ES8505482A1 - Tumour imaging with radiolabelled monoclonal antibodies - Google Patents

Tumour imaging with radiolabelled monoclonal antibodies

Info

Publication number
ES8505482A1
ES8505482A1 ES529310A ES529310A ES8505482A1 ES 8505482 A1 ES8505482 A1 ES 8505482A1 ES 529310 A ES529310 A ES 529310A ES 529310 A ES529310 A ES 529310A ES 8505482 A1 ES8505482 A1 ES 8505482A1
Authority
ES
Spain
Prior art keywords
monoclonal antibodies
tumour
tumour imaging
radiolabelled monoclonal
radiolabelled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529310A
Other languages
Spanish (es)
Other versions
ES529310A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
University of California
Original Assignee
Hybritech Inc
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc, University of California filed Critical Hybritech Inc
Publication of ES529310A0 publication Critical patent/ES529310A0/en
Publication of ES8505482A1 publication Critical patent/ES8505482A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1066—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Monoclonal antibodies to tumour associated antigens have bound to them a metallic radionuclide, either directly or by means of a chelating agent such as diethylenetriaminepentaacetic acid (DTPA) conjugated to the antibody. When parenterally administered to a subject, the labelled monoclonal antibody localizes in the tumour and can be detected by photoscanning to detect emitted radiation.
ES529310A 1981-10-27 1984-01-31 Tumour imaging with radiolabelled monoclonal antibodies Expired ES8505482A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31528681A 1981-10-27 1981-10-27

Publications (2)

Publication Number Publication Date
ES529310A0 ES529310A0 (en) 1985-05-16
ES8505482A1 true ES8505482A1 (en) 1985-05-16

Family

ID=23223718

Family Applications (2)

Application Number Title Priority Date Filing Date
ES516797A Granted ES516797A0 (en) 1981-10-27 1982-10-25 A PROCEDURE FOR PREPARING A MONOCLONAL ANTIBODY FOR AN ANTIGEN ASSOCIATED WITH A TUMOR.
ES529310A Expired ES8505482A1 (en) 1981-10-27 1984-01-31 Tumour imaging with radiolabelled monoclonal antibodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES516797A Granted ES516797A0 (en) 1981-10-27 1982-10-25 A PROCEDURE FOR PREPARING A MONOCLONAL ANTIBODY FOR AN ANTIGEN ASSOCIATED WITH A TUMOR.

Country Status (18)

Country Link
JP (1) JPS58135820A (en)
AT (1) AT392004B (en)
BE (1) BE894829A (en)
CA (1) CA1202892A (en)
CH (1) CH653040A5 (en)
DE (1) DE3239410A1 (en)
DK (1) DK164682C (en)
ES (2) ES516797A0 (en)
FI (1) FI82379C (en)
FR (1) FR2515046B1 (en)
GB (1) GB2109407B (en)
IL (1) IL67068A0 (en)
IT (1) IT1153857B (en)
LU (1) LU84441A1 (en)
NL (1) NL8204108A (en)
NO (1) NO169947C (en)
SE (1) SE8206073L (en)
ZA (1) ZA827806B (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
CA1225930A (en) * 1982-06-07 1987-08-25 Otto A. Gansow Metal chelate conjugated monoclonal antibodies
US4741900A (en) * 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
GB2139645A (en) * 1983-04-08 1984-11-14 Kureha Chemical Ind Co Ltd Antibody to human prostrate cancer
GB2140030A (en) * 1983-04-08 1984-11-21 Kureha Chemical Ind Co Ltd Monoclonal antibody to human urinary bladder cancer
JPS59199636A (en) * 1983-04-26 1984-11-12 Nippon Mejifuijitsukusu Kk Radioactive diagnostic agent and production thereof
US4677058A (en) * 1983-05-19 1987-06-30 Karl Tryggvason Detecting malignant cells with monoclonal antibodies specific to type IV collagenase enzyme
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
JPS60201260A (en) * 1984-03-27 1985-10-11 Yamasa Shoyu Co Ltd Myocardial myosin diagnosing agent
JP2507982B2 (en) * 1984-04-10 1996-06-19 武田薬品工業株式会社 Method for producing human carcinoembryonic antigen-reactive monoclonal antibody
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4837003A (en) * 1984-09-13 1989-06-06 Mallinckrodt, Inc. Radiolabeled antibody fragments
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US5242679A (en) * 1985-01-14 1993-09-07 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4986256A (en) * 1985-02-28 1991-01-22 The United States Of America As Represented By The Department Of Health And Human Services Use of paramagnetic metalloporphyrins as contrast agents for tumors in MRI imaging
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US4830847A (en) * 1985-06-28 1989-05-16 The Procter & Gamble Company Diphosphonate-derivatized macromolecules
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US5082930A (en) * 1986-05-29 1992-01-21 Mallinckrodt Medical, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US4925804A (en) * 1986-06-17 1990-05-15 Baxter International Inc. Interligand metal transfer assay
US4831175A (en) * 1986-09-05 1989-05-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
US5246692A (en) * 1986-09-05 1993-09-21 The United States Of America As Represented By The Secretary Of Health And Human Services Backbone polysubstituted chelates for forming a metal chelate-protein conjugate
FR2604092B1 (en) * 1986-09-19 1990-04-13 Immunotech Sa IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO
CA1340014C (en) * 1986-10-27 1998-08-25 Bryan Michael Longenecker Carcinoma-marking monoclonal antibodies elicited with synthetic asialo-gmi antigen
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
DE3710730A1 (en) * 1987-03-31 1988-10-20 Schering Ag SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5177192A (en) * 1987-04-02 1993-01-05 Centocor, Incorporated Method for labeling antibodies with a metal ion
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
US4838274A (en) * 1987-09-18 1989-06-13 Air Products And Chemicals, Inc. Perfluoro-crown ethers in fluorine magnetic resonance imaging
US5217704A (en) * 1987-11-06 1993-06-08 Abbott Laboratories Methods and materials for the preparation of metal labelled antibody solutions
US5648471A (en) * 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
US4867962A (en) * 1988-02-26 1989-09-19 Neorx Corporation Functionally specific antibodies
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5688488A (en) * 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
EP0955066A3 (en) * 1992-07-31 2002-08-28 Australian Nuclear Science And Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
US5807535A (en) * 1992-07-31 1998-09-15 Australian Nuclear Science & Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
US6663866B1 (en) 1996-08-28 2003-12-16 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4323546A (en) * 1978-05-22 1982-04-06 Nuc Med Inc. Method and composition for cancer detection in humans
US4272503A (en) * 1978-05-25 1981-06-09 New England Nuclear Corporation Reductant composition for technetium-99m and method for making technetium-99m labelled ligands
US4311688A (en) * 1979-10-29 1982-01-19 Serono Laboratories Inc. Composition and method for cancer detection in humans
WO1981002522A1 (en) * 1980-03-03 1981-09-17 M Goldenberg Tumor localization and therapy with labeled antibodies and antibody fragments specific to tumor-associated markers

Also Published As

Publication number Publication date
NO823530L (en) 1983-04-28
NO169947B (en) 1992-05-18
FI82379C (en) 1991-03-11
ES529310A0 (en) 1985-05-16
LU84441A1 (en) 1983-06-13
DE3239410C2 (en) 1991-12-19
IL67068A0 (en) 1983-02-23
DK164682C (en) 1992-12-21
NL8204108A (en) 1983-05-16
ATA391682A (en) 1990-07-15
AT392004B (en) 1991-01-10
DK164682B (en) 1992-08-03
GB2109407A (en) 1983-06-02
GB2109407B (en) 1985-12-18
DE3239410A1 (en) 1983-05-19
CH653040A5 (en) 1985-12-13
SE8206073L (en) 1983-04-28
FR2515046B1 (en) 1985-11-29
ES8404857A1 (en) 1984-05-16
FR2515046A1 (en) 1983-04-29
DK474182A (en) 1983-04-28
CA1202892A (en) 1986-04-08
IT1153857B (en) 1987-01-21
ZA827806B (en) 1983-08-31
FI823633A0 (en) 1982-10-25
FI823633L (en) 1983-04-28
NO169947C (en) 1992-08-26
SE8206073D0 (en) 1982-10-26
FI82379B (en) 1990-11-30
BE894829A (en) 1983-02-14
IT8223932A0 (en) 1982-10-26
ES516797A0 (en) 1984-05-16
JPS58135820A (en) 1983-08-12
JPH0564130B2 (en) 1993-09-14

Similar Documents

Publication Publication Date Title
ES8505482A1 (en) Tumour imaging with radiolabelled monoclonal antibodies
EP0778849A4 (en) Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
ZA805813B (en) Composition and method for cancer detection in humans
EP0270340A3 (en) Detection of necrotic malignant tissue ansd associated therapy
GB8719042D0 (en) Conjugate compounds
KR920700690A (en) Radiation immunotherapeutics using α-particle release
DE3578625D1 (en) RADIOACTIVELY MARKED ANTIBODY PIECES.
MY104946A (en) Antigen antibody conjugate.
NO860938L (en) MONOCLONAL ANTIBODIES AGAINST METAL CHELATES.
ATE79372T1 (en) MARKED ANTIBODY FRAGMENTS.
GB8519457D0 (en) Tumour imaging agents
ES8609731A1 (en) Sialylated lewis X epitope, antibodies and diagnosis.
ES445768A1 (en) Diagnostic reagent system
EP0327389A3 (en) Tumour imaging
Grassi et al. Radioiodination and other labeling techniques
ES8401261A1 (en) Procedure for immunological determinations using two antibodies, the second antibody being purified by affinity chromatography, and supports therefor.
Wang et al. Heterobifunctional reagents: A new approach to radiolabeling of monoclonal antibodies
Mohd FRAGMENTATION, LABELING AND BIODISTRIBUTION STUDIES OF KS1/4, A MONOCLONAL ANTIBODY.
JPS57163319A (en) Preparation of antibody
Paik et al. Method of stably radiolabeling antibodies with technetium and rhenium
JPS52151725A (en) Diagnostic reagent for neoplasm
JPS5340578A (en) Analyzer for charged particle ray.s energy
JPS53124613A (en) Preparation of anti-ursodeoxycholic acid antibody, and detection reagent containing the same
Zabel Radioiodinated anti-T antibodies and peanut lectin for detection of T antigen expressing tumours
EP0273754A3 (en) Method of enhancing the biodistribution of antibody for localization in lesions

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980302