JPS5742632A - Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same - Google Patents

Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same

Info

Publication number
JPS5742632A
JPS5742632A JP55119313A JP11931380A JPS5742632A JP S5742632 A JPS5742632 A JP S5742632A JP 55119313 A JP55119313 A JP 55119313A JP 11931380 A JP11931380 A JP 11931380A JP S5742632 A JPS5742632 A JP S5742632A
Authority
JP
Japan
Prior art keywords
double
glutamic acid
chain dna
preparation
reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55119313A
Other languages
Japanese (ja)
Inventor
Takeshi Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP55119313A priority Critical patent/JPS5742632A/en
Publication of JPS5742632A publication Critical patent/JPS5742632A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:Double-chain DNA bonded to D-glutamic acid-D-lysine copolymer. The appearance: amorphous white powder; melting point: 263W264°C (decomp.); solubility: soluble in water, 0.01M phosphoric acid buffer solution and physiological saline; insoluble in methanol, acetone, ethyl acetate; specific rotatory power [α]D25=+36.67; pH: 5.8W6.0 (in 1.2% aqueous solution); color reactions: positive to α-naphthol and diphenylamine reactions, negative to Liebermann, Zimmermann and ferric chloride reactions; elementary analyses (%): C 42, H 6, N 13.
USE: A remedy for autoimmune diseases such as systemic lupus erythematosus.
PREPARATION: DNA is treated into double-chain DNA, which is oxidized with an oxidizing agent such as sodium periodate. The oxidized product is made to react with D-glutamic acid-D-lysine copolymer and reduced with sodium borohydride or the like to produce the objective compound.
COPYRIGHT: (C)1982,JPO&Japio
JP55119313A 1980-08-29 1980-08-29 Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same Pending JPS5742632A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55119313A JPS5742632A (en) 1980-08-29 1980-08-29 Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55119313A JPS5742632A (en) 1980-08-29 1980-08-29 Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same

Publications (1)

Publication Number Publication Date
JPS5742632A true JPS5742632A (en) 1982-03-10

Family

ID=14758342

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55119313A Pending JPS5742632A (en) 1980-08-29 1980-08-29 Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same

Country Status (1)

Country Link
JP (1) JPS5742632A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0192660A (en) * 1987-01-30 1989-04-11 Nippon Dpc Corp Measurement of anti-dna antibody value in biological liquid and kit therefor
US5091374A (en) * 1987-07-17 1992-02-25 Hem Research Inc. Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function
US6992180B1 (en) 1982-06-23 2006-01-31 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides
US7220854B1 (en) 1982-06-23 2007-05-22 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6992180B1 (en) 1982-06-23 2006-01-31 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides
US7220854B1 (en) 1982-06-23 2007-05-22 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides
US8097405B1 (en) 1982-06-23 2012-01-17 Enzo Biochem, Inc. Nucleic acid sequencing processes using non-radioactive detectable modified or labeled nucleotides or nucleotide analogs, and other processes for nucleic acid detection and chromosomal characterization using such non-radioactive detectable modified or labeled nucleotides or nucleotide analogs
JPH0192660A (en) * 1987-01-30 1989-04-11 Nippon Dpc Corp Measurement of anti-dna antibody value in biological liquid and kit therefor
JPH0562301B2 (en) * 1987-01-30 1993-09-08 Nitsuhon Deii Pii Shii Corp
US5091374A (en) * 1987-07-17 1992-02-25 Hem Research Inc. Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function

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