ES8505671A1 - Procedimiento para preparar derivados de acido 7 -(metiltiofluorado) acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)-tiometil-1-destia-1-oxa-3-cefem-4-carboxilico - Google Patents

Procedimiento para preparar derivados de acido 7 -(metiltiofluorado) acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)-tiometil-1-destia-1-oxa-3-cefem-4-carboxilico

Info

Publication number
ES8505671A1
ES8505671A1 ES534289A ES534289A ES8505671A1 ES 8505671 A1 ES8505671 A1 ES 8505671A1 ES 534289 A ES534289 A ES 534289A ES 534289 A ES534289 A ES 534289A ES 8505671 A1 ES8505671 A1 ES 8505671A1
Authority
ES
Spain
Prior art keywords
carboxy
hydrogen
protecting group
hydroxyalkyl
antibacterial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534289A
Other languages
English (en)
Other versions
ES534289A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of ES534289A0 publication Critical patent/ES534289A0/es
Publication of ES8505671A1 publication Critical patent/ES8505671A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE ACIDO 7B-(METILTIO FLUORADO) ACETAMIDO-7A-METOXI-3-1-(2-HIDROXIALQUIL)-1H-TERTRAZOL-5-ILTIOMETIL-1-DESTIA-1-OXA-3-CEFEM-4-CARBOXILICO.CONSISTE EN METOXILAR AL DERIVADO DEL ACIDO 7J-(METILO FLUORADO)-TIOCETAMIDO-3-1-(2-HIDROXIALQUIL)-1H-TETRAZOL-5-ILTIOMETIL-1-DESTIA-1-OXA-3-CEFEM-54-CARBOXILICO DE FORMULA (II), CON UN REACTIVO N-HALOGENANTE Y CON UN AGENTE DE ELIMINACION DE HALURO DE HIDROGENO Y METANOL, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: RFFCH2- O F2CH-; R F 2-HIDROXIALQUILO OPCIONALMENTE PROTEGIDO; Y R, H, UN ATOMO DE METAL LIGERO O UN GRUPO PROTECTOR DE CARBOXI.SE UTILIZAN COMO INHIBIDORES DEL DESARROLLO BACTERIANO EN SERES HUMANOS, ANIMALES Y PLANTAS.
ES534289A 1982-12-23 1984-07-13 Procedimiento para preparar derivados de acido 7 -(metiltiofluorado) acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)-tiometil-1-destia-1-oxa-3-cefem-4-carboxilico Expired ES8505671A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57234472A JPS59139385A (ja) 1982-12-23 1982-12-23 フルオロメチルチオオキサセフアロスポリン

Publications (2)

Publication Number Publication Date
ES534289A0 ES534289A0 (es) 1985-06-01
ES8505671A1 true ES8505671A1 (es) 1985-06-01

Family

ID=16971542

Family Applications (6)

Application Number Title Priority Date Filing Date
ES527595A Granted ES527595A0 (es) 1982-12-23 1983-11-28 Un procedimiento para preparar derivados de acido 7 -(metiltio fluorado)acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)tiometil-1-destia-1-oxa-3-cefem-4-carboxilico
ES534290A Expired ES8505672A1 (es) 1982-12-23 1984-07-13 Procedimiento para preparar derivados de acido 7 -(metiltiofluorado) acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)-tiometil-1-destia-1-oxa-3-cefem-4-carboxilico
ES534291A Expired ES8703458A1 (es) 1982-12-23 1984-07-13 Un procedimiento para preparar acido 7b-(metiltio fluorado)acetamide-7x-metaxi-3--1-(2-hidroxialquil)-ih-tetrazol-5-il- tiometil-1-destia-1-oxa-3-cefem-4-carboxilico.
ES534289A Expired ES8505671A1 (es) 1982-12-23 1984-07-13 Procedimiento para preparar derivados de acido 7 -(metiltiofluorado) acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)-tiometil-1-destia-1-oxa-3-cefem-4-carboxilico
ES534288A Expired ES8505670A1 (es) 1982-12-23 1984-07-13 Procedimiento para preparar derivados de acido 7 -(metiltiofluorado) acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)-tiometil-1-destia-1-oxa-3-cefem-4-carboxilico
ES556846A Expired ES8708227A1 (es) 1982-12-23 1986-07-01 Un procedimiento para preparar acido 7beta-(metiltio-fluorado)acetamido-7alfa-metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)tiometil-1-destia-1-oxa-3-cefem-4-carboxilico.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES527595A Granted ES527595A0 (es) 1982-12-23 1983-11-28 Un procedimiento para preparar derivados de acido 7 -(metiltio fluorado)acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)tiometil-1-destia-1-oxa-3-cefem-4-carboxilico
ES534290A Expired ES8505672A1 (es) 1982-12-23 1984-07-13 Procedimiento para preparar derivados de acido 7 -(metiltiofluorado) acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)-tiometil-1-destia-1-oxa-3-cefem-4-carboxilico
ES534291A Expired ES8703458A1 (es) 1982-12-23 1984-07-13 Un procedimiento para preparar acido 7b-(metiltio fluorado)acetamide-7x-metaxi-3--1-(2-hidroxialquil)-ih-tetrazol-5-il- tiometil-1-destia-1-oxa-3-cefem-4-carboxilico.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES534288A Expired ES8505670A1 (es) 1982-12-23 1984-07-13 Procedimiento para preparar derivados de acido 7 -(metiltiofluorado) acetamido-7 -metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)-tiometil-1-destia-1-oxa-3-cefem-4-carboxilico
ES556846A Expired ES8708227A1 (es) 1982-12-23 1986-07-01 Un procedimiento para preparar acido 7beta-(metiltio-fluorado)acetamido-7alfa-metoxi-3-(1-(2-hidroxialquil)-1h-tetrazol-5-il)tiometil-1-destia-1-oxa-3-cefem-4-carboxilico.

Country Status (26)

Country Link
US (1) US4532233A (es)
JP (1) JPS59139385A (es)
KR (1) KR890000095B1 (es)
AT (1) AT383807B (es)
AU (1) AU558547B2 (es)
BE (1) BE898541A (es)
CA (1) CA1236099A (es)
CH (1) CH656619A5 (es)
DE (1) DE3345989A1 (es)
DK (1) DK159447C (es)
ES (6) ES527595A0 (es)
FI (1) FI74016C (es)
FR (1) FR2538391B1 (es)
GB (1) GB2132198B (es)
HK (1) HK89988A (es)
HU (1) HU189014B (es)
IE (1) IE56401B1 (es)
IL (1) IL70488A (es)
IT (1) IT1160238B (es)
NL (1) NL192740C (es)
NO (1) NO167740C (es)
NZ (1) NZ206413A (es)
PH (1) PH19352A (es)
PT (1) PT77831B (es)
SE (2) SE461527B (es)
ZA (1) ZA838920B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6045514A (ja) * 1983-08-22 1985-03-12 Shionogi & Co Ltd 安定な抗菌性凍結乾燥製剤
JP2004168775A (ja) * 2002-11-08 2004-06-17 Orchid Chemicals & Pharmaceuticals Ltd オキサセファロスポリンの改良合成法
TWI338008B (en) * 2004-02-20 2011-03-01 Shionogi & Co Crystal of oxacephem
JP2009530268A (ja) * 2006-03-15 2009-08-27 カルテージア， エッセ ア エッセ ディ エマヌエーラ ミリアヴァッカ エ コンパニーア （１−オキサ−又は１−チア−）３−セフェム誘導体及び関連する中間体の調製方法
CN102952149B (zh) * 2012-11-09 2015-06-24 浙江新和成股份有限公司 一种氟氧头孢中间体的一锅合成法
KR101314500B1 (ko) * 2012-12-28 2013-10-07 제일약품주식회사 안정성이 개선된 옥사세펨 제제 및 그 제조방법
CN103524534B (zh) * 2013-09-02 2016-08-17 上海龙翔生物医药开发有限公司 氟氧头孢钠的制备方法
CN104327100B (zh) * 2014-09-30 2016-09-28 华北制药河北华民药业有限责任公司 高纯度氟氧头孢钠制备工艺
CN105399755B (zh) * 2015-11-03 2018-05-11 浙江永宁药业股份有限公司 一种氟氧头孢酸的合成方法
CN105801601B (zh) * 2016-04-02 2018-01-26 丽珠医药集团股份有限公司 一种氟氧头孢钠合成方法
CN108424418A (zh) * 2017-02-15 2018-08-21 山东致纯医药科技有限公司 一种氟氧头孢钠杂质
KR102115644B1 (ko) * 2017-09-13 2020-05-27 주식회사 동도물산 7α-알콕시옥사세펨 중간체의 제조방법
CN110028522A (zh) * 2019-04-22 2019-07-19 山西千岫制药有限公司 一种氟氧头孢母核的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
JPS5690088A (en) * 1979-11-02 1981-07-21 Meiji Seika Kaisha Ltd Novel cephalosporin analog compound
JPS56103185A (en) * 1980-01-22 1981-08-18 Shionogi & Co Ltd Malonamidoxa-dethia-cephem compound

Also Published As

Publication number Publication date
CA1259989C (es) 1989-09-26
PT77831B (en) 1986-03-26
IT8368343A0 (it) 1983-12-22
FI74016C (fi) 1987-12-10
FI74016B (fi) 1987-08-31
KR890000095B1 (ko) 1989-03-07
FI834682A0 (fi) 1983-12-19
AU2211383A (en) 1984-06-28
ES534288A0 (es) 1985-06-01
NO167740B (no) 1991-08-26
ES8506024A1 (es) 1985-06-16
ES534289A0 (es) 1985-06-01
GB2132198A (en) 1984-07-04
FR2538391B1 (fr) 1986-12-19
DE3345989A1 (de) 1984-06-28
ES556846A0 (es) 1987-10-01
IL70488A (en) 1988-03-31
JPS59139385A (ja) 1984-08-10
IE832951L (en) 1984-06-23
GB2132198B (en) 1986-10-01
DK589583D0 (da) 1983-12-21
DK159447C (da) 1991-04-08
ES8703458A1 (es) 1987-02-16
HUT34200A (en) 1985-02-28
IL70488A0 (en) 1984-03-30
AT383807B (de) 1987-08-25
FI834682A (fi) 1984-06-24
NL192740B (nl) 1997-09-01
FR2538391A1 (fr) 1984-06-29
SE461527B (sv) 1990-02-26
HK89988A (en) 1988-11-11
ES8505670A1 (es) 1985-06-01
NO167740C (no) 1991-12-04
ES527595A0 (es) 1985-06-16
KR840007007A (ko) 1984-12-04
DE3345989C2 (es) 1992-09-24
IE56401B1 (en) 1991-07-17
IT1160238B (it) 1987-03-04
DK159447B (da) 1990-10-15
SE470132B (sv) 1993-11-15
ES8708227A1 (es) 1987-10-01
SE8802008L (sv) 1988-05-30
PT77831A (en) 1984-01-01
NL192740C (nl) 1998-01-06
SE8307079L (sv) 1984-06-24
CA1236099A (en) 1988-05-03
ES534291A0 (es) 1987-02-16
NL8304409A (nl) 1984-07-16
SE8802008D0 (sv) 1988-05-30
SE8307079D0 (sv) 1983-12-21
DK589583A (da) 1984-06-24
AU558547B2 (en) 1987-02-05
ES534290A0 (es) 1985-06-01
BE898541A (fr) 1984-04-16
HU189014B (en) 1986-06-30
PH19352A (en) 1986-04-02
US4532233A (en) 1985-07-30
GB8333186D0 (en) 1984-01-18
ZA838920B (en) 1984-07-25
CH656619A5 (de) 1986-07-15
ES8505672A1 (es) 1985-06-01
ATA446883A (de) 1987-01-15
JPS6225671B2 (es) 1987-06-04
NZ206413A (en) 1986-05-09
NO834729L (no) 1984-06-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050322