JPS5742632A - Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same - Google Patents
Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the sameInfo
- Publication number
- JPS5742632A JPS5742632A JP55119313A JP11931380A JPS5742632A JP S5742632 A JPS5742632 A JP S5742632A JP 55119313 A JP55119313 A JP 55119313A JP 11931380 A JP11931380 A JP 11931380A JP S5742632 A JPS5742632 A JP S5742632A
- Authority
- JP
- Japan
- Prior art keywords
- double
- glutamic acid
- chain dna
- preparation
- reactions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:Double-chain DNA bonded to D-glutamic acid-D-lysine copolymer. The appearance: amorphous white powder; melting point: 263W264°C (decomp.); solubility: soluble in water, 0.01M phosphoric acid buffer solution and physiological saline; insoluble in methanol, acetone, ethyl acetate; specific rotatory power [α]D25=+36.67; pH: 5.8W6.0 (in 1.2% aqueous solution); color reactions: positive to α-naphthol and diphenylamine reactions, negative to Liebermann, Zimmermann and ferric chloride reactions; elementary analyses (%): C 42, H 6, N 13.
USE: A remedy for autoimmune diseases such as systemic lupus erythematosus.
PREPARATION: DNA is treated into double-chain DNA, which is oxidized with an oxidizing agent such as sodium periodate. The oxidized product is made to react with D-glutamic acid-D-lysine copolymer and reduced with sodium borohydride or the like to produce the objective compound.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55119313A JPS5742632A (en) | 1980-08-29 | 1980-08-29 | Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55119313A JPS5742632A (en) | 1980-08-29 | 1980-08-29 | Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5742632A true JPS5742632A (en) | 1982-03-10 |
Family
ID=14758342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55119313A Pending JPS5742632A (en) | 1980-08-29 | 1980-08-29 | Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5742632A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0192660A (en) * | 1987-01-30 | 1989-04-11 | Nippon Dpc Corp | Measurement of anti-dna antibody value in biological liquid and kit therefor |
US5091374A (en) * | 1987-07-17 | 1992-02-25 | Hem Research Inc. | Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function |
US6992180B1 (en) | 1982-06-23 | 2006-01-31 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides |
US7220854B1 (en) | 1982-06-23 | 2007-05-22 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides |
-
1980
- 1980-08-29 JP JP55119313A patent/JPS5742632A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6992180B1 (en) | 1982-06-23 | 2006-01-31 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides |
US7220854B1 (en) | 1982-06-23 | 2007-05-22 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides |
US8097405B1 (en) | 1982-06-23 | 2012-01-17 | Enzo Biochem, Inc. | Nucleic acid sequencing processes using non-radioactive detectable modified or labeled nucleotides or nucleotide analogs, and other processes for nucleic acid detection and chromosomal characterization using such non-radioactive detectable modified or labeled nucleotides or nucleotide analogs |
JPH0192660A (en) * | 1987-01-30 | 1989-04-11 | Nippon Dpc Corp | Measurement of anti-dna antibody value in biological liquid and kit therefor |
JPH0562301B2 (en) * | 1987-01-30 | 1993-09-08 | Nitsuhon Deii Pii Shii Corp | |
US5091374A (en) * | 1987-07-17 | 1992-02-25 | Hem Research Inc. | Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function |
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