ES8506575A1 - Procedimiento para la preparacion de nuevos derivados de acidos fenilalcanoicos. - Google Patents

Procedimiento para la preparacion de nuevos derivados de acidos fenilalcanoicos.

Info

Publication number
ES8506575A1
ES8506575A1 ES531814A ES531814A ES8506575A1 ES 8506575 A1 ES8506575 A1 ES 8506575A1 ES 531814 A ES531814 A ES 531814A ES 531814 A ES531814 A ES 531814A ES 8506575 A1 ES8506575 A1 ES 8506575A1
Authority
ES
Spain
Prior art keywords
preparation
new
acid derivatives
phenylalkanoic acid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531814A
Other languages
English (en)
Other versions
ES531814A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8506575A1 publication Critical patent/ES8506575A1/es
Publication of ES531814A0 publication Critical patent/ES531814A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/54—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings and other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDOS FENILALCANOICOS Y DE SUS SALES Y ESTERES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES HIDROGENO O ALQUILO C1-3.CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); SEGUIDA DE LA EVENTUAL SALIFICACION O ESTERIFICACION DEL PRODUCTO FORMADO. LA REDUCCION SE PUEDE LLEVAR A CABO EN UNA SOLA ETAPA, CON UN BOROHIDRURO, EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE LA DEL BAN/O DE HIELO Y LA DE REFLUJO DEL DISOLVENTE; O BIEN EN DOS ETAPAS, PRIMERO REDUCCION AL CORRESPONDIENTE COMPUESTO HIDROXI CON LOS REACTIVOS ANTERIORES, SEGUIDA DE REDUCCION CATALICITA, CON HIDROGENO Y UN CATALIZADOR DE CLORURO DE PALADIO O DE PLATINO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANALGESICA, ANTIINFLAMATORIA E INMUNORREGULADORA.
ES531814A 1983-04-21 1984-04-18 Procedimiento para la preparacion de nuevos derivados de acidos fenilalcanoicos. Granted ES531814A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58070794A JPS59196839A (ja) 1983-04-21 1983-04-21 フエニル酢酸誘導体

Publications (2)

Publication Number Publication Date
ES8506575A1 true ES8506575A1 (es) 1985-08-01
ES531814A0 ES531814A0 (es) 1985-08-01

Family

ID=13441797

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531814A Granted ES531814A0 (es) 1983-04-21 1984-04-18 Procedimiento para la preparacion de nuevos derivados de acidos fenilalcanoicos.

Country Status (8)

Country Link
US (2) US4595699A (es)
EP (1) EP0123535B1 (es)
JP (1) JPS59196839A (es)
CA (1) CA1230127A (es)
DE (1) DE3460335D1 (es)
DK (1) DK162600C (es)
ES (1) ES531814A0 (es)
FI (1) FI80014C (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6038323A (ja) * 1983-08-10 1985-02-27 Sankyo Co Ltd 眼科用消炎剤
FR2601670B1 (fr) * 1986-07-17 1988-10-07 Cird Nouveaux derives bicycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique
US4748272A (en) * 1986-08-01 1988-05-31 Rorer Pharmaceutical Corp. Phenoxyphenylacetates for use as potential modulators of arichidonic acid pathways
US5179124A (en) * 1988-01-25 1993-01-12 University Of Iowa Research Foundation Anti-inflammatory for use in external and internal eye inflammations
US4968718A (en) * 1988-01-25 1990-11-06 University Of Iowa Research Foundation Topically effective, nonsteroidal drug for use in external and internal eye inflammations
CA2115256A1 (en) * 1991-08-10 1993-02-18 Masaru Saita Phenylalkanoic acid derivatives, process for producing the same and process for separating optical isomers thereof
ES2183140T3 (es) 1996-02-13 2003-03-16 Searle & Co Combinaciones, que tienen efectos inmunosupresores, que contienen un inhibidor de ciclooxigenasa-2 y un inhibidor de leucotrieno a4 hidrolasa.
CA2246265A1 (en) 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations having immunosuppressive effects, containing cyclooxygenase-2-inhibitors and 5-lipoxygenase inhibitors
CA2246356A1 (en) 1996-02-13 1997-08-21 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist
TWI249519B (en) 2000-08-29 2006-02-21 Nobex Corp Immunoregulatory compounds and derivatives and methods of treating diseases therewith
US8048924B2 (en) 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
US7932366B2 (en) 2004-07-07 2011-04-26 Biocon Limited Synthesis of azo bonded immunoregulatory compounds
KR100906478B1 (ko) 2008-01-10 2009-07-08 강원대학교산학협력단 호모알렌일 알코올 유도체와 인듐을 이용한 이의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS584699B2 (ja) * 1977-04-05 1983-01-27 三共株式会社 置換フエニル酢酸誘導体及びその製法
US4161538A (en) * 1977-04-05 1979-07-17 Sankyo Company Limited Substituted phenylacetic acid derivatives and process for the preparation thereof
DD141422A5 (de) * 1978-01-27 1980-04-30 Schering Ag Verfahren zur herstellung von phenylessigsaeure-derivaten
EP0007319B1 (de) * 1978-07-21 1981-09-16 Schering Aktiengesellschaft Neue Indan-1-carbonsäure-Derivate, Verfahren zu ihrer Herstellung, und diese Verbindungen enthaltende pharmazeutische Präparate
AT358018B (de) * 1978-07-28 1980-08-11 Sankyo Co Verfahren zur herstellung von neuen substituierten phenylessigsaeuren und deren nied. alkylestern und salzen
JPS57106617A (en) * 1980-12-23 1982-07-02 Sankyo Co Ltd Analgesic and anti-inflammatory agent

Also Published As

Publication number Publication date
US4595699A (en) 1986-06-17
US4622421A (en) 1986-11-11
FI80014C (fi) 1990-04-10
FI841594A (fi) 1984-10-22
FI841594A0 (fi) 1984-04-19
EP0123535A1 (en) 1984-10-31
ES531814A0 (es) 1985-08-01
JPH0329056B2 (es) 1991-04-23
DK201284A (da) 1984-10-22
EP0123535B1 (en) 1986-07-23
FI80014B (fi) 1989-12-29
DK201284D0 (da) 1984-04-18
CA1230127A (en) 1987-12-08
DK162600C (da) 1992-04-06
JPS59196839A (ja) 1984-11-08
DK162600B (da) 1991-11-18
DE3460335D1 (en) 1986-08-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601