ATE166650T1 - Spiroazacyclischderivate als substanz p antagonisten - Google Patents

Spiroazacyclischderivate als substanz p antagonisten

Info

Publication number
ATE166650T1
ATE166650T1 AT94909413T AT94909413T ATE166650T1 AT E166650 T1 ATE166650 T1 AT E166650T1 AT 94909413 T AT94909413 T AT 94909413T AT 94909413 T AT94909413 T AT 94909413T AT E166650 T1 ATE166650 T1 AT E166650T1
Authority
AT
Austria
Prior art keywords
pct
compounds
antagonists
substance
sec
Prior art date
Application number
AT94909413T
Other languages
English (en)
Inventor
Manoj C Desai
Lawrence A Vincent
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE166650T1 publication Critical patent/ATE166650T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
AT94909413T 1993-03-04 1993-12-10 Spiroazacyclischderivate als substanz p antagonisten ATE166650T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2638293A 1993-03-04 1993-03-04

Publications (1)

Publication Number Publication Date
ATE166650T1 true ATE166650T1 (de) 1998-06-15

Family

ID=21831515

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94909413T ATE166650T1 (de) 1993-03-04 1993-12-10 Spiroazacyclischderivate als substanz p antagonisten

Country Status (13)

Country Link
US (1) US5688806A (de)
EP (1) EP0687268B1 (de)
JP (1) JP2832754B2 (de)
CN (1) CN1099035A (de)
AT (1) ATE166650T1 (de)
AU (1) AU6226494A (de)
CA (1) CA2157117C (de)
DE (1) DE69318854T2 (de)
DK (1) DK0687268T3 (de)
ES (1) ES2116587T3 (de)
FI (1) FI105916B (de)
IL (1) IL108769A0 (de)
WO (1) WO1994020500A1 (de)

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US5929094A (en) * 1996-10-25 1999-07-27 Merck & Co., Inc. Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists
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US5945428A (en) * 1996-11-01 1999-08-31 Schering Corporation Substituted oximes, hydrazones and olefins as neurokinin antagonists
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MX2007000428A (es) 2004-07-15 2008-03-05 Amr Technology Inc Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina.
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CA2664113C (en) 2006-09-22 2013-05-28 Merck & Co., Inc. Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
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US8106086B2 (en) 2007-04-02 2012-01-31 Msd K.K. Indoledione derivative
JP5501227B2 (ja) 2007-06-27 2014-05-21 メルク・シャープ・アンド・ドーム・コーポレーション ヒストンデアセチラーゼ阻害剤としての４−カルボキシベンジルアミノ誘導体
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US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
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ES2662072T3 (es) 2009-05-12 2018-04-05 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma
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HUE044815T2 (hu) 2010-08-17 2019-11-28 Sirna Therapeutics Inc Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával
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WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
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CN103732592A (zh) 2011-04-21 2014-04-16 默沙东公司 ***-1受体抑制剂
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Also Published As

Publication number Publication date
EP0687268B1 (de) 1998-05-27
IL108769A0 (en) 1994-06-24
DE69318854T2 (de) 1998-10-08
FI941022A0 (fi) 1994-03-03
FI941022A (fi) 1994-09-05
CA2157117A1 (en) 1994-09-15
AU6226494A (en) 1994-09-26
EP0687268A1 (de) 1995-12-20
WO1994020500A1 (en) 1994-09-15
JPH08503226A (ja) 1996-04-09
DE69318854D1 (de) 1998-07-02
CN1099035A (zh) 1995-02-22
DK0687268T3 (da) 1998-10-12
JP2832754B2 (ja) 1998-12-09
CA2157117C (en) 1999-01-05
ES2116587T3 (es) 1998-07-16
FI105916B (fi) 2000-10-31
US5688806A (en) 1997-11-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee