ES8700324A1 - Un metodo de detectar un primer compuesto que comprende al menos un resto de base en una muesta - Google Patents
Un metodo de detectar un primer compuesto que comprende al menos un resto de base en una muestaInfo
- Publication number
- ES8700324A1 ES8700324A1 ES539316A ES539316A ES8700324A1 ES 8700324 A1 ES8700324 A1 ES 8700324A1 ES 539316 A ES539316 A ES 539316A ES 539316 A ES539316 A ES 539316A ES 8700324 A1 ES8700324 A1 ES 8700324A1
- Authority
- ES
- Spain
- Prior art keywords
- polynucleotides
- utilizing
- preparing
- methods
- labeled nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
METODO DE DETECCION DE UN PRIMER COMPUESTO QUE COMPRENDE AL MENOS UN RESTO DE BASE EN UNA MUESTRA, EMPLEANDO NUCLEOTIDOS O POLINUCLEOTIDOS QUE SE MARCAN RADIACTIVAMENTE CON ISOTOPOS O HIDROGENO (3H), FOSFORO (32P), CARBONO (14C) O YODO (125I). EL METODO COMPRENDE LAS OPERACIONES DE PONER EN CONTACTO UN PRIMER COMPUESTO CON UN SEGUNDO COMPUESTO QUE TIENE UNIDO COVALENTEMENTE UN RESTO DE BASE, UN RESTO DE AZUCAR Y UN RESTO QUE CONTIENE P, POR UN RESTO QUIMICO CAPAZ DE COMPLEJAR IONES. LOS NUCLEOTIDOS MODIFICADOS DE ACUERDO CON ESTE INVENTO Y MARCADO RADIACTIVAMENTE CON HIDRO-3, FOSFORO-32, CARBONO-14 O YODO-125 SON UTILES PARA DETECTAR, COMPROBAR, LOCALIZAR Y AISLAR ACIDOS NUCLEICOS Y OTRAS MOLECULAS DE INTERES CIENTIFICO O CLINICO, Y COMO SONDAS EN INVESTIGACION BIOMEDICA, DIAGNOSIS CLINICA Y TECNOLOGIA DE ADN RECOMBINANTE. INCLUSO DETECTAR E IDENTIFICAR AGENTES ETIOLOGICOS QUE CONTIENE ACIDO NUCLEICO Y SELECCIONAR BACTERIAS PARA LA RESISTENCIA A LOS ANTIBIOTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39144082A | 1982-06-23 | 1982-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES539316A0 ES539316A0 (es) | 1986-10-01 |
ES8700324A1 true ES8700324A1 (es) | 1986-10-01 |
Family
ID=23546604
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523503A Expired ES8700270A1 (es) | 1982-06-23 | 1983-06-22 | Un metodo para producir nucleotidos. |
ES539316A Expired ES8700324A1 (es) | 1982-06-23 | 1985-01-02 | Un metodo de detectar un primer compuesto que comprende al menos un resto de base en una muesta |
ES547319A Expired ES8802257A1 (es) | 1982-06-23 | 1985-09-26 | Un metodo para detectar cuantitativamente una secuencia seleccionada de oligo-o-poli-desoxinucleotido en una muestra. |
ES547320A Expired ES8606903A1 (es) | 1982-06-23 | 1985-09-26 | Un metodo para entregar un agente seleccionado a un lugar biologico caracterizado por la presencia de una secuencia de adn seleccionada. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523503A Expired ES8700270A1 (es) | 1982-06-23 | 1983-06-22 | Un metodo para producir nucleotidos. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES547319A Expired ES8802257A1 (es) | 1982-06-23 | 1985-09-26 | Un metodo para detectar cuantitativamente una secuencia seleccionada de oligo-o-poli-desoxinucleotido en una muestra. |
ES547320A Expired ES8606903A1 (es) | 1982-06-23 | 1985-09-26 | Un metodo para entregar un agente seleccionado a un lugar biologico caracterizado por la presencia de una secuencia de adn seleccionada. |
Country Status (11)
Country | Link |
---|---|
US (2) | US6992180B1 (es) |
EP (7) | EP0285058A3 (es) |
JP (4) | JP2625095B2 (es) |
AT (3) | ATE119164T1 (es) |
AU (2) | AU585199B2 (es) |
CA (1) | CA1223831A (es) |
DE (3) | DE3382782T2 (es) |
DK (1) | DK291183A (es) |
ES (4) | ES8700270A1 (es) |
IL (1) | IL69051A (es) |
NO (1) | NO832292L (es) |
Families Citing this family (207)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2540122B1 (fr) * | 1983-01-27 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application |
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US4948882A (en) * | 1983-02-22 | 1990-08-14 | Syngene, Inc. | Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis |
CA1254525A (en) * | 1983-04-13 | 1989-05-23 | Christine L. Brakel | Kit for terminally chemically labeling dna |
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CA1228811A (en) | 1983-05-05 | 1987-11-03 | Robert G. Pergolizzi | Assay method utilizing polynucleotide sequences |
JPH0743376B2 (ja) * | 1983-05-31 | 1995-05-15 | オルジェニックス リミテッド | 核酸配列の検定方法及び分子遺伝子プローブ |
CA1338856C (en) * | 1983-07-05 | 1997-01-21 | Jannis Stavrianopoulos | In vivo labelling of polynucleotide sequences |
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USRE43096E1 (en) | 1984-01-16 | 2012-01-10 | California Institute Of Technology | Tagged extendable primers and extension products |
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US4748111A (en) * | 1984-03-12 | 1988-05-31 | Molecular Diagnostics, Inc. | Nucleic acid-protein conjugate used in immunoassay |
CA1260372A (en) * | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
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US4766062A (en) * | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
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US4957858A (en) * | 1986-04-16 | 1990-09-18 | The Salk Instute For Biological Studies | Replicative RNA reporter systems |
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1983
- 1983-06-21 CA CA000430882A patent/CA1223831A/en not_active Expired
- 1983-06-22 AT AT88104961T patent/ATE119164T1/de not_active IP Right Cessation
- 1983-06-22 EP EP19880104962 patent/EP0285058A3/en not_active Withdrawn
- 1983-06-22 EP EP88104961A patent/EP0285057B1/en not_active Revoked
- 1983-06-22 EP EP88104963A patent/EP0286898B1/en not_active Revoked
- 1983-06-22 EP EP94105993A patent/EP0618228A1/en not_active Withdrawn
- 1983-06-22 DE DE3382782T patent/DE3382782T2/de not_active Expired - Lifetime
- 1983-06-22 AT AT88104963T patent/ATE165605T1/de not_active IP Right Cessation
- 1983-06-22 EP EP83106112A patent/EP0097373B1/en not_active Expired - Lifetime
- 1983-06-22 DE DE8383106112T patent/DE3382626T2/de not_active Expired - Lifetime
- 1983-06-22 ES ES523503A patent/ES8700270A1/es not_active Expired
- 1983-06-22 EP EP19880104965 patent/EP0302175A3/en not_active Withdrawn
- 1983-06-22 AT AT83106112T patent/ATE81342T1/de not_active IP Right Cessation
- 1983-06-22 EP EP19880104964 patent/EP0285950A3/en not_active Ceased
- 1983-06-22 IL IL69051A patent/IL69051A/xx unknown
- 1983-06-22 DE DE3382822T patent/DE3382822T2/de not_active Expired - Lifetime
- 1983-06-23 AU AU16179/83A patent/AU585199B2/en not_active Ceased
- 1983-06-23 DK DK291183A patent/DK291183A/da not_active Application Discontinuation
- 1983-06-23 JP JP58113599A patent/JP2625095B2/ja not_active Expired - Lifetime
- 1983-06-23 NO NO832292A patent/NO832292L/no unknown
-
1985
- 1985-01-02 ES ES539316A patent/ES8700324A1/es not_active Expired
- 1985-09-26 ES ES547319A patent/ES8802257A1/es not_active Expired
- 1985-09-26 ES ES547320A patent/ES8606903A1/es not_active Expired
-
1989
- 1989-09-15 AU AU41493/89A patent/AU4149389A/en not_active Abandoned
-
1993
- 1993-06-10 JP JP5177184A patent/JP2760466B2/ja not_active Expired - Lifetime
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1995
- 1995-06-07 US US08/479,997 patent/US6992180B1/en not_active Expired - Lifetime
- 1995-06-07 US US08/486,069 patent/US8097405B1/en active Active
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1997
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1999
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