的方法和生物传感器
BR0212988-4A BR0212988A (pt) 2001-09-24 2002-09-24 Método e biossensor para análise
PCT/FI2002/000763 WO2003027679A1 (en) 2001-09-24 2002-09-24 Method and biosensor for analysis
EP02762479A EP1436622A1 (en) 2001-09-24 2002-09-24 Method and biosensor for analysis
JP2003531180A JP4234596B2 (ja) 2001-09-24 2002-09-24 分析のための方法及びバイオセンサー
US11/785,238 US7510882B2 (en) 2001-09-24 2007-04-16 Method and biosensor for analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20011877A FI118061B (sv) 2001-09-24 2001-09-24 Förfarande och biogivare för analys
FI20011877 2001-09-24

Publications (3)

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FI20011877A0 FI20011877A0 (sv) 2001-09-24
FI20011877A FI20011877A (sv) 2003-03-25
FI118061B true FI118061B (sv) 2007-06-15

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Country Status (7)

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US (2) US7332327B2 (sv)
EP (1) EP1436622A1 (sv)
JP (1) JP4234596B2 (sv)
CN (1) CN1281957C (sv)
BR (1) BR0212988A (sv)
FI (1) FI118061B (sv)
WO (1) WO2003027679A1 (sv)

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WO2003027679A1 (en) 2003-04-03
US7332327B2 (en) 2008-02-19
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