FI105916B - Förfarande för framställning av terapeutiskt användbara 3R-3,7-difenyl-1,8-diazaspiro[5,5]undekanderivat - Google Patents
Förfarande för framställning av terapeutiskt användbara 3R-3,7-difenyl-1,8-diazaspiro[5,5]undekanderivat Download PDFInfo
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- FI105916B FI105916B FI941022A FI941022A FI105916B FI 105916 B FI105916 B FI 105916B FI 941022 A FI941022 A FI 941022A FI 941022 A FI941022 A FI 941022A FI 105916 B FI105916 B FI 105916B
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- phenyl
- compounds
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- diazaspiro
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Claims (3)
1. Förfarande för framställning av terapeutiskt användbara 3R-3,7-difenyl-l,8-diazaspiro[5,5]undekan- 5 derivat med formeln (I) eller farmaceutiskt godtagbara salter därav, H HN^S—R 10 (I) 15 där R är fenyl, som är valfritt substituerad med 1-3 substituenter, som oberoende av varandra är (Cl_6) alkyl, som valfritt är substituerad med 1-3 fluoratomer, eller (Ci-Cg) alkoxi, som valfritt är substituerad med 1-3 fluoratomer, kännetecknat därav, att man 20 (a) reducerar en förening med följande formel, : y 25 f (XVIII) ·····* O t I H IL ··· • ·· · ·«· • · · • · « där R är ovan definierad, eller ... 30 (b1) omsätter en förening med följande formel, • · • · • · · .***. H R • « · J I OH 35 *! n • · · • · · • · 25 1 0 5 9 1 6 där R är ovan definierad, med 1,1'-tiokarbonyldiimidazol eller en organisk tertiär aminbas; och , (b2) isolerar den fasta produkten frän ovannämnda reaktion och omsätter denna med azo-bis-isobutyronitril 5 och sedan med tributyltennhydrid, varvid erhälls en före-ning med formeln (XVIII), och (b3) reducerar föreningen med formeln (XVIII), och (c) sedan valfritt omvandlar den sä erhällna föreningen med formeln (I) till ett farmaceutiskt godtagbart io salt därav.
2. Förfarande enligt patentkrav 1, kanne-t e c k n a t därav, att man framställer (±) - [3R- [3a,6a(R1)]]-3-fenyl-7-fenyl-l,8-diazaspiro[5.5]undekan eller ett farmaceutiskt godtagbart salt därav. 15
3. Förfarande enligt patentkrav 1, kanne- t e c k n a t därav, att man framställer (±) - [3R- [3a,6a(R1)]]-3-(2-metoxifenyl)-7-fenyl-l,8-diazaspiro-[5.5]undekan eller ett farmaceutiskt godtagbart salt därav. • f « · • I « « < < « 1 ( ( ( ( ( I ( r « « < • · • · · » • · · · ··· • · · • · · ·»· • · • · - M« • · · • 1 M· • · • · · · · • · • 1 · • · • · • · · • · · · • · » * · » • · · • ·
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2638293A | 1993-03-04 | 1993-03-04 | |
| US2638293 | 1993-03-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI941022A0 FI941022A0 (sv) | 1994-03-03 |
| FI941022A FI941022A (sv) | 1994-09-05 |
| FI105916B true FI105916B (sv) | 2000-10-31 |
Family
ID=21831515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI941022A FI105916B (sv) | 1993-03-04 | 1994-03-03 | Förfarande för framställning av terapeutiskt användbara 3R-3,7-difenyl-1,8-diazaspiro[5,5]undekanderivat |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5688806A (sv) |
| EP (1) | EP0687268B1 (sv) |
| JP (1) | JP2832754B2 (sv) |
| CN (1) | CN1099035A (sv) |
| AT (1) | ATE166650T1 (sv) |
| AU (1) | AU6226494A (sv) |
| CA (1) | CA2157117C (sv) |
| DE (1) | DE69318854T2 (sv) |
| DK (1) | DK0687268T3 (sv) |
| ES (1) | ES2116587T3 (sv) |
| FI (1) | FI105916B (sv) |
| IL (1) | IL108769A0 (sv) |
| WO (1) | WO1994020500A1 (sv) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
| EP0655246A1 (en) * | 1993-11-30 | 1995-05-31 | Pfizer Inc. | Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria |
| US5688960A (en) * | 1995-05-02 | 1997-11-18 | Schering Corporation | Substituted oximes, hydrazones and olefins useful as neurokinin antagonists |
| US5696267A (en) * | 1995-05-02 | 1997-12-09 | Schering Corporation | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
| TW458774B (en) | 1995-10-20 | 2001-10-11 | Pfizer | Antiemetic pharmaceutical compositions |
| JP2000500760A (ja) * | 1995-11-23 | 2000-01-25 | メルク シヤープ エンド ドーム リミテツド | スピロピペリジン誘導体およびタキキニン拮抗薬としてのその使用 |
| GB9603137D0 (en) * | 1996-02-15 | 1996-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| GB9603136D0 (en) * | 1996-02-15 | 1996-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| UA49011C2 (uk) * | 1996-03-14 | 2002-09-16 | Варнер-Ламберт Компані | Похідні циклічної амінокислоти, фармацевтична композиція та спосіб лікування |
| EA001574B1 (ru) * | 1996-06-21 | 2001-06-25 | Мерк Шарп Энд Домэ Лимитед | Производные спиропиперидина и их использование в качестве терапевтических агентов |
| GB9613969D0 (en) * | 1996-07-03 | 1996-09-04 | Merck Sharp & Dohme | Therapeutic agents |
| JP2001501203A (ja) * | 1996-09-25 | 2001-01-30 | メルク シヤープ エンド ドーム リミテツド | スピロアザシクロ誘導体、該誘導体の製造およびタキキニン拮抗薬としての該誘導体の使用 |
| GB9625843D0 (en) * | 1996-12-12 | 1997-01-29 | Merck & Co Inc | Phenyl spiroethercycloalkyl tachykinn receptor antagonists |
| US5929094A (en) * | 1996-10-25 | 1999-07-27 | Merck & Co., Inc. | Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists |
| US5789422A (en) * | 1996-10-28 | 1998-08-04 | Schering Corporation | Substituted arylalkylamines as neurokinin antagonists |
| US5945428A (en) * | 1996-11-01 | 1999-08-31 | Schering Corporation | Substituted oximes, hydrazones and olefins as neurokinin antagonists |
| DE69731657T2 (de) * | 1996-12-02 | 2005-12-01 | Merck Sharp & Dohme Ltd., Hoddesdon | Die verwendung von nk-1 rezeptor antagonisten für die behandlung von substanz-verwendung störungen |
| GB9708484D0 (en) * | 1997-04-25 | 1997-06-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9711114D0 (en) * | 1997-05-29 | 1997-07-23 | Merck Sharp & Dohme | Therapeutic agents |
| US7101547B1 (en) | 1999-01-22 | 2006-09-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies |
| GB9902881D0 (en) * | 1999-02-09 | 1999-03-31 | Merck Sharp & Dohme | Therapeutic agents |
| JP2001172178A (ja) * | 1999-10-25 | 2001-06-26 | Pfizer Prod Inc | 偏頭痛治療用のｎｋ−１レセプターアンタゴニスト及びエレトリプタン |
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| EP0273659A1 (en) * | 1986-12-27 | 1988-07-06 | Takeda Chemical Industries, Ltd. | Azaspiro compounds, their production and use |
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| EP0360390A1 (en) * | 1988-07-25 | 1990-03-28 | Glaxo Group Limited | Spirolactam derivatives |
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| US5075317A (en) * | 1989-06-21 | 1991-12-24 | Fisons Corporation | Spirofurane derivatives |
| ATE115581T1 (de) * | 1991-03-01 | 1994-12-15 | Pfizer | 1-azabicyclo(3.2.2>nonan-3-aminderivate. |
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
-
1993
- 1993-12-10 US US08/513,798 patent/US5688806A/en not_active Expired - Fee Related
- 1993-12-10 AU AU62264/94A patent/AU6226494A/en not_active Abandoned
- 1993-12-10 DE DE69318854T patent/DE69318854T2/de not_active Expired - Fee Related
- 1993-12-10 WO PCT/US1993/011793 patent/WO1994020500A1/en active IP Right Grant
- 1993-12-10 JP JP6519951A patent/JP2832754B2/ja not_active Expired - Fee Related
- 1993-12-10 DK DK94909413T patent/DK0687268T3/da active
- 1993-12-10 EP EP94909413A patent/EP0687268B1/en not_active Expired - Lifetime
- 1993-12-10 CA CA002157117A patent/CA2157117C/en not_active Expired - Fee Related
- 1993-12-10 ES ES94909413T patent/ES2116587T3/es not_active Expired - Lifetime
- 1993-12-10 AT AT94909413T patent/ATE166650T1/de not_active IP Right Cessation
-
1994
- 1994-02-24 IL IL10876994A patent/IL108769A0/xx unknown
- 1994-03-03 CN CN94102227A patent/CN1099035A/zh active Pending
- 1994-03-03 FI FI941022A patent/FI105916B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0687268T3 (da) | 1998-10-12 |
| FI941022A0 (sv) | 1994-03-03 |
| IL108769A0 (en) | 1994-06-24 |
| DE69318854T2 (de) | 1998-10-08 |
| AU6226494A (en) | 1994-09-26 |
| US5688806A (en) | 1997-11-18 |
| CA2157117A1 (en) | 1994-09-15 |
| DE69318854D1 (de) | 1998-07-02 |
| WO1994020500A1 (en) | 1994-09-15 |
| CN1099035A (zh) | 1995-02-22 |
| ATE166650T1 (de) | 1998-06-15 |
| JP2832754B2 (ja) | 1998-12-09 |
| FI941022A (sv) | 1994-09-05 |
| EP0687268A1 (en) | 1995-12-20 |
| JPH08503226A (ja) | 1996-04-09 |
| ES2116587T3 (es) | 1998-07-16 |
| EP0687268B1 (en) | 1998-05-27 |
| CA2157117C (en) | 1999-01-05 |
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