FI113179B - Anomeriska fluorribocylaminer - Google Patents
Anomeriska fluorribocylaminer Download PDFInfo
- Publication number
- FI113179B FI113179B FI944281A FI944281A FI113179B FI 113179 B FI113179 B FI 113179B FI 944281 A FI944281 A FI 944281A FI 944281 A FI944281 A FI 944281A FI 113179 B FI113179 B FI 113179B
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- FI
- Finland
- Prior art keywords
- formula
- compound
- reaction product
- mixture
- reaction
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
- Noodles (AREA)
Claims (10)
1. Förening enligt formel I 1 / '-V
5 R20 F eller en blandning av dess stereoisomerer; väri vardera R2 är H eller vardera R2 är en identisk eller olik hydroxi-skyddsgrupp; eller dess salt. 10
2. Förening enligt formel II .o. On / \ r2'o f eller en blandning av dess stereoisomerer; vari vardera . .j 15 R2' är en identisk eller olik hydroxiskyddsgrupp. ·. 3. Förfarande för framställning av en förening en- ; ligt formel I •V-T R‘0 F 2 0 * i eller en blandning av dess stereoisomerer; i vilken formel vardera R2' är en identisk eller olik hydroxiskyddsgrupp; » . eller dess sait, kännetecknat av att 113179 a) en förening enligt formel III li'Ol/'V "?—Γ R- Ο ΐ 5 eller en blandning av dess stereoisomerer; i vilken formel R1 är en lämnande grupp och R2’ har definierats ovan; bringas att reagera med azidnukleofil; b) reaktionsprodukten i steg a) reduceras; och c) eventuellt bildas ett sait av reaktionsproduk-10 ten i steg b).
4. Förfarande enligt patentkrav 3, känneteck-n a t av att steg a) och b) utförs i samma kari.
5. Förfarande enligt patentkrav 3, känneteck-15 n at av att steg a), b) och c) utförs i samma kari.
6. Förfarande för framställning av en förening en-liqt formel Ib : (C ib »>—r :. HO F I 20 eller en blandning av dess stereoisomerer, eller dess » · ’ sait, kännetecknat av att a) en förening enligt formel III • » » * · ^y, m RJ0 F * · » > · 113179 eller en blandning av dess stereoisomerer, i vilken formel R1 är en lämnande grupp och R2' är en identisk eller olik hydroxiskyddsgrupp; bringas att reagera med azidnukleofil; b) reaktionsprodukten i steg a) reduceras; 5 c) skyddsgruppen avlägsnas frän bäda hydroxisubs- tituenterna i reaktionsprodukten i steg b); och d) eventuellt bildas ett salt av reaktionsprodukten i steg c) .
7. Förfarande enligt patentkrav 6, känneteck-10 n a t av att steg a), b) och c) utförs i samma kari.
8. Förfarande enligt patentkrav 6, känneteck-nat av att steg a), b) , c) och d) utförs i samma kari.
9. Förfarande för framställning av en förening enligt följande formel
0. M R‘ C-ι N. Nj
15 Rl'° F väri R2' är en identisk eller olik hydroxiskyddsgrupp, j kännetecknat av att en förening enligt följande for mel 1 ΒΥ°>}
20 F väri R1 är en lämnande grupp och R2' har definierats ovan; * » · l bringas att reagera med azidreagens. > » 113179
10. Förfarande för framställning av en förening enligt följande formel R4 R“0— ’ V Q’h r2o f 5 väri R2 har definierats ovan, R3 är H, Ci-4-alkyl, brom, klor, fluor eller jod och R4 är NH2 eller OH; eller dess sait, kännetecknat av att a) en förening enligt formel III V/°vXWBl jjj „)-f
10 R‘ C F * » · ♦ . eller en blandning av dess stereoisomerer, i vilken formel
3 I ; * *. * R1 är en lämnande grupp och R2' har definierats ovan; * · bringas att reagera med azidnukleof il ; 15 b) reaktionsprodukten i steg a) reduceras; c) eventuellt bildas ett sait av reaktionsproduk- s » · ten i steg b); d) föreningen enligt formel I kondenseras med en ’ ** acyklisk förening enligt formel VI 20 .,.: r3 ‘ ‘ I ...: r5o-ch=c~c n=c*o vi Q o . väri R3 har definierats ovan och R5 är Ci-4-alkyl; 113179 e) reaktionsprodukten i steg d) cykliseras; f) eventuellt avlägsnas skyddet frän reaktionsprodukten i steg e), g) eventuellt omvandlas hydroxigruppen i 4-ställ-5 ning i reaktionsprodukten i steg f) tili en amingrupp; och h) eventuellt omvandlas reaktionsprodukten i steg g) tili ett sait. » ‘ 1 »
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/122,876 US5480992A (en) | 1993-09-16 | 1993-09-16 | Anomeric fluororibosyl amines |
US12287693 | 1993-09-16 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI944281A0 FI944281A0 (sv) | 1994-09-15 |
FI944281A FI944281A (sv) | 1995-03-17 |
FI113179B true FI113179B (sv) | 2004-03-15 |
Family
ID=22405359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI944281A FI113179B (sv) | 1993-09-16 | 1994-09-15 | Anomeriska fluorribocylaminer |
Country Status (15)
Country | Link |
---|---|
US (3) | US5480992A (sv) |
EP (1) | EP0647654B1 (sv) |
JP (1) | JP3762445B2 (sv) |
KR (1) | KR100322355B1 (sv) |
AT (1) | ATE186731T1 (sv) |
BR (1) | BR9403572A (sv) |
CA (1) | CA2130124C (sv) |
DE (1) | DE69421665T2 (sv) |
DK (1) | DK0647654T3 (sv) |
ES (1) | ES2139714T3 (sv) |
FI (1) | FI113179B (sv) |
GR (1) | GR3032603T3 (sv) |
HU (1) | HU220672B1 (sv) |
IL (2) | IL110932A (sv) |
TW (1) | TW342392B (sv) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6906495B2 (en) * | 2002-05-13 | 2005-06-14 | Splashpower Limited | Contact-less power transfer |
US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
US20070191598A1 (en) * | 2006-02-07 | 2007-08-16 | Chemagis Ltd. | Process for Preparing Gemcitabine and Associated Intermediates |
US20070249823A1 (en) * | 2006-04-20 | 2007-10-25 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
US20080262215A1 (en) * | 2007-04-23 | 2008-10-23 | Chemagis Ltd. | Gemcitabine production process |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2270235B1 (sv) * | 1974-02-15 | 1982-09-03 | Sanofi Sa | |
FR2315500A2 (fr) * | 1975-06-24 | 1977-01-21 | Labaz | Procede de preparation d'un diazidocyclohexanediol |
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
US4879377A (en) * | 1983-11-18 | 1989-11-07 | Bristol-Myers Company | Nucleoside process |
CA1264738A (en) * | 1984-12-04 | 1990-01-23 | Eli Lilly And Company | Treatment of tumors in mammals |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
JPH0232093A (ja) * | 1988-06-08 | 1990-02-01 | Merrell Dow Pharmaceut Inc | 抗レトロウィルスジフルオロ化ヌクレオシド類 |
-
1993
- 1993-09-16 US US08/122,876 patent/US5480992A/en not_active Expired - Lifetime
-
1994
- 1994-08-11 TW TW083107347A patent/TW342392B/zh not_active IP Right Cessation
- 1994-08-15 CA CA002130124A patent/CA2130124C/en not_active Expired - Fee Related
- 1994-09-12 EP EP94306670A patent/EP0647654B1/en not_active Expired - Lifetime
- 1994-09-12 DE DE69421665T patent/DE69421665T2/de not_active Expired - Lifetime
- 1994-09-12 DK DK94306670T patent/DK0647654T3/da active
- 1994-09-12 ES ES94306670T patent/ES2139714T3/es not_active Expired - Lifetime
- 1994-09-12 AT AT94306670T patent/ATE186731T1/de active
- 1994-09-12 IL IL11093294A patent/IL110932A/xx not_active IP Right Cessation
- 1994-09-14 JP JP21985394A patent/JP3762445B2/ja not_active Expired - Fee Related
- 1994-09-15 KR KR1019940023346A patent/KR100322355B1/ko not_active IP Right Cessation
- 1994-09-15 HU HU9402646A patent/HU220672B1/hu not_active IP Right Cessation
- 1994-09-15 BR BR9403572A patent/BR9403572A/pt not_active Application Discontinuation
- 1994-09-15 FI FI944281A patent/FI113179B/sv not_active IP Right Cessation
-
1995
- 1995-05-30 US US08/453,736 patent/US5541345A/en not_active Expired - Lifetime
- 1995-05-30 US US08/453,734 patent/US5594155A/en not_active Expired - Lifetime
-
2000
- 2000-02-09 GR GR20000400301T patent/GR3032603T3/el unknown
- 2000-07-10 IL IL13724800A patent/IL137248A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0647654A3 (sv) | 1995-05-03 |
DE69421665T2 (de) | 2000-05-25 |
EP0647654B1 (en) | 1999-11-17 |
KR100322355B1 (ko) | 2002-11-30 |
JPH07149783A (ja) | 1995-06-13 |
CA2130124A1 (en) | 1995-03-17 |
IL110932A0 (en) | 1994-11-28 |
US5541345A (en) | 1996-07-30 |
TW342392B (en) | 1998-10-11 |
ES2139714T3 (es) | 2000-02-16 |
HU9402646D0 (en) | 1994-12-28 |
IL137248A0 (en) | 2001-07-24 |
JP3762445B2 (ja) | 2006-04-05 |
ATE186731T1 (de) | 1999-12-15 |
IL110932A (en) | 2003-05-29 |
DK0647654T3 (da) | 2000-03-13 |
KR950008529A (ko) | 1995-04-19 |
DE69421665D1 (de) | 1999-12-23 |
CA2130124C (en) | 2004-08-10 |
US5480992A (en) | 1996-01-02 |
FI944281A0 (sv) | 1994-09-15 |
US5594155A (en) | 1997-01-14 |
EP0647654A2 (en) | 1995-04-12 |
FI944281A (sv) | 1995-03-17 |
BR9403572A (pt) | 1995-05-16 |
HUT72590A (en) | 1996-05-28 |
GR3032603T3 (en) | 2000-05-31 |
HU220672B1 (hu) | 2002-04-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |