FI112078B - Nukleosidianalogien stereoselektiivinen synteesi kaksirenkaista välituotetta käyttämällä - Google Patents

Nukleosidianalogien stereoselektiivinen synteesi kaksirenkaista välituotetta käyttämällä Download PDF

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Publication number
FI112078B
FI112078B FI950535A FI950535A FI112078B FI 112078 B FI112078 B FI 112078B FI 950535 A FI950535 A FI 950535A FI 950535 A FI950535 A FI 950535A FI 112078 B FI112078 B FI 112078B
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FI
Finland
Prior art keywords
formula
process according
halogen
compound
alkyl
Prior art date
Application number
FI950535A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI950535A (fi
FI950535A0 (fi
Inventor
Haolun Jin
Tarek S Mansour
Colleen A Evans
Arshad M Siddiqui
Allan H L Tse
Original Assignee
Shire Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Biochem Inc filed Critical Shire Biochem Inc
Publication of FI950535A publication Critical patent/FI950535A/fi
Publication of FI950535A0 publication Critical patent/FI950535A0/fi
Application granted granted Critical
Publication of FI112078B publication Critical patent/FI112078B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/08—Bridged systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI950535A 1993-06-07 1995-02-07 Nukleosidianalogien stereoselektiivinen synteesi kaksirenkaista välituotetta käyttämällä FI112078B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9311709 1993-06-07
GB939311709A GB9311709D0 (en) 1993-06-07 1993-06-07 Stereoselective synthesis of nucleoside analogues using bicycle intermediate
PCT/CA1994/000311 WO1994029301A1 (en) 1993-06-07 1994-06-07 Stereoselective synthesis of nucleoside analogues using bicyclic intermediate
CA9400311 1994-06-07

Publications (3)

Publication Number Publication Date
FI950535A FI950535A (fi) 1995-02-07
FI950535A0 FI950535A0 (fi) 1995-02-07
FI112078B true FI112078B (fi) 2003-10-31

Family

ID=10736757

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950535A FI112078B (fi) 1993-06-07 1995-02-07 Nukleosidianalogien stereoselektiivinen synteesi kaksirenkaista välituotetta käyttämällä

Country Status (22)

Country Link
US (1) US5763606A (ja)
EP (1) EP0654031B1 (ja)
JP (1) JP3110461B2 (ja)
KR (1) KR100304072B1 (ja)
CN (1) CN1046720C (ja)
AT (1) ATE188215T1 (ja)
AU (1) AU668829B2 (ja)
BR (1) BR9405423A (ja)
CA (1) CA2141029C (ja)
DE (1) DE69422374T2 (ja)
DK (1) DK0654031T3 (ja)
ES (1) ES2139744T3 (ja)
FI (1) FI112078B (ja)
GB (1) GB9311709D0 (ja)
HK (1) HK1008673A1 (ja)
HU (1) HU219199B (ja)
NO (1) NO303449B1 (ja)
NZ (1) NZ267379A (ja)
OA (1) OA10349A (ja)
PL (1) PL180870B1 (ja)
RU (1) RU2139870C1 (ja)
WO (1) WO1994029301A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684164A (en) * 1988-04-11 1997-11-04 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
WO1996012716A1 (en) * 1994-10-22 1996-05-02 Chong Kun Dang Corp. Nucleoside derivatives and process for preparing thereof
JP4249393B2 (ja) 1998-08-12 2009-04-02 トライアングル・ファーマシューティカルズ，インコーポレイテッド １，３−オキサチオランヌクレオチドの製造方法
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2308559C (en) 2000-05-16 2005-07-26 Brantford Chemicals Inc. 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues
CN102911166B (zh) * 2001-03-01 2016-08-17 基利得科学公司 顺-ftc的多晶型物及其它晶型
ES2308136T3 (es) * 2003-01-14 2008-12-01 Gilead Sciences, Inc. Composiciones y procedimientos para la politerapia antiviral.
WO2005074654A2 (en) * 2004-02-03 2005-08-18 Emory University Methods to manufacture 1,3-dioxolane nucleosides
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
AU9125991A (en) * 1990-12-05 1992-07-08 University Of Georgia Research Foundation, Inc., The Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US5332814A (en) * 1991-11-12 1994-07-26 Ciba-Geigy Corporation Process for the preparation of carbacyclic nucleosides, and intermediates

Also Published As

Publication number Publication date
ES2139744T3 (es) 2000-02-16
CN1110479A (zh) 1995-10-18
EP0654031A1 (en) 1995-05-24
KR100304072B1 (ko) 2001-11-22
HU219199B (en) 2001-03-28
JPH08505643A (ja) 1996-06-18
HU9500364D0 (en) 1995-05-29
CN1046720C (zh) 1999-11-24
DE69422374T2 (de) 2000-06-29
OA10349A (en) 2001-10-18
BR9405423A (pt) 1999-05-25
PL180870B1 (pl) 2001-04-30
HK1008673A1 (en) 1999-05-14
RU95108553A (ru) 1996-11-20
NO950432D0 (no) 1995-02-06
DE69422374D1 (de) 2000-02-03
ATE188215T1 (de) 2000-01-15
HUT73630A (en) 1996-08-28
AU668829B2 (en) 1996-05-16
DK0654031T3 (da) 2000-06-13
US5763606A (en) 1998-06-09
GB9311709D0 (en) 1993-07-21
CA2141029A1 (en) 1994-12-22
NO303449B1 (no) 1998-07-13
WO1994029301A1 (en) 1994-12-22
FI950535A (fi) 1995-02-07
NZ267379A (en) 1997-04-24
CA2141029C (en) 2000-07-25
EP0654031B1 (en) 1999-12-29
RU2139870C1 (ru) 1999-10-20
NO950432L (no) 1995-03-13
AU6966794A (en) 1995-01-03
PL307350A1 (en) 1995-05-15
JP3110461B2 (ja) 2000-11-20
FI950535A0 (fi) 1995-02-07

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US5466806A (en) Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
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US5684164A (en) Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
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FI112078B (fi) Nukleosidianalogien stereoselektiivinen synteesi kaksirenkaista välituotetta käyttämällä
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