ES8504822A1 - Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado - Google Patents

Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado

Info

Publication number
ES8504822A1
ES8504822A1 ES531061A ES531061A ES8504822A1 ES 8504822 A1 ES8504822 A1 ES 8504822A1 ES 531061 A ES531061 A ES 531061A ES 531061 A ES531061 A ES 531061A ES 8504822 A1 ES8504822 A1 ES 8504822A1
Authority
ES
Spain
Prior art keywords
preparation
alkyl
formula
useful
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531061A
Other languages
English (en)
Other versions
ES531061A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8300454A external-priority patent/FR2539417A1/fr
Priority claimed from FR8300453A external-priority patent/FR2541280B1/fr
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of ES531061A0 publication Critical patent/ES531061A0/es
Publication of ES8504822A1 publication Critical patent/ES8504822A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55Acids; Esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/041,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/061,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL PIRROLO ORTOCONDENSADO Y DE SUS SALES DE ADICION DE ACIDOS, DE FORMULA (I), EN LA QUE A, R, R1 Y R2 PUEDEN SER VARIOS RADICALES; Y M Y N VALEN 1 O 2 Y 0-2, RESPECTIVAMENTE.CONSISTE EN LA REACCION DE UN HALOGENURO DE FORMULA R2Z CON UN COMPUESTO DE FORMULA (II), EN LAS QUE Z ES UN HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), SEGUIDA DE LA SEPARACION DEL PRODUCTO OBTENIDO.ESTOS COMPUESTOS TIENEN APLICACIONES COMO INTERMEDIOS PARA LA PREPARACION DE MEDICAMENTOS.
ES531061A 1983-01-13 1984-03-28 Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado Expired ES8504822A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8300454A FR2539417A1 (fr) 1983-01-13 1983-01-13 Nouveaux pyrrolo-1, 2 heterocycles, leur preparation et les medicaments qui les contiennent
FR8300453A FR2541280B1 (fr) 1983-01-13 1983-01-13 Nouveaux derives du 1h, 3h-pyrrolo (1,2c) thiazolecarboxamide-7, leur preparation et les medicaments qui les contiennent

Publications (2)

Publication Number Publication Date
ES531061A0 ES531061A0 (es) 1985-04-16
ES8504822A1 true ES8504822A1 (es) 1985-04-16

Family

ID=26223238

Family Applications (3)

Application Number Title Priority Date Filing Date
ES528875A Granted ES528875A0 (es) 1983-01-13 1984-01-13 Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado
ES531061A Expired ES8504822A1 (es) 1983-01-13 1984-03-28 Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado
ES531060A Granted ES531060A0 (es) 1983-01-13 1984-03-28 Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES528875A Granted ES528875A0 (es) 1983-01-13 1984-01-13 Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES531060A Granted ES531060A0 (es) 1983-01-13 1984-03-28 Procedimiento para la preparacion de un nuevo derivado del pirrolo ortocondensado

Country Status (21)

Country Link
US (1) US4539400A (es)
EP (1) EP0124384B1 (es)
KR (1) KR910001285B1 (es)
AU (1) AU562833B2 (es)
BG (3) BG37839A3 (es)
CA (1) CA1221366A (es)
DD (1) DD216021A5 (es)
DE (1) DE3465199D1 (es)
DK (1) DK14084A (es)
ES (3) ES528875A0 (es)
FI (1) FI80457C (es)
GR (1) GR81681B (es)
HU (3) HU193276B (es)
IE (1) IE56840B1 (es)
IL (1) IL70665A (es)
MA (1) MA20003A1 (es)
NO (1) NO167205C (es)
NZ (1) NZ206808A (es)
PL (2) PL142254B1 (es)
PT (1) PT77953B (es)
SU (1) SU1277899A3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557111B1 (fr) * 1983-12-21 1986-04-11 Rhone Poulenc Sante Nouveaux derives ortho-condenses du pyrrole, leur preparation et les medicaments qui les contiennent
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
EP0479951A4 (en) * 1989-06-26 1992-12-09 The Research Foundation Of State University Of New York Bis-acyloxymethyl derivatives
DE4419246A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Heteroarylsubstituierte Pyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419315A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie
DE4419247A1 (de) * 1994-06-01 1995-12-07 Merckle Gmbh Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie
DE10004157A1 (de) * 2000-02-01 2001-08-02 Merckle Gmbh Chem Pharm Fabrik 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1401707A (fr) * 1963-07-03 1965-06-04 Kodak Pathe Nouveaux colorants, nouveaux composés intermédiaires servant à les préparer et produits photographiques les contenant
US3544590A (en) * 1967-04-28 1970-12-01 Exxon Research Engineering Co Cyclic amines and the process for their formation
US3642807A (en) * 1970-06-18 1972-02-15 Schering Corp Certain 1-/dilower-alkyl amino-loweralkyl/-2-phenyl indolizines and quaternary salts thereof
US3865839A (en) * 1973-03-01 1975-02-11 Hoechst Co American Thiopyranopyrrolylsalicyclic acids and derivatives thereof

Also Published As

Publication number Publication date
PT77953A (fr) 1984-02-01
CA1221366A (fr) 1987-05-05
NZ206808A (en) 1986-04-11
NO167205C (no) 1991-10-23
MA20003A1 (fr) 1984-10-01
FI80457B (fi) 1990-02-28
PT77953B (fr) 1986-06-11
EP0124384B1 (fr) 1987-08-05
BG37840A3 (en) 1985-08-15
ES8501770A1 (es) 1984-12-01
AU562833B2 (en) 1987-06-18
HU193276B (en) 1987-09-28
PL142254B1 (en) 1987-10-31
BG37996A3 (en) 1985-09-16
AU2320384A (en) 1984-07-19
HUT34192A (en) 1985-02-28
EP0124384A1 (fr) 1984-11-07
PL251306A1 (en) 1985-09-24
ES8407059A1 (es) 1984-09-01
HU196216B (en) 1988-10-28
US4539400A (en) 1985-09-03
IL70665A0 (en) 1984-04-30
FI80457C (fi) 1990-06-11
IE840065L (en) 1984-07-13
NO167205B (no) 1991-07-08
GR81681B (es) 1984-12-12
FI840108A (fi) 1984-07-14
SU1277899A3 (ru) 1986-12-15
IL70665A (en) 1987-08-31
ES531061A0 (es) 1985-04-16
DK14084D0 (da) 1984-01-12
HU196215B (en) 1988-10-28
PL142255B1 (en) 1987-10-31
PL251305A1 (en) 1985-09-24
NO840108L (no) 1984-07-16
ES528875A0 (es) 1984-09-01
IE56840B1 (en) 1992-01-01
ES531060A0 (es) 1984-12-01
DK14084A (da) 1984-07-14
DD216021A5 (de) 1984-11-28
DE3465199D1 (en) 1987-09-10
KR840007417A (ko) 1984-12-07
KR910001285B1 (ko) 1991-02-28
FI840108A0 (fi) 1984-01-12
BG37839A3 (en) 1985-08-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612