ES8604590A1 - Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas. - Google Patents

Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas.

Info

Publication number
ES8604590A1
ES8604590A1 ES544417A ES544417A ES8604590A1 ES 8604590 A1 ES8604590 A1 ES 8604590A1 ES 544417 A ES544417 A ES 544417A ES 544417 A ES544417 A ES 544417A ES 8604590 A1 ES8604590 A1 ES 8604590A1
Authority
ES
Spain
Prior art keywords
alkyl
pyrimido
piperazino
pyrimidines
alkylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES544417A
Other languages
English (en)
Other versions
ES544417A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES544417A0 publication Critical patent/ES544417A0/es
Publication of ES8604590A1 publication Critical patent/ES8604590A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 8-ALQUILTIO-2-PIPERAZINO-PIRIMIDO5,4-DPIRIMIDINAS, DE FORMULA GENERAL (I), EN LA QUE R1 SIGNIFICA UN GRUPO ALQUILO CON 1 A 6 ATOMOS DE CARBONO, EVENTUALMENTE SUSTITUIDO CON UN GRUPO HIDROXI A PARTIR DEL CARBONO 2; Y R3 SIGNIFICA UN GRUPO ALILO, UN GRUPO ALQUILO CON 1 A 6 ATOMOS DE CARBONO O UN GRUPO CICLOALQUILO, Y SUS SALES DE ADICION DE ACIDOS ORGANICOS O INORGANICOS, FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UNA PIRIMIDO5,4-DPIRIMIDINA, DE FORMULA GENERAL (II), EN LA QUE X REPRESENTA UN GRUPO LABIL NUCLEOFUGO, CON UNA PIPERAZINA, DE FORMULA GENERAL (III), EN LA QUE R4 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO PROTECTOR SEPARABLE. DE APLICACION EN MEDICINA Y FARMACIA POR SU EFECTO INHIBITORIO DE PDE DE TUMORES, POR SU EFECTO INHIBITORIO DE METASTASIS Y POR SU EFECTO INHIBITORIO SOBRE EL CRECIMIENTO DE TUMORES.
ES544417A 1984-06-22 1985-06-21 Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas. Expired ES8604590A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843423092 DE3423092A1 (de) 1984-06-22 1984-06-22 Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES544417A0 ES544417A0 (es) 1986-02-01
ES8604590A1 true ES8604590A1 (es) 1986-02-01

Family

ID=6238919

Family Applications (1)

Application Number Title Priority Date Filing Date
ES544417A Expired ES8604590A1 (es) 1984-06-22 1985-06-21 Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas.

Country Status (19)

Country Link
US (1) US4714698A (es)
EP (1) EP0167817B1 (es)
JP (1) JPH0694465B2 (es)
KR (1) KR920007435B1 (es)
AT (1) ATE46511T1 (es)
AU (1) AU579869B2 (es)
CA (1) CA1241325A (es)
DE (2) DE3423092A1 (es)
DK (1) DK282285A (es)
ES (1) ES8604590A1 (es)
FI (1) FI80455C (es)
GR (1) GR851467B (es)
IE (1) IE58432B1 (es)
IL (1) IL75596A0 (es)
NO (1) NO161620C (es)
NZ (1) NZ212515A (es)
PH (1) PH21319A (es)
PT (1) PT80670B (es)
ZA (1) ZA854683B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH075594B2 (ja) * 1986-03-25 1995-01-25 三井石油化学工業株式会社 新規ピリドピリミジン誘導体
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW414798B (en) * 1994-09-07 2000-12-11 Thomae Gmbh Dr K Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
EP1660092A2 (en) 2003-07-03 2006-05-31 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
EP1833482A4 (en) 2005-01-03 2011-02-16 Myriad Genetics Inc COMPOUNDS AND ITS THERAPEUTIC USE
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP2029600B1 (de) * 2006-05-24 2012-03-14 Boehringer Ingelheim International GmbH Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1116676B (de) * 1955-03-14 1961-11-09 Thomae Gmbh Dr K Verfahren zur Herstellung von Pyrimido [5, 4-d] pyrimidinen
US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
US3322755A (en) * 1964-03-10 1967-05-30 Boehringer Sohn Ingelheim Basic-substituted 1, 2, 3, 4-tetrahydropyrimido [5, 4-d]-pyrimidines
GB1190419A (en) * 1966-08-16 1970-05-06 Yamanouchi Pharma Co Ltd Substituted Pyrimido-Pyrimidines and a process for the preparation thereof
DE2926804A1 (de) * 1979-07-03 1981-01-22 Thomae Gmbh Dr K Neue 2-(perhydro-1,4-diazino)-pyrimido- eckige klammer auf 5,4-d eckige klammer zu pyrimidine, deren herstellung und verwendung als arzneimittel
DE3069211D1 (en) * 1979-07-03 1984-10-25 Thomae Gmbh Dr K 2-(perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
FI80455B (fi) 1990-02-28
AU4396885A (en) 1986-01-02
PT80670A (de) 1985-07-01
CA1241325A (en) 1988-08-30
DE3423092A1 (de) 1986-01-02
DK282285A (da) 1985-12-23
PT80670B (de) 1987-05-08
AU579869B2 (en) 1988-12-15
FI852445L (fi) 1985-12-23
NZ212515A (en) 1988-10-28
JPS6115883A (ja) 1986-01-23
NO852514L (no) 1985-12-23
US4714698A (en) 1987-12-22
NO161620C (no) 1989-09-06
ZA854683B (en) 1987-02-25
PH21319A (en) 1987-09-28
ES544417A0 (es) 1986-02-01
IE851545L (en) 1985-12-22
KR920007435B1 (ko) 1992-09-01
KR860000287A (ko) 1986-01-27
DK282285D0 (da) 1985-06-21
IE58432B1 (en) 1993-09-22
FI852445A0 (fi) 1985-06-20
JPH0694465B2 (ja) 1994-11-24
DE3573119D1 (en) 1989-10-26
EP0167817A1 (de) 1986-01-15
GR851467B (es) 1985-11-25
FI80455C (fi) 1990-06-11
IL75596A0 (en) 1985-10-31
NO161620B (no) 1989-05-29
EP0167817B1 (de) 1989-09-20
ATE46511T1 (de) 1989-10-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612