ES8800571A1 - Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona. - Google Patents

Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona.

Info

Publication number
ES8800571A1
ES8800571A1 ES543517A ES543517A ES8800571A1 ES 8800571 A1 ES8800571 A1 ES 8800571A1 ES 543517 A ES543517 A ES 543517A ES 543517 A ES543517 A ES 543517A ES 8800571 A1 ES8800571 A1 ES 8800571A1
Authority
ES
Spain
Prior art keywords
oxazolidine
derivatives
medicinal
halogen
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543517A
Other languages
English (en)
Other versions
ES543517A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Publication of ES8800571A1 publication Critical patent/ES8800571A1/es
Publication of ES543517A0 publication Critical patent/ES543517A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE 1,3-OXAZOLIDINA-2-ONA, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS DEL MISMO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), EN LA QUE R ES UN GRUPO ALQUILO DE CADENA RECTA O RAMIFICADA QUE TIENE ENTRE 3 Y 8 ATOMOS DE CARBONO; X ES UN ATOMO DE HIDROGENO, HALOGENO O UN GRUPO ALQUILO C1-C3; Y N ES UN NUMERO ENTERO COMPRENDIDO ENTRE 4 Y 6, CON UN DERIVADO DE ACIDO CARBOXILICO DE FORMULA GENERAL (III), EN LA QUE A ES UN ATOMO DE HALOGENO O UN GRUPO ALCOXILO C1-C3 O TRICLOROMETILOXI, A UNA TEMPERATURA COMPRENDIDA ENTRE -15 Y 40 GRADOS, Y EN PRESENCIA DE UNA BASE. DE APLICACION COMO AGENTES NEUROTRANSMIDORES EXCITANTES DEL SISTEMA NERVIOSO. *FORMULA*
ES543517A 1984-09-28 1985-05-27 Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona. Expired ES8800571A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59203624A JPS6183170A (ja) 1984-09-28 1984-09-28 新規な１，３−オキサゾリジン−２−オン誘導体およびその製造法

Publications (2)

Publication Number Publication Date
ES8800571A1 true ES8800571A1 (es) 1987-11-01
ES543517A0 ES543517A0 (es) 1987-11-01

Family

ID=16477122

Family Applications (2)

Application Number Title Priority Date Filing Date
ES543517A Expired ES8800571A1 (es) 1984-09-28 1985-05-27 Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona.
ES557075A Expired ES8802152A1 (es) 1984-09-28 1986-09-18 Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557075A Expired ES8802152A1 (es) 1984-09-28 1986-09-18 Procedimiento para preparar un derivado de 1,3-oxazolidina-2-ona.

Country Status (27)

Country Link
US (1) US4644063A (es)
JP (1) JPS6183170A (es)
KR (1) KR900004323B1 (es)
AR (1) AR240924A1 (es)
AT (1) AT392069B (es)
AU (1) AU566419B2 (es)
BR (1) BR8502707A (es)
CA (1) CA1252092A (es)
CH (1) CH663207A5 (es)
CS (1) CS273606B2 (es)
DE (1) DE3519261C2 (es)
DK (1) DK165952C (es)
ES (2) ES8800571A1 (es)
FR (1) FR2571052B1 (es)
GB (2) GB8512975D0 (es)
HU (1) HU199132B (es)
IN (1) IN162060B (es)
IT (1) IT1208807B (es)
MX (2) MX161397A (es)
MY (1) MY102081A (es)
NL (1) NL193191C (es)
NZ (1) NZ212143A (es)
PH (1) PH20852A (es)
RO (1) RO91422B (es)
SE (1) SE463100B (es)
SU (2) SU1402263A3 (es)
ZA (1) ZA854001B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6183147A (ja) * 1984-09-28 1986-04-26 Nippon Chemiphar Co Ltd 新規なアミノアルコール誘導体およびその製造法並びにそれを有効成分とするグルタミン酸遮断剤
JPH0759570B2 (ja) * 1986-05-06 1995-06-28 三井東圧化学株式会社 ２−オキサゾリジノン類の製造方法
JPH0713017B2 (ja) * 1986-06-18 1995-02-15 日本ケミファ株式会社 脳細胞保護作用を有する医薬組成物
ES2053748T3 (es) * 1987-09-10 1994-08-01 Merck Sharp & Dohme Oxazoles y tiazoles para el tratamiento de la demencia senil.
ATE106243T1 (de) * 1988-03-24 1994-06-15 Sankyo Co Verwendung von isoxazolinonen als cerebro-aktive medikamente.
JPH0314562A (ja) * 1988-04-11 1991-01-23 Nippon Chemiphar Co Ltd 新規なアルキレンジアミン誘導体およびグルタミン酸遮断剤
US5187171A (en) * 1989-01-09 1993-02-16 G. D. Searle & Co. Use of a glycine b partial agonist as an antipsychotic
TW300895B (es) * 1992-07-14 1997-03-21 Nippon Chemiphar Co
ATE161533T1 (de) * 1993-09-15 1998-01-15 Merck Sharp & Dohme Imidanolon- und oxanolonderivate als dopaminantagonisten
DE4425613A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
US6037354A (en) * 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
AU2014230940B2 (en) 2013-03-14 2016-12-08 Akzo Nobel Chemicals International B.V. Cellulose ether as a drift control agent and rainfastness agent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2437389A (en) * 1948-03-09 Oxazoeidones and erocesstok
DE1135461B (de) * 1959-05-08 1962-08-30 Knoll Ag Verfahren zur Herstellung von basisch substituierten Phthalimidinen
FR1301267A (fr) * 1961-04-04 1962-08-17 Science Union Et Compagnie Soc Nouveaux dérivés de l'oxazolidinone-2 et leurs procédés de préparation
US3131197A (en) * 1963-03-13 1964-04-28 Smith Kline French Lab 5-(3, 4-carbonyldioxyphenyl)-3-isopropyl-2-oxazolidone
US3576808A (en) * 1967-09-15 1971-04-27 Miles Lab N-4-phenyl-1-piperazinylalkyl-5-phenyl-oxazolidinones
GB1222708A (en) * 1968-10-22 1971-02-17 Delalande Sa Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation
FR2179582B1 (es) * 1972-04-13 1975-10-10 Synthelabo

Also Published As

Publication number Publication date
ATA165685A (de) 1990-07-15
GB2165237A (en) 1986-04-09
GB8512975D0 (en) 1985-06-26
SE8502525L (sv) 1986-03-29
RO91422A (ro) 1987-06-30
IT1208807B (it) 1989-07-10
NL193191C (nl) 1999-02-02
AR240924A2 (es) 1991-03-27
HU199132B (en) 1990-01-29
PH20852A (en) 1987-05-19
MY102081A (en) 1992-03-31
FR2571052A1 (fr) 1986-04-04
HUT39168A (en) 1986-08-28
ZA854001B (en) 1986-01-29
GB2165237B (en) 1987-12-09
DK230185A (da) 1986-03-29
NL8501579A (nl) 1986-04-16
AU566419B2 (en) 1987-10-22
BR8502707A (pt) 1986-05-27
GB8513685D0 (en) 1985-07-03
FR2571052B1 (fr) 1988-03-04
DK165952C (da) 1993-07-05
JPS6183170A (ja) 1986-04-26
JPH0469150B2 (es) 1992-11-05
DE3519261C2 (de) 1997-01-16
NZ212143A (en) 1987-11-27
IT8567500A0 (it) 1985-05-30
DK230185D0 (da) 1985-05-23
MX161397A (es) 1990-09-20
US4644063A (en) 1987-02-17
DK165952B (da) 1993-02-15
SE463100B (sv) 1990-10-08
CH663207A5 (fr) 1987-11-30
CS392785A2 (en) 1990-08-14
RO91422B (ro) 1987-07-02
ES8802152A1 (es) 1988-04-01
ES543517A0 (es) 1987-11-01
KR900004323B1 (ko) 1990-06-22
AT392069B (de) 1991-01-25
CS273606B2 (en) 1991-03-12
NL193191B (nl) 1998-10-01
SU1431679A3 (ru) 1988-10-15
IN162060B (es) 1988-03-19
AU4469785A (en) 1986-04-10
ES557075A0 (es) 1988-04-01
AR240924A1 (es) 1991-03-27
SU1402263A3 (ru) 1988-06-07
MX21592A (es) 1994-01-31
SE8502525D0 (sv) 1985-05-22
DE3519261A1 (de) 1986-04-10
KR860002502A (ko) 1986-04-26
CA1252092A (en) 1989-04-04

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