US5393762A
(en)
*
|
1993-06-04 |
1995-02-28 |
Pfizer Inc. |
Pharmaceutical agents for treatment of emesis
|
EP0655246A1
(en)
*
|
1993-11-30 |
1995-05-31 |
Pfizer Inc. |
Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
|
US5688960A
(en)
*
|
1995-05-02 |
1997-11-18 |
Schering Corporation |
Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
|
US5696267A
(en)
*
|
1995-05-02 |
1997-12-09 |
Schering Corporation |
Substituted oximes, hydrazones and olefins as neurokinin antagonists
|
TW458774B
(en)
|
1995-10-20 |
2001-10-11 |
Pfizer |
Antiemetic pharmaceutical compositions
|
WO1997019084A1
(en)
*
|
1995-11-23 |
1997-05-29 |
Merck Sharp & Dohme Limited |
Spiro-piperidine derivatives and their use as tachykinin antagonists
|
GB9603137D0
(en)
*
|
1996-02-15 |
1996-04-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9603136D0
(en)
*
|
1996-02-15 |
1996-04-17 |
Merck Sharp & Dohme |
Therapeutic agents
|
NZ331143A
(en)
*
|
1996-03-14 |
2001-06-29 |
Warner Lambert Co |
Substituted cyclic amino acids as pharmaceutical agents
|
JP2000510153A
(ja)
*
|
1996-06-21 |
2000-08-08 |
メルク シヤープ エンド ドーム リミテツド |
スピロ―ピペリジン誘導体及び該誘導体の治療薬としての使用
|
GB9613969D0
(en)
*
|
1996-07-03 |
1996-09-04 |
Merck Sharp & Dohme |
Therapeutic agents
|
AU723414B2
(en)
*
|
1996-09-25 |
2000-08-24 |
Merck Sharp & Dohme Limited |
Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists
|
GB9625843D0
(en)
*
|
1996-12-12 |
1997-01-29 |
Merck & Co Inc |
Phenyl spiroethercycloalkyl tachykinn receptor antagonists
|
US5929094A
(en)
*
|
1996-10-25 |
1999-07-27 |
Merck & Co., Inc. |
Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists
|
US5789422A
(en)
*
|
1996-10-28 |
1998-08-04 |
Schering Corporation |
Substituted arylalkylamines as neurokinin antagonists
|
US5945428A
(en)
*
|
1996-11-01 |
1999-08-31 |
Schering Corporation |
Substituted oximes, hydrazones and olefins as neurokinin antagonists
|
DE69731657T2
(de)
*
|
1996-12-02 |
2005-12-01 |
Merck Sharp & Dohme Ltd., Hoddesdon |
Die verwendung von nk-1 rezeptor antagonisten für die behandlung von substanz-verwendung störungen
|
GB9708484D0
(en)
*
|
1997-04-25 |
1997-06-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
GB9711114D0
(en)
|
1997-05-29 |
1997-07-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
US7101547B1
(en)
|
1999-01-22 |
2006-09-05 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies
|
GB9902881D0
(en)
|
1999-02-09 |
1999-03-31 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2324116A1
(en)
*
|
1999-10-25 |
2001-04-25 |
Susan Beth Sobolov-Jaynes |
Nk-1 receptor antagonists and eletriptan for the treatment of migraine
|
AU2399601A
(en)
|
1999-12-21 |
2001-07-03 |
Takeda Chemical Industries Ltd. |
Novel tachykinin-like polypeptides and use thereof
|
US20020049211A1
(en)
*
|
2000-09-06 |
2002-04-25 |
Sobolov-Jaynes Susan Beth |
Combination treatment for depression and anxiety
|
EP1192952A3
(en)
*
|
2000-09-28 |
2003-03-26 |
Pfizer Products Inc. |
Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
|
CZ200434A3
(cs)
*
|
2001-07-20 |
2005-02-16 |
Pfizer Products Inc. |
Léčivo pro léčení abnormálního úzkosného chování u domácích zvířat a způsob screeningu zkoušené sloučeniny za účelem stanovení anxiolytické účinnosti u psů
|
ZA200701232B
(en)
|
2004-07-15 |
2008-08-27 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
|
JP2008510711A
(ja)
*
|
2004-08-20 |
2008-04-10 |
ターガセプト,インコーポレイテッド |
嗜癖治療におけるn−アリールジアザスピラ環状化合物の使用
|
ATE550019T1
(de)
|
2005-05-17 |
2012-04-15 |
Merck Sharp & Dohme |
Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
|
US7956050B2
(en)
|
2005-07-15 |
2011-06-07 |
Albany Molecular Research, Inc. |
Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
EP1940842B1
(en)
|
2005-09-29 |
2012-05-30 |
Merck Sharp & Dohme Corp. |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
EP2698157B1
(en)
|
2006-09-22 |
2015-05-20 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
EP2109608B1
(en)
|
2007-01-10 |
2011-03-23 |
Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. |
Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
|
AU2008233662B2
(en)
|
2007-04-02 |
2012-08-23 |
Msd K.K. |
Indoledione derivative
|
US8389553B2
(en)
|
2007-06-27 |
2013-03-05 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
CN102014631A
(zh)
|
2008-03-03 |
2011-04-13 |
泰格尔医药科技公司 |
酪氨酸激酶抑制剂
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
EP2413932A4
(en)
|
2009-04-01 |
2012-09-19 |
Merck Sharp & Dohme |
INHIBITORS OF AKT ACTIVITY
|
WO2010132437A1
(en)
|
2009-05-12 |
2010-11-18 |
Albany Molecular Research, Inc. |
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
|
JP5739415B2
(ja)
|
2009-05-12 |
2015-06-24 |
ブリストル−マイヤーズ スクウィブ カンパニー |
(S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用
|
CA2760837C
(en)
|
2009-05-12 |
2018-04-03 |
Albany Molecular Research, Inc. |
7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
|
EP2488028B1
(en)
|
2009-10-14 |
2020-08-19 |
Merck Sharp & Dohme Corp. |
Substituted piperidines that increase p53 activity and the uses thereof
|
AU2011261375B2
(en)
|
2010-06-04 |
2016-09-22 |
Albany Molecular Research, Inc. |
Glycine transporter-1 inhibitors, methods of making them, and uses thereof
|
WO2011163330A1
(en)
|
2010-06-24 |
2011-12-29 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
CN103068980B
(zh)
|
2010-08-02 |
2017-04-05 |
瑟纳治疗公司 |
使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制
|
KR102072631B1
(ko)
|
2010-08-17 |
2020-02-03 |
시르나 쎄러퓨틱스 인코퍼레이티드 |
짧은 간섭 핵산 (siNA)을 사용한 B형 간염 바이러스 (HBV) 유전자 발현의 RNA 간섭 매개 억제
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
EP3766975A1
(en)
|
2010-10-29 |
2021-01-20 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
WO2012087772A1
(en)
|
2010-12-21 |
2012-06-28 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
US20140046059A1
(en)
|
2011-04-21 |
2014-02-13 |
Piramal Enterprises Limited |
Process for the preparation of morpholino sulfonyl indole derivatives
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
US20150299696A1
(en)
|
2012-05-02 |
2015-10-22 |
Sirna Therapeutics, Inc. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
WO2014052563A2
(en)
|
2012-09-28 |
2014-04-03 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
JP6440625B2
(ja)
|
2012-11-14 |
2018-12-19 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
精神***病を処置するための方法および組成物
|
ES2651347T3
(es)
|
2012-11-28 |
2018-01-25 |
Merck Sharp & Dohme Corp. |
Composiciones y métodos para el tratamiento del cáncer
|
CA2895504A1
(en)
|
2012-12-20 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Substituted imidazopyridines as hdm2 inhibitors
|
US9540377B2
(en)
|
2013-01-30 |
2017-01-10 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as HDM2 inhibitors
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
US10947234B2
(en)
|
2017-11-08 |
2021-03-16 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
WO2020033284A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|